fleroxacin has been researched along with Chronic Kidney Failure in 2 studies
Fleroxacin: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
fleroxacin : A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For the other new quinolones, a decrease in glomerular filtration rate below 20-30 ml/min induces an increase in terminal half-life and a decrease in plasma and renal clearance, related to the degree of renal impairment." | 2.38 | Pharmacokinetics of quinolones in renal insufficiency. ( Borsa-Lebas, F; Dhib, M; Fillastre, JP; Humbert, G; Leroy, A; Moulin, B, 1990) |
| " In healthy subjects, Cmax was 6." | 1.28 | Disposition of fleroxacin, a new trifluoroquinolone, and its metabolites. Pharmacokinetics in renal failure and influence of haemodialysis. ( Dhib, M; Fillastre, JP; Godin, M; Leroy, A; Moulin, B; Singlas, E; Sultan, E; Taburet, AM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singlas, E | 1 |
| Leroy, A | 2 |
| Sultan, E | 1 |
| Godin, M | 1 |
| Moulin, B | 2 |
| Taburet, AM | 1 |
| Dhib, M | 2 |
| Fillastre, JP | 2 |
| Borsa-Lebas, F | 1 |
| Humbert, G | 1 |
1 review available for fleroxacin and Chronic Kidney Failure
| Article | Year |
|---|---|
Pharmacokinetics of quinolones in renal insufficiency.
Topics: Anti-Infective Agents; Ciprofloxacin; Enoxacin; Fleroxacin; Fluoroquinolones; Glomerular Filtration | 1990 |
1 other study available for fleroxacin and Chronic Kidney Failure
| Article | Year |
|---|---|
Disposition of fleroxacin, a new trifluoroquinolone, and its metabolites. Pharmacokinetics in renal failure and influence of haemodialysis.
Topics: Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Female; Fleroxacin; Humans; Kidney Failure, Chron | 1990 |