Page last updated: 2024-10-27

fleroxacin and Escherichia coli Infections

fleroxacin has been researched along with Escherichia coli Infections in 7 studies

Fleroxacin: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
fleroxacin : A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.

Escherichia coli Infections: Infections with bacteria of the species ESCHERICHIA COLI.

Research Excerpts

ExcerptRelevanceReference
"A clinical study was conducted on fleroxacin (FLRX) in 143 patients and carriers with infectious enteritis (shigellosis, Salmonella enteritis, Campylobacter enteritis, pathogenic Escherichia coli enteritis, Vibrio parahaemolyticus enteritis, cholera, multiple bacterial infections, pathogen-negative enteritis)."9.07[Basic and clinical studies of fleroxacin on infectious enteritis. Research Group of AM-833 on infectious enteritis]. ( Ajisawa, A; Masuda, G; Murata, M; Negishi, M; Nitta, Y; Sagara, H; Takizawa, Y; Tomizawa, I; Tsunoda, T; Yamaguchi, T, 1994)
"A clinical study was conducted on fleroxacin (FLRX) in 143 patients and carriers with infectious enteritis (shigellosis, Salmonella enteritis, Campylobacter enteritis, pathogenic Escherichia coli enteritis, Vibrio parahaemolyticus enteritis, cholera, multiple bacterial infections, pathogen-negative enteritis)."5.07[Basic and clinical studies of fleroxacin on infectious enteritis. Research Group of AM-833 on infectious enteritis]. ( Ajisawa, A; Masuda, G; Murata, M; Negishi, M; Nitta, Y; Sagara, H; Takizawa, Y; Tomizawa, I; Tsunoda, T; Yamaguchi, T, 1994)
" A rabbit model of CAUTI using a closed urinary catheter drainage system and the mutant strain of Escherichia coli (WE 6933) were used to examine three dosage regimens (30 mg/kg q8h i."1.29Therapeutic efficacy of fleroxacin for eliminating catheter-associated urinary tract infection in a rabbit model. ( Cleeland, R; Costerton, JW; Lam, K; McKay, SG; Morck, DW; Olson, ME; Prosser, B, 1993)
"[18F]fleroxacin was synthesized and shown to be identical physically, chemically, and in its antimicrobial activity to the commercially produced product."1.29Pharmacokinetics of fleroxacin as studied by positron emission tomography and [18F]fleroxacin. ( Alpert, NM; Babich, J; Callahan, RJ; Cleeland, R; Correia, JA; Liu, YY; Livni, E; Prosser, B; Rubin, RH; Tham, E, 1993)
"Fleroxacin was more potent than norfloxacin."1.27Comparative activities of norfloxacin and fleroxacin in experimental infections due to Salmonella typhimurium and Escherichia coli. ( Fabrig, J; Hof, H, 1988)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's6 (85.71)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Albrecht, HA1
Beskid, G1
Chan, KK1
Christenson, JG1
Cleeland, R4
Deitcher, KH1
Georgopapadakou, NH1
Keith, DD1
Pruess, DL1
Sepinwall, J1
Sagara, H1
Tomizawa, I1
Takizawa, Y1
Nitta, Y1
Tsunoda, T1
Yamaguchi, T1
Masuda, G1
Negishi, M1
Ajisawa, A1
Murata, M1
Morck, DW1
Olson, ME1
McKay, SG1
Lam, K1
Prosser, B2
Costerton, JW1
Rubin, RH1
Livni, E2
Babich, J2
Alpert, NM2
Liu, YY2
Tham, E1
Callahan, RJ2
Correia, JA2
Georgopoulos, A1
Feistauer, SM1
Graninger, W1
Pfleger, S1
Georgopoulos, M1
Fischman, AJ1
Thom, E1
Prosser, BL1
Hof, H1
Fabrig, J1

Trials

1 trial available for fleroxacin and Escherichia coli Infections

ArticleYear
[Basic and clinical studies of fleroxacin on infectious enteritis. Research Group of AM-833 on infectious enteritis].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 1994, Volume: 68, Issue:11

    Topics: Adolescent; Adult; Aged; Campylobacter Infections; Drug Administration Schedule; Dysentery, Bacillar

1994

Other Studies

6 other studies available for fleroxacin and Escherichia coli Infections

ArticleYear
Cephalosporin 3'-quinolone esters with a dual mode of action.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: Animals; Anti-Infective Agents; Cefotaxime; Cephalosporins; Chemical Phenomena; Chemistry; Ciproflox

1990
Therapeutic efficacy of fleroxacin for eliminating catheter-associated urinary tract infection in a rabbit model.
    The American journal of medicine, 1993, Mar-22, Volume: 94, Issue:3A

    Topics: Animals; Catheters, Indwelling; Disease Models, Animal; Escherichia coli Infections; Fleroxacin; Mal

1993
Pharmacokinetics of fleroxacin as studied by positron emission tomography and [18F]fleroxacin.
    The American journal of medicine, 1993, Mar-22, Volume: 94, Issue:3A

    Topics: Animals; Escherichia coli Infections; Fleroxacin; Fluorine Radioisotopes; Male; Mice; Muscular Disea

1993
Antibacterial activity of sparfloxacin against experimental renal infections in mice.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:2

    Topics: Abscess; Animals; Anti-Infective Agents; Ciprofloxacin; Escherichia coli Infections; Female; Fleroxa

1992
Pharmacokinetics of 18F-labeled fleroxacin in rabbits with Escherichia coli infections, studied with positron emission tomography.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:10

    Topics: Animals; Escherichia coli Infections; Fleroxacin; Male; Mice; Rabbits; Rats; Rats, Sprague-Dawley; S

1992
Comparative activities of norfloxacin and fleroxacin in experimental infections due to Salmonella typhimurium and Escherichia coli.
    The Journal of antimicrobial chemotherapy, 1988, Volume: 22 Suppl D

    Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Escherichia coli Infections; Female; Fleroxacin; Mice

1988