flb-457 and Marijuana-Use

Stress and cannabis use are risk factors for the development of psychosis. We have previously shown that subjects at clinical high risk for psychosis (CHR) exhibit a higher striatal dopamine response to stress compared with healthy volunteers (HV), with chronic cannabis use blunting this response. However, it is unknown if this abnormal dopamine response extends to the prefrontal cortex (PFC). Here, we investigated dorsolateral PFC (dlPFC) and medial PFC (mPFC) dopamine release using [

Topics: Adult; Carbon Radioisotopes; Case-Control Studies; Dopamine; Female; Humans; Hydrocortisone; Male; Marijuana Abuse; Marijuana Use; Positron-Emission Tomography; Prefrontal Cortex; Prodromal Symptoms; Psychotic Disorders; Pyrrolidines; Radiopharmaceuticals; Risk; Salicylamides; Saliva; Stress, Psychological; Young Adult