flecainide has been researched along with Metabolic Acidosis in 4 studies
Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
| Excerpt | Relevance | Reference |
|---|---|---|
| "As a molecular model of the effect of ischemia on drug block of the transient outward potassium current, the effect of acidosis on the blocking properties of flecainide and quinidine on Kv4." | 7.72 | Extracellular acidosis modulates drug block of Kv4.3 currents by flecainide and quinidine. ( Bauskin, A; Breit, S; Bursill, J; Campbell, T; Singarayar, S; Vandenberg, J; Wu, W; Wyse, K, 2003) |
| "Conditions leading to localized extracellular acidosis may facilitate heterogeneity of action of dofetilide and flecainide, but not amiodarone via modification of hERG channel blockade." | 3.77 | Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis. ( DU, CY; El Harchi, A; Hancox, JC; Orchard, CH; Zhang, YH, 2011) |
| "As a molecular model of the effect of ischemia on drug block of the transient outward potassium current, the effect of acidosis on the blocking properties of flecainide and quinidine on Kv4." | 3.72 | Extracellular acidosis modulates drug block of Kv4.3 currents by flecainide and quinidine. ( Bauskin, A; Breit, S; Bursill, J; Campbell, T; Singarayar, S; Vandenberg, J; Wu, W; Wyse, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DU, CY | 1 |
| El Harchi, A | 1 |
| Zhang, YH | 1 |
| Orchard, CH | 1 |
| Hancox, JC | 1 |
| Singarayar, S | 1 |
| Bursill, J | 1 |
| Wyse, K | 1 |
| Bauskin, A | 1 |
| Wu, W | 1 |
| Vandenberg, J | 1 |
| Breit, S | 1 |
| Campbell, T | 1 |
| Auzinger, GM | 1 |
| Scheinkestel, CD | 1 |
| Matsuo, S | 1 |
| Koh, Y | 1 |
| Sato, R | 1 |
| Munakata, K | 1 |
| Kishida, H | 1 |
4 other studies available for flecainide and Metabolic Acidosis
| Article | Year |
|---|---|
Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis.
Topics: Acidosis; Amiodarone; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; ERG1 Potassium Chann | 2011 |
Extracellular acidosis modulates drug block of Kv4.3 currents by flecainide and quinidine.
Topics: Acidosis; Animals; Anti-Arrhythmia Agents; Biological Transport, Active; Cricetinae; Cricetulus; Dis | 2003 |
Successful extracorporeal life support in a case of severe flecainide intoxication.
Topics: Acidosis; Adult; Anti-Arrhythmia Agents; Drug Overdose; Electrocardiography; Epinephrine; Extracorpo | 2001 |
Electrophysiological effects of flecainide on guinea pig ventricular muscle in high [K+]o, acidosis and hypoxia.
Topics: Acidosis; Action Potentials; Animals; Arrhythmias, Cardiac; Coronary Disease; Female; Flecainide; Gu | 1987 |