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fk 224 and Asthma

fk 224 has been researched along with Asthma in 7 studies

*Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). [MeSH]

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (71.43)18.2507
2000's2 (28.57)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Braun, A; Hoyle, GW; Lommatzsch, M; Quarcoo, D; Renz, H; Schierhorn, K; Schulte-Herbrüggen, O1
Fujimura, M; Nakao, S; Nishitsuji, M; Oribe, Y1
Joos, GF; Kips, JC; Pauwels, RA; Van Schoor, J1
Jörres, RA; Magnussen, H; Rabe, KF; Schmidt, D1
Fujimura, M; Ishiura, Y; Matsuda, T; Myou, S; Tsujiura, M1
Ichinose, M; Inoue, H; Nakajima, N; Takahashi, T; Takishima, T; Yamauchi, H1
Ezaki, M; Hashimoto, M; Hayashi, K; Imanaka, H; Kiyoto, S; Kohsaka, M; Nishikawa, M; Okuhara, M; Shigematsu, N; Yamashita, M1

Trials

3 trial(s) available for fk 224 and Asthma

ArticleYear
The effect of inhaled FK224, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics.
    American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:6 Pt 1

    Topics: Administration, Inhalation; Asthma; Bronchoconstriction; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Receptors, Neurokinin-2; Respiratory Function Tests

1996
Reproducibility of airway response to inhaled bradykinin and effect of the neurokinin receptor antagonist FK-224 in asthmatic subjects.
    European journal of clinical pharmacology, 1996, Volume: 50, Issue:4

    Topics: Administration, Inhalation; Adult; Analysis of Variance; Asthma; Bradykinin; Bronchoconstriction; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Peptides, Cyclic

1996
Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist.
    Lancet (London, England), 1992, Nov-21, Volume: 340, Issue:8830

    Topics: Administration, Inhalation; Adult; Asthma; Bradykinin; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Placebos; Tachykinins

1992

Other Studies

4 other study(ies) available for fk 224 and Asthma

ArticleYear
Nerve growth factor induces increased airway inflammation via a neuropeptide-dependent mechanism in a transgenic animal model of allergic airway inflammation.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2004, Volume: 34, Issue:7

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Eosinophils; Humans; Interleukin-5; Leukocyte Count; Lung; Mice; Mice, Transgenic; Models, Animal; Nerve Growth Factors; Ovalbumin; Peptides, Cyclic; Receptors, Tachykinin; Tachykinins

2004
A guinea pig model for cough variant asthma and role of tachykinins.
    Experimental lung research, 2004, Volume: 30, Issue:8

    Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Cough; Disease Models, Animal; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Peptides, Cyclic; Procaterol; Tachykinins

2004
Role of sensory neuropeptides in post-allergic propranolol-induced bronchoconstriction in guinea pigs in vivo.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1996, Volume: 26, Issue:12

    Topics: Adrenergic beta-Antagonists; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Dipeptides; Guinea Pigs; Indoles; Male; Neurokinin A; Peptides, Cyclic; Propranolol; Substance P

1996
WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
    The Journal of antibiotics, 1992, Volume: 45, Issue:7

    Topics: Animals; Asthma; Fermentation; Guinea Pigs; In Vitro Techniques; Lactones; Microscopy, Electron, Scanning; Peptides, Cyclic; Streptomyces; Substance P; Tachykinins

1992