flavin-adenine-dinucleotide has been researched along with Klebsiella-Infections* in 2 studies
2 other study(ies) available for flavin-adenine-dinucleotide and Klebsiella-Infections
Article | Year |
---|---|
Identification of the BolA Protein Reveals a Novel Virulence Factor in K. pneumoniae That Contributes to Survival in Host.
BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mouse infection model, we revealed Topics: Bacterial Proteins; Biotin; Cadaverine; Flavin-Adenine Dinucleotide; Guanosine; Guanosine Tetraphosphate; Humans; Klebsiella Infections; Klebsiella pneumoniae; Liver Abscess; Siderophores; Spermine; Type II Secretion Systems; Type VI Secretion Systems; Virulence Factors | 2022 |
Effect of respiratory infection on tissue riboflavin and flavin enzymes in mice.
The effects of Klebsiella pneumoniae infection on red blood cell and liver riboflavin levels and a few flavin enzymes were examined to verify our earlier hypothesis based on human experience that upper respiratory infections result in mobilization of riboflavin from tissues into blood, resulting in a rise in red blood cell riboflavin and an increased saturation of erythrocyte glutathione reductase (EGR) with its coenzyme flavin adenine dinucleotide (FAD; reduction in EGR activation coefficient, AC, values). Thirty-six-day-old male mice fed a diet marginally sufficient in riboflavin were injected with a single sublethal dose of K. pneumoniae. Batches of control, deficient infected and deficient uninfected animals were killed during the peak period of infection and after recovery. Infection brought about a significant rise in basal EGR activity due to greater saturation with coenzyme FAD and a concomitant reduction in EGR-AC values. On recovery, basal EGR activity decreased, and EGR-AC values increased to levels beyond control values, suggesting riboflavin deficiency. In the liver, acyl-coenzyme A dehydrogenase showed a significant decrease and pyridoxamine-phosphate oxidase activity a significant increase. Both the enzymes normalized after recovery. D-amino acid oxidase activity did not change. Topics: Analysis of Variance; Animals; Erythrocytes; Flavin-Adenine Dinucleotide; Flavins; Glutathione Reductase; Klebsiella Infections; Klebsiella pneumoniae; Liver; Male; Mice; Respiratory Tract Infections; Riboflavin | 1991 |