flecainide has been researched along with Drug Overdose in 40 studies
Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 12-year-old girl developed generalized tonic-clonic seizures following ingestion of flecainide 1500 mg (15 tablets)." | 7.67 | Generalized seizures as the presentation of flecainide toxicity. ( Kennerdy, A; Sheridan, DJ; Thomas, P, 1989) |
| "Takotsubo syndrome, also known as stress cardiomyopathy, is predominantly reported in postmenopausal women and it is often triggered by a physical or emotional stressor." | 6.72 | Takotsubo cardiomyopathy and flecainide toxicity: a case report and brief literature review. ( Acconcia, MC; Barillà, F; Carbone, I; Gaudio, C; Moretti, A; Pannarale, G; Polselli, M; Quaglione, R; Torromeo, C, 2021) |
| "Magnesium sulphate was added to conventional medical therapy in the treatment of persistent severe hypotension and wide QRS complex tachyarrhythmia in an 18-year-old woman presenting with a 1200 mg flecainide overdose." | 3.76 | Management of persistent wide QRS in flecainide overdose with magnesium sulphate. ( Frost, I; Singh, VK; Sinha, A; Williamson, DG, 2010) |
| "A 2-year-old male with a history of a persistent junctional reciprocating tachycardia had been receiving flecainide 4." | 3.75 | Life-threatening flecainide intoxication in a young child secondary to medication error. ( Buffo-Sequiera, I; D'Alessandro, LC; Freeman, D; Gloor, J; Rieder, MJ, 2009) |
| "After suicidal ingestion of 3 g flecainide a 34-year-old woman showed somnolence, cerebral convulsion, disturbances of atrioventricular and intraventricular conduction and ventricular asystole." | 3.68 | [Successful treatment of flecainide (Tambocor) poisoning--effect of hemodialysis/hemoperfusion?]. ( Dirks, E; Gieshoff, B; Hager, W; Stahlmann, R; Wehr, M, 1990) |
| "A 12-year-old girl developed generalized tonic-clonic seizures following ingestion of flecainide 1500 mg (15 tablets)." | 3.67 | Generalized seizures as the presentation of flecainide toxicity. ( Kennerdy, A; Sheridan, DJ; Thomas, P, 1989) |
| "Takotsubo syndrome, also known as stress cardiomyopathy, is predominantly reported in postmenopausal women and it is often triggered by a physical or emotional stressor." | 2.72 | Takotsubo cardiomyopathy and flecainide toxicity: a case report and brief literature review. ( Acconcia, MC; Barillà, F; Carbone, I; Gaudio, C; Moretti, A; Pannarale, G; Polselli, M; Quaglione, R; Torromeo, C, 2021) |
| "Flecainide is a 1C antidysrhythmic that is primarily used for ventricular tachycardia or premature ventricular contractions when other treatment is ineffective." | 1.72 | Flecainide poisoning and prolongation of elimination due to alkalinization. ( Georgakakos, PK; McCabe, DJ; Radke, JB; Walsh, RD; Wilson, BZ, 2022) |
| " The drug's slow rate of elimination and high oral bioavailability make successful management extremely challenging." | 1.62 | Management of life-threatening flecainide overdose: a case report of an infant. ( Tuncer, T, 2021) |
| "Flecainide intoxication is a severe intoxication that can lead to cardiogenic shock." | 1.51 | Renal failure, shock, and loss of pacemaker capture: A case of flecainide intoxication. ( Heldens, M; Melman, PG; van der Nat, GAM, 2019) |
| "Flecainide is a Class Ic antiarrythmic agent associated with adverse events due to its pro-arrythmic effects." | 1.42 | Life-threatening flecainide overdose treated with intralipid and extracorporeal membrane oxygenation. ( Bernard, KR; Brumfield, E; Kabrhel, C, 2015) |
| "Flecainide is a Vaughan Williams Class Ic antidysrhythmic associated with PR, QRS, and QTc prolongation on the electrocardiogram and development of life-threatening cardiac toxicity in overdose." | 1.39 | A life-threatening flecainide overdose treated with intravenous fat emulsion. ( Cole, JB; Dolan, JA; Ellsworth, H; Harris, CR; Stellpflug, SJ, 2013) |
| "Flecainide is a class IC antidysrhythmic primarily indicated for ventricular dysrhythmias and supraventricular tachycardia (SVT)." | 1.39 | A case of near-fatal flecainide overdose in a neonate successfully treated with sodium bicarbonate. ( Hoffman, RS; Jang, DH; Nelson, LS, 2013) |
| "An amiodarone infusion was started and continued over a period of 72 h." | 1.31 | Amiodarone used in successful resuscitation after near-fatal flecainide overdose. ( Board, PN; Siegers, A, 2002) |
| "Flecainide acetate is a potent class Ic anti-arrhythmic drug with major sodium channel blocking actions." | 1.30 | Survival in a case of life-threatening flecainide overdose. ( Bourke, JP; Gascoigne, AD; Hanley, NA, 1998) |
| "Flecainide acetate is a potent class 1C antiarrhythmic agent used mainly for the treatment of supraventricular arrhythmias." | 1.30 | Fatal flecainide intoxication. ( Bodiwala, GG; Bouch, DC; Brazil, E, 1998) |
| "Flecainide was detected by GC/MS in gastric contents, blood and liver as well." | 1.30 | Fatal flecainide intoxication. ( Augsburger, M; Giroud, C; Mangin, P; Michaud, K; Romain, N, 1999) |
| "Flecainide was identified by ultraviolet (UV) spectrophotometry and gas chromatography-mass spectrometry (GC-MS)." | 1.29 | Unsuspected self-poisoning with flecainide and alcohol. ( Quigley, C; Sadler, DW, 1995) |
| "Flecainide acetate is a new potent class I antiarrhythmic agent." | 1.28 | The electrocardiographic changes in a case of flecainide overdose. ( Chung, PK; Tuso, P, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.50) | 18.7374 |
| 1990's | 11 (27.50) | 18.2507 |
| 2000's | 7 (17.50) | 29.6817 |
| 2010's | 16 (40.00) | 24.3611 |
| 2020's | 5 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| McCabe, DJ | 1 |
| Walsh, RD | 1 |
| Georgakakos, PK | 1 |
| Radke, JB | 1 |
| Wilson, BZ | 1 |
| Ghataoura, R | 1 |
| Patil, S | 1 |
| Tuncer, T | 1 |
| Moretti, A | 1 |
| Polselli, M | 1 |
| Carbone, I | 1 |
| Pannarale, G | 1 |
| Acconcia, MC | 1 |
| Torromeo, C | 1 |
| Quaglione, R | 1 |
| Barillà, F | 1 |
| Gaudio, C | 1 |
| Yaradılmış, RM | 1 |
| Öztürk, B | 1 |
| Ozturk, Z | 1 |
| Özgür, S | 1 |
| Tuygun, N | 1 |
| Karacan, CD | 1 |
| Ben Kilani, M | 1 |
| Naccache, S | 1 |
| Tlili, R | 1 |
| Mbarek, D | 1 |
| Longo, S | 1 |
| Ben Ameur, Y | 1 |
| Boujnah, MR | 1 |
| Dokter, M | 1 |
| Talarico, G | 1 |
| Armbrust, S | 1 |
| Below, E | 1 |
| Bockholdt, B | 1 |
| Viland, J | 1 |
| Langørgen, J | 1 |
| Wendelbo, Ø | 1 |
| Heldens, M | 1 |
| van der Nat, GAM | 1 |
| Melman, PG | 1 |
| Wilgenhof, A | 1 |
| Michiels, V | 1 |
| Cosyns, B | 1 |
| Lloyd, T | 1 |
| Zimmerman, J | 1 |
| Griffin, GD | 1 |
| Chubb, H | 1 |
| Cooklin, M | 1 |
| Rosenthal, E | 1 |
| Kwan, D | 1 |
| Vohra, R | 1 |
| Dyer, JE | 1 |
| Dornhoffer, P | 1 |
| Brumfield, E | 1 |
| Bernard, KR | 1 |
| Kabrhel, C | 1 |
| Mukhtar, O | 1 |
| Archer, JR | 1 |
| Dargan, PI | 1 |
| Wood, DM | 1 |
| Steinmetz, M | 1 |
| Nickenig, G | 1 |
| Sauerbruch, T | 1 |
| Eyer, F | 1 |
| Rabe, C | 1 |
| Tessitore, E | 1 |
| Ramlawi, M | 1 |
| Tobler, O | 1 |
| Sunthorn, H | 1 |
| Yavari, A | 1 |
| Fryer, J | 1 |
| Walker, DM | 1 |
| D'Alessandro, LC | 1 |
| Rieder, MJ | 1 |
| Gloor, J | 1 |
| Freeman, D | 1 |
| Buffo-Sequiera, I | 1 |
| Williamson, DG | 1 |
| Sinha, A | 1 |
| Frost, I | 1 |
| Singh, VK | 1 |
| Cabrera Ortega, M | 1 |
| Gell Aboy, J | 1 |
| Díaz Berto, E | 1 |
| Monagas Docasal, V | 1 |
| Ellsworth, H | 1 |
| Stellpflug, SJ | 1 |
| Cole, JB | 1 |
| Dolan, JA | 1 |
| Harris, CR | 1 |
| Jang, DH | 1 |
| Hoffman, RS | 1 |
| Nelson, LS | 1 |
| Hudson, CJ | 1 |
| Whitner, TE | 1 |
| Rinaldi, MJ | 1 |
| Littmann, L | 1 |
| López Sánchez, M | 1 |
| Ballesteros Sanz, MA | 1 |
| Devin, R | 1 |
| Garrett, P | 1 |
| Anstey, C | 1 |
| Sadler, DW | 1 |
| Quigley, C | 1 |
| Yasui, RK | 1 |
| Culclasure, TF | 1 |
| Kaufman, D | 1 |
| Freed, CR | 1 |
| Hanley, NA | 1 |
| Bourke, JP | 1 |
| Gascoigne, AD | 1 |
| Lovecchio, F | 1 |
| Berlin, R | 1 |
| Brubacher, JR | 1 |
| Sholar, JB | 1 |
| Brazil, E | 1 |
| Bodiwala, GG | 1 |
| Bouch, DC | 1 |
| Corkeron, MA | 1 |
| van Heerden, PV | 1 |
| Newman, SM | 1 |
| Dusci, L | 1 |
| Romain, N | 1 |
| Giroud, C | 1 |
| Michaud, K | 1 |
| Augsburger, M | 1 |
| Mangin, P | 1 |
| Auzinger, GM | 1 |
| Scheinkestel, CD | 1 |
| Siegers, A | 1 |
| Board, PN | 1 |
| Brimacombe, J | 1 |
| Talbutt, P | 1 |
| Dirks, E | 1 |
| Gieshoff, B | 1 |
| Stahlmann, R | 1 |
| Wehr, M | 1 |
| Hager, W | 1 |
| Chung, PK | 1 |
| Tuso, P | 1 |
| Köppel, C | 1 |
| Oberdisse, U | 1 |
| Heinemeyer, G | 1 |
| Kennerdy, A | 1 |
| Thomas, P | 1 |
| Sheridan, DJ | 1 |
2 reviews available for flecainide and Drug Overdose
| Article | Year |
|---|---|
Flecainide toxicity: a presentation to the emergency department with literature review.
Topics: Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Bisoprolol; Drug Overdose; Electrocardiograph | 2020 |
Takotsubo cardiomyopathy and flecainide toxicity: a case report and brief literature review.
Topics: Adult; Anti-Arrhythmia Agents; Drug Overdose; Female; Flecainide; Humans; Takotsubo Cardiomyopathy | 2021 |
38 other studies available for flecainide and Drug Overdose
| Article | Year |
|---|---|
Flecainide poisoning and prolongation of elimination due to alkalinization.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Flecainide; Humans | 2022 |
Management of life-threatening flecainide overdose: a case report of an infant.
Topics: Anti-Arrhythmia Agents; Drug Overdose; Electrocardiography; Flecainide; Humans; Infant; Infant, Newb | 2021 |
Fatal Intoxication of Flecainide Overdose: A Case Report.
Topics: Drug Overdose; Electrocardiography; Flecainide; Humans | 2022 |
Attempted suicide by Flécainide overdose: A case report.
Topics: Adolescent; Drug Overdose; Electrocardiography; Female; Flecainide; Humans; Suicide, Attempted | 2017 |
[Fatal flecainide intoxication in a 17-year-old girl].
Topics: Adolescent; Anti-Arrhythmia Agents; Autopsy; Drug Overdose; Electrocardiography; Fatal Outcome; Fema | 2018 |
A somnolent woman in her fifties with acute circulatory failure.
Topics: Anti-Arrhythmia Agents; Charcoal; Drug Overdose; Electrocardiography; Female; Flecainide; Humans; Mi | 2019 |
Renal failure, shock, and loss of pacemaker capture: A case of flecainide intoxication.
Topics: Aged; Anti-Arrhythmia Agents; Bradycardia; Buffers; Cardiotonic Agents; Drug Overdose; Electrocardio | 2019 |
An irregular, extremely broad QRS complex rhythm.
Topics: Accidental Falls; Aged; Anti-Arrhythmia Agents; Drug Overdose; Electrocardiography; Fatigue; Female; | 2019 |
Irreversible third-degree heart block and pacemaker implant in a case of flecainide toxicity.
Topics: Aged, 80 and over; Drug Overdose; Electrocardiography; Emergency Service, Hospital; Female; Flecaini | 2013 |
Brugada phenocopy with a flecainide overdose: a pharmacological dose effect?
Topics: Adolescent; Anti-Arrhythmia Agents; Brugada Syndrome; Cardiac Pacing, Artificial; Drug Overdose; Ele | 2014 |
An infant with a heartbreaking medication error.
Topics: Drug Overdose; Extracorporeal Membrane Oxygenation; Flecainide; Humans; Infant; Male; Medication Err | 2014 |
Life-threatening flecainide overdose treated with intralipid and extracorporeal membrane oxygenation.
Topics: Adult; Anti-Arrhythmia Agents; Drug Overdose; Electrocardiography; Extracorporeal Membrane Oxygenati | 2015 |
Lesson of the month 1: Acute flecainide overdose and the potential utility of lipid emulsion therapy.
Topics: Adolescent; Drug Overdose; Emulsions; Female; Flecainide; Humans; Phospholipids; Soybean Oil | 2015 |
Effect of hemoperfusion on flecainide serum concentration - a case report.
Topics: Adolescent; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Drug Overdose; Female; Flecainide | 2017 |
Brugada Pattern Caused by a Flecainide Overdose.
Topics: Atrial Fibrillation; Bipolar Disorder; Brugada Syndrome; Consciousness Disorders; Drug Overdose; Ele | 2017 |
A dangerous secret.
Topics: Adolescent; Anti-Arrhythmia Agents; Diagnosis, Differential; Drug Overdose; Electrocardiography; Fle | 2009 |
Life-threatening flecainide intoxication in a young child secondary to medication error.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Bradycardia; Cardiopulmonary Resuscitation; Child, Pre | 2009 |
Management of persistent wide QRS in flecainide overdose with magnesium sulphate.
Topics: Adolescent; Anti-Arrhythmia Agents; Drug Overdose; Electrocardiography; Female; Flecainide; Humans; | 2010 |
[Acute flecainide overdose].
Topics: Anti-Arrhythmia Agents; Drug Overdose; Flecainide; Humans; Infant; Male | 2011 |
A life-threatening flecainide overdose treated with intravenous fat emulsion.
Topics: Anti-Arrhythmia Agents; Drug Overdose; Emergency Treatment; Fat Emulsions, Intravenous; Flecainide; | 2013 |
A case of near-fatal flecainide overdose in a neonate successfully treated with sodium bicarbonate.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Overdose; Flecainide; Humans; Infant, Newborn; Ma | 2013 |
Brugada electrocardiographic pattern elicited by inadvertent flecainide overdose.
Topics: Aged; Bundle-Branch Block; Drug Overdose; Electrocardiography; Flecainide; Humans; Male | 2004 |
[Flecainide overdose: report of a case].
Topics: Adult; Anti-Arrhythmia Agents; Drug Overdose; Female; Flecainide; Humans; Suicide, Attempted | 2005 |
Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.
Topics: Adult; Anti-Arrhythmia Agents; Cardiovascular Diseases; Charcoal; Drug Overdose; Electrocardiography | 2007 |
Unsuspected self-poisoning with flecainide and alcohol.
Topics: Adult; Chromatography, Gas; Chromatography, High Pressure Liquid; Drug Overdose; Ethanol; Fatal Outc | 1995 |
Flecainide overdose: is cardiopulmonary support the treatment?
Topics: Adult; Anti-Arrhythmia Agents; Bradycardia; Cardiopulmonary Bypass; Drug Overdose; Fatal Outcome; Fe | 1997 |
Survival in a case of life-threatening flecainide overdose.
Topics: Adolescent; Anti-Arrhythmia Agents; Bradycardia; Creatine Kinase; Drug Overdose; Electrocardiography | 1998 |
Hypertonic sodium bicarbonate in an acute flecainide overdose.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Buffers; Drug Overdose; Electrocardiography; Emergency Treatmen | 1998 |
Fatal flecainide intoxication.
Topics: Adult; Anti-Arrhythmia Agents; Drug Overdose; Electrocardiography; Fatal Outcome; Flecainide; Humans | 1998 |
Extracorporeal circulatory support in near-fatal flecainide overdose.
Topics: Adult; Anti-Arrhythmia Agents; Cardiopulmonary Bypass; Drug Overdose; Electrocardiography; Extracorp | 1999 |
Fatal flecainide intoxication.
Topics: Aged; Anti-Arrhythmia Agents; Bile; Body Fluids; Cerebral Cortex; Drug Overdose; Fatal Outcome; Flec | 1999 |
Successful extracorporeal life support in a case of severe flecainide intoxication.
Topics: Acidosis; Adult; Anti-Arrhythmia Agents; Drug Overdose; Electrocardiography; Epinephrine; Extracorpo | 2001 |
Amiodarone used in successful resuscitation after near-fatal flecainide overdose.
Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Drug Overdose; Female; Flecainide | 2002 |
Severe flecainide overdose.
Topics: Adult; Drug Overdose; Female; Flecainide; Humans | 1991 |
[Successful treatment of flecainide (Tambocor) poisoning--effect of hemodialysis/hemoperfusion?].
Topics: Adult; Drug Overdose; Electrocardiography; Female; Flecainide; Heart Arrest; Hemoperfusion; Humans; | 1990 |
The electrocardiographic changes in a case of flecainide overdose.
Topics: Adult; Drug Overdose; Electrocardiography; Female; Flecainide; Heart Block; Humans | 1990 |
Clinical course and outcome in class IC antiarrhythmic overdose.
Topics: Ajmaline; Anti-Arrhythmia Agents; Bicarbonates; Bradycardia; Drug Overdose; Flecainide; Hemoperfusio | 1990 |
Generalized seizures as the presentation of flecainide toxicity.
Topics: Child; Drug Overdose; Electrocardiography; Female; Flecainide; Humans; Myocardial Contraction; Seizu | 1989 |