flavin-mononucleotide and Carbon-Monoxide-Poisoning

The article deals with the materials, which have been received in the process of the examination and treatment of 48 patients with acute severe carbon monoxide and burning products poisonings on fires. It has been registered that the including of citoflavin into the complex program of the intensive therapy of acute severe carbon monoxide and burning products poisonings on fires leads to a decrease of hypoxia and manifestations of acute toxicohypoxic cerebral deficiency, which significantly improves the clinics of acute severe poisonings.

Topics: Acute Disease; Adult; Blood Gas Analysis; Carbon Monoxide Poisoning; Combined Modality Therapy; Critical Care; Drug Combinations; Drug Therapy, Combination; Female; Fires; Flavin Mononucleotide; Humans; Hypoxia; Hypoxia, Brain; Inosine Diphosphate; Male; Neuroprotective Agents; Niacinamide; Oxygen; Respiration, Artificial; Succinates; Treatment Outcome

Results of an analysis of the efficiency of using cytoflavin, a drug possessing cytoprotective and antihypoxemic properties, in a group of 215 patients with a diagnosis of acute carbon monoxide poisoning in 2004-2010 are compared to analogous data for 215 patients with same diagnosis treated in 1999-2004 without cytoflavin administration. It is established that timely application of cytoflavin (against the standard treatment of CO poisoning) favored lower expressiveness of post-hypoxemic encephalopathythatis characteristic of the given pathology.

Topics: Adult; Carbon Monoxide; Carbon Monoxide Poisoning; Carboxyhemoglobin; Case-Control Studies; Drug Administration Schedule; Drug Combinations; Female; Flavin Mononucleotide; Humans; Hypoxia; Infusions, Intravenous; Inosine Diphosphate; Male; Middle Aged; Neuroprotective Agents; Niacinamide; Retrospective Studies; Russia; Severity of Illness Index; Succinates; Survival Rate; Unconsciousness

The article presents the materials obtained in the course of treatment of 64 patients with severe poisoning with carbon monoxide and the products of combustion. It is established that acute carbon monoxide poisoning and combustion products in elderly and senile age is accompanied by more pronounced metabolic disorders, higher frequency of complications and lethality. Intensive therapy of severe poisoning with carbon monoxide has its own peculiarities. The use of Cytoflavin with antihypoxic purpose can lead to the development of metabolic desynchronization. To correct the hypoxic disorders in elderly and senile patients is more appropriate to use Reamberine, not having a negative effect on the indices of central hemodynamics and effectively reducing the depth of metabolic disorders.

Topics: Adult; Aged; Aged, 80 and over; Carbon Monoxide; Carbon Monoxide Poisoning; Drug Combinations; Female; Flavin Mononucleotide; Humans; Inosine Diphosphate; Male; Meglumine; Middle Aged; Niacinamide; Succinates; Treatment Outcome

The article deals with the materials, which have been received in the process of the examination and treatment of 44 patients with acute severe methadone poisonings. It has been revealed, that gravity of these patients' condition depends on the intensity of hypoxia due to breath deficiency because of methadone. The development of hypoxia, in its turn, causes violations of antiradical protection system and intensification of processes of peroxide lipid oxidation. It has been registered that the including of reamberin into the complex program of the intensive therapy of acute severe methadone poisonings leads to a more rapid restoration of antiradical protection system and to a decrease of activity of processes of peroxide lipid oxidation. The correction of hypoxia and free-radical violations led to the improvement of the acute poisonings clinics, what was characterized by a decrease of coma-period duration, duration of treatment with artificial lung ventilation, a decrease of secondary lung complications and a decrease of lethality.

Topics: Adult; Carbon Monoxide; Carbon Monoxide Poisoning; Drug Combinations; Female; Fires; Flavin Mononucleotide; Humans; Inosine Diphosphate; Male; Middle Aged; Niacinamide; Oxygen; Oxygen Consumption; Respiration, Artificial; Succinates