flavin-mononucleotide and Thyroid-Diseases

The objective of the research was to develop and evaluate the algorithm of prevention and treatment of postoperative hypoparathyroidism (PHPT) based on determining parathyroid glands (PTG) viability and the use of antihypoxant-antioxidant therapy in the postoperative period. The research was based on the results of a comprehensive examination and treatment of 60 patients who were operated for thyroid gland diseases. The patients underwent inpatient treatment at the surgical department of Ivano-Frankivsk Central City Clinical Hospital and Ivano-Frankivsk Regional Oncology Center from 2015 to 2017. We proposed an algorithm for surgical prevention and treatment of PHPT during thyroid gland surgeries which consisted in the following. We performed a visual assessment of PTG intraoperatively and evaluated each gland from 0 to 3 points according to the degree of its viability affection. If the gland was evaluated at 0-2 points, we left it in situ, since there was a high probability of maintaining its function. If it was evaluated at 3 points, its autotransplantation was performed. Cytoflavin drug was applied in a dose of 10 ml per 200 0.9% NaCl intravenously once a day during 7 days in the postoperative period for the purpose of antihypoxant-antioxidant therapy. 2 groups of patients were formed in order to evaluate the effectiveness of the algorithm. Each group consisted of 30 people. Patients of Group I underwent surgery on thyroid gland according to generally accepted rules. Patients of Group II underwent interventions according to the above-mentioned algorithm. The use of our proposed algorithm (intraoperative assessment of PTG viability and antihypoxant-antioxidant therapy in the postoperative period) significantly reduces the frequency of permanent PHPT justifying indications to its application.

Topics: Antioxidants; Drug Combinations; Flavin Mononucleotide; Humans; Hypoparathyroidism; Hypoxia; Inosine Diphosphate; Middle Aged; Niacinamide; Parathyroid Glands; Postoperative Complications; Succinates; Thyroid Diseases

The cognitive functions assessment in 68 patients operated on thyroid gland is presented. It is elicited that attention decrease, short-term memory upset, depressed work-capacity develop after intervention. It is shown that cytoflavin use within the intervention and early postoperative period permit to decrease cognitive dysfunction signs.

Topics: Adolescent; Adult; Aged; Antioxidants; Cognition Disorders; Drug Combinations; Drug Monitoring; Female; Flavin Mononucleotide; Humans; Inosine Diphosphate; Intraoperative Care; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Niacinamide; Postoperative Care; Postoperative Complications; Recovery of Function; Succinates; Thyroid Diseases; Thyroid Gland; Thyroidectomy; Treatment Outcome