flavin-mononucleotide and Hypercholesterolemia

This comparative study of the influence of cytoflavin and cardioxipin on the parameters of 24-hour arterial pressure monitoring in 56 patients with chronic cerebral circulation insufficiency, arterial hypertension and hypercholesterolemia included 32 women and 24 men aged 42-72 years divided into 3 groups matchedfor the stage of diseases, age, sex, severity of AH, total cholesterol level, and antihypertensive therapy. Patients of group 1 were treated without cytoflavin and cardioxipin. Those in group 2 received daily i/v droplet infusion of 10 mg/kg cardioxipin (20-30 droplets/min). Patients of group 3 were given daily i/v droplet infusion of 10 ml cytoflavin in 200 ml 0.9% sodium chloride solution for 10 days. 24-hour arterial pressure monitoring was used to estimate the influence of the two drugs on systolic and diastolic pressure, its daily rhythm, AP variability and frequency of elevation. The study showed that both therapeutic modalities improved daily AP rhythm as manifested in a significant increase of the number of patients with the dipper rhythm and a decrease in the number of systolic/diastolic non-dipper patients. Moreover cytoflavin significantly decreased the number of systolic over-dippers compared with control group.

Topics: Adult; Aged; Antihypertensive Agents; Arterial Pressure; Blood Pressure Monitoring, Ambulatory; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Female; Flavin Mononucleotide; Follow-Up Studies; Humans; Hypercholesterolemia; Hypertension; Infusions, Intravenous; Inosine Diphosphate; Male; Middle Aged; Niacinamide; Retrospective Studies; Succinates; Treatment Outcome

Topics: Aged; Arteriosclerosis; Cholesterol; Choline; Drug Combinations; Fatty Acids; Female; Flavin Mononucleotide; Heparin; Humans; Hypercholesterolemia; Hyperlipidemias; Male; Middle Aged; Niacinamide; Phospholipids; Triglycerides; Vitamin B 12