fleroxacin has been researched along with Abscess in 6 studies
Fleroxacin: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
fleroxacin : A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.
Abscess: Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the potential efficacy of fleroxacin in combination with clindamycin or metronidazole in mixed aerobic and anaerobic infections, we used a rat model of intra-abdominal abscesses in which the inoculum consisted of pooled rat feces mixed with BaSO4." | 7.69 | Activity of fleroxacin alone and in combination with clindamycin or metronidazole in experimental intra-abdominal abscesses. ( Eliopoulos, GM; Ferraro, MJ; Holden, J; Moellering, RC; Pefanis, A; Thauvin-Eliopoulos, C, 1994) |
| "The penetration, pharmacokinetics and therapeutic efficacy of fleroxacin and pefloxacin were investigated in a rat abscess model." | 7.67 | The pharmacokinetics and therapeutic efficacy of fleroxacin and pefloxacin in a rat abscess model. ( Barzilai, A; Keren, G; Leibovitz, E; Rubinstein, E; Shabtai, M, 1989) |
| "Using a recently developed, low mortality model of an intra-abdominal abscess in the Wistar rat, we have studied the penetration of fleroxacin into the abscess." | 7.67 | The penetration of fleroxacin into intra-abdominal abscesses. ( Keighley, MR; Tudor, RG; Yoshioka, K; Youngs, DJ, 1988) |
| "To assess the potential efficacy of fleroxacin in combination with clindamycin or metronidazole in mixed aerobic and anaerobic infections, we used a rat model of intra-abdominal abscesses in which the inoculum consisted of pooled rat feces mixed with BaSO4." | 3.69 | Activity of fleroxacin alone and in combination with clindamycin or metronidazole in experimental intra-abdominal abscesses. ( Eliopoulos, GM; Ferraro, MJ; Holden, J; Moellering, RC; Pefanis, A; Thauvin-Eliopoulos, C, 1994) |
| "We conducted clinical studies on fleroxacin (FLRX), a new pyridone carboxylic acid derivative, for the treatment of periproctal abscess, secondary infections (due to wounds, burns or surgical operations), mastitis or areolitis and others with once daily dose of 200 mg or 300 mg." | 3.68 | [Clinical study on fleroxacin in surgical infections]. ( Ishikawa, M; Ishikawa, S; Kinoshita, H; Mashita, K; Mizuno, A; Morimoto, K; Sakai, K; Shinagawa, N; Suzuki, T; Yura, J, 1991) |
| "The penetration, pharmacokinetics and therapeutic efficacy of fleroxacin and pefloxacin were investigated in a rat abscess model." | 3.67 | The pharmacokinetics and therapeutic efficacy of fleroxacin and pefloxacin in a rat abscess model. ( Barzilai, A; Keren, G; Leibovitz, E; Rubinstein, E; Shabtai, M, 1989) |
| "Using a recently developed, low mortality model of an intra-abdominal abscess in the Wistar rat, we have studied the penetration of fleroxacin into the abscess." | 3.67 | The penetration of fleroxacin into intra-abdominal abscesses. ( Keighley, MR; Tudor, RG; Yoshioka, K; Youngs, DJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pefanis, A | 1 |
| Thauvin-Eliopoulos, C | 1 |
| Holden, J | 1 |
| Eliopoulos, GM | 1 |
| Ferraro, MJ | 1 |
| Moellering, RC | 1 |
| Georgopoulos, A | 1 |
| Feistauer, SM | 1 |
| Graninger, W | 1 |
| Pfleger, S | 1 |
| Georgopoulos, M | 1 |
| Yura, J | 1 |
| Shinagawa, N | 1 |
| Ishikawa, S | 1 |
| Mashita, K | 1 |
| Kinoshita, H | 1 |
| Morimoto, K | 1 |
| Sakai, K | 1 |
| Mizuno, A | 1 |
| Ishikawa, M | 1 |
| Suzuki, T | 1 |
| Leibovitz, E | 1 |
| Keren, G | 1 |
| Shabtai, M | 1 |
| Barzilai, A | 1 |
| Rubinstein, E | 1 |
| Tudor, RG | 2 |
| Youngs, DJ | 2 |
| Yoshioka, K | 2 |
| Burdon, DW | 1 |
| Keighley, MR | 2 |
6 other studies available for fleroxacin and Abscess
| Article | Year |
|---|---|
Activity of fleroxacin alone and in combination with clindamycin or metronidazole in experimental intra-abdominal abscesses.
Topics: Abdomen; Abscess; Animals; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Clindamycin | 1994 |
Antibacterial activity of sparfloxacin against experimental renal infections in mice.
Topics: Abscess; Animals; Anti-Infective Agents; Ciprofloxacin; Escherichia coli Infections; Female; Fleroxa | 1992 |
[Clinical study on fleroxacin in surgical infections].
Topics: Abscess; Administration, Oral; Adolescent; Adult; Aged; Bacteria; Ciprofloxacin; Drug Resistance, Mi | 1991 |
The pharmacokinetics and therapeutic efficacy of fleroxacin and pefloxacin in a rat abscess model.
Topics: Abscess; Animals; Anti-Bacterial Agents; Ciprofloxacin; Colony Count, Microbial; Disease Models, Ani | 1989 |
A comparison of the penetration of two quinolones into intra-abdominal abscess.
Topics: Abdomen; Abscess; Administration, Oral; Animals; Anti-Infective Agents; Ciprofloxacin; Disease Model | 1988 |
The penetration of fleroxacin into intra-abdominal abscesses.
Topics: Abdomen; Abscess; Animals; Anti-Infective Agents; Ciprofloxacin; Fleroxacin; Male; Rats; Rats, Inbre | 1988 |