flecainide has been researched along with Kidney Failure, Chronic in 10 studies
Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Poisoning with flecainide acetate is rare and associated with a high mortality." | 8.80 | [Severe flecainide acetate poisoning. Apropos of a case]. ( Chevrolet, JC; Elamly, A; Maury, P; Metzger, J; Schoenenberger, I; Veragut, B; Vuille, C, 1999) |
| "Poisoning with flecainide acetate is rare and associated with a high mortality." | 4.80 | [Severe flecainide acetate poisoning. Apropos of a case]. ( Chevrolet, JC; Elamly, A; Maury, P; Metzger, J; Schoenenberger, I; Veragut, B; Vuille, C, 1999) |
| "Cardiac arrhythmias are frequent by hemodialyzed patients and may lead to the prescription of antiarrhythmic drugs among which flecainide." | 3.73 | [Be careful in using flecainide by hemodialyzed patients]. ( Aliouche, CP; Montagnac, R; Schillinger, F; Schoen, E, 2006) |
| " For patients with ventricular premature complexes, the half-life is longer (mean 20 hours), and twice-daily oral dosage is effective." | 2.37 | Metabolism of flecainide. ( Conard, GJ; Ober, RE, 1984) |
| "Flecainide intoxication is a severe intoxication that can lead to cardiogenic shock." | 1.51 | Renal failure, shock, and loss of pacemaker capture: A case of flecainide intoxication. ( Heldens, M; Melman, PG; van der Nat, GAM, 2019) |
| "Flecainide is a sodium channel blocker used mainly in the treatment of supraventricular arrhythmias." | 1.35 | Paranoid psychosis and myoclonus: flecainide toxicity in renal failure. ( Lee, D; Maclean, D; Sheerin, NS; Ting, SM, 2008) |
| " The average plasma half-life was prolonged by about twofold that of healthy subjects but most patients were within the range of values for healthy subjects." | 1.27 | Pharmacokinetics of flecainide acetate in patients with severe renal impairment. ( McQuinn, RL; Walls, J; Williams, AJ, 1988) |
| " Therefore, CLCR alone is not a good predictor of plasma elimination half-life following a single oral dose of flecainide." | 1.27 | Oral flecainide pharmacokinetics in patients with impaired renal function. ( Blair, AD; Burgess, E; Conard, GJ; Cutler, RE; Forland, SC; Fox, JM; Kvam, DC; Weeks, CE, 1988) |
| " It is suggested that the dosage reduction required for patients taking flecainide during CAPD should be similar to that for patients with end-stage renal disease but not on dialysis." | 1.27 | Pharmacokinetics of flecainide in a patient undergoing continuous ambulatory peritoneal dialysis. ( Bailie, GR; Waldek, S, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Plant, A | 1 |
| Gold, D | 1 |
| Walker, J | 1 |
| Heldens, M | 1 |
| van der Nat, GAM | 1 |
| Melman, PG | 1 |
| Kiblboeck, D | 1 |
| Braeuer-Mocker, M | 1 |
| Siostrzonek, P | 1 |
| Reisinger, J | 1 |
| Montagnac, R | 1 |
| Schoen, E | 1 |
| Aliouche, CP | 1 |
| Schillinger, F | 1 |
| Ting, SM | 1 |
| Lee, D | 1 |
| Maclean, D | 1 |
| Sheerin, NS | 1 |
| Conard, GJ | 2 |
| Ober, RE | 1 |
| Maury, P | 1 |
| Vuille, C | 1 |
| Metzger, J | 1 |
| Veragut, B | 1 |
| Schoenenberger, I | 1 |
| Elamly, A | 1 |
| Chevrolet, JC | 1 |
| Williams, AJ | 1 |
| McQuinn, RL | 1 |
| Walls, J | 1 |
| Forland, SC | 1 |
| Burgess, E | 1 |
| Blair, AD | 1 |
| Cutler, RE | 1 |
| Kvam, DC | 1 |
| Weeks, CE | 1 |
| Fox, JM | 1 |
| Bailie, GR | 1 |
| Waldek, S | 1 |
2 reviews available for flecainide and Kidney Failure, Chronic
| Article | Year |
|---|---|
Metabolism of flecainide.
Topics: Animals; Anti-Arrhythmia Agents; Biotransformation; Blood Proteins; Chromatography, High Pressure Li | 1984 |
[Severe flecainide acetate poisoning. Apropos of a case].
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Flutter; Biological Availability; Calcium Gluconate | 1999 |
8 other studies available for flecainide and Kidney Failure, Chronic
| Article | Year |
|---|---|
More than merely potassium: an uncommon cause for sine waves in renal failure.
Topics: Aged; Anti-Arrhythmia Agents; Bradycardia; Electrocardiography; Flecainide; Humans; Kidney Failure, | 2020 |
Renal failure, shock, and loss of pacemaker capture: A case of flecainide intoxication.
Topics: Aged; Anti-Arrhythmia Agents; Bradycardia; Buffers; Cardiotonic Agents; Drug Overdose; Electrocardio | 2019 |
A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrioventricular Block; Cardiopulmonary Resuscita | 2012 |
[Be careful in using flecainide by hemodialyzed patients].
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Flecainide; Humans; Kidney Failure, Chronic; Mal | 2006 |
Paranoid psychosis and myoclonus: flecainide toxicity in renal failure.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Diabetes Mellitus, Type 2; Dose-Response Relationship, | 2008 |
Pharmacokinetics of flecainide acetate in patients with severe renal impairment.
Topics: Administration, Oral; Adult; Female; Flecainide; Humans; Infusions, Intravenous; Kidney Failure, Chr | 1988 |
Oral flecainide pharmacokinetics in patients with impaired renal function.
Topics: Administration, Oral; Adult; Aged; Creatinine; Dose-Response Relationship, Drug; Female; Flecainide; | 1988 |
Pharmacokinetics of flecainide in a patient undergoing continuous ambulatory peritoneal dialysis.
Topics: Biological Availability; Flecainide; Humans; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal | 1988 |