fleroxacin has been researched along with Seizures in 4 studies
Fleroxacin: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
fleroxacin : A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical risk of convulsion for each combination was estimated using a pharmacodynamic model based on receptor occupancy using the in vitro data set obtained and pharmacokinetic parameters in humans collected from the literature." | 1.35 | Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents. ( Kim, J; Ohtani, H; Sawada, Y; Tsujimoto, M, 2009) |
| "Convulsant activity of pazufloxacin mesilate (PZFX mesilate), a new quinolone antibacterial agent for intravenous use, in combination with nonsteroidal anti-inflammatory drug (NSAID) was investigated in mice after intravenous or intracerebroventricular administration." | 1.31 | [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration]. ( Fukuda, H; Kawamura, Y, 2002) |
| "No convulsion was evoked in mice at high oral combination doses of fleroxacin and fenbufen." | 1.28 | Possibility for induction of convulsion by fleroxacin and its disposition in the central nervous system in animals. ( Hori, S; Kawahara, F; Kobayashi, F; Ooie, T; Saito, S; Sakai, O; Shimada, J; Taga, F; Uchida, H, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, J | 1 |
| Ohtani, H | 1 |
| Tsujimoto, M | 1 |
| Sawada, Y | 1 |
| Fukuda, H | 1 |
| Kawamura, Y | 1 |
| Christ, W | 1 |
| Taga, F | 1 |
| Kobayashi, F | 1 |
| Saito, S | 1 |
| Ooie, T | 1 |
| Kawahara, F | 1 |
| Uchida, H | 1 |
| Shimada, J | 1 |
| Hori, S | 1 |
| Sakai, O | 1 |
4 other studies available for fleroxacin and Seizures
| Article | Year |
|---|---|
Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Cipr | 2009 |
[Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration].
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agent | 2002 |
Central nervous system toxicity of quinolones: human and animal findings.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System; Cip | 1990 |
Possibility for induction of convulsion by fleroxacin and its disposition in the central nervous system in animals.
Topics: Animals; Brain; Central Nervous System; Ciprofloxacin; Cisterna Magna; Dogs; Fleroxacin; In Vitro Te | 1990 |