flavin-mononucleotide and Leukemia--Myelogenous--Chronic--BCR-ABL-Positive

The appropriate folding of catalytic RNA is a prerequisite for effective catalysis. A novel ribozyme, the maxizyme, has been generated and its activity can be controlled allosterically. The maxizymes work both in vitro and in vivo indicating the potential utility of this novel class of ribozyme as a gene-inactivating agent with a biosensor function.

Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Antineoplastic Agents; Binding Sites; Catalysis; Dimerization; DNA; Flavin Mononucleotide; Fusion Proteins, bcr-abl; Genes, abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred NOD; Mice, SCID; Models, Molecular; Neoplasm Transplantation; Nucleic Acid Conformation; Plasmids; RNA; RNA, Catalytic; RNA, Transfer; Sequence Deletion; Structure-Activity Relationship; Substrate Specificity; Tumor Cells, Cultured; Xenograft Model Antitumor Assays