flecainide has been researched along with Torsade de Pointes in 13 studies
Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although flecainide has a risk of proarrhythmia in patients with structural heart disease, its mechanism has been mainly ascribed to use-dependency and a rapid ventricular response to organized atrial tachyarrhythmias or to ventricular tachycardia." | 7.79 | Flecainide-associated bradycardia-dependent torsade de pointes: another potential mechanism of proarrhythmia. ( Kim, HS; Kim, SS; Pak, HN; Park, JS, 2013) |
| "Although flecainide has a risk of proarrhythmia in patients with structural heart disease, its mechanism has been mainly ascribed to use-dependency and a rapid ventricular response to organized atrial tachyarrhythmias or to ventricular tachycardia." | 3.79 | Flecainide-associated bradycardia-dependent torsade de pointes: another potential mechanism of proarrhythmia. ( Kim, HS; Kim, SS; Pak, HN; Park, JS, 2013) |
| "Flecainide is an antiarrhythmic considered safe in patients who have no structural cardiopathy, and frequently used in the prevention of atrial fibrillation." | 1.34 | Torsade-de-pointes in a patient under flecainide treatment, an unusual case of proarrhythmicity. ( Doncel Vecino, LJ; López-Mínguez, JR; Merchán Herrera, A; Moreno Sánchez, N; Nogales Asensio, JM; Villar Mariscal, C, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Kramer, J | 1 |
| Obejero-Paz, CA | 1 |
| Myatt, G | 1 |
| Kuryshev, YA | 1 |
| Bruening-Wright, A | 1 |
| Verducci, JS | 1 |
| Brown, AM | 1 |
| Nogawa, H | 1 |
| Muraki, Y | 1 |
| Kawai, T | 1 |
| Kuninishi, Y | 1 |
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Melgari, D | 1 |
| Zhang, Y | 1 |
| El Harchi, A | 1 |
| Dempsey, CE | 1 |
| Hancox, JC | 1 |
| Aziz, PF | 1 |
| Tanel, RE | 1 |
| Zelster, IJ | 1 |
| Pass, RH | 1 |
| Wieand, TS | 1 |
| Vetter, VL | 1 |
| Vogel, RL | 1 |
| Shah, MJ | 1 |
| Kim, HS | 1 |
| Pak, HN | 1 |
| Park, JS | 1 |
| Kim, SS | 1 |
| Thevenin, J | 1 |
| Da Costa, A | 1 |
| Roche, F | 1 |
| Romeyer, C | 1 |
| Messier, M | 1 |
| Isaaz, K | 1 |
| Nogales Asensio, JM | 1 |
| Moreno Sánchez, N | 1 |
| Doncel Vecino, LJ | 1 |
| Villar Mariscal, C | 1 |
| López-Mínguez, JR | 1 |
| Merchán Herrera, A | 1 |
| Lehtonen, A | 1 |
| Fodstad, H | 1 |
| Laitinen-Forsblom, P | 1 |
| Toivonen, L | 1 |
| Kontula, K | 1 |
| Swan, H | 1 |
| Hallman, K | 1 |
| Carlsson, L | 1 |
| Ohki, R | 1 |
| Takahashi, M | 1 |
| Mizuno, O | 1 |
| Fujikawa, H | 1 |
| Mitsuhashi, T | 1 |
| Katsuki, T | 1 |
| Ikeda, U | 1 |
| Shimada, K | 1 |
| Stiefelhagen, P | 1 |
| Andrivet, P | 1 |
| Beaslay, V | 1 |
| Canh, VD | 1 |
13 other studies available for flecainide and Torsade de Pointes
| Article | Year |
|---|---|
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp T | 2013 |
Pharmacological characterisation of electrocardiogram J-T
Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifed | 2022 |
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Flecainide; Gene Expression Regulation; HEK293 Cells; | 2015 |
Congenital long QT syndrome and 2:1 atrioventricular block: an optimistic outcome in the current era.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Atrioventricular Block; Child; Child, Preschool | 2010 |
Flecainide-associated bradycardia-dependent torsade de pointes: another potential mechanism of proarrhythmia.
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Female; Flecainide; Humans; Torsade | 2013 |
Flecainide induced ventricular tachycardia (torsades de pointes).
Topics: Aged; Anti-Arrhythmia Agents; Electrocardiography; Female; Flecainide; Humans; Torsades de Pointes | 2003 |
Torsade-de-pointes in a patient under flecainide treatment, an unusual case of proarrhythmicity.
Topics: Aged; Anti-Arrhythmia Agents; Female; Flecainide; Humans; Torsades de Pointes | 2007 |
Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes.
Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; DNA Mutational Analysis; Electrocardiog | 2007 |
Prevention of class III-induced proarrhythmias by flecainide in an animal model of the acquired long QT syndrome.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Disease Models, | 1995 |
Torsades de pointes ventricular tachycardia induced by mosapride and flecainide in the presence of hypokalemia.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzamides; Drug Therapy, Combination; Electrocar | 2001 |
[Intermittent atrial fibrillation. An "idiopathic" emergency. Torsade de pointes].
Topics: Atrial Fibrillation; Diagnosis, Differential; Electrocardiography, Ambulatory; Emergencies; Flecaini | 2001 |
Torsades de pointe with flecainide-amiodarone therapy.
Topics: Aged; Amiodarone; Electrocardiography; Female; Flecainide; Humans; Torsades de Pointes | 1990 |