flb-457 and Psychotic-Disorders

Stress and cannabis use are risk factors for the development of psychosis. We have previously shown that subjects at clinical high risk for psychosis (CHR) exhibit a higher striatal dopamine response to stress compared with healthy volunteers (HV), with chronic cannabis use blunting this response. However, it is unknown if this abnormal dopamine response extends to the prefrontal cortex (PFC). Here, we investigated dorsolateral PFC (dlPFC) and medial PFC (mPFC) dopamine release using [

Topics: Adult; Carbon Radioisotopes; Case-Control Studies; Dopamine; Female; Humans; Hydrocortisone; Male; Marijuana Abuse; Marijuana Use; Positron-Emission Tomography; Prefrontal Cortex; Prodromal Symptoms; Psychotic Disorders; Pyrrolidines; Radiopharmaceuticals; Risk; Salicylamides; Saliva; Stress, Psychological; Young Adult

Research suggests decreased cortical dopamine is a neural correlate of cognitive deficits in schizophrenia. Evidence of impaired cognitive task-induced cortical dopamine release was demonstrated in patients with psychosis. However, whether cortical dopamine release in response to a cognitive task in clinical high risk for psychosis (CHR) is also impaired, is currently unknown. We aimed to test dopamine release in the dorsolateral prefrontal cortex (DLPFC) and the anterior cingulate cortex (ACC) in antipsychotic-free CHR participants and healthy controls (HC) performing the Wisconsin Card Sorting Task (WCST). Two [

Topics: Adolescent; Adult; Cognition; Dopamine; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Motor Activity; Neuropsychological Tests; Positron-Emission Tomography; Prefrontal Cortex; Prodromal Symptoms; Psychotic Disorders; Pyrrolidines; Radiopharmaceuticals; Risk; Salicylamides; Young Adult