fleroxacin has been researched along with Disease Models, Animal in 8 studies
Fleroxacin: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
fleroxacin : A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The penetration, pharmacokinetics and therapeutic efficacy of fleroxacin and pefloxacin were investigated in a rat abscess model." | 7.67 | The pharmacokinetics and therapeutic efficacy of fleroxacin and pefloxacin in a rat abscess model. ( Barzilai, A; Keren, G; Leibovitz, E; Rubinstein, E; Shabtai, M, 1989) |
| "The penetration, pharmacokinetics and therapeutic efficacy of fleroxacin and pefloxacin were investigated in a rat abscess model." | 3.67 | The pharmacokinetics and therapeutic efficacy of fleroxacin and pefloxacin in a rat abscess model. ( Barzilai, A; Keren, G; Leibovitz, E; Rubinstein, E; Shabtai, M, 1989) |
| " A rabbit model of CAUTI using a closed urinary catheter drainage system and the mutant strain of Escherichia coli (WE 6933) were used to examine three dosage regimens (30 mg/kg q8h i." | 1.29 | Therapeutic efficacy of fleroxacin for eliminating catheter-associated urinary tract infection in a rabbit model. ( Cleeland, R; Costerton, JW; Lam, K; McKay, SG; Morck, DW; Olson, ME; Prosser, B, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Fishman, JA | 1 |
| Queener, SF | 1 |
| Roth, RS | 1 |
| Bartlett, MS | 1 |
| Morck, DW | 1 |
| Olson, ME | 1 |
| McKay, SG | 1 |
| Lam, K | 1 |
| Prosser, B | 1 |
| Cleeland, R | 1 |
| Costerton, JW | 1 |
| Tomioka, H | 1 |
| Sato, K | 1 |
| Saito, H | 1 |
| Chuard, C | 1 |
| Lucet, JC | 2 |
| Rohner, P | 2 |
| Herrmann, M | 2 |
| Auckenthaler, R | 2 |
| Waldvogel, FA | 2 |
| Lew, DP | 2 |
| Leibovitz, E | 1 |
| Keren, G | 1 |
| Shabtai, M | 1 |
| Barzilai, A | 1 |
| Rubinstein, E | 1 |
| Tudor, RG | 1 |
| Youngs, DJ | 1 |
| Yoshioka, K | 1 |
| Burdon, DW | 1 |
| Keighley, MR | 1 |
8 other studies available for fleroxacin and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Activity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse model.
Topics: Animals; Disease Models, Animal; Fleroxacin; Mice; Mice, Inbred BALB C; Mice, SCID; Pneumocystis; Pn | 1993 |
Therapeutic efficacy of fleroxacin for eliminating catheter-associated urinary tract infection in a rabbit model.
Topics: Animals; Catheters, Indwelling; Disease Models, Animal; Escherichia coli Infections; Fleroxacin; Mal | 1993 |
Comparative in vitro and in vivo activity of fleroxacin and ofloxacin against various mycobacteria.
Topics: Animals; Disease Models, Animal; Female; Fleroxacin; Leprosy; Mice; Mice, Inbred BALB C; Microbial S | 1991 |
Resistance of Staphylococcus aureus recovered from infected foreign body in vivo to killing by antimicrobials.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Diffusion Chambers, Culture; D | 1991 |
Treatment of experimental foreign body infection caused by methicillin-resistant Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Disease Models, Animal; Drug Therapy, Combination; Fl | 1990 |
The pharmacokinetics and therapeutic efficacy of fleroxacin and pefloxacin in a rat abscess model.
Topics: Abscess; Animals; Anti-Bacterial Agents; Ciprofloxacin; Colony Count, Microbial; Disease Models, Ani | 1989 |
A comparison of the penetration of two quinolones into intra-abdominal abscess.
Topics: Abdomen; Abscess; Administration, Oral; Animals; Anti-Infective Agents; Ciprofloxacin; Disease Model | 1988 |