flinderole-a has been researched along with Malaria* in 1 studies
1 other study(ies) available for flinderole-a and Malaria
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Indole based antimalarial compounds targeting the melatonin pathway: Their design, synthesis and biological evaluation.
Malaria, one of the most severe global diseases, infects nearly 300 million people causing death of about a million population annually. Herein we have reported design, synthesis and biological evaluation of potent antimalarial compounds that target melatonin hormone as a potential pathway for the inhibition of the parasite proliferation. The molecular design is based on melatonin and indole based synthetic and natural antimalarial agents. The library of compounds was accessed via an iodine catalyzed one pot organocatalytic ring opening of 1-aryltetrahydro-β-carbolines followed by in situ imination of the resulting C Topics: Antimalarials; Dose-Response Relationship, Drug; Drug Design; Indoles; Malaria; Melatonin; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Receptor, Melatonin, MT1; Structure-Activity Relationship | 2019 |