fleroxacin has been researched along with Staphylococcal Infections in 9 studies
Fleroxacin: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
fleroxacin : A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.
Staphylococcal Infections: Infections with bacteria of the genus STAPHYLOCOCCUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a multicenter, randomized trial, we compared the efficacy, safety, and length of hospital stay for patients with staphylococcal infections treated either with an oral combination of a fluoroquinolone (fleroxacin) plus rifampicin or with standard parenteral treatment (flucloxacillin or vancomycin)." | 5.11 | A randomized clinical trial to compare fleroxacin-rifampicin with flucloxacillin or vancomycin for the treatment of staphylococcal infection. ( Bregenzer, T; Flueckiger, U; Francioli, P; Genné, D; Harbarth, S; Jacobs, F; Lew, DP; Petignat, C; Schockmel, G; Schrenzel, J; Zimmerli, W, 2004) |
| "Fleroxacin elimination was slightly increased (about 15%) through induction of metabolic clearance to N-demethyl-fleroxacin." | 1.29 | Influence of rifampin on fleroxacin pharmacokinetics. ( Dayer, P; Leemann, T; Lew, DP; Portmann, R; Schrenzel, J; Weidekamm, E, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schrenzel, J | 2 |
| Harbarth, S | 1 |
| Schockmel, G | 1 |
| Genné, D | 1 |
| Bregenzer, T | 1 |
| Flueckiger, U | 1 |
| Petignat, C | 1 |
| Jacobs, F | 1 |
| Francioli, P | 1 |
| Zimmerli, W | 1 |
| Lew, DP | 6 |
| Dayer, P | 1 |
| Leemann, T | 1 |
| Weidekamm, E | 1 |
| Portmann, R | 1 |
| Georgopoulos, A | 1 |
| Feistauer, SM | 1 |
| Graninger, W | 1 |
| Pfleger, S | 1 |
| Georgopoulos, M | 1 |
| Chuard, C | 2 |
| Herrmann, M | 3 |
| Vaudaux, P | 1 |
| Waldvogel, FA | 4 |
| Lucet, JC | 2 |
| Rohner, P | 2 |
| Auckenthaler, R | 2 |
| Kaatz, GW | 2 |
| Seo, SM | 2 |
| Barriere, SL | 2 |
| Albrecht, LM | 2 |
| Rybak, MJ | 2 |
| Bouchenaki, N | 1 |
| Vaudaux, PE | 1 |
| Huggler, E | 1 |
1 trial available for fleroxacin and Staphylococcal Infections
| Article | Year |
|---|---|
A randomized clinical trial to compare fleroxacin-rifampicin with flucloxacillin or vancomycin for the treatment of staphylococcal infection.
Topics: Administration, Oral; Adult; Aged; Bacteremia; Catheters, Indwelling; Drug Therapy, Combination; Fem | 2004 |
8 other studies available for fleroxacin and Staphylococcal Infections
| Article | Year |
|---|---|
Influence of rifampin on fleroxacin pharmacokinetics.
Topics: Adult; Anti-Bacterial Agents; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug | 1993 |
Antibacterial activity of sparfloxacin against experimental renal infections in mice.
Topics: Abscess; Animals; Anti-Infective Agents; Ciprofloxacin; Escherichia coli Infections; Female; Fleroxa | 1992 |
Successful therapy of experimental chronic foreign-body infection due to methicillin-resistant Staphylococcus aureus by antimicrobial combinations.
Topics: Animals; Cells, Cultured; Chronic Disease; Drug Interactions; Drug Therapy, Combination; Fleroxacin; | 1991 |
Resistance of Staphylococcus aureus recovered from infected foreign body in vivo to killing by antimicrobials.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Diffusion Chambers, Culture; D | 1991 |
Development of resistance to fleroxacin during therapy of experimental methicillin-susceptible Staphylococcus aureus endocarditis.
Topics: Animals; Drug Resistance, Microbial; Endocarditis, Bacterial; Fleroxacin; Male; Methicillin; Methici | 1991 |
Successful single-dose prophylaxis of Staphylococcus aureus foreign body infections in guinea pigs by fleroxacin.
Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Fleroxacin; Foreign Bodies; Guinea Pigs; Microbial Se | 1990 |
Treatment of experimental foreign body infection caused by methicillin-resistant Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Disease Models, Animal; Drug Therapy, Combination; Fl | 1990 |
Efficacy of fleroxacin in experimental methicillin-resistant Staphylococcus aureus endocarditis.
Topics: Animals; Ciprofloxacin; Drug Resistance, Microbial; Endocarditis, Bacterial; Fleroxacin; Male; Methi | 1989 |