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fleroxacin and Bronchitis

fleroxacin has been researched along with Bronchitis in 7 studies

Fleroxacin: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
fleroxacin : A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.

Bronchitis: Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.

Research Excerpts

ExcerptRelevanceReference
"The pharmacokinetics of fleroxacin, a new broad-spectrum fluoroquinolone, were measured by positron emission tomography (PET) with [18F]fleroxacin in five patients with acute bacterial exacerbations of chronic bronchitis and in five patients with symptomatic, complicated urinary tract infection."9.08Pharmacokinetics of [18F]fleroxacin in patients with acute exacerbations of chronic bronchitis and complicated urinary tract infection studied by positron emission tomography. ( Alpert, NM; Babich, JW; Bonab, A; Chodosh, S; Cleeland, R; Correia, JA; Fischman, AJ; Kamitsuka, P; Liu, YY; Livni, E; McGovern, F; Prosser, BL; Rubin, RH, 1996)
"The objective of this double-blind, multicenter study was to compare the efficacy and safety of oral fleroxacin, 400 mg once daily for 7 days, with amoxicillin, 500 mg administered every 8 hours for 7 days, in the treatment of acute exacerbation of chronic bronchitis."9.07Fleroxacin versus amoxicillin in the treatment of acute exacerbation of chronic bronchitis. ( Ulmer, W, 1993)
"In a multicenter study the efficacy and safety of oral fleroxacin at 400 mg once a day and amoxicillin at 500 mg three times daily for 7 days were compared for the treatment of patients with acute bacterial exacerbations of chronic bronchitis due to drug-susceptible bacteria."9.07Efficacy of fleroxacin versus amoxicillin in acute exacerbations of chronic bronchitis. ( Chodosh, S, 1993)
"Fleroxacin, administered intravenously at a dosage of 400 mg once a day, was compared with ceftazidime, 0."6.67Intravenous fleroxacin versus ceftazidime in the treatment of acute nonpneumococcal lower respiratory tract infections. ( Farkas, SA, 1993)
"To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment."5.09The pharmacokinetics of oral fleroxacin and ciprofloxacin in plasma and sputum during acute and chronic dosing. ( Begg, EJ; Buttimore, RC; Graham, GG; Neill, AM; Robson, RA; Saunders, DA; Town, GI, 2000)
"The pharmacokinetics of fleroxacin, a new broad-spectrum fluoroquinolone, were measured by positron emission tomography (PET) with [18F]fleroxacin in five patients with acute bacterial exacerbations of chronic bronchitis and in five patients with symptomatic, complicated urinary tract infection."5.08Pharmacokinetics of [18F]fleroxacin in patients with acute exacerbations of chronic bronchitis and complicated urinary tract infection studied by positron emission tomography. ( Alpert, NM; Babich, JW; Bonab, A; Chodosh, S; Cleeland, R; Correia, JA; Fischman, AJ; Kamitsuka, P; Liu, YY; Livni, E; McGovern, F; Prosser, BL; Rubin, RH, 1996)
"The objective of this double-blind, multicenter study was to compare the efficacy and safety of oral fleroxacin, 400 mg once daily for 7 days, with amoxicillin, 500 mg administered every 8 hours for 7 days, in the treatment of acute exacerbation of chronic bronchitis."5.07Fleroxacin versus amoxicillin in the treatment of acute exacerbation of chronic bronchitis. ( Ulmer, W, 1993)
"In a multicenter study the efficacy and safety of oral fleroxacin at 400 mg once a day and amoxicillin at 500 mg three times daily for 7 days were compared for the treatment of patients with acute bacterial exacerbations of chronic bronchitis due to drug-susceptible bacteria."5.07Efficacy of fleroxacin versus amoxicillin in acute exacerbations of chronic bronchitis. ( Chodosh, S, 1993)
"Fleroxacin, administered intravenously at a dosage of 400 mg once a day, was compared with ceftazidime, 0."2.67Intravenous fleroxacin versus ceftazidime in the treatment of acute nonpneumococcal lower respiratory tract infections. ( Farkas, SA, 1993)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (85.71)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Okada, F1
Murakami, T1
Tokumitsu, Y1
Jones, RN1
Erwin, ME1
Hager, HL1
Hohl, PE1
Ulmer, W1
Chodosh, S2
Farkas, SA1
Fischman, AJ1
Livni, E1
Babich, JW1
Alpert, NM1
Bonab, A1
McGovern, F1
Kamitsuka, P1
Liu, YY1
Cleeland, R1
Prosser, BL1
Correia, JA1
Rubin, RH1
Begg, EJ1
Robson, RA1
Saunders, DA1
Graham, GG1
Buttimore, RC1
Neill, AM1
Town, GI1

Trials

5 trials available for fleroxacin and Bronchitis

ArticleYear
Fleroxacin versus amoxicillin in the treatment of acute exacerbation of chronic bronchitis.
    The American journal of medicine, 1993, Mar-22, Volume: 94, Issue:3A

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amoxicillin; Bacteria; Bronchitis; Chronic Disease; D

1993
Efficacy of fleroxacin versus amoxicillin in acute exacerbations of chronic bronchitis.
    The American journal of medicine, 1993, Mar-22, Volume: 94, Issue:3A

    Topics: Acute Disease; Aged; Amoxicillin; Bacteria; Bacterial Infections; Bronchitis; Chronic Disease; Confi

1993
Intravenous fleroxacin versus ceftazidime in the treatment of acute nonpneumococcal lower respiratory tract infections.
    The American journal of medicine, 1993, Mar-22, Volume: 94, Issue:3A

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Bacteria; Bronchitis; Ceftazidime; Female; Fleroxacin

1993
Pharmacokinetics of [18F]fleroxacin in patients with acute exacerbations of chronic bronchitis and complicated urinary tract infection studied by positron emission tomography.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:3

    Topics: Acute Disease; Adult; Aged; Anti-Infective Agents; Bronchitis; Chronic Disease; Fleroxacin; Fluorine

1996
The pharmacokinetics of oral fleroxacin and ciprofloxacin in plasma and sputum during acute and chronic dosing.
    British journal of clinical pharmacology, 2000, Volume: 49, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Area Under Curve; Bronchiectasis; Bronchitis;

2000

Other Studies

2 other studies available for fleroxacin and Bronchitis

ArticleYear
Two cases of fleroxacin-induced insomnia.
    International clinical psychopharmacology, 1994,Winter, Volume: 9, Issue:4

    Topics: Aged; Bronchitis; Bronchopneumonia; Female; Fleroxacin; Humans; Middle Aged; Sleep Initiation and Ma

1994
Interlaboratory variations of fluoroquinolone susceptibility testing. An international study to validate the quality of microbiology results reported during the fleroxacin clinical trials.
    Diagnostic microbiology and infectious disease, 1993, Volume: 17, Issue:3

    Topics: Bacteria; Bronchitis; Clinical Trials as Topic; Europe; False Positive Reactions; Fleroxacin; Humans

1993