fleroxacin has been researched along with Chronic Disease in 6 studies
Fleroxacin: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
fleroxacin : A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pharmacokinetics of fleroxacin, a new broad-spectrum fluoroquinolone, were measured by positron emission tomography (PET) with [18F]fleroxacin in five patients with acute bacterial exacerbations of chronic bronchitis and in five patients with symptomatic, complicated urinary tract infection." | 9.08 | Pharmacokinetics of [18F]fleroxacin in patients with acute exacerbations of chronic bronchitis and complicated urinary tract infection studied by positron emission tomography. ( Alpert, NM; Babich, JW; Bonab, A; Chodosh, S; Cleeland, R; Correia, JA; Fischman, AJ; Kamitsuka, P; Liu, YY; Livni, E; McGovern, F; Prosser, BL; Rubin, RH, 1996) |
| "The objective of this double-blind, multicenter study was to compare the efficacy and safety of oral fleroxacin, 400 mg once daily for 7 days, with amoxicillin, 500 mg administered every 8 hours for 7 days, in the treatment of acute exacerbation of chronic bronchitis." | 9.07 | Fleroxacin versus amoxicillin in the treatment of acute exacerbation of chronic bronchitis. ( Ulmer, W, 1993) |
| "In a multicenter study the efficacy and safety of oral fleroxacin at 400 mg once a day and amoxicillin at 500 mg three times daily for 7 days were compared for the treatment of patients with acute bacterial exacerbations of chronic bronchitis due to drug-susceptible bacteria." | 9.07 | Efficacy of fleroxacin versus amoxicillin in acute exacerbations of chronic bronchitis. ( Chodosh, S, 1993) |
| "To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment." | 5.09 | The pharmacokinetics of oral fleroxacin and ciprofloxacin in plasma and sputum during acute and chronic dosing. ( Begg, EJ; Buttimore, RC; Graham, GG; Neill, AM; Robson, RA; Saunders, DA; Town, GI, 2000) |
| "The pharmacokinetics of fleroxacin, a new broad-spectrum fluoroquinolone, were measured by positron emission tomography (PET) with [18F]fleroxacin in five patients with acute bacterial exacerbations of chronic bronchitis and in five patients with symptomatic, complicated urinary tract infection." | 5.08 | Pharmacokinetics of [18F]fleroxacin in patients with acute exacerbations of chronic bronchitis and complicated urinary tract infection studied by positron emission tomography. ( Alpert, NM; Babich, JW; Bonab, A; Chodosh, S; Cleeland, R; Correia, JA; Fischman, AJ; Kamitsuka, P; Liu, YY; Livni, E; McGovern, F; Prosser, BL; Rubin, RH, 1996) |
| "The objective of this double-blind, multicenter study was to compare the efficacy and safety of oral fleroxacin, 400 mg once daily for 7 days, with amoxicillin, 500 mg administered every 8 hours for 7 days, in the treatment of acute exacerbation of chronic bronchitis." | 5.07 | Fleroxacin versus amoxicillin in the treatment of acute exacerbation of chronic bronchitis. ( Ulmer, W, 1993) |
| "In a multicenter study the efficacy and safety of oral fleroxacin at 400 mg once a day and amoxicillin at 500 mg three times daily for 7 days were compared for the treatment of patients with acute bacterial exacerbations of chronic bronchitis due to drug-susceptible bacteria." | 5.07 | Efficacy of fleroxacin versus amoxicillin in acute exacerbations of chronic bronchitis. ( Chodosh, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, P | 1 |
| Ulmer, W | 1 |
| Chodosh, S | 2 |
| Fischman, AJ | 1 |
| Livni, E | 1 |
| Babich, JW | 1 |
| Alpert, NM | 1 |
| Bonab, A | 1 |
| McGovern, F | 1 |
| Kamitsuka, P | 1 |
| Liu, YY | 1 |
| Cleeland, R | 1 |
| Prosser, BL | 1 |
| Correia, JA | 1 |
| Rubin, RH | 1 |
| Begg, EJ | 1 |
| Robson, RA | 1 |
| Saunders, DA | 1 |
| Graham, GG | 1 |
| Buttimore, RC | 1 |
| Neill, AM | 1 |
| Town, GI | 1 |
| Chuard, C | 1 |
| Herrmann, M | 1 |
| Vaudaux, P | 1 |
| Waldvogel, FA | 1 |
| Lew, DP | 1 |
5 trials available for fleroxacin and Chronic Disease
| Article | Year |
|---|---|
[Clinical observation on shufei granule in improving right ventricular function of patients with chronic pulmonary heart disease].
Topics: Adult; Aged; Chronic Disease; Drug Therapy, Combination; Drugs, Chinese Herbal; Dyphylline; Female; | 2006 |
Fleroxacin versus amoxicillin in the treatment of acute exacerbation of chronic bronchitis.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amoxicillin; Bacteria; Bronchitis; Chronic Disease; D | 1993 |
Efficacy of fleroxacin versus amoxicillin in acute exacerbations of chronic bronchitis.
Topics: Acute Disease; Aged; Amoxicillin; Bacteria; Bacterial Infections; Bronchitis; Chronic Disease; Confi | 1993 |
Pharmacokinetics of [18F]fleroxacin in patients with acute exacerbations of chronic bronchitis and complicated urinary tract infection studied by positron emission tomography.
Topics: Acute Disease; Adult; Aged; Anti-Infective Agents; Bronchitis; Chronic Disease; Fleroxacin; Fluorine | 1996 |
The pharmacokinetics of oral fleroxacin and ciprofloxacin in plasma and sputum during acute and chronic dosing.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Area Under Curve; Bronchiectasis; Bronchitis; | 2000 |
1 other study available for fleroxacin and Chronic Disease
| Article | Year |
|---|---|
Successful therapy of experimental chronic foreign-body infection due to methicillin-resistant Staphylococcus aureus by antimicrobial combinations.
Topics: Animals; Cells, Cultured; Chronic Disease; Drug Interactions; Drug Therapy, Combination; Fleroxacin; | 1991 |