fipronil has been researched along with Neuroblastoma in 2 studies
fipronil: has low mammalian toxicity; structure given in first source
fipronil : A racemate comprising equimolar amounts of (R)- and (S)-fipronil.
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile : A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to evaluate the neurotoxic potential of the pesticide fipronil (FIP) towards the differentiation of mouse N2a neuroblastoma cells." | 7.77 | Fipronil interferes with the differentiation of mouse N2a neuroblastoma cells. ( Flaskos, J; Hargreaves, AJ; Harris, W; Sachana, M; Sidiropoulou, E; Woldehiwet, Z, 2011) |
| "Fipronil (FPN) is a phenylpyrazole insecticide that acts on insect GABA receptors." | 1.38 | Reactive oxygen species and mitogen-activated protein kinase induce apoptotic death of SH-SY5Y cells in response to fipronil. ( Ki, YW; Koh, HC; Lee, JE; Park, JH; Shin, IC, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sidiropoulou, E | 1 |
| Sachana, M | 1 |
| Flaskos, J | 1 |
| Harris, W | 1 |
| Hargreaves, AJ | 1 |
| Woldehiwet, Z | 1 |
| Ki, YW | 1 |
| Lee, JE | 1 |
| Park, JH | 1 |
| Shin, IC | 1 |
| Koh, HC | 1 |
2 other studies available for fipronil and Neuroblastoma
| Article | Year |
|---|---|
Fipronil interferes with the differentiation of mouse N2a neuroblastoma cells.
Topics: Animals; Axons; Cell Differentiation; Extracellular Signal-Regulated MAP Kinases; Insecticides; MAP | 2011 |
Reactive oxygen species and mitogen-activated protein kinase induce apoptotic death of SH-SY5Y cells in response to fipronil.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Humans; Insecticide | 2012 |