Page last updated: 2024-10-27

fipronil and Flea Infestations

fipronil has been researched along with Flea Infestations in 32 studies

fipronil: has low mammalian toxicity; structure given in first source
fipronil : A racemate comprising equimolar amounts of (R)- and (S)-fipronil.
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile : A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively.

Flea Infestations: Parasitic attack by members of the order SIPHONAPTERA.

Research Excerpts

ExcerptRelevanceReference
"Sylvatic plague is a widespread, primarily flea-vectored disease in western North America."5.91FLEA CONTROL ON PRAIRIE DOGS (CYNOMYS SPP.) WITH FIPRONIL BAIT PELLETS: POTENTIAL PLAGUE MITIGATION TOOL FOR RAPID FIELD APPLICATION AND WILDLIFE CONSERVATION. ( Biggins, DE; Cordova, J; Eads, DA; Hicks, H; Livieri, TM; Matchett, MR, 2023)
"Fipronil baits have been used to suppress adult fleas for plague mitigation."5.91LETHAL EFFECTS ON FLEA LARVAE OF FIPRONIL IN HOST FECES: POTENTIAL BENEFITS FOR PLAGUE MITIGATION. ( Biggins, DE; Eads, DA; Hughes, JP; Tretten, TN, 2023)
"During 5- and 10-day laboratory trials in Colorado, USA, 2016-2017, FIP grain had no detectable acute toxic effect on 20 BTPDs that readily consumed the grain."5.72Assembling a safe and effective toolbox for integrated flea control and plague mitigation: Fipronil experiments with prairie dogs. ( Biggins, D; Childers, E; Dobesh, P; Eads, D; Grady, AC; Grassel, S; Halsell, E; Hughes, J; Kaczor, N; Livieri, T; Lucas, D; Noble, L; Tretten, T; Vasquez, M, 2022)
" The efficacy achieved by the fipronil (s)-methoprene formulation against flea infestations on these pets was lower than in previous investigations using the same study design."5.17Evaluation of indoxacarb and fipronil (s)-methoprene topical spot-on formulations to control flea populations in naturally infested dogs and cats in private residences in Tampa FL. USA. ( Chwala, M; Davenport, J; Dryden, MW; Fadl, G; Ford, P; Heaney, K; Jones, E; Martinez-Perez de Zeiders, MF; Payne, PA; Smith, V; Sun, F, 2013)
"The rapid flea knock-down effect and speed of kill demonstrated by the spot on combination of fipronil + permethrin provide a reliable strategy against flea infestations in dogs."3.83Knock-down and speed of kill of a combination of fipronil and permethrin for the prevention of Ctenocephalides felis flea infestation in dogs. ( Beugnet, F; Fankhauser, B; Fourie, JJ; Halos, L, 2016)
"A new fipronil-based spot-on formulation was evaluated against experimental flea infestations in cats in two studies."3.77Assay of two 10% (w/v) fipronil spot-on formulations against feline infestations with Ctenocephalides felis. ( Bonneau, SG; Cadiergues, MC; Fourier, JJ, 2011)
" Lotilaner tablets were safe and provided superior flea control to fipronil/(S)-methoprene."2.87A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling fleas in client-owned cats in Europe. ( Cavalleri, D; Murphy, M; Nanchen, S; Seewald, W, 2018)
" Both products were safe and well tolerated."2.87Field effectiveness and safety of fluralaner plus moxidectin (Bravecto® Plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats. ( Gil, MJ; Loehlein, W; Pobel, T; Roepke, RKA; Rohdich, N; Wolf, O; Zschiesche, E, 2018)
" In laboratory studies, lotilaner was shown to be safe and to produce a rapid flea and tick knockdown, with a sustained speed of kill for at least a month post-treatment."2.84A randomised, blinded, controlled field study to assess the efficacy and safety of lotilaner tablets (Credelio™) in controlling fleas in client-owned dogs in European countries. ( Cavalleri, D; Drake, J; Murphy, M; Nanchen, S; Seewald, W, 2017)
"Sylvatic plague is a widespread, primarily flea-vectored disease in western North America."1.91FLEA CONTROL ON PRAIRIE DOGS (CYNOMYS SPP.) WITH FIPRONIL BAIT PELLETS: POTENTIAL PLAGUE MITIGATION TOOL FOR RAPID FIELD APPLICATION AND WILDLIFE CONSERVATION. ( Biggins, DE; Cordova, J; Eads, DA; Hicks, H; Livieri, TM; Matchett, MR, 2023)
"Fipronil baits have been used to suppress adult fleas for plague mitigation."1.91LETHAL EFFECTS ON FLEA LARVAE OF FIPRONIL IN HOST FECES: POTENTIAL BENEFITS FOR PLAGUE MITIGATION. ( Biggins, DE; Eads, DA; Hughes, JP; Tretten, TN, 2023)
"During 5- and 10-day laboratory trials in Colorado, USA, 2016-2017, FIP grain had no detectable acute toxic effect on 20 BTPDs that readily consumed the grain."1.72Assembling a safe and effective toolbox for integrated flea control and plague mitigation: Fipronil experiments with prairie dogs. ( Biggins, D; Childers, E; Dobesh, P; Eads, D; Grady, AC; Grassel, S; Halsell, E; Hughes, J; Kaczor, N; Livieri, T; Lucas, D; Noble, L; Tretten, T; Vasquez, M, 2022)
" Cats in Group 2 were treated once on Day 0 with BROADLINE(®) at the minimum recommended dosage of 0."1.40Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against adult and immature stages of the cat flea (Ctenocephalides felis) on cats. ( Baker, C; Chester, ST; Everett, WR; Fourie, JJ; Knaus, M; Prullage, JB; Rehbein, S; Rosentel, JK; Tielemans, E; Young, DR, 2014)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's26 (81.25)24.3611
2020's6 (18.75)2.80

Authors

AuthorsStudies
Eads, D1
Livieri, T1
Tretten, T1
Hughes, J1
Kaczor, N1
Halsell, E1
Grassel, S1
Dobesh, P3
Childers, E3
Lucas, D1
Noble, L1
Vasquez, M1
Grady, AC1
Biggins, D1
Matchett, MR1
Eads, DA4
Cordova, J1
Livieri, TM3
Hicks, H1
Biggins, DE4
Tretten, TN1
Hughes, JP1
Cooper, AR1
Nixon, E1
Rose Vineer, H1
Abdullah, S1
Newbury, H1
Wall, R1
Cruz, BC1
Teixeira, WFP1
Gomes, LVC1
Maciel, WG1
Felippelli, G1
Buzzulini, C1
Ferreira, LL1
Santos, TRD1
Soares, VE1
Sakamoto, CAM1
Monteiro, CMO1
Lopes, WDZ1
da Costa, AJ1
Noble, LE1
Vasquez, MC1
Geurden, T1
Becskei, C1
Farkas, R1
Lin, D1
Rugg, D2
Chatzis, MK1
Psemmas, D1
Papadopoulos, E1
Navarro, C1
Saridomichelakis, MN1
Poché, DM2
Hartman, D1
Polyakova, L2
Poché, RM2
Delcombel, R1
Karembe, H1
Nare, B1
Burton, A1
Liebenberg, J1
Fourie, J3
Varloud, M1
Cavalleri, D2
Murphy, M2
Seewald, W2
Drake, J1
Nanchen, S2
Torres-Poché, Z1
Yeszhanov, A1
Belyaev, A1
Dvořák, V1
Sayakova, Z1
Aimakhanov, B1
Wheeler, DW1
Trout, CM1
Thompson, CM1
Winkle, JR1
White, WH1
Rohdich, N2
Zschiesche, E2
Wolf, O1
Loehlein, W1
Pobel, T1
Gil, MJ1
Roepke, RKA1
Bowser, J1
Broerman, K1
Griebel, RL1
Beugnet, F6
Delport, P1
Luus, H1
Crafford, D1
Dryden, MW4
Payne, PA2
Smith, V2
Chwala, M1
Jones, E1
Davenport, J2
Fadl, G1
Martinez-Perez de Zeiders, MF1
Heaney, K1
Ford, P1
Sun, F1
Roepke, RK1
Baker, C1
Tielemans, E1
Prullage, JB1
Chester, ST1
Knaus, M1
Rehbein, S1
Fourie, JJ4
Young, DR1
Everett, WR2
Rosentel, JK1
Soll, M1
Bouhsira, E2
Franc, M3
Fankhauser, B2
Dumont, P1
Halos, L2
Hunter, JS1
Kunkle, B1
Chester, TS1
Soll, MD1
Davis, WL1
Settje, T1
Hostetler, J1
Cadiergues, MC1
Bonneau, SG1
Fourier, JJ1
Vicki, S1
Riggs, B1
Kobuszewski, D1
Yoon, SS1
Roques, M1
Manavella, C1
Vermot, S1
Cramer, LG1
Ollagnier, C1
Doyle, V1
Murray, M1
Chalvet-Monfray, K2
Ryan, WG1
Bell, M1
Rumschlag, AJ1
Young, LM1
Snyder, DE1
Kužner, J1
Turk, S1
Grace, S1
Soni-Gupta, J1
Marchiondo, AA1

Trials

13 trials available for fipronil and Flea Infestations

ArticleYear
Efficacy and safety of a new spot-on formulation of selamectin plus sarolaner in the treatment of naturally occurring flea and tick infestations in cats presented as veterinary patients in Europe.
    Veterinary parasitology, 2017, Volume: 238 Suppl 1

    Topics: Administration, Topical; Animals; Antiparasitic Agents; Cat Diseases; Cats; Europe; Female; Flea Inf

2017
A field trial of a fixed combination of permethrin and fipronil (Effitix
    Parasites & vectors, 2017, Apr-28, Volume: 10, Issue:1

    Topics: Animals; Disease Transmission, Infectious; Dog Diseases; Dogs; Drug Combinations; Flea Infestations;

2017
A randomised, blinded, controlled field study to assess the efficacy and safety of lotilaner tablets (Credelio™) in controlling fleas in client-owned dogs in European countries.
    Parasites & vectors, 2017, Nov-01, Volume: 10, Issue:1

    Topics: Administration, Oral; Animals; Dog Diseases; Dogs; Europe; Female; Flea Infestations; Germany; Hospi

2017
A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling fleas in client-owned cats in Europe.
    Parasites & vectors, 2018, Jul-13, Volume: 11, Issue:1

    Topics: Animals; Cat Diseases; Cats; Dermatitis; Drug Combinations; Female; Flea Infestations; France; Insec

2018
Field effectiveness and safety of fluralaner plus moxidectin (Bravecto® Plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats.
    Parasites & vectors, 2018, Nov-19, Volume: 11, Issue:1

    Topics: Administration, Topical; Animals; Cat Diseases; Cats; Flea Infestations; Germany; Insecticides; Isox

2018
Preventive efficacy of Frontline® Combo and Certifect® against Dipylidium caninum infestation of cats and dogs using a natural flea (Ctenocephalides felis) infestation model.
    Parasite (Paris, France), 2013, Volume: 20

    Topics: Administration, Topical; Animals; Cat Diseases; Cats; Cestode Infections; Dog Diseases; Dogs; Drug C

2013
Evaluation of indoxacarb and fipronil (s)-methoprene topical spot-on formulations to control flea populations in naturally infested dogs and cats in private residences in Tampa FL. USA.
    Parasites & vectors, 2013, Dec-28, Volume: 6

    Topics: Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Flea Infestations; Florida; Insecticides; Methopren

2013
A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto (fluralaner) against Frontline (fipronil) in flea- and tick-infested dogs.
    Parasites & vectors, 2014, Mar-04, Volume: 7

    Topics: Acaricides; Administration, Oral; Administration, Topical; Animals; Dog Diseases; Dogs; Female; Flea

2014
Evaluation and comparison of a flumethrin-imidacloprid collar and repeated monthly treatments of fipronil/(s)-methoprene to control flea, Ctenocephalides f. felis, infestations on cats for eight months.
    Parasites & vectors, 2016, 05-17, Volume: 9, Issue:1

    Topics: Animals; Cat Diseases; Cats; Ctenocephalides; Drug Therapy, Combination; Female; Flea Infestations;

2016
Efficacy of fipronil, amitraz and (S)-methoprene combination spot-on for dogs against adult dog fleas (Ctenocephalides canis, Curtis, 1826).
    Veterinary parasitology, 2011, Jul-15, Volume: 179, Issue:4

    Topics: Administration, Topical; Animals; Ctenocephalides; Dog Diseases; Dogs; Drug Combinations; Female; Fl

2011
Comparative efficacy on dogs of a single topical treatment with the pioneer fipronil/(S)-methoprene and an oral treatment with spinosad against Ctenocephalides felis.
    Parasite (Paris, France), 2011, Volume: 18, Issue:4

    Topics: Administration, Oral; Administration, Topical; Animals; Ctenocephalides; Dog Diseases; Dogs; Drug Co

2011
Comparative efficacy on dogs of a single topical treatment with fipronil/(S)-methoprene or weekly physiological hygiene shampoos against Ctenocephalides felis in a simulated flea-infested environment.
    Parasite (Paris, France), 2012, Volume: 19, Issue:2

    Topics: Administration, Topical; Animals; Baths; Ctenocephalides; Dog Diseases; Dogs; Female; Flea Infestati

2012
Confirmation of the efficacy of a novel fipronil spot-on for the treatment and control of fleas, ticks and chewing lice on dogs.
    Veterinary parasitology, 2013, Mar-31, Volume: 193, Issue:1-3

    Topics: Administration, Topical; Animals; Dog Diseases; Dogs; Female; Flea Infestations; Insecticides; Lice

2013

Other Studies

19 other studies available for fipronil and Flea Infestations

ArticleYear
Assembling a safe and effective toolbox for integrated flea control and plague mitigation: Fipronil experiments with prairie dogs.
    PloS one, 2022, Volume: 17, Issue:8

    Topics: Animals; Ecosystem; Ferrets; Flea Infestations; Insecticides; Nitriles; Plague; Pyrazoles; Pyrethrin

2022
FLEA CONTROL ON PRAIRIE DOGS (CYNOMYS SPP.) WITH FIPRONIL BAIT PELLETS: POTENTIAL PLAGUE MITIGATION TOOL FOR RAPID FIELD APPLICATION AND WILDLIFE CONSERVATION.
    Journal of wildlife diseases, 2023, 01-01, Volume: 59, Issue:1

    Topics: Animals; Animals, Wild; Ferrets; Flea Infestations; Plague; Rodent Diseases; Sciuridae; Siphonaptera

2023
LETHAL EFFECTS ON FLEA LARVAE OF FIPRONIL IN HOST FECES: POTENTIAL BENEFITS FOR PLAGUE MITIGATION.
    Journal of wildlife diseases, 2023, 01-01, Volume: 59, Issue:1

    Topics: Animals; Flea Infestations; Larva; Plague; Rodent Diseases; Sciuridae; Siphonaptera; Yersinia pestis

2023
Fleas infesting cats and dogs in Great Britain: spatial distribution of infestation risk and its relation to treatment.
    Medical and veterinary entomology, 2020, Volume: 34, Issue:4

    Topics: Animals; Cat Diseases; Cats; Ctenocephalides; Dog Diseases; Dogs; Flea Infestations; Geography; Inse

2020
Does bathing affect tick and flea burdens and ectoparasiticide effectiveness of a spot-on formulation (fipronil + (S)-methoprene) for dogs?
    Veterinary parasitology, 2020, Volume: 283

    Topics: Administration, Topical; Animals; Baths; Dog Diseases; Dogs; Female; Flea Infestations; Insecticides

2020
Fipronil Pellets Reduce Flea Abundance on Black-Tailed Prairie Dogs: Potential Tool for Plague Management and Black-Footed Ferret Conservation.
    Journal of wildlife diseases, 2021, 04-01, Volume: 57, Issue:2

    Topics: Animals; Ferrets; Flea Infestations; Insecticides; Plague; Pyrazoles; Sciuridae; Siphonaptera

2021
Efficacy of a fipronil bait in reducing the number of fleas (Oropsylla spp.) infesting wild black-tailed prairie dogs.
    Journal of vector ecology : journal of the Society for Vector Ecology, 2017, Volume: 42, Issue:1

    Topics: Animals; Flea Infestations; Plague; Pyrazoles; Rodent Diseases; Sciuridae; Siphonaptera; Yersinia pe

2017
Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats.
    Parasites & vectors, 2017, Jul-19, Volume: 10, Issue:1

    Topics: Animals; Cat Diseases; Cats; Ctenocephalides; Drug Synergism; Flea Infestations; Guanidines; Insecti

2017
Field evaluation of a 0.005% fipronil bait, orally administered to Rhombomys opimus, for control of fleas (Siphonaptera: Pulicidae) and phlebotomine sand flies (Diptera: Psychodidae) in the Central Asian Republic of Kazakhstan.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:7

    Topics: Animals; Disease Vectors; Feeding Behavior; Female; Flea Infestations; Gerbillinae; Insect Control;

2018
Evaluation of an 11.2% spinetoram topical spot-on solution for the control of experimental and natural flea (Ctenocephalides felis) infestations on cats in Europe.
    Veterinary parasitology, 2018, Jul-15, Volume: 258

    Topics: Administration, Topical; Animals; Cats; Ctenocephalides; Dermatitis; Dogs; Drug Compounding; Flea In

2018
Evaluation of Five Pulicides to Suppress Fleas on Black-Tailed Prairie Dogs: Encouraging Long-Term Results with Systemic 0.005% Fipronil.
    Vector borne and zoonotic diseases (Larchmont, N.Y.), 2019, Volume: 19, Issue:6

    Topics: Animals; Flea Infestations; Insect Control; Insecticide Resistance; Insecticides; Nitriles; Plague;

2019
Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against adult and immature stages of the cat flea (Ctenocephalides felis) on cats.
    Veterinary parasitology, 2014, Apr-28, Volume: 202, Issue:1-2

    Topics: Animals; Antiparasitic Agents; Cat Diseases; Cats; Ctenocephalides; Drug Combinations; Flea Infestat

2014
Sustained speed of kill and repellency of a novel combination of fipronil and permethrin against Ctenocephalides canis flea infestations in dogs.
    Parasites & vectors, 2015, Jan-27, Volume: 8

    Topics: Administration, Topical; Animals; Ctenocephalides; Dog Diseases; Dogs; Drug Evaluation; Drug Therapy

2015
Efficacy of a new combination of fipronil and permethrin against Ctenocephalides felis flea infestation in dogs.
    Parasites & vectors, 2015, Jan-29, Volume: 8

    Topics: Administration, Topical; Animals; Ctenocephalides; Dog Diseases; Dogs; Drug Evaluation; Drug Therapy

2015
Knock-down and speed of kill of a combination of fipronil and permethrin for the prevention of Ctenocephalides felis flea infestation in dogs.
    Parasites & vectors, 2016, Feb-02, Volume: 9

    Topics: Animals; Chemoprevention; Ctenocephalides; Dog Diseases; Dogs; Drug Therapy, Combination; Flea Infes

2016
Results of a European multicentric field efficacy study of fipronil-(S) methoprene combination on flea infestation of dogs and cats during 2009 summer.
    Parasite (Paris, France), 2010, Volume: 17, Issue:4

    Topics: Animals; Antiparasitic Agents; Cat Diseases; Cats; Dog Diseases; Dogs; Drug Therapy, Combination; Eu

2010
Assay of two 10% (w/v) fipronil spot-on formulations against feline infestations with Ctenocephalides felis.
    Journal of feline medicine and surgery, 2011, Volume: 13, Issue:4

    Topics: Animals; Cat Diseases; Cats; Ctenocephalides; Female; Flea Infestations; Insecticides; Male; Pyrazol

2011
Efficacy of dinotefuran-pyriproxyfen, dinotefuran-pyriproxyfen-permethrin and fipronil-(S)-methoprene topical spot-on formulations to control flea populations in naturally infested pets and private residences in Tampa, FL.
    Veterinary parasitology, 2011, Dec-15, Volume: 182, Issue:2-4

    Topics: Administration, Topical; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Flea Infestations; Florida

2011
Assessment of owner-administered monthly treatments with oral spinosad or topical spot-on fipronil/(S)-methoprene in controlling fleas and associated pruritus in dogs.
    Veterinary parasitology, 2013, Jan-31, Volume: 191, Issue:3-4

    Topics: Animals; Communicable Disease Control; Dog Diseases; Dogs; Drug Combinations; Female; Flea Infestati

2013