flavokawain-b and Thyroid-Neoplasms

flavokawain-b has been researched along with Thyroid-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for flavokawain-b and Thyroid-Neoplasms

Article	Year
Adenosine 5'-monophosphate-activated protein kinase-dependent mTOR pathway is involved in flavokawain B-induced autophagy in thyroid cancer cells. Cancer science, 2018, Volume: 109, Issue:8 Flavokawain B (FKB), a natural kava chalcone, shows potent antitumor activity in various types of cancer, although the mechanism of action remains unclear. In this study, we report that FKB has profound effects on the metabolic state of human thyroid cancer (TCa) cells, leading to high autophagy flux through upregulation of AMP-activated protein kinase, which in turn inhibits mTOR and activates Beclin-1 in TCa cells. We further report that the autophagy induced by FKB plays a prosurvival role in TCa cells both in vitro and in vivo. In conclusion, our findings provide evidence that combination treatment with FKB and pharmacological autophagy inhibitors will be a potential therapeutic strategy for the treatment of TCa. Topics: Adenosine Monophosphate; Antineoplastic Agents, Phytogenic; Autophagy; Beclin-1; Cell Line, Tumor; Flavonoids; Humans; Thyroid Gland; Thyroid Neoplasms; TOR Serine-Threonine Kinases; Up-Regulation	2018

Article

Year

Adenosine 5'-monophosphate-activated protein kinase-dependent mTOR pathway is involved in flavokawain B-induced autophagy in thyroid cancer cells.

Cancer science, 2018, Volume: 109, Issue:8

Flavokawain B (FKB), a natural kava chalcone, shows potent antitumor activity in various types of cancer, although the mechanism of action remains unclear. In this study, we report that FKB has profound effects on the metabolic state of human thyroid cancer (TCa) cells, leading to high autophagy flux through upregulation of AMP-activated protein kinase, which in turn inhibits mTOR and activates Beclin-1 in TCa cells. We further report that the autophagy induced by FKB plays a prosurvival role in TCa cells both in vitro and in vivo. In conclusion, our findings provide evidence that combination treatment with FKB and pharmacological autophagy inhibitors will be a potential therapeutic strategy for the treatment of TCa.

Topics: Adenosine Monophosphate; Antineoplastic Agents, Phytogenic; Autophagy; Beclin-1; Cell Line, Tumor; Flavonoids; Humans; Thyroid Gland; Thyroid Neoplasms; TOR Serine-Threonine Kinases; Up-Regulation

2018