flavoxate has been researched along with Muscle Contraction in 21 studies
Flavoxate: A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist.
flavoxate : A carboxylic ester resulting from the formal condensation of 3-methylflavone-8-carboxylic acid with 2-(1-piperidinyl)ethanol.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of flavoxate, a smooth muscle relaxant, was investigated in 6 elderly patients with uninhibited detrusor contractions associated with urinary incontinence." | 7.66 | The effect of flavoxate on uninhibited detrusor contractions and urinary incontinence in the elderly. ( Asher, MJ; Briggs, RS; Castleden, CM, 1980) |
| "The antispasmodic effects of the flavone compounds flavoxate hydrochloride, 3-methylflavone carboxylic acid (MFCA), and REC 15/2053 (and in the case of the detrusor, oxybutynin), on the human detrusor, prostatic adenoma, prostatic capsule, and bladder neck, were studied by the in vitro isometric method." | 3.68 | Antispasmodic effects of flavoxate, MFCA, and REC 15/2053 on smooth muscle of human prostate and urinary bladder. ( Caine, M; Gin, S; Pietra, C; Ruffmann, R, 1991) |
| "The effect of flavoxate, a smooth muscle relaxant, was investigated in 6 elderly patients with uninhibited detrusor contractions associated with urinary incontinence." | 3.66 | The effect of flavoxate on uninhibited detrusor contractions and urinary incontinence in the elderly. ( Asher, MJ; Briggs, RS; Castleden, CM, 1980) |
| "Flavoxate has had a long history of use in the treatment of overactive bladder, despite the lack of documentation on its clinical efficacy and mechanism(s) of action." | 1.42 | Short-Term Flavoxate Treatment Alters Detrusor Contractility Characteristics: Renewed Interest in Clinical Use? ( Lam, WP; Leung, PC; Liang, W; Tang, HC; Yew, DT; Zhang, X, 2015) |
| "3." | 1.28 | Pharmacological properties of tiropramide, an antispasmodic drug. ( Hisayama, T; Iwase, M; Nagai, H; Sakuma, N; Takayanagi, I, 1989) |
| " Terodiline (10(-6) M) parallelly shifted the dose-response curve for carbachol in rabbit detrusor to the right, and high doses of terodiline (3 X 10(-6)-3 X 10(-5) M) inhibited the maximal contraction." | 1.27 | [Effect of terodiline hydrochloride in isolated rabbit detrusor]. ( Abe, M; Ikeda, S; Ono, Y; Ujiie, A; Yamazaki, Y, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (57.14) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, HC | 1 |
| Lam, WP | 1 |
| Zhang, X | 1 |
| Leung, PC | 1 |
| Yew, DT | 1 |
| Liang, W | 1 |
| Nishijima, S | 1 |
| Sugaya, K | 2 |
| Miyazato, M | 1 |
| Shimabukuro, S | 1 |
| Morozumi, M | 1 |
| Ogawa, Y | 1 |
| Tomoda, T | 1 |
| Aishima, M | 1 |
| Takano, N | 1 |
| Nakano, T | 1 |
| Seki, N | 1 |
| Yonemitsu, Y | 1 |
| Sueishi, K | 1 |
| Naito, S | 1 |
| Ito, Y | 1 |
| Teramoto, N | 1 |
| Madersbacher, H | 1 |
| Briggs, RS | 1 |
| Castleden, CM | 1 |
| Asher, MJ | 1 |
| Testa, R | 1 |
| Guarneri, L | 1 |
| Bernasconi, P | 1 |
| Angelico, P | 1 |
| Ibba, M | 1 |
| Poggesi, E | 1 |
| Meli, A | 2 |
| Kimura, Y | 2 |
| Sasaki, Y | 2 |
| Hamada, K | 1 |
| Fukui, H | 1 |
| Ukai, Y | 2 |
| Yoshikuni, Y | 2 |
| Kimura, K | 2 |
| Nishizawa, O | 1 |
| Oka, M | 1 |
| Itoh, Y | 1 |
| Taniguchi, N | 1 |
| Jonas, U | 1 |
| Petri, E | 1 |
| Kissel, J | 1 |
| Benson, GS | 1 |
| Sarshik, SA | 1 |
| Raezer, DM | 1 |
| Wein, AJ | 1 |
| Haruno, A | 2 |
| Uruno, T | 1 |
| Murakami, F | 1 |
| Wada, K | 1 |
| Hizukuri, M | 1 |
| Igarashi, M | 1 |
| Yoshida, K | 1 |
| Matsuoka, Y | 1 |
| Sunagane, N | 1 |
| Kubota, K | 1 |
| Caine, M | 1 |
| Gin, S | 1 |
| Pietra, C | 3 |
| Ruffmann, R | 1 |
| Kishimoto, T | 1 |
| Aoki, K | 1 |
| Okamiya, Y | 1 |
| Takeshita, T | 1 |
| Naruchi, T | 1 |
| Kaneko, S | 1 |
| Suzuki, N | 1 |
| Kitazato, K | 1 |
| Yamazaki, Y | 2 |
| Nagai, M | 1 |
| Iriki, M | 1 |
| Tsuchiya, K | 1 |
| Kosaka, M | 1 |
| Takayanagi, I | 1 |
| Hisayama, T | 1 |
| Iwase, M | 1 |
| Sakuma, N | 1 |
| Nagai, H | 1 |
| Cazzulani, P | 3 |
| Abbiati, GA | 1 |
| Ceserani, R | 1 |
| Oliva, D | 1 |
| Civelli, M | 1 |
| Tajana, A | 1 |
| Nardi, D | 1 |
| Subissi, A | 1 |
| Maggi, CA | 1 |
| Abe, M | 1 |
| Ono, Y | 1 |
| Ujiie, A | 1 |
| Ikeda, S | 1 |
| Panzarasa, R | 1 |
| De Stefani, C | 1 |
| Graziani, G | 1 |
21 other studies available for flavoxate and Muscle Contraction
| Article | Year |
|---|---|
Short-Term Flavoxate Treatment Alters Detrusor Contractility Characteristics: Renewed Interest in Clinical Use?
Topics: Animals; Flavoxate; In Vitro Techniques; Male; Mice; Muscle Contraction; Urinary Bladder; Urological | 2015 |
Activation of the rostral pontine reticular formation increases the spinal glycine level and inhibits bladder contraction in rats.
Topics: Animals; Benzilates; Carbachol; Flavoxate; Glycine; Muscle Contraction; Rats; Rats, Sprague-Dawley; | 2005 |
The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder.
Topics: Adult; Aged; Aged, 80 and over; Barium; Calcium Channel Blockers; Calcium Channels, L-Type; Flavoxat | 2005 |
[Diagnosis of functional neurogenic urination disorders from the urologist's viewpoint].
Topics: Female; Flavoxate; Humans; Middle Aged; Muscle Contraction; Muscle Relaxation; Urethritis; Urinary B | 1980 |
The effect of flavoxate on uninhibited detrusor contractions and urinary incontinence in the elderly.
Topics: Aged; Dose-Response Relationship, Drug; Flavonoids; Flavoxate; Humans; Muscle Contraction; Urinary I | 1980 |
Effects of terflavoxate on stimulated contractions of urinary bladder in vitro.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Carbachol; Electric Stimulation; Flavo | 1993 |
Mechanisms of the suppression of the bladder activity by flavoxate.
Topics: Animals; Atropine; Calcium; Carbachol; Cats; Electric Stimulation; Female; Flavoxate; Injections, In | 1996 |
Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats.
Topics: Animals; Brain; Cyclic AMP; Female; Flavoxate; GTP-Binding Proteins; Muscle Contraction; Muscle, Smo | 1996 |
Effect of flavoxate on hyperactive detrusor muscle.
Topics: Adolescent; Adult; Aged; Child; Female; Flavonoids; Flavoxate; Humans; Male; Middle Aged; Muscle Con | 1979 |
Bladder muscle contractility. Comparative effects and mechanisms of action of atropine, propantheline, flavoxate, and imipramine.
Topics: Animals; Atropine; Barium; Bethanechol Compounds; Chlorides; Dogs; Female; Flavonoids; Flavoxate; Im | 1977 |
Effects of propiverine hydrochloride on the spontaneous contractions of isolated guinea-pig urinary bladder strip and rhythmic urinary bladder contractions of anesthetized dog.
Topics: Anesthesia; Animals; Benzilates; Blood Pressure; Dogs; Female; Flavoxate; Guinea Pigs; Heart Rate; I | 1992 |
[Effects of tiropramide hydrochloride on the isolated detrusor and intravesical pressure of the bladder in situ in rats].
Topics: Animals; Butylamines; Dose-Response Relationship, Drug; Flavoxate; In Vitro Techniques; Male; Mandel | 1992 |
Antispasmodic effects of flavoxate, MFCA, and REC 15/2053 on smooth muscle of human prostate and urinary bladder.
Topics: Adenoma; Dose-Response Relationship, Drug; Flavoxate; Humans; Male; Mandelic Acids; Muscle Contracti | 1991 |
Effects of clenbuterol on resting tension and contractile response in vesicourethral smooth muscle of rabbits.
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Atropine; Clenbuterol; Dose-Response Relationship, | 1989 |
[Effect of propiverine hydrochloride on the function of the bladder in dogs].
Topics: Animals; Benzilates; Dogs; Dose-Response Relationship, Drug; Female; Flavoxate; Male; Muscle Contrac | 1989 |
Pharmacological properties of tiropramide, an antispasmodic drug.
Topics: Animals; Calcium; Cecum; Female; Flavoxate; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; | 1989 |
Pharmacological activities of the main metabolite of flavoxate 3-methylflavone-8-carboxylic acid.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium Channel Blockers; Female; Flavonoids; Flavoxat | 1988 |
Rociverine citrate: a new spasmolytic agent, potentially useful in the treatment of urinary bladder hyperreflexia.
Topics: Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Cyclohexanecarboxylic Acids; Flavoxate; | 1986 |
[Effect of terodiline hydrochloride in isolated rabbit detrusor].
Topics: Animals; Butylamines; Calcium Channel Blockers; Depression, Chemical; Dose-Response Relationship, Dr | 1987 |
Effects of flavoxate on urinary bladder contraction, micturition reflex and urodynamic parameters.
Topics: Animals; Flavonoids; Flavoxate; Male; Muscle Contraction; Parasympatholytics; Rabbits; Rats; Rats, I | 1986 |
Mechanism of flavoxate antispasmodic activity comparative in vitro studies.
Topics: Anesthetics, Local; Animals; Calcium Channel Blockers; Electric Stimulation; Female; Flavonoids; Fla | 1985 |