flavokawain-b and Liver-Neoplasms

Hepatocellular carcinoma (HCC) is associated with a high mortality rate due to early recurrence and its metastasis features. To this day, effective treatment options for metastatic HCC remain a major challenge to patient treatment. Flavokawain B (FKB) is a naturally occurring chalcone molecule capable of providing effective therapy against this life-threatening disease.. This study investigated the anti-metastatic effects of FKB on the growth and development of metastatic HCC.. HepG2 cells were used in this study and a neutral red assay was performed to determine the IC. FKB inhibited the proliferation of HepG2 cells at an IC. Our data suggest that FKB inhibited HepG2 proliferation and further suppressed its metastasis partly by regulating the STAT3/Hif-1α/VEGF signalling pathway. FKB could be a potential alternative and viable strategy against HCC.

Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; STAT3 Transcription Factor; Uridine Kinase; Vascular Endothelial Growth Factor A