flecainide and Aging
flecainide has been researched along with Aging in 6 studies
Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Adverse events including death are more frequent in older patients taking study drugs (P less than 0." | 2.67 | Effects of advancing age on the efficacy and side effects of antiarrhythmic drugs in post-myocardial infarction patients with ventricular arrhythmias. The CAST Investigators. ( Akiyama, T; Barker, AH; Campbell, WB; Friedman, L; Josephson, RA; Keller, M; Papa, L; Pawitan, Y; Rubbert, P, 1992) |
| " However, TDM is not necessarily used to adjust the dosage of antiarrhythmic drugs because there is a lack of information regarding the therapeutic range of the serum concentration and the selection of patients who require TDM." | 2.58 | [Use of Pharmacogenetic Information for Therapeutic Drug Monitoring of an Antiarrhythmic Drug]. ( Doki, K, 2018) |
| "However, the mechanisms of cardiac arrhythmias in DM1 are unknown." | 1.42 | Abnormal sodium current properties contribute to cardiac electrical and contractile dysfunction in a mouse model of myotonic dystrophy type 1. ( Algalarrondo, V; Azibi, K; Balse, E; Beldjord, C; Coulombe, A; Duboc, D; Eymard, B; Fischmeister, R; Gourdon, G; Hatem, SN; Sebag, F; Wahbi, K, 2015) |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Doki, K | 1 |
| Algalarrondo, V | 1 |
| Wahbi, K | 1 |
| Sebag, F | 1 |
| Gourdon, G | 1 |
| Beldjord, C | 1 |
| Azibi, K | 1 |
| Balse, E | 1 |
| Coulombe, A | 1 |
| Fischmeister, R | 1 |
| Eymard, B | 1 |
| Duboc, D | 1 |
| Hatem, SN | 1 |
| Wickenden, AD | 1 |
| Kaprielian, R | 1 |
| Parker, TG | 1 |
| Jones, OT | 1 |
| Backx, PH | 1 |
| Han, HS | 1 |
| Hewett, KW | 1 |
| McKay, CA | 1 |
| Gillette, PC | 1 |
| Case, CL | 1 |
| Akiyama, T | 1 |
| Pawitan, Y | 1 |
| Campbell, WB | 1 |
| Papa, L | 1 |
| Barker, AH | 1 |
| Rubbert, P | 1 |
| Friedman, L | 1 |
| Keller, M | 1 |
| Josephson, RA | 1 |
| Yabek, SM | 1 |
| Kato, R | 1 |
| Ikeda, N | 1 |
| Singh, BN | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000526] | Phase 3 | 0 participants | Interventional | 1986-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for flecainide and Aging
| Article | Year |
|---|---|
[Use of Pharmacogenetic Information for Therapeutic Drug Monitoring of an Antiarrhythmic Drug].
Topics: Adrenergic beta-Antagonists; Aging; Anti-Arrhythmia Agents; Asian People; Cytochrome P-450 CYP2D6; D | 2018 |
Trials
1 trial available for flecainide and Aging
| Article | Year |
|---|---|
Effects of advancing age on the efficacy and side effects of antiarrhythmic drugs in post-myocardial infarction patients with ventricular arrhythmias. The CAST Investigators.
Topics: Adult; Age Factors; Aged; Aging; Arrhythmias, Cardiac; Drug Therapy, Combination; Encainide; Flecain | 1992 |
Other Studies
4 other studies available for flecainide and Aging
| Article | Year |
|---|---|
Abnormal sodium current properties contribute to cardiac electrical and contractile dysfunction in a mouse model of myotonic dystrophy type 1.
Topics: Action Potentials; Aging; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Brugada Syndrome; C | 2015 |
Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle.
Topics: Action Potentials; Aging; Animals; Anti-Arrhythmia Agents; Blotting, Western; Cells, Cultured; Elect | 1997 |
Different effects of flecainide on atrioventricular conduction properties in the adult and immature rabbit heart.
Topics: Aging; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Atrioventricular Node; Flecainide; Heart C | 1997 |
Effects of flecainide on the cellular electrophysiology of neonatal and adult cardiac fibers.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Dogs; Electrophysiology; Female; Flecainide; He | 1987 |