Page last updated: 2024-10-27

flecainide and Aging

flecainide has been researched along with Aging in 6 studies

Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" Adverse events including death are more frequent in older patients taking study drugs (P less than 0."2.67Effects of advancing age on the efficacy and side effects of antiarrhythmic drugs in post-myocardial infarction patients with ventricular arrhythmias. The CAST Investigators. ( Akiyama, T; Barker, AH; Campbell, WB; Friedman, L; Josephson, RA; Keller, M; Papa, L; Pawitan, Y; Rubbert, P, 1992)
" However, TDM is not necessarily used to adjust the dosage of antiarrhythmic drugs because there is a lack of information regarding the therapeutic range of the serum concentration and the selection of patients who require TDM."2.58[Use of Pharmacogenetic Information for Therapeutic Drug Monitoring of an Antiarrhythmic Drug]. ( Doki, K, 2018)
"However, the mechanisms of cardiac arrhythmias in DM1 are unknown."1.42Abnormal sodium current properties contribute to cardiac electrical and contractile dysfunction in a mouse model of myotonic dystrophy type 1. ( Algalarrondo, V; Azibi, K; Balse, E; Beldjord, C; Coulombe, A; Duboc, D; Eymard, B; Fischmeister, R; Gourdon, G; Hatem, SN; Sebag, F; Wahbi, K, 2015)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's3 (50.00)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Doki, K1
Algalarrondo, V1
Wahbi, K1
Sebag, F1
Gourdon, G1
Beldjord, C1
Azibi, K1
Balse, E1
Coulombe, A1
Fischmeister, R1
Eymard, B1
Duboc, D1
Hatem, SN1
Wickenden, AD1
Kaprielian, R1
Parker, TG1
Jones, OT1
Backx, PH1
Han, HS1
Hewett, KW1
McKay, CA1
Gillette, PC1
Case, CL1
Akiyama, T1
Pawitan, Y1
Campbell, WB1
Papa, L1
Barker, AH1
Rubbert, P1
Friedman, L1
Keller, M1
Josephson, RA1
Yabek, SM1
Kato, R1
Ikeda, N1
Singh, BN1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00000526]Phase 30 participants Interventional1986-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for flecainide and Aging

ArticleYear
[Use of Pharmacogenetic Information for Therapeutic Drug Monitoring of an Antiarrhythmic Drug].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2018, Volume: 138, Issue:9

    Topics: Adrenergic beta-Antagonists; Aging; Anti-Arrhythmia Agents; Asian People; Cytochrome P-450 CYP2D6; D

2018

Trials

1 trial available for flecainide and Aging

ArticleYear
Effects of advancing age on the efficacy and side effects of antiarrhythmic drugs in post-myocardial infarction patients with ventricular arrhythmias. The CAST Investigators.
    Journal of the American Geriatrics Society, 1992, Volume: 40, Issue:7

    Topics: Adult; Age Factors; Aged; Aging; Arrhythmias, Cardiac; Drug Therapy, Combination; Encainide; Flecain

1992

Other Studies

4 other studies available for flecainide and Aging

ArticleYear
Abnormal sodium current properties contribute to cardiac electrical and contractile dysfunction in a mouse model of myotonic dystrophy type 1.
    Neuromuscular disorders : NMD, 2015, Volume: 25, Issue:4

    Topics: Action Potentials; Aging; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Brugada Syndrome; C

2015
Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle.
    The Journal of physiology, 1997, Oct-15, Volume: 504 ( Pt 2)

    Topics: Action Potentials; Aging; Animals; Anti-Arrhythmia Agents; Blotting, Western; Cells, Cultured; Elect

1997
Different effects of flecainide on atrioventricular conduction properties in the adult and immature rabbit heart.
    Cardiovascular drugs and therapy, 1997, Volume: 11, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Atrioventricular Node; Flecainide; Heart C

1997
Effects of flecainide on the cellular electrophysiology of neonatal and adult cardiac fibers.
    American heart journal, 1987, Volume: 113, Issue:1

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Dogs; Electrophysiology; Female; Flecainide; He

1987