flavin-adenine-dinucleotide and Anemia--Hemolytic

flavin-adenine-dinucleotide has been researched along with Anemia--Hemolytic* in 2 studies

Other Studies

2 other study(ies) available for flavin-adenine-dinucleotide and Anemia--Hemolytic

Article	Year
Partial glutathione reductase deficiency as a cause of diverse clinical manifestations in a family with unstable hemoglobin (Hemoglobin Haná, β63(E7) His-Asn). Blood cells, molecules & diseases, 2010, Oct-15, Volume: 45, Issue:3 Hemoglobin Haná [β63(E7) His-Asn] is an unstable hemoglobin variant that was described in a Czech proband and her sister with Heinz body hemolytic anemia. The mother bearing the same mutation was asymptomatic; nevertheless, all three carriers had the same proportion of the mutant globin chains. Assessment of several erythrocyte antioxidant parameters revealed that both symptomatic children, unlike their asymptomatic mother, had significantly decreased glutathione reductase (GR) activity. Their GR activities were restorable in vitro by flavin adenine dinucleotide. The riboflavin supplementation improved their glutathione metabolism and ameliorated their hemolysis. Pre- and post-treatment assessment of the B(2) vitamers indicated suboptimal pre-treatment vitamin B(2) status in both children. This study provides evidence that partial GR deficiency may alter the clinical manifestation of an unstable hemoglobinopathy. Topics: Adolescent; Adult; Amino Acid Substitution; Anemia, Hemolytic; Family; Female; Flavin-Adenine Dinucleotide; Glutathione; Glutathione Reductase; Heinz Bodies; Hemoglobinopathies; Hemoglobins, Abnormal; Humans; Male; Mutation, Missense; Riboflavin; Vitamin B Complex	2010
[Interference of reticulocyte metabolism with enzyme activity analyses in haemolytic anaemias (author's transl)]. Wiener klinische Wochenschrift, 1977, Dec-23, Volume: 89, Issue:24 This paper outlines the procedure for the preparation of leucocyte-free reticulocytes and normocytes and details the activities of the key enzymes in reticulocytes, normocytes and leucocytes. An assesment of the error in normocyte enzyme analyses due to contamination with reticulocytes and leucocytes is enabled by these means. Topics: Anemia, Hemolytic; Bone Marrow Cells; Cell Separation; Erythrocytes; Flavin-Adenine Dinucleotide; Humans; Leukocytes; Reticulocytes	1977

Article

Year

Partial glutathione reductase deficiency as a cause of diverse clinical manifestations in a family with unstable hemoglobin (Hemoglobin Haná, β63(E7) His-Asn).

Blood cells, molecules & diseases, 2010, Oct-15, Volume: 45, Issue:3

Hemoglobin Haná [β63(E7) His-Asn] is an unstable hemoglobin variant that was described in a Czech proband and her sister with Heinz body hemolytic anemia. The mother bearing the same mutation was asymptomatic; nevertheless, all three carriers had the same proportion of the mutant globin chains. Assessment of several erythrocyte antioxidant parameters revealed that both symptomatic children, unlike their asymptomatic mother, had significantly decreased glutathione reductase (GR) activity. Their GR activities were restorable in vitro by flavin adenine dinucleotide. The riboflavin supplementation improved their glutathione metabolism and ameliorated their hemolysis. Pre- and post-treatment assessment of the B(2) vitamers indicated suboptimal pre-treatment vitamin B(2) status in both children. This study provides evidence that partial GR deficiency may alter the clinical manifestation of an unstable hemoglobinopathy.

Topics: Adolescent; Adult; Amino Acid Substitution; Anemia, Hemolytic; Family; Female; Flavin-Adenine Dinucleotide; Glutathione; Glutathione Reductase; Heinz Bodies; Hemoglobinopathies; Hemoglobins, Abnormal; Humans; Male; Mutation, Missense; Riboflavin; Vitamin B Complex

2010

[Interference of reticulocyte metabolism with enzyme activity analyses in haemolytic anaemias (author's transl)].

Wiener klinische Wochenschrift, 1977, Dec-23, Volume: 89, Issue:24

This paper outlines the procedure for the preparation of leucocyte-free reticulocytes and normocytes and details the activities of the key enzymes in reticulocytes, normocytes and leucocytes. An assesment of the error in normocyte enzyme analyses due to contamination with reticulocytes and leucocytes is enabled by these means.

Topics: Anemia, Hemolytic; Bone Marrow Cells; Cell Separation; Erythrocytes; Flavin-Adenine Dinucleotide; Humans; Leukocytes; Reticulocytes

1977