flb-457 and Phobia--Social

Alterations in the dopamine system are hypothesized to influence the expression of social anxiety disorder (SAD) symptoms. However, molecular imaging studies comparing dopamine function between patients and control subjects have yielded conflicting results. Importantly, while all previous investigations focused on the striatum, findings from activation and blood flow studies indicate that prefrontal and limbic brain regions have a central role in the pathophysiology. The objective of this study was to investigate extrastriatal dopamine D2-receptor (D2-R) availability in SAD. We examined 12 SAD patients and 16 healthy controls using positron emission tomography and the high-affinity D2-R radioligand [

Topics: Adult; Analysis of Variance; Brain Mapping; Carbon Isotopes; Dopamine Antagonists; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Phobia, Social; Positron-Emission Tomography; Prefrontal Cortex; Protein Binding; Psychiatric Status Rating Scales; Pyrrolidines; Receptors, Dopamine D2; Salicylamides; Young Adult