Page last updated: 2024-10-27

flecainide and Embryopathies

flecainide has been researched along with Embryopathies in 52 studies

Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).

Research Excerpts

ExcerptRelevanceReference
"An infant with intrauterine supraventricular tachycardia and fetal hydrops, successfully treated with administration of flecainide acetate to the mother had conjugated hyperbilirubinemia shortly after birth."7.69Conjugated hyperbilirubinemia in a newborn infant after maternal (transplacental) treatment with flecainide acetate for fetal tachycardia and fetal hydrops. ( Carlson, DE; Cocjin, J; Rosenthal, P; Santulli, TV; Vanderhal, AL, 1995)
"Fourteen mothers were treated with flecainide for fetal atrial tachycardias associated with intrauterine cardiac failure."7.68Flecainide in the treatment of fetal tachycardias. ( Allan, LD; Chita, SK; Maxwell, D; Priestley, K; Sharland, GK, 1991)
" Flecainide appeared to be safe (no deaths with usual oral dosing, < 1% serious proarrhythmia) and effective (73% to 100% control, depending on mechanism) in children with supraventricular tachycardia."6.38Flecainide acetate for treatment of tachyarrhythmias in children: review of world literature on efficacy, safety, and dosing. ( Garson, A; Perry, JC, 1992)
"We performed a systematic review and meta-analysis to compare digoxin, flecainide, or sotalol as first-line therapy for fetal tachycardia."4.95Transplacental treatment of fetal tachycardia: A systematic review and meta-analysis. ( Frommelt, MA; Hill, GD; Kovach, JR; Saudek, DE; Singh, AK; Wehrheim, K, 2017)
" In the case of atrial flutters the pregnant woman is treated with sotalol administered orally and, if no sinus rhythm is obtained nor a reduced ventricular rhythm occurs, subsequently with digoxin."4.81[Protocols for the treatment of supraventricular tachycardias in the fetus]. ( Ambachtsheer, EB; Meijboom, EJ; Oudijk, MA; Stoutenbeek, P, 2001)
"High-dose flecainide and digoxin combination offers effective treatment strategy in fetuses with hydrops and tachyarrhythmia with favourable outcomes."4.12Favourable outcome for hydrops or cardiac failure associated with fetal tachyarrhythmia: a 20-year review. ( Beattie, RB; Tunca Sahin, G; Uzun, O, 2022)
"Flecainide is an effective therapy for supraventricular tachycardias in a twin pregnancy."3.74Diagnosis, treatment, observation and outcome of fetal supraventricular tachycardia in a twin pregnancy. ( Gronemeyer, D; Hatzmann, W; Reinhard, J; Schiermeier, S; van Leeuwen, P, 2008)
"An infant with intrauterine supraventricular tachycardia and fetal hydrops, successfully treated with administration of flecainide acetate to the mother had conjugated hyperbilirubinemia shortly after birth."3.69Conjugated hyperbilirubinemia in a newborn infant after maternal (transplacental) treatment with flecainide acetate for fetal tachycardia and fetal hydrops. ( Carlson, DE; Cocjin, J; Rosenthal, P; Santulli, TV; Vanderhal, AL, 1995)
"We report a case of fetal supraventricular tachycardia with intra uterine cardiac failure, treated with oral administration of flecainide acetate (Flecaine) to the mother."3.69[Flecaine: drug of choice for supraventricular tachycardias with anasarca. A case report]. ( Barjot, P; Febbraro, W; Hamel, P; Iselin, M; Lindet, Y; Muller, G, 1997)
"Fourteen mothers were treated with flecainide for fetal atrial tachycardias associated with intrauterine cardiac failure."3.68Flecainide in the treatment of fetal tachycardias. ( Allan, LD; Chita, SK; Maxwell, D; Priestley, K; Sharland, GK, 1991)
"Neonatal tachyarrhythmia was observed in 31."2.90Antenatal Therapy for Fetal Supraventricular Tachyarrhythmias: Multicenter Trial. ( Hagiwara, A; Hamasaki, T; Horigome, H; Ikeda, T; Inamura, N; Kato, H; Katsuragi, S; Kawataki, M; Maeno, Y; Miyoshi, T; Nii, M; Sago, H; Sakaguchi, H; Shimizu, W; Shiraishi, I; Taketazu, M; Ueda, K; Yamamoto, H; Yasukochi, S; Yoda, H, 2019)
"Long QT syndrome was identified postnatally on the electrocardiogram, and was confirmed by genetic testing which showed a mutation in the KCNH2 gene (p."2.45Fetal ventricular tachycardia secondary to long QT syndrome treated with maternal intravenous magnesium: case report and review of the literature. ( Gill, H; Maxwell, D; Rosenthal, E; Simpson, JM, 2009)
" Flecainide appeared to be safe (no deaths with usual oral dosing, < 1% serious proarrhythmia) and effective (73% to 100% control, depending on mechanism) in children with supraventricular tachycardia."2.38Flecainide acetate for treatment of tachyarrhythmias in children: review of world literature on efficacy, safety, and dosing. ( Garson, A; Perry, JC, 1992)
"Fetal supraventricular tachycardia is a relatively uncommon cardiac rhythm abnormality which is often associated with adverse perinatal outcomes if untreated."1.62Management of Fetal Supraventricular Tachycardia: Case Series from a Tertiary Perinatal Cardiac Center. ( Broom, E; Gardener, G; Gooi, A; Kostner, K; Kumar, S; Lee-Tannock, A; Petersen, S; Thomas, JT; Ward, C, 2021)
"Hydrops was present 28 of 84 (33%)."1.43Flecainide versus digoxin for fetal supraventricular tachycardia: Comparison of two drug treatment protocols. ( Dominguez, TE; Janoušek, J; Marek, J; Škovránek, J; Sridharan, S; Sullivan, I; Tomek, V; Wolfenden, J; Yates, R, 2016)
"Transplacental flecainide is an established therapy for fetal supraventricular tachycardia (SVT), but there is a paucity of data regarding the dose-response relationship."1.40Correlation of maternal flecainide concentrations and therapeutic effect in fetal supraventricular tachycardia. ( Andrews, RE; Callaghan, N; Miller, O; Rosenthal, E; Sharland, GK; Simpson, JM; Vigneswaran, TV, 2014)
" This case report describes a novel approach to fetal cardioversion using oral maternal bolus dosing of flecainide."1.39A novel method of fetal cardioversion. ( Sanghavi, DM, 2013)
"Flecainide and digoxin were superior to sotalol in converting SVT to a normal rhythm and in slowing both AF and SVT to better-tolerated ventricular rates and therefore might be considered first to treat significant fetal tachyarrhythmia."1.37Comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study. ( Api, O; Blom, NA; Carvalho, JS; Clur, SA; De Groot, E; Jaeggi, ET; Manlhiot, C; McCrindle, BW; Rammeloo, L; Ryan, G, 2011)
"Tachycardia was observed in 15% of cases (three cases of supraventricular tachycardia [SVT] and two cases of auricular flutter [AF])."1.31[Fetal arrhythmias: diagnosis, prognosis, treatment; apropos of 33 cases]. ( Dubos, JP; Dufour, P; Puech, F; Subtil, D; Vaast, P; Vaksmann, G; Valat, AS; Vautier-Rit, S, 2000)
"Flecainide use can cause the absence of accelerations and poor variability in the FHR."1.29The effect of flecainide acetate on fetal heart rate variability: a case report. ( de Jong, CL; de Vries, JI; van Geijn, HP; van Gelder-Hasker, MR, 1995)
"Fetal hydrops was seen in 22 patients."1.29Management outcome and follow-up of fetal tachycardia. ( Brenner, JI; Copel, JA; Kleinman, CS; Meijboom, EJ; Stoutenbeek, P; van Engelen, AD; Weijtens, O, 1994)
"Flecainide was effective in restoring sinus rhythm in all non-hydropic fetuses where digoxin treatment failed, and in 43 per cent of hydropic fetuses."1.29The efficacy of flecainide versus digoxin in the management of fetal supraventricular tachycardia. ( Den Hollander, NS; Frohn-Mulder, IM; Hess, J; Stewart, PA; Witsenburg, M; Wladimiroff, JW, 1995)
"The fetus required no further treatment in pregnancy or at follow up."1.28Intermittent fetal tachycardia and fetal hydrops. ( James, DK; Martin, R; Smoleniec, JS, 1991)
"Encainide was completely effective in 54% (22 of 41 study patients) and partially effective in an additional 24% (10 of 41 patients), when combined with propranolol or verapamil."1.27Encainide for resistant supraventricular tachycardia in children: follow-up report. ( Garson, A; Gothing, C; Moak, JP; Smith, RT; Strasburger, JF, 1988)
"In cases of non-immune hydrops fetalis caused by tachyarrhythmias, the transplacental passage of antiarrhythmic drugs may be hampered."1.27Direct intrauterine fetal treatment of fetal tachyarrhythmia with severe hydrops fetalis by antiarrhythmic drugs. ( Bald, R; Gembruch, U; Hansmann, M, 1988)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19903 (5.77)18.7374
1990's16 (30.77)18.2507
2000's16 (30.77)29.6817
2010's14 (26.92)24.3611
2020's3 (5.77)2.80

Authors

AuthorsStudies
Tunca Sahin, G1
Beattie, RB1
Uzun, O2
Broom, E1
Thomas, JT1
Petersen, S1
Gooi, A1
Ward, C1
Gardener, G1
Kostner, K1
Lee-Tannock, A1
Kumar, S1
Miyoshi, T2
Maeno, Y2
Hamasaki, T2
Inamura, N2
Yasukochi, S2
Kawataki, M2
Horigome, H2
Yoda, H2
Taketazu, M2
Nii, M2
Hagiwara, A2
Kato, H2
Shimizu, W2
Shiraishi, I2
Sakaguchi, H2
Ueda, K2
Katsuragi, S2
Yamamoto, H2
Sago, H2
Ikeda, T2
Refaat, M1
El Dick, J1
Sabra, M1
Bitar, F1
Tayeh, C1
Abutaqa, M1
Arabi, M1
Hill, GD1
Kovach, JR1
Saudek, DE1
Singh, AK1
Wehrheim, K1
Frommelt, MA1
Shozu, M1
Alsaied, T1
Baskar, S1
Fares, M1
Alahdab, F1
Czosek, RJ1
Murad, MH1
Prokop, LJ1
Divanovic, AA1
Enzensberger, C1
Kreymborg, KG1
Valeske, K1
Apitz, C1
Akintürk, H1
Schranz, D1
Axt-Fliedner, R1
Vigneswaran, TV1
Callaghan, N1
Andrews, RE1
Miller, O1
Rosenthal, E3
Sharland, GK2
Simpson, JM2
Cuneo, BF1
Benson, DW1
Schmidt, JJ1
Ramazan, L1
Bockemeyer, C1
Günter, HH1
Martens-Lobenhoffer, J1
Ganzenmüller, T1
Bode-Böger, SM1
Kielstein, JT1
Van Hare, GF1
Sridharan, S1
Sullivan, I1
Tomek, V1
Wolfenden, J1
Škovránek, J1
Yates, R1
Janoušek, J1
Dominguez, TE1
Marek, J1
Ekiz, A1
Kaya, B1
Bornaun, H1
Acar, DK1
Avci, ME1
Bestel, A1
Yildirim, G1
Van Leeuwen, P2
Schiermeier, S2
Hailer, B1
Lange, S1
Geue, D1
Hatzmann, W2
Grönemeyer, D2
Reinhard, J1
Maxwell, D2
Gill, H1
Jaeggi, ET1
Carvalho, JS1
De Groot, E1
Api, O1
Clur, SA1
Rammeloo, L1
McCrindle, BW1
Ryan, G1
Manlhiot, C1
Blom, NA1
Babaoglu, K1
Sinha, A1
Massias, S1
Beattie, B1
Sanghavi, DM1
D'Souza, D1
MacKenzie, WE1
Martin, WL1
Rasheed, A1
Simpson, J1
Jouannic, JM1
Delahaye, S1
Le Bidois, J1
Fermont, L1
Villain, E1
Dommergues, M1
Dumez, Y1
Hall, CM1
Ward Platt, MP1
Malvino, E1
Bruno, MC1
Gallo, JP1
Medrano, JC1
Ferrante, D1
Gerli, S1
Clerici, G1
Mattei, A1
Di Renzo, GC1
Campbell, JQ1
Best, TH1
Eswaran, H1
Lowery, CL1
van Gelder-Hasker, MR1
de Jong, CL1
de Vries, JI1
van Geijn, HP1
Vanderhal, AL1
Cocjin, J1
Santulli, TV1
Carlson, DE1
Rosenthal, P1
van Engelen, AD1
Weijtens, O1
Brenner, JI1
Kleinman, CS1
Copel, JA1
Stoutenbeek, P2
Meijboom, EJ2
Blanch, G1
Walkinshaw, SA1
Walsh, K1
Frohn-Mulder, IM1
Stewart, PA1
Witsenburg, M1
Den Hollander, NS1
Wladimiroff, JW1
Hess, J1
Hamel, P2
Febbraro, W1
Barjot, P2
Lindet, Y1
Muller, G1
Iselin, M1
Azancot-Benisty, A2
Areias, JC1
Oberhänsli, I1
Schmidt, KG1
Tulzer, G1
Viart, P1
Calmelet, P1
Maragnes, P1
Herlicoviez, M1
Edwards, A1
Peek, MJ1
Curren, J1
Midgley, DY1
Harding, K1
Schmolling, J1
Renke, K1
Richter, O1
Pfeiffer, K1
Schlebusch, H1
Höller, T1
Vautier-Rit, S1
Dufour, P1
Vaksmann, G1
Subtil, D1
Vaast, P1
Valat, AS1
Dubos, JP1
Puech, F1
Kähler, C1
Schleussner, E1
Schneider, U1
Seewald, HJ1
Oudijk, MA1
Ambachtsheer, EB1
Krapp, M1
Baschat, AA1
Gembruch, U2
Geipel, A1
Germer, U1
Jacqz-Aigrain, E1
Guirgis, NM1
Decrepy, A1
Oury, JF1
Blot, P1
Perry, JC2
Garson, A2
Mills, M1
Smoleniec, JS1
Martin, R1
James, DK1
Allan, LD1
Chita, SK1
Priestley, K1
Ayres, NA1
Carpenter, RJ1
Kofinas, AD1
Simon, NV1
Sagel, H1
Lyttle, E1
Smith, N1
King, K1
Wren, C1
Hunter, S1
Strasburger, JF1
Smith, RT1
Moak, JP1
Gothing, C1
Hansmann, M1
Bald, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Safety Assessment for Sotalol Protocol in Outpatient Unit[NCT05418036]Phase 4110 participants (Anticipated)Interventional2020-10-26Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for flecainide and Embryopathies

ArticleYear
Sotalol as an effective adjunct therapy in the management of supraventricular tachycardia induced fetal hydrops fetalis.
    Journal of neonatal-perinatal medicine, 2020, Volume: 13, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Digoxin; Drug Therapy, Combination; Female; Fetal Diseases; Flecainid

2020
Transplacental treatment of fetal tachycardia: A systematic review and meta-analysis.
    Prenatal diagnosis, 2017, Volume: 37, Issue:11

    Topics: Anti-Arrhythmia Agents; Digoxin; Female; Fetal Diseases; Fetal Therapies; Flecainide; Humans; Pregna

2017
First-Line Antiarrhythmic Transplacental Treatment for Fetal Tachyarrhythmia: A Systematic Review and Meta-Analysis.
    Journal of the American Heart Association, 2017, Dec-15, Volume: 6, Issue:12

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Echocardiography; Female; Fetal Diseases; Fetal Therap

2017
Fetal ventricular tachycardia secondary to long QT syndrome treated with maternal intravenous magnesium: case report and review of the literature.
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2009, Volume: 34, Issue:4

    Topics: Adult; Anti-Arrhythmia Agents; Female; Fetal Diseases; Flecainide; Humans; Injections, Intravenous;

2009
[Protocols for the treatment of supraventricular tachycardias in the fetus].
    Nederlands tijdschrift voor geneeskunde, 2001, Jun-23, Volume: 145, Issue:25

    Topics: Anti-Arrhythmia Agents; Atrial Flutter; Clinical Protocols; Digoxin; Drug Therapy, Combination; Fema

2001
Flecainide acetate for treatment of tachyarrhythmias in children: review of world literature on efficacy, safety, and dosing.
    American heart journal, 1992, Volume: 124, Issue:6

    Topics: Arrhythmias, Cardiac; Child; Child, Preschool; Fetal Diseases; Flecainide; Humans; Infant; Tachycard

1992

Trials

3 trials available for flecainide and Embryopathies

ArticleYear
Antenatal Therapy for Fetal Supraventricular Tachyarrhythmias: Multicenter Trial.
    Journal of the American College of Cardiology, 2019, 08-20, Volume: 74, Issue:7

    Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Atrial Flutter; Cesarean Section; Digoxin; Fema

2019
Clinical and pharmacologic study of fetal supraventricular tachyarrhythmias.
    The Journal of pediatrics, 1992, Volume: 121, Issue:4

    Topics: Digoxin; Drug Therapy, Combination; Fetal Diseases; Flecainide; Humans; Prospective Studies; Retrosp

1992
Treatment of fetal supraventricular tachycardia with flecainide acetate after digoxin failure.
    American journal of obstetrics and gynecology, 1991, Volume: 165, Issue:3

    Topics: Adult; Digoxin; Female; Fetal Diseases; Flecainide; Humans; Pregnancy; Tachycardia, Supraventricular

1991

Other Studies

43 other studies available for flecainide and Embryopathies

ArticleYear
Favourable outcome for hydrops or cardiac failure associated with fetal tachyarrhythmia: a 20-year review.
    Cardiology in the young, 2022, Volume: 32, Issue:7

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cesarean Section; Digoxin; Female; Fetal Diseases; Fle

2022
Management of Fetal Supraventricular Tachycardia: Case Series from a Tertiary Perinatal Cardiac Center.
    Fetal diagnosis and therapy, 2021, Volume: 48, Issue:11-12

    Topics: Anti-Arrhythmia Agents; Female; Fetal Diseases; Flecainide; Humans; Hydrops Fetalis; Pregnancy; Retr

2021
Antenatal antiarrhythmic treatment for fetal tachyarrhythmias: a study protocol for a prospective multicentre trial.
    BMJ open, 2017, Aug-29, Volume: 7, Issue:8

    Topics: Anti-Arrhythmia Agents; Atrial Flutter; Child Development; Child, Preschool; Digoxin; Drug Therapy,

2017
Management of idiopathic giant dilatation of the right atrium with subsequent atrial tachycardia.
    Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:3

    Topics: Adult; Anti-Arrhythmia Agents; Digoxin; Echocardiography; Female; Fetal Diseases; Flecainide; Heart

2013
Correlation of maternal flecainide concentrations and therapeutic effect in fetal supraventricular tachycardia.
    Heart rhythm, 2014, Volume: 11, Issue:11

    Topics: Adult; Algorithms; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Echocardiography; Femal

2014
Use of maternal flecainide concentration in management of fetal supraventricular tachycardia: a step in the right direction.
    Heart rhythm, 2014, Volume: 11, Issue:11

    Topics: Anti-Arrhythmia Agents; Female; Fetal Diseases; Flecainide; Humans; Pregnancy; Tachycardia, Supraven

2014
Acute interstitial nephritis due to flecainide therapy in the 38(th) week of pregnancy.
    BMC nephrology, 2016, Mar-15, Volume: 17

    Topics: Acute Disease; Acute Kidney Injury; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal;

2016
Flecainide vs digoxin for fetal supraventricular tachycardia: Comparison of 2 drug protocols.
    Heart rhythm, 2016, Volume: 13, Issue:9

    Topics: Anti-Arrhythmia Agents; Digoxin; Fetal Diseases; Flecainide; Humans; Tachycardia; Tachycardia, Supra

2016
Flecainide versus digoxin for fetal supraventricular tachycardia: Comparison of two drug treatment protocols.
    Heart rhythm, 2016, Volume: 13, Issue:9

    Topics: Administration, Intravenous; Administration, Oral; Adult; Anti-Arrhythmia Agents; Clinical Protocols

2016
Flecainide as first-line treatment for fetal supraventricular tachycardia.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2018, Volume: 31, Issue:4

    Topics: Adult; Anti-Arrhythmia Agents; Echocardiography; Female; Fetal Diseases; Fetal Heart; Flecainide; Ge

2018
Effect of prenatal antiarrhythmic treatment on cardiac function in a twin pregnancy.
    Pacing and clinical electrophysiology : PACE, 2008, Volume: 31, Issue:9

    Topics: Adult; Anti-Arrhythmia Agents; Diseases in Twins; Female; Fetal Diseases; Flecainide; Humans; Pregna

2008
Diagnosis, treatment, observation and outcome of fetal supraventricular tachycardia in a twin pregnancy.
    Fetal diagnosis and therapy, 2008, Volume: 24, Issue:4

    Topics: Adrenergic beta-Agonists; Adult; Anti-Arrhythmia Agents; Echocardiography; Female; Fenoterol; Fetal

2008
Comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study.
    Circulation, 2011, Oct-18, Volume: 124, Issue:16

    Topics: Anti-Arrhythmia Agents; Digoxin; Drug Evaluation; Female; Fetal Diseases; Fetal Therapies; Flecainid

2011
Rapid control of foetal supraventricular tachycardia with digoxin and flecainide combination treatment.
    Cardiology in the young, 2012, Volume: 22, Issue:4

    Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Atrial Flutter; Digoxin; Drug Therapy, Combination; Echoc

2012
A novel method of fetal cardioversion.
    Pediatric cardiology, 2013, Volume: 34, Issue:3

    Topics: Administration, Oral; Arrhythmias, Cardiac; Digoxin; Dose-Response Relationship, Drug; Drug Administ

2013
Transplacental flecainide therapy in the treatment of fetal supraventricular tachycardia.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2002, Volume: 22, Issue:3

    Topics: Adult; Anti-Arrhythmia Agents; Cardiotocography; Electrocardiography; Female; Fetal Diseases; Flecai

2002
Neonatal ECG changes caused by supratherapeutic flecainide following treatment for fetal supraventricular tachycardia.
    Heart (British Cardiac Society), 2003, Volume: 89, Issue:4

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Fetal Diseases; Flecainid

2003
[Results of prenatal management of fetuses with supraventricular tachycardia. A series of 66 cases].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 2003, Volume: 32, Issue:4

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Flutter; Clinical Protocols; Digoxin; Echocardiography; F

2003
Neonatal flecainide toxicity following supraventricular tachycardia treatment.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:9

    Topics: Anti-Arrhythmia Agents; Dobutamine; Enoximone; Female; Fetal Diseases; Flecainide; Humans; Infant, N

2003
[Fetal supraventricular tachyarrhythmias refractory to initial therapy].
    Medicina, 2005, Volume: 65, Issue:2

    Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Digoxin; Female; Fetal Diseases; Flecainide; Humans; Male

2005
Flecainide treatment of fetal tachycardia and hydrops fetalis in a twin pregnancy.
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2006, Volume: 28, Issue:1

    Topics: Anti-Arrhythmia Agents; Echocardiography; Female; Fetal Diseases; Flecainide; Humans; Hydrops Fetali

2006
Fetal and maternal magnetocardiography during flecainide therapy for supraventricular tachycardia.
    Obstetrics and gynecology, 2006, Volume: 108, Issue:3 Pt 2

    Topics: Anti-Arrhythmia Agents; Diseases in Twins; Electrocardiography; Female; Fetal Diseases; Flecainide;

2006
The effect of flecainide acetate on fetal heart rate variability: a case report.
    Obstetrics and gynecology, 1995, Volume: 86, Issue:4 Pt 2

    Topics: Adult; Female; Fetal Diseases; Flecainide; Heart Rate, Fetal; Humans; Pregnancy; Tachycardia, Suprav

1995
Conjugated hyperbilirubinemia in a newborn infant after maternal (transplacental) treatment with flecainide acetate for fetal tachycardia and fetal hydrops.
    The Journal of pediatrics, 1995, Volume: 126, Issue:6

    Topics: Female; Fetal Diseases; Flecainide; Humans; Hydrops Fetalis; Infant; Infant, Newborn; Jaundice, Neon

1995
Management outcome and follow-up of fetal tachycardia.
    Journal of the American College of Cardiology, 1994, Nov-01, Volume: 24, Issue:5

    Topics: Atrial Flutter; Digoxin; Echocardiography; Female; Fetal Diseases; Fetal Heart; Flecainide; Follow-U

1994
Cardioversion of fetal tachyarrhythmia with adenosine.
    Lancet (London, England), 1994, Dec-10, Volume: 344, Issue:8937

    Topics: Adenosine; Adult; Digoxin; Female; Fetal Diseases; Flecainide; Heart Rate, Fetal; Humans; Infant, Ne

1994
The efficacy of flecainide versus digoxin in the management of fetal supraventricular tachycardia.
    Prenatal diagnosis, 1995, Volume: 15, Issue:13

    Topics: Anti-Arrhythmia Agents; Digoxin; Edema; Female; Fetal Diseases; Flecainide; Humans; Pregnancy; Retro

1995
[Flecaine: drug of choice for supraventricular tachycardias with anasarca. A case report].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1997, Volume: 26, Issue:1

    Topics: Anti-Arrhythmia Agents; Electrocardiography; Female; Fetal Diseases; Flecainide; Heart Failure; Huma

1997
[European protocol for the management of fetal supraventricular tachycardia. European Association of Pediatric Cardiology].
    Archives des maladies du coeur et des vaisseaux, 1997, Volume: 90, Issue:5

    Topics: Anti-Arrhythmia Agents; Digoxin; Drug Therapy, Combination; Electrocardiography; Female; Fetal Death

1997
Flecainide against fetal supraventricular tachycardia complicated by hydrops fetalis.
    Acta obstetricia et gynecologica Scandinavica, 1998, Volume: 77, Issue:3

    Topics: Anti-Arrhythmia Agents; Female; Fetal Diseases; Flecainide; Follow-Up Studies; Humans; Hydrops Fetal

1998
Transplacental flecainide therapy for fetal supraventricular tachycardia in a twin pregnancy.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1999, Volume: 39, Issue:1

    Topics: Adult; Anti-Arrhythmia Agents; Diseases in Twins; Ethics, Medical; Female; Fetal Diseases; Flecainid

1999
The Mirror syndrome.
    European journal of obstetrics, gynecology, and reproductive biology, 2000, Volume: 88, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Female; Fetal Diseases; Flecainide; Humans; Hydrops Fetalis; Pre-Ecla

2000
Digoxin, flecainide, and amiodarone transfer across the placenta and the effects of an elevated umbilical venous pressure on the transfer rate.
    Therapeutic drug monitoring, 2000, Volume: 22, Issue:5

    Topics: Amiodarone; Anti-Arrhythmia Agents; Area Under Curve; Digoxin; Female; Fetal Diseases; Flecainide; H

2000
[Fetal arrhythmias: diagnosis, prognosis, treatment; apropos of 33 cases].
    Gynecologie, obstetrique & fertilite, 2000, Volume: 28, Issue:10

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Cardiac Complexes, Premature; Echocardiog

2000
Prenatal diagnosis of the Wolf-Parkinson-White-syndrome by fetal magnetocardiography.
    BJOG : an international journal of obstetrics and gynaecology, 2001, Volume: 108, Issue:3

    Topics: Adult; Anti-Arrhythmia Agents; Electrocardiography; Female; Fetal Diseases; Flecainide; Humans; Magn

2001
Flecainide in the intrauterine treatment of fetal supraventricular tachycardia.
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2002, Volume: 19, Issue:2

    Topics: Anti-Arrhythmia Agents; Cardiotocography; Digoxin; Female; Fetal Diseases; Flecainide; Humans; Hydro

2002
Treatment of fetal supraventricular tachycardia with flecainide acetate after digoxin failure.
    American journal of obstetrics and gynecology, 1992, Volume: 166, Issue:6 Pt 1

    Topics: Adult; Digoxin; Female; Fetal Diseases; Flecainide; Humans; Pregnancy; Tachycardia, Supraventricular

1992
Intermittent fetal tachycardia and fetal hydrops.
    Archives of disease in childhood, 1991, Volume: 66, Issue:10 Spec No

    Topics: Adult; Female; Fetal Diseases; Flecainide; Humans; Hydrops Fetalis; Pregnancy; Tachycardia, Supraven

1991
Flecainide in the treatment of fetal tachycardias.
    British heart journal, 1991, Volume: 65, Issue:1

    Topics: Cardiac Output, Low; Digoxin; Female; Fetal Death; Fetal Diseases; Flecainide; Humans; Pregnancy; Ta

1991
Fetal supraventricular tachycardia treated with flecainide acetate.
    The Journal of pediatrics, 1991, Volume: 118, Issue:2

    Topics: Adult; Female; Fetal Diseases; Fetal Heart; Flecainide; Humans; Infant, Newborn; Male; Pregnancy; Ta

1991
Maternal administration of flecainide to terminate and suppress fetal tachycardia.
    British medical journal (Clinical research ed.), 1988, Jan-23, Volume: 296, Issue:6617

    Topics: Female; Fetal Diseases; Flecainide; Humans; Maternal-Fetal Exchange; Pregnancy; Tachycardia

1988
Encainide for resistant supraventricular tachycardia in children: follow-up report.
    The American journal of cardiology, 1988, Dec-20, Volume: 62, Issue:19

    Topics: Administration, Oral; Adolescent; Anilides; Anti-Arrhythmia Agents; Child; Child, Preschool; Drug Th

1988
Direct intrauterine fetal treatment of fetal tachyarrhythmia with severe hydrops fetalis by antiarrhythmic drugs.
    Fetal therapy, 1988, Volume: 3, Issue:4

    Topics: Anti-Arrhythmia Agents; Female; Fetal Diseases; Flecainide; Humans; Hydrops Fetalis; Medigoxin; Preg

1988