flecainide has been researched along with Symptom Cluster in 20 studies
Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of quinidine bisulfate (mean dose, 1483+/-240 mg) on the prevention of inducible and spontaneous ventricular fibrillation (VF) were prospectively evaluated in 25 patients (24 men, 1 woman; age, 19 to 80 years) with Brugada syndrome." | 8.82 | Efficacy of quinidine in high-risk patients with Brugada syndrome. ( Belhassen, B; Glick, A; Viskin, S, 2004) |
| "The flecainide test is widely used in Brugada syndrome." | 7.72 | Flecainide test in Brugada syndrome: a reproducible but risky tool. ( Ceriotti, C; Galimberti, P; Gasparini, M; Mantica, M; Napolitano, C; Priori, SG; Simonini, S, 2003) |
| " We describe the case of a 62-year-old male with latent Brugada syndrome in whom the intravenous infusion of flecainide for paroxysmal atrial fibrillation caused ECG abnormalities similar to those of an acute septal myocardial infarction." | 7.72 | [Infusion of flecainide in a patient with atrial fibrillation and latent Brugada's syndrome has determined modifications of the electrocardiogram similar to those of a septal myocardial infarct]. ( Carotenuto, F; Cirillo, R; D'Errico, L; di Palma, F; Fontana, D; Granato, L; Pagano, V; Sestri, C; Vitiello, N, 2003) |
| "We have linked 2 inactivation gating defects ("closed-state" fast inactivation and intermediate inactivation) to flecainide sensitivity in patients carrying LQT3 and Brugada syndrome mutations." | 7.71 | Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes. ( Balser, JR; Bezzina, CR; George, AL; Roden, DM; Viswanathan, PC; Wilde, AA, 2001) |
| "Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported." | 6.41 | Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome. ( Fuhrman, C; Perchet, H; Robain, A, 2000) |
| "Six patients with short QT syndrome, five of whom had received an implantable cardioverter-defibrillator (ICD) and one child, were tested with different antiarrhythmic drugs, including flecainide, sotalol, ibutilide, and hydroquinidine, to determine whether they could prolong the QT interval into the normal range and thus prevent symptoms and arrhythmia recurrences." | 5.11 | Short QT syndrome: pharmacological treatment. ( Antzelevitch, C; Bianchi, F; Borggrefe, M; Brugada, R; Calò, L; Gaita, F; Giustetto, C; Haissaguerre, M; Schimpf, R; Wolpert, C, 2004) |
| "The effects of quinidine bisulfate (mean dose, 1483+/-240 mg) on the prevention of inducible and spontaneous ventricular fibrillation (VF) were prospectively evaluated in 25 patients (24 men, 1 woman; age, 19 to 80 years) with Brugada syndrome." | 4.82 | Efficacy of quinidine in high-risk patients with Brugada syndrome. ( Belhassen, B; Glick, A; Viskin, S, 2004) |
| "The flecainide test is widely used in Brugada syndrome." | 3.72 | Flecainide test in Brugada syndrome: a reproducible but risky tool. ( Ceriotti, C; Galimberti, P; Gasparini, M; Mantica, M; Napolitano, C; Priori, SG; Simonini, S, 2003) |
| " We describe the case of a 62-year-old male with latent Brugada syndrome in whom the intravenous infusion of flecainide for paroxysmal atrial fibrillation caused ECG abnormalities similar to those of an acute septal myocardial infarction." | 3.72 | [Infusion of flecainide in a patient with atrial fibrillation and latent Brugada's syndrome has determined modifications of the electrocardiogram similar to those of a septal myocardial infarct]. ( Carotenuto, F; Cirillo, R; D'Errico, L; di Palma, F; Fontana, D; Granato, L; Pagano, V; Sestri, C; Vitiello, N, 2003) |
| "Using tissue Doppler echocardiography, we studied how these contractile variables change on induction of the characteristic ST-segment changes of Brugada syndrome by flecainide challenge." | 3.72 | Delay in right ventricular activation contributes to Brugada syndrome. ( de Groot, IK; Sogaard, P; Tan, HL; Tukkie, R; Vleugels, J; Wilde, AA, 2004) |
| "We have linked 2 inactivation gating defects ("closed-state" fast inactivation and intermediate inactivation) to flecainide sensitivity in patients carrying LQT3 and Brugada syndrome mutations." | 3.71 | Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes. ( Balser, JR; Bezzina, CR; George, AL; Roden, DM; Viswanathan, PC; Wilde, AA, 2001) |
| "These findings demonstrate that, in Brugada syndrome, spontaneous or ajmaline-induced changes in the surface ECG may be paralleled by significant variations in the right ventricular endocardial electrogram that may result in ICD malfunction." | 3.70 | Spatial and temporal heterogeneity of depolarization and repolarization may complicate implantable cardioverter defibrillator therapy in Brugada syndrome. ( Bella, PD; Carbucicchio, C; Schmidinger, H; Stix, G, 2000) |
| "The short QT syndrome is characterized by familial sudden death, short refractory periods, and inducible ventricular fibrillation." | 2.71 | Short QT Syndrome: a familial cause of sudden death. ( Bianchi, F; Borggrefe, M; Gaita, F; Giustetto, C; Grossi, S; Riccardi, R; Richiardi, E; Schimpf, R; Wolpert, C, 2003) |
| "Brugada syndrome is characterized by an ST segment elevation in leads V1-V3 and a high incidence of ventricular fibrillation (VF)." | 2.69 | Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. ( Aihara, N; Antzelevitch, C; Kamakura, S; Kurita, T; Shimizu, W; Sunagawa, K; Suyama, K; Taguchi, A; Takaki, H, 2000) |
| "Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported." | 2.41 | Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome. ( Fuhrman, C; Perchet, H; Robain, A, 2000) |
| "We discovered that flecainide prevents arrhythmias in a mouse model of CPVT by inhibiting cardiac ryanodine receptor-mediated Ca(2+) release and thereby directly targeting the underlying molecular defect." | 1.35 | Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. ( Chopra, N; Davies, SS; Duff, HJ; Hwang, HS; Knollmann, BC; Laver, D; Roach, DE; Roden, DM; Watanabe, H; Wilde, AA, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 18 (90.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Watanabe, H | 1 |
| Chopra, N | 1 |
| Laver, D | 1 |
| Hwang, HS | 1 |
| Davies, SS | 1 |
| Roach, DE | 1 |
| Duff, HJ | 1 |
| Roden, DM | 2 |
| Wilde, AA | 3 |
| Knollmann, BC | 1 |
| Gabriel, L | 1 |
| Chenu, P | 1 |
| Guédès, A | 1 |
| Dangoisse, V | 1 |
| Marchandise, B | 1 |
| Blommaert, D | 1 |
| Jamart, J | 1 |
| De Roy, L | 1 |
| Schroeder, E | 1 |
| Cabezón Ruiz, S | 1 |
| Errazquin Sáenz de Tejada, F | 1 |
| Pedrote Martínez, A | 1 |
| Morán Risco, JE | 1 |
| Marín Morgado, J | 1 |
| Fernández Pérez, JM | 1 |
| Gasparini, M | 1 |
| Priori, SG | 2 |
| Mantica, M | 1 |
| Napolitano, C | 2 |
| Galimberti, P | 1 |
| Ceriotti, C | 1 |
| Simonini, S | 1 |
| Mok, NS | 1 |
| Chan, NY | 1 |
| Chahine, M | 1 |
| Baroudi, G | 1 |
| Vitiello, N | 1 |
| Cirillo, R | 1 |
| Fontana, D | 1 |
| Granato, L | 1 |
| Sestri, C | 1 |
| Pagano, V | 1 |
| D'Errico, L | 1 |
| Carotenuto, F | 1 |
| di Palma, F | 1 |
| Gaita, F | 2 |
| Giustetto, C | 2 |
| Bianchi, F | 2 |
| Wolpert, C | 2 |
| Schimpf, R | 2 |
| Riccardi, R | 1 |
| Grossi, S | 1 |
| Richiardi, E | 1 |
| Borggrefe, M | 2 |
| Tukkie, R | 1 |
| Sogaard, P | 1 |
| Vleugels, J | 1 |
| de Groot, IK | 1 |
| Tan, HL | 1 |
| Haissaguerre, M | 1 |
| Calò, L | 1 |
| Brugada, R | 1 |
| Antzelevitch, C | 2 |
| Belhassen, B | 1 |
| Glick, A | 1 |
| Viskin, S | 1 |
| Sinha, MK | 1 |
| Dasgupta, D | 1 |
| Lyons, JP | 1 |
| Nishizaki, M | 1 |
| Fujii, H | 1 |
| Sakurada, H | 1 |
| Kimura, A | 1 |
| Hiraoka, M | 1 |
| Haghjoo, M | 1 |
| Arya, A | 1 |
| Emkanjoo, Z | 1 |
| Sadr-Ameli, MA | 1 |
| Füessl, HS | 1 |
| Itoh, E | 1 |
| Suzuki, K | 1 |
| Tanabe, Y | 1 |
| Robain, A | 1 |
| Perchet, H | 1 |
| Fuhrman, C | 1 |
| Stix, G | 1 |
| Bella, PD | 1 |
| Carbucicchio, C | 1 |
| Schmidinger, H | 1 |
| Shimizu, W | 1 |
| Suyama, K | 1 |
| Kurita, T | 1 |
| Taguchi, A | 1 |
| Aihara, N | 1 |
| Takaki, H | 1 |
| Sunagawa, K | 1 |
| Kamakura, S | 1 |
| Viswanathan, PC | 1 |
| Bezzina, CR | 1 |
| George, AL | 1 |
| Balser, JR | 1 |
| Alings, M | 1 |
| Dekker, L | 1 |
| Sadée, A | 1 |
| Wilde, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Randomized Crossover Trial of Oral Flecainide for Catecholaminergic Polymorphic Ventricular Tachycardia[NCT01117454] | 14 participants (Actual) | Interventional | 2011-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Hypothesis: the addition of oral flecainide to standard therapy will reduce ventricular ectopy and/or VT on treadmill exercise treadmill testing in patients with CPVT, compared to placebo plus standard therapy. (NCT01117454)
Timeframe: 3 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Flecainide | 2 |
| Placebo | 9 |
2 reviews available for flecainide and Symptom Cluster
| Article | Year |
|---|---|
Efficacy of quinidine in high-risk patients with Brugada syndrome.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cohort Studies; | 2004 |
Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.
Topics: Abnormalities, Multiple; Acute Disease; Anti-Arrhythmia Agents; Flecainide; Heart Defects, Congenita | 2000 |
3 trials available for flecainide and Symptom Cluster
| Article | Year |
|---|---|
Short QT Syndrome: a familial cause of sudden death.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Complexes, Premature; Ch | 2003 |
Short QT syndrome: pharmacological treatment.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Child; Death, Sudden, Cardiac | 2004 |
Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Bundle-Branch Block; Disopyramide; Electrocardiography; Flecain | 2000 |
15 other studies available for flecainide and Symptom Cluster
| Article | Year |
|---|---|
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Child; Flecainide; Heart Rate; Human | 2009 |
A possible association between takotsubo cardiomyopathy and treatment with flecainide.
Topics: Aged; Anti-Arrhythmia Agents; Contraindications; Female; Flecainide; Humans; Male; Middle Aged; Retr | 2011 |
[Normal conventional electrocardiogram with negative pharmacological stress test does not rule out Brugada syndrome].
Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Death, Sudden, Cardiac; Electrocardiography; Exe | 2003 |
Flecainide test in Brugada syndrome: a reproducible but risky tool.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Death, Sudden, Cardiac; Electrocardi | 2003 |
A newly characterized SCN5A mutation underlying Brugada syndrome unmasked by hyperthermia.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bundle-Branch Block; Cholangitis; Death, Sudden, Cardi | 2003 |
[Infusion of flecainide in a patient with atrial fibrillation and latent Brugada's syndrome has determined modifications of the electrocardiogram similar to those of a septal myocardial infarct].
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Death, Sudden, Cardiac; Echocardiography; Electrocardio | 2003 |
Delay in right ventricular activation contributes to Brugada syndrome.
Topics: Action Potentials; Adult; Anti-Arrhythmia Agents; Calcium Channels, L-Type; Echocardiography, Dopple | 2004 |
Flecainide challenge test for the diagnosis of Brugada syndrome.
Topics: Anti-Arrhythmia Agents; Bundle-Branch Block; Electrocardiography; Flecainide; Humans; Male; Middle A | 2004 |
Spontaneous T wave alternans in a patient with Brugada syndrome--responses to intravenous administration of class I antiarrhythmic drug, glucose tolerance test, and atrial pacing.
Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiac Pacing, Artificial; Death, Sudden, Cardi | 2005 |
Clinical and electrophysiologic profile of Brugada syndrome in Iranian patients.
Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Defibrillators, Implantable; Electric Stimulatio | 2005 |
[Reason for worry: syncope in the morning].
Topics: Anti-Arrhythmia Agents; Circadian Rhythm; Death, Sudden, Cardiac; Diagnosis, Differential; Electroca | 2005 |
A case of vasospastic angina presenting Brugada-type ECG abnormalities.
Topics: Acetylcholine; Aged; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cardiovascular Agents; Chest | 1999 |
Spatial and temporal heterogeneity of depolarization and repolarization may complicate implantable cardioverter defibrillator therapy in Brugada syndrome.
Topics: Adrenergic beta-Agonists; Adult; Ajmaline; Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiac Paci | 2000 |
Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cell Line; Electrocardiography; Flecainide; Green Fluo | 2001 |
Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome.
Topics: Adult; Electrocardiography; Flecainide; Humans; Male; Middle Aged; Quinidine; Syndrome; Treatment Ou | 2001 |