Page last updated: 2024-09-02

fingolimod hydrochloride and Lymphocytopenia

fingolimod hydrochloride has been researched along with Lymphocytopenia in 69 studies

Research

Studies (69)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.45)	18.2507
2000's	20 (28.99)	29.6817
2010's	36 (52.17)	24.3611
2020's	12 (17.39)	2.80

Authors

Authors	Studies
Álvarez-Cermeño, JC; Fernández, O; Hernández, MA; Marzo, ME; Meca-Lallana, JE; Meca-Lallana, V; Montalbán, X; Muñoz, D; Olascoaga, J; Oreja-Guevara, C; Pato, A; Ramió-Torrentà, L; Rodríguez-Antigüedad, A	1
Bovis, F; Buttari, F; Cellerino, M; Centonze, D; Cola, G; Fantozzi, R; Grimaldi, A; Inglese, M; Landi, D; Lucchini, M; Lus, G; Marfia, GA; Mataluni, G; Mirabella, M; Nicoletti, CG; Ponzano, M; Signoriello, E	1
Ahmed, A; Carol, HA; Ochfeld, EN	1
Cervasi, B; Deleage, C; Easley, K; Estes, JD; Gill, KP; Harper, JL; Jean, SM; King, CT; Lederman, MM; Micci, L; Mudd, JC; Padhan, K; Paganini, S; Paiardini, M; Petrovas, C; Pino, M; Silvestri, G	1
Boffa, G; Bruschi, N; Capello, E; Cellerino, M; Inglese, M; Lapucci, C; Novi, G; Sbragia, E; Uccelli, A	1
Aktas, O; Bielor, C; Hartung, HP; Kremer, D; MacKenzie, C; Müller, AK; Weyers, V; Wienemann, T	1
Valencia-Sanchez, C; Wingerchuk, DM	1
Bowen, JD; Brink, J; Brown, TR; Lucassen, EB; Repovic, P; Smoot, K; Wundes, A	1
Amor, S; Baker, D; Giovannoni, G; Kang, AS; Schmierer, K	1
Derfuss, T; Kuhle, J; Nagy, S	1
Engelhardt, B; Enzmann, G; Homann, T; Huwiler, A; Kleuser, B; Stark, H; Stepanovska, B; Tietz, S; Zivkovic, A	1
Ciftci, O; Ekmekyapar, T; Ozcan, C	1
Bonavita, S; Miele, G; Sparaco, M	1
Carreón Guarnizo, E; García Vazquez, E; Hernández Clares, R; Meca Lallana, JE; Sánchez Pedreño, P	1
Avasarala, J; Jain, S; Urrea-Mendoza, E	1
Alshaker, H; Chao, Y; Cooper, C; Pchejetski, D; Srivats, S; Wang, Q	1
Antel, J; Bar-Or, A; Fitz-Gerald, L; Ghadiri, M; Giacomini, PS; Haegert, D; Li, R; Nyirenda, M; Rezk, A	1
Calvi, A; Carandini, T; De Riz, M; Galimberti, D; Ghezzi, L; Lecchi, E; Maurichi, A; Pellegrinelli, A; Pietroboni, A; Scarioni, M; Scarpini, E	1
Diallo, R; Hiepe, F; Kohler, S; Meisel, A; Pelz, A; Schaffert, H	1
Baharnoori, M; Chitnis, T; Chua, A; Diaz-Cruz, C; Gonzalez, CT; Healy, BC; Stankiewicz, J; Weiner, HL	1
Corbett, A; Kermode, AG; Reddel, SW; Triplett, J	1
Breville, G; Lalive, PH; Lascano, AM; Merkler, D; Roth, S	1
Girard, M; Labrie, M; Muccilli, A; Nehme, A; Odier, C; Poppe, AY	1
Brede, M; Deppermann, C; Göb, E; Göbel, K; Herrmann, AM; Kleinschnitz, C; Kraft, P; Lorenz, K; Meuth, SG; Nieswandt, B; Pfeilschifter, W; Schuhmann, MK; Stoll, G; Thielmann, I	1
Erminio, C; La Mantia, L; Marazzi, MR; Prone, V; Protti, A	1
Albert-Weissenberger, C; Hennig, N; Hopp, S; Kleinschnitz, C; Mencl, S; Schuhmann, MK; Sirén, AL	1
Chen, XG; Han, WJ; Jin, J; Li, G; Wang, XJ; Xiao, Q; Yin, DL; Zhou, WQ	1
Dehmel, T; Hartung, HP; Holmen, C; Kieseier, BC; Leussink, VI; Nordin, N; Olsson, T; Ramanujam, R; Warnke, C; Wolfram, K	1
de Jong, B; Derfuss, T; Giovannoni, G; Izquierdo, G; Juliusson, G; Mazibrada, G; Molyneux, P; Nicholas, R; Overell, J; Ziemssen, T	1
Accoto, S; De Blasi, V; De Donno, A; De Masi, R; Idolo, A; Orlando, S; Pasca, S; Scarpello, R; Spagnolo, L	1
Enderes, J; Heidecke, CD; Müller, J; Schulze, T; Tran, BT; van der Linde, J; von Bernstorff, W	1
Brait, VH; Gavaldà, A; Godessart, N; Planas, AM; Tarrasón, G	1
Giese, T; Meuer, S; Morath, C; Sommerer, C; Zeier, M	1
Altman, JD; Moseley, NB; Premenko-Lanier, M; Pruett, ST; Romagnoli, PA	1
Davis, MD; Foss, FW; Kennedy, PC; Kharel, Y; Lynch, KR; Macdonald, TL; Mathews, TP; Snyder, AH	1
Marsolais, D; Oldstone, MB; Rosen, H; Walsh, KB; Welch, MJ	1
Li, F; Li, Q	1
Blaho, VA; Guo, C; Hla, T; Im, DS; Khanna, KM; Lefrancois, L; Oo, ML; Thangada, S	1
Antel, J; Bar-Or, A; Haegert, DG; Johnson, TA; Keezer, M; Lapierre, Y; Shames, I	1
Cho, WY; Jo, SK; Kim, HK; Kim, MG; Ko, YS; Lee, HY; Lee, SY	1
Blaho, V; Chang, SH; Han, DK; Hla, T; Hwang, SI; Oo, ML; Rezaul, K; Thangada, S; Wu, MT	1
Antel, JP; Bar-Or, A; Blain, M; Durafourt, BA; Evans, BL; Johnson, TA; Lapierre, Y	1
David, M; Huang, T; Kennedy, PC; Lynch, KR; Macdonald, TL; Mathews, TP; Peyruchaud, O; Tomsig, JL; Zhu, R	1
Cahalan, SM; Cameron, MD; Gonzalez-Cabrera, PJ; Kago, T; Leaf, NB; Nguyen, N; Rosen, H; Sarkisyan, G	1
Do, JS; Foucras, G; Kamada, N; Min, B; Nuñez, G; Paul, WE; Schenk, AF; Shaw, M	1
Hall, LJ; Hurley, G; MacSharry, J; Melgar, S; Murphy, CT; Nally, K; Quinlan, A; Shanahan, F	1
Chen, XG; Jin, J; Li, C; Li, Y; Zhang, HJ; Zhou, WQ	1
Cervera, C	1
Lopez, AF; Pitman, MR; Pitson, SM; Woodcock, JM	1
Bermel, RA; Cohen, JA; Hara-Cleaver, C; Ontaneda, D; Rudick, RA	1
Park, K; Tanaka, K; Tanaka, M	1
Böhler, T; Brookman, L; Brunkhorst, R; Budde, K; L Schmouder, R; Mayer, T; Nashan, B; Nedelman, J; Neumayer, HH; Skerjanec, A; W Lücker, P	1
Goetzl, EJ; Gräler, MH	1
Ahn, MY; Alfonso, C; Chun, J; Gray, N; Jo, E; Lefebvre, S; Liao, J; Peterson, MS; Rosen, H; Sanna, MG; Webb, B	1
Böhler, T; Budde, K; Dragun, D; Neumayer, HH; Schütz, M; Waiser, J	1
Chun, J; Hale, J; Lariosa-Willingham, K; Lin, FF; Mandala, S; Rao, TS; Tham, CS; Webb, M; Yu, N	1
Allende, ML; Hajdu, R; Kawai, H; Keohane, CA; Mandala, S; Mi, Y; Olivera, A; Proia, RL; Rosenbach, M; Sasaki, T; Spiegel, S; van Echten-Deckert, G	1
Felipe, CR; Garcia, R; Machado, PG; Medina-Pestana, JO; Park, SI; Schmouder, R; Skerjanec, A; Tedesco-Silva, H	1
Fukuzawa, M; Hagiwara, N; Ikeda, T; Inoue, M; Koshinaga, T; Sugito, K	1
Burcin, TL; Engelhard, VH; Kharel, Y; Lee, S; Ley, K; Lynch, KR; Macdonald, TL; Morris, MA; Pearson-White, S; Setiady, Y; Sheasley-O'neill, SL; Snyder, AH; Tung, KS; Zhu, R; Zigler, MA	1
Brinkmann, V; Gibb, DR; Ley, K; Morris, MA; Picard, F; Straume, M	1
Aoyama, K; Asakura, S; Hashimoto, D; Koyama, M; Matsuoka, K; Sakoda, Y; Tanimoto, M; Teshima, T	1
Bueno, V; Burdmann, EA; Franco, M; Gallo, AP; Silva, LB	1
Bea, F; Blessing, E; Dengler, TJ; Grone, HJ; Hansson, GK; Katus, HA; Klingenberg, R; Nofer, JR; Preusch, M; Rudling, M	1
Hupfeld, CJ; Kendall, MR	1
Amemiya, H; Hiromitsu, K; Li, XK; Suzuki, K; Suzuki, S; Yan, H	1
Brinkmann, V; Hengartner, H; Ochsenbein, AF; Odermatt, B; Pinschewer, DD; Zinkernagel, RM	1
Bergstrom, J; Card, D; Hajdu, R; Hale, J; Keohane, C; Lynch, CL; Mandala, S; Milligan, J; Parsons, W; Quackenbush, E; Rosen, H; Rosenbach, M; Rupprecht, K; Shei, GJ; Thornton, R; Xie, J	1
Albert, R; Baumruker, T; Brinkmann, V; Bruns, C; Cottens, S; Davis, MD; Foster, CA; Heise, CE; Hiestand, P; Hof, R; Lynch, KR; Prieschl, E; Zollinger, M	1

Reviews

3 review(s) available for fingolimod hydrochloride and Lymphocytopenia

Article	Year
The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic. Multiple sclerosis and related disorders, 2020, Volume: 43 Topics: Alemtuzumab; Antibodies, Monoclonal, Humanized; Antibodies, Viral; Betacoronavirus; CD8-Positive T-Lymphocytes; Cladribine; Coronavirus Infections; COVID-19; Crotonates; Cytokine Release Syndrome; Deprescriptions; Dimethyl Fumarate; Fingolimod Hydrochloride; Glatiramer Acetate; Hematopoietic Stem Cell Transplantation; Humans; Hydroxybutyrates; Immune Evasion; Immunity, Innate; Immunologic Factors; Immunosuppressive Agents; Interferon-beta; Lymphopenia; Macrophages; Monocytes; Multiple Sclerosis; Natalizumab; Nitriles; Pandemics; Pneumonia, Viral; Respiratory Distress Syndrome; SARS-CoV-2; Toluidines	2020
[Infections and fingolimod]. Revista de neurologia, 2012, Aug-16, Volume: 55, Issue:4 Topics: Community-Acquired Infections; Contraindications; Disease Management; Disease Susceptibility; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunocompromised Host; Immunologic Memory; Immunologic Surveillance; Immunosuppressive Agents; Kidney Transplantation; Leukoencephalopathy, Progressive Multifocal; Lymphopenia; Multiple Sclerosis, Relapsing-Remitting; Opportunistic Infections; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Vaccination	2012
Molecular targets of FTY720 (fingolimod). Current molecular medicine, 2012, Volume: 12, Issue:10 Topics: Antineoplastic Agents; Apoptosis; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Lysophospholipids; Multiple Sclerosis; Neoplasms; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2012

Trials

6 trial(s) available for fingolimod hydrochloride and Lymphocytopenia

Article	Year
Initial lymphocyte count and low BMI may affect fingolimod-induced lymphopenia. Neurology, 2014, Dec-02, Volume: 83, Issue:23 Topics: Adult; Aged; Body Mass Index; Cohort Studies; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphocyte Count; Lymphopenia; Middle Aged; Multiple Sclerosis; Propylene Glycols; Sphingosine	2014
Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients. Clinical immunology (Orlando, Fla.), 2010, Volume: 137, Issue:1 Topics: Adult; CD8-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; Female; Fingolimod Hydrochloride; Follow-Up Studies; Humans; Immunosuppressive Agents; Lymph Nodes; Lymphocyte Count; Lymphocytes; Lymphopenia; Mediastinum; Middle Aged; Multiple Sclerosis; Patient Dropouts; Propylene Glycols; Receptors, CCR7; Sphingosine; Withholding Treatment	2010
Reduction of the peripheral blood CD56(bright) NK lymphocyte subset in FTY720-treated multiple sclerosis patients. Journal of immunology (Baltimore, Md. : 1950), 2011, Jul-01, Volume: 187, Issue:1 Topics: CD56 Antigen; Cells, Cultured; Chemotaxis, Leukocyte; Down-Regulation; Fingolimod Hydrochloride; Humans; Immunophenotyping; Immunosuppressive Agents; Killer Cells, Natural; Lymphocyte Count; Lymphopenia; Multiple Sclerosis, Relapsing-Remitting; Propylene Glycols; Sphingosine	2011
Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2003, Volume: 3, Issue:7 Topics: Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Subsets; Lymphopenia; Propylene Glycols; Sphingosine	2003
FTY720 mediates apoptosis-independent lymphopenia in human renal allograft recipients: different effects on CD62L+ and CCR5+ T lymphocytes. Transplantation, 2004, May-15, Volume: 77, Issue:9 Topics: Apoptosis; Biomarkers; CD11a Antigen; CD3 Complex; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Integrin alpha4; Kidney Transplantation; L-Selectin; Lymphopenia; Propylene Glycols; Receptors, CCR5; Sphingosine; T-Lymphocytes	2004
Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2005, Volume: 38, Issue:5 Topics: Adolescent; Adult; Aged; Cyclosporine; Dose-Response Relationship, Drug; Female; Fingolimod Hydrochloride; Follow-Up Studies; Humans; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Count; Lymphocytes; Lymphopenia; Male; Middle Aged; Mycophenolic Acid; Propylene Glycols; Sphingosine; Time Factors	2005

Other Studies

60 other study(ies) available for fingolimod hydrochloride and Lymphocytopenia

Article	Year
Four-year safety and effectiveness data from patients with multiple sclerosis treated with fingolimod: The Spanish GILENYA registry. PloS one, 2021, Volume: 16, Issue:10 Topics: Adult; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Male; Middle Aged; Multiple Sclerosis; Recurrence; Registries; Retrospective Studies; Spain; Treatment Outcome	2021
Influence of Previous Disease-Modifying Drug Exposure on T-Lymphocyte Dynamic in Patients With Multiple Sclerosis Treated With Ocrelizumab. Neurology(R) neuroimmunology & neuroinflammation, 2022, Volume: 9, Issue:3 Topics: Antibodies, Monoclonal, Humanized; Fingolimod Hydrochloride; Humans; Lymphopenia; Multiple Sclerosis; Retrospective Studies	2022
In-utero exposure to immunosuppressive medications resulting in abnormal newborn screening for severe combined immunodeficiency: a case series on natural history and management. Immunologic research, 2022, Volume: 70, Issue:5 Topics: Actins; Azathioprine; Female; Fingolimod Hydrochloride; Humans; Hydroxychloroquine; Infant; Infant, Newborn; Infliximab; Lymphopenia; Mitogens; Neonatal Screening; Receptors, Antigen, T-Cell; Severe Combined Immunodeficiency; Vaccines	2022
Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence. PLoS pathogens, 2019, Volume: 15, Issue:10 Topics: Animals; Female; Fingolimod Hydrochloride; Germinal Center; Immunosuppressive Agents; Lymphopenia; Macaca mulatta; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer	2019
Fingolimod and Dimethyl-Fumarate-Derived Lymphopenia is not Associated with Short-Term Treatment Response and Risk of Infections in a Real-Life MS Population. CNS drugs, 2020, Volume: 34, Issue:4 Topics: Adult; Dimethyl Fumarate; Disease Progression; Female; Fingolimod Hydrochloride; Humans; Infections; Lymphocyte Count; Lymphocytes; Lymphopenia; Male; Multiple Sclerosis; Recurrence; Retrospective Studies; Risk	2020
Cryptococcal meningoencephalitis in an IgG BMC neurology, 2020, Apr-27, Volume: 20, Issue:1 Topics: Cryptococcosis; Female; Fingolimod Hydrochloride; Humans; Immunoglobulin G; Immunosuppressive Agents; Lymphopenia; Meningoencephalitis; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Opportunistic Infections	2020
A fine balance: Immunosuppression and immunotherapy in a patient with multiple sclerosis and COVID-19. Multiple sclerosis and related disorders, 2020, Volume: 42 Topics: Antibodies, Monoclonal, Humanized; Betacoronavirus; C-Reactive Protein; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Deprescriptions; Female; Ferritins; Fibrin Fibrinogen Degradation Products; Fingolimod Hydrochloride; Humans; Immunologic Factors; Immunosuppressive Agents; Interleukin-6; L-Lactate Dehydrogenase; Lymphopenia; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Pandemics; Pneumonia, Viral; Respiration, Artificial; SARS-CoV-2; Severity of Illness Index	2020
COVID-19 in MS: Initial observations from the Pacific Northwest. Neurology(R) neuroimmunology & neuroinflammation, 2020, 09-03, Volume: 7, Issue:5 Topics: Adult; Aged; Coronavirus Infections; COVID-19; Crotonates; Dimethyl Fumarate; Female; Fingolimod Hydrochloride; Glatiramer Acetate; Humans; Hydroxybutyrates; Immunocompromised Host; Immunosuppressive Agents; Interferons; Lymphopenia; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nitriles; Northwestern United States; Nursing Homes; Oregon; Pandemics; Pneumonia, Viral; Severity of Illness Index; Toluidines; Travel; Washington	2020
Lymphocyte recovery after fingolimod discontinuation in patients with MS. Neurology(R) neuroimmunology & neuroinflammation, 2020, Volume: 7, Issue:6 Topics: Adult; Female; Fingolimod Hydrochloride; Follow-Up Studies; Humans; Immune Reconstitution; Immunosuppressive Agents; Lymphocyte Count; Lymphopenia; Male; Middle Aged; Multiple Sclerosis	2020
Morpholino Analogues of Fingolimod as Novel and Selective S1P International journal of molecular sciences, 2020, Sep-04, Volume: 21, Issue:18 Topics: Animals; Central Nervous System; CHO Cells; Cricetulus; Disease Models, Animal; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Immunosuppressive Agents; Ligands; Lymphopenia; Lysophospholipids; Mice; Morpholinos; Multiple Sclerosis; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Spinal Cord; T-Lymphocytes	2020
Relationships of total leukocyte, neutrophil and lymphocyte levels with the menstrual cycle in patients receiving fingolimod treatment. European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:1 Topics: Adolescent; Adult; Cell Proliferation; Female; Fingolimod Hydrochloride; Humans; Leukocytes; Lymphocyte Count; Lymphocytes; Lymphopenia; Menstrual Cycle; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Neutrophils; Young Adult	2021
Severe lymphopenia switching from Fingolimod to Siponimod. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021, Volume: 42, Issue:11 Topics: Azetidines; Benzyl Compounds; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting	2021
Aggressive cutaneous leishmaniasis in a patient with multiple sclerosis treated with fingolimod. Neurologia, 2018, Volume: 33, Issue:5 Topics: Adult; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Leishmaniasis, Cutaneous; Lymphopenia; Multiple Sclerosis, Relapsing-Remitting	2018
Approach to Fingolimod-Induced Lymphopenia in Multiple Sclerosis Patients: Do We Have a Roadmap? Journal of clinical pharmacology, 2017, Volume: 57, Issue:11 Topics: Brain; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Multiple Sclerosis, Relapsing-Remitting; Product Surveillance, Postmarketing	2017
New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth. Breast cancer research and treatment, 2017, Volume: 165, Issue:3 Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Docetaxel; Female; Fingolimod Hydrochloride; Humans; Lymphopenia; Mice; Nanoparticles; Neoplasm Metastasis; Neoplasm Staging; Taxoids; Tumor Burden; Xenograft Model Antitumor Assays	2017
Reconstitution of the peripheral immune repertoire following withdrawal of fingolimod. Multiple sclerosis (Houndmills, Basingstoke, England), 2017, Volume: 23, Issue:9 Topics: Adult; Aged; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Fingolimod Hydrochloride; Follow-Up Studies; Humans; Immunosuppressive Agents; Lymphocyte Count; Lymphopenia; Male; Middle Aged; Multiple Sclerosis	2017
Merkel cell carcinoma in a patient with relapsing-remitting multiple sclerosis treated with fingolimod. Journal of the neurological sciences, 2017, 10-15, Volume: 381 Topics: Carcinoma, Merkel Cell; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Skin Neoplasms	2017
S1P receptor antagonists fingolimod and siponimod do not improve the outcome of experimental autoimmune myasthenia gravis mice after disease onset. European journal of immunology, 2018, Volume: 48, Issue:3 Topics: Animals; Antibody Formation; Azetidines; Benzyl Compounds; Cytokines; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Male; Mice; Mice, Inbred C57BL; Myasthenia Gravis, Autoimmune, Experimental; Plasma Cells; Receptors, Lysosphingolipid; T-Lymphocytes	2018
Predictors of hematological abnormalities in multiple sclerosis patients treated with fingolimod and dimethyl fumarate and impact of treatment switch on lymphocyte and leukocyte count. Multiple sclerosis and related disorders, 2018, Volume: 20 Topics: Adult; Dimethyl Fumarate; Drug Substitution; Female; Fingolimod Hydrochloride; Follow-Up Studies; Humans; Immunosuppressive Agents; Leukocyte Count; Leukopenia; Lymphocyte Count; Lymphopenia; Male; Middle Aged; Multiple Sclerosis; Prognosis; Prospective Studies; Retrospective Studies	2018
Warts and all: Fingolimod and unusual HPV-associated lesions. Multiple sclerosis (Houndmills, Basingstoke, England), 2019, Volume: 25, Issue:11 Topics: Ankle; Antineoplastic Agents; Anus Neoplasms; Carcinoma, Squamous Cell; Cryotherapy; Fingers; Fingolimod Hydrochloride; Foot Dermatoses; Hand Dermatoses; Humans; Imiquimod; Immunosuppressive Agents; Lymphopenia; Multiple Sclerosis, Relapsing-Remitting; Papillomavirus Infections; Warts	2019
Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patient. Multiple sclerosis and related disorders, 2019, Volume: 34 Topics: Adult; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Multiple Sclerosis, Relapsing-Remitting; Natalizumab; Treatment Adherence and Compliance	2019
Varicella-zoster virus vasculopathy in a multiple sclerosis patient on fingolimod. Journal of the neurological sciences, 2019, Aug-15, Volume: 403 Topics: Adult; Constriction, Pathologic; Female; Fingolimod Hydrochloride; Herpesvirus 3, Human; Humans; Lymphopenia; Multiple Sclerosis, Relapsing-Remitting; Risk Factors; Vascular Diseases	2019
FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection. Stroke, 2013, Volume: 44, Issue:11 Topics: Animals; Brain Ischemia; Enzyme Inhibitors; Fingolimod Hydrochloride; Homeodomain Proteins; Hypoxia; Immunosuppressive Agents; Inflammation; Lymphocytes; Lymphopenia; Male; Mice; Mice, Transgenic; Middle Cerebral Artery; Neurons; Neuroprotective Agents; Propylene Glycols; Sphingosine; Stroke; Thrombosis	2013
Multiple sclerosis rebound after fingolimod discontinuation for lymphopenia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014, Volume: 35, Issue:9 Topics: Adult; Female; Fingolimod Hydrochloride; Gadolinium; Humans; Immunosuppressive Agents; Lymphopenia; Magnetic Resonance Imaging; Multiple Sclerosis, Relapsing-Remitting; Propylene Glycols; Sphingosine	2014
FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation. Journal of neuroimmunology, 2014, Sep-15, Volume: 274, Issue:1-2 Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Disease Models, Animal; Encephalitis; Fingolimod Hydrochloride; Flow Cytometry; Immunosuppressive Agents; Lymphopenia; Mice; Mice, Inbred C57BL; Propylene Glycols; Signal Transduction; Sphingosine; T-Lymphocytes; Treatment Outcome	2014
[Design, synthesis and biological evaluation of fingolimod analogues containing diphenyl ether moiety]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:6 Topics: Animals; Fingolimod Hydrochloride; Heart Rate; Immunosuppressive Agents; Lymphopenia; Phenyl Ethers; Structure-Activity Relationship	2014
A pragmatic approach to dealing with fingolimod-related lymphopaenia in Europe. Multiple sclerosis and related disorders, 2015, Volume: 4, Issue:1 Topics: Europe; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Multiple Sclerosis	2015
Dramatic recovery of steroid-refractory relapsed multiple sclerosis following Fingolimod discontinuation using selective immune adsorption. BMC neurology, 2015, Jul-31, Volume: 15 Topics: Adsorption; Adult; Autoantibodies; Female; Fingolimod Hydrochloride; Humans; Immunoglobulin G; Immunologic Factors; Lymphopenia; Magnetic Resonance Imaging; Methylprednisolone; Multiple Sclerosis; Myelin Sheath; Natalizumab; Plasma Exchange; Steroids; Treatment Outcome	2015
FTY720-Induced Lymphopenia Does Not Aggravate Mortality in a Murine Model of Polymicrobial Abdominal Sepsis. Shock (Augusta, Ga.), 2017, Volume: 47, Issue:3 Topics: Animals; Disease Models, Animal; Female; Fingolimod Hydrochloride; Flow Cytometry; Lymphopenia; Mice; Mice, Inbred C57BL; Peritonitis; Sepsis	2017
Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice. Stroke, 2016, Volume: 47, Issue:12 Topics: Animals; Cerebral Infarction; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphopenia; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Receptors, Lysosphingolipid; Reperfusion Injury; Sphingosine	2016
Activity of nuclear factor of activated T cells is independent of the number of peripheral lymphocytes in FTY720-treated patients. Transplantation proceedings, 2008, Volume: 40, Issue:5 Topics: Cyclosporine; Fingolimod Hydrochloride; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Kidney Transplantation; Lymphocyte Activation; Lymphopenia; Methylprednisolone; NFATC Transcription Factors; Propylene Glycols; RNA, Messenger; Sphingosine; T-Lymphocytes	2008
Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection. Nature, 2008, Aug-14, Volume: 454, Issue:7206 Topics: Animals; Chronic Disease; Fingolimod Hydrochloride; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Lymphopenia; Mice; Mice, Inbred C57BL; Propylene Glycols; Sphingosine; T-Lymphocytes; Time Factors	2008
Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorganic & medicinal chemistry, 2009, Aug-15, Volume: 17, Issue:16 Topics: Animals; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Mice; Prodrugs; Propanols; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Structure-Activity Relationship	2009
Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection. Virology, 2010, Feb-20, Volume: 397, Issue:2 Topics: Animals; Antiviral Agents; beta-Alanine; Fingolimod Hydrochloride; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Lymphopenia; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Propylene Glycols; Sphingosine; Thiophenes; Treatment Outcome	2010
Effects of different dose of FTY720 on lymphocyte cell cycle arrest in cardiac transplantation model of rats. Immunopharmacology and immunotoxicology, 2010, Volume: 32, Issue:4 Topics: Animals; Blood; Cell Cycle; Cell Division; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Interphase; Lymph Nodes; Lymphocyte Count; Lymphocytes; Lymphopenia; Male; Propylene Glycols; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sphingosine; Thymus Gland	2010
Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. The Journal of experimental medicine, 2010, Jul-05, Volume: 207, Issue:7 Topics: Amino Acid Substitution; Animals; Base Sequence; Cell Membrane; Chemotaxis, Leukocyte; Endocytosis; Fingolimod Hydrochloride; Kinetics; Lymphopenia; Lysophospholipids; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutant Proteins; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes	2010
CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:1 Topics: Acute Kidney Injury; Animals; CD4-Positive T-Lymphocytes; Dendritic Cells; Fingolimod Hydrochloride; Flow Cytometry; Forkhead Transcription Factors; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Kidney; Lymphocyte Culture Test, Mixed; Lymphopenia; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Propylene Glycols; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Spleen; T-Lymphocytes, Regulatory	2011
Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice. The Journal of clinical investigation, 2011, Volume: 121, Issue:6 Topics: Animals; Capillary Leak Syndrome; Dose-Response Relationship, Drug; Endocytosis; Fingolimod Hydrochloride; Gene Knock-In Techniques; Lymphopenia; Lysophospholipids; Mice; Organophosphates; Peptide Hydrolases; Phosphorylation; Propylene Glycols; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pulmonary Edema; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Recombinant Fusion Proteins; Sphingosine; Sphingosine-1-Phosphate Receptors; Ubiquitin-Protein Ligases; Ubiquitination	2011
Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:3 Topics: Animals; Benzene Derivatives; Blotting, Western; Calcium; Capillary Permeability; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Cyclobutanes; Female; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Lymphocyte Count; Lymphopenia; Mammary Neoplasms, Experimental; Mass Spectrometry; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Prodrugs; Propylene Glycols; Protein Conformation; Radioligand Assay; Receptors, Lysosphingolipid; Sphingosine; Structure-Activity Relationship	2011
S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis. Molecular pharmacology, 2012, Volume: 81, Issue:2 Topics: Animals; Central Nervous System; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Immunosuppressive Agents; Indans; Lymphopenia; Mice; Multiple Sclerosis; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2012
Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions. Cellular immunology, 2012, Volume: 272, Issue:2 Topics: Animals; Autoantigens; Cell Proliferation; Fingolimod Hydrochloride; Homeostasis; Immunologic Memory; Lymph Nodes; Lymphocyte Activation; Lymphopenia; Mice; Mice, Inbred C57BL; Propylene Glycols; Receptors, Antigen, T-Cell; Sphingosine; Spleen; T-Lymphocytes	2012
The sphingosine-1-phosphate analogue FTY720 impairs mucosal immunity and clearance of the enteric pathogen Citrobacter rodentium. Infection and immunity, 2012, Volume: 80, Issue:8 Topics: Animals; Citrobacter rodentium; Enterobacteriaceae Infections; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Immunity, Mucosal; Immunosuppressive Agents; Lymphopenia; Mice; Mice, Inbred Strains; Propylene Glycols; RNA, Messenger; Specific Pathogen-Free Organisms; Sphingosine	2012
[Immunosuppressive effect of S1P1 receptor agonist FTY720]. Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:4 Topics: Animals; Cricetinae; Cricetulus; Female; Fingolimod Hydrochloride; Graft Survival; Heart Rate; Immunosuppressive Agents; Lymphocyte Count; Lymphocytes; Lymphopenia; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Confocal; Propylene Glycols; Protein Binding; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Skin Transplantation; Sphingosine; Transplantation, Homologous	2012
Early tolerability and safety of fingolimod in clinical practice. Journal of the neurological sciences, 2012, Dec-15, Volume: 323, Issue:1-2 Topics: Adult; Bradycardia; Chest Pain; Drug Substitution; Female; Fingolimod Hydrochloride; Headache; Humans; Hypertension; Lymphopenia; Macular Edema; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nausea; Patient Acceptance of Health Care; Product Surveillance, Postmarketing; Propylene Glycols; Retrospective Studies; Sphingosine	2012
Reduced fingolimod dosage treatment for patients with multiple sclerosis and lymphopenia or neutropenia. Multiple sclerosis (Houndmills, Basingstoke, England), 2013, Volume: 19, Issue:9 Topics: Adult; Aged; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Multiple Sclerosis, Relapsing-Remitting; Neutropenia; Propylene Glycols; Sphingosine	2013
The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:3 Topics: Animals; Chemotaxis; Dose-Response Relationship, Drug; Down-Regulation; Drug Design; Endocytosis; Fingolimod Hydrochloride; Gene Targeting; Humans; Immunosuppressive Agents; Jurkat Cells; Lymphocyte Subsets; Lymphopenia; Lysophospholipids; Mice; Propylene Glycols; Protein Isoforms; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Recombinant Fusion Proteins; Signal Transduction; Sphingosine; Transduction, Genetic; Transfection	2004
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. The Journal of biological chemistry, 2004, Apr-02, Volume: 279, Issue:14 Topics: Animals; Calcium; Cell Movement; CHO Cells; Cricetinae; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Heart Rate; Immunosuppressive Agents; Lymphatic System; Lymphocytes; Lymphopenia; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phosphorylation; Propylene Glycols; Protein Kinases; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Signal Transduction; Sphingosine	2004
Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. Journal of neuroimmunology, 2004, Volume: 153, Issue:1-2 Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Immunosuppressive Agents; Interferon-gamma; Lymphocytes; Lymphopenia; Mice; Mice, Inbred Strains; Mitoxantrone; Molecular Sequence Data; Myelin Proteins; Myelin Proteolipid Protein; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Propylene Glycols; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Time Factors	2004
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. The Journal of biological chemistry, 2004, Dec-10, Volume: 279, Issue:50 Topics: Animals; Base Sequence; DNA; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocytes; Lymphopenia; Lysophospholipids; Mice; Mice, Knockout; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine	2004
The effect of a novel immunosuppressant, FTY720, in mice without secondary lymphoid organs. Surgery today, 2005, Volume: 35, Issue:8 Topics: Animals; Fingolimod Hydrochloride; Graft Survival; Immunosuppressive Agents; Lymphatic Diseases; Lymphocyte Count; Lymphocytes; Lymphoid Tissue; Lymphopenia; Male; Mice; Propylene Glycols; Skin Transplantation; Sphingosine; Splenectomy; T-Lymphocytopenia, Idiopathic CD4-Positive	2005
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. The Journal of biological chemistry, 2005, Nov-04, Volume: 280, Issue:44 Topics: Animals; Fingolimod Hydrochloride; Flow Cytometry; Homozygote; Immunosuppressive Agents; Lymphocytes; Lymphopenia; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Propylene Glycols; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine	2005
Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720. European journal of immunology, 2005, Volume: 35, Issue:12 Topics: Animals; Cell Movement; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymph Nodes; Lymphoid Tissue; Lymphopenia; Male; Mice; Mice, Inbred C57BL; Models, Biological; Propylene Glycols; Sphingosine; T-Lymphocytes	2005
FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease. European journal of immunology, 2007, Volume: 37, Issue:1 Topics: Adjuvants, Immunologic; Administration, Oral; Adoptive Transfer; Animals; Apoptosis; Bone Marrow Transplantation; Cells, Cultured; Female; Fingolimod Hydrochloride; Graft vs Host Disease; Lymphocyte Activation; Lymphocyte Depletion; Lymphopenia; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Propylene Glycols; Sphingosine; T-Lymphocytes	2007
Tacrolimus in combination with FTY720--an analysis of renal and blood parameters. International immunopharmacology, 2006, Dec-20, Volume: 6, Issue:13-14 Topics: Animals; Biomarkers; Blood Glucose; Creatinine; Diabetes Mellitus; Diuresis; Drug Synergism; Fingolimod Hydrochloride; Immunosuppressive Agents; Kidney; Lymphocyte Count; Lymphopenia; Male; Mice; Mice, Inbred C57BL; Potassium; Propylene Glycols; Sodium; Sphingosine; Tacrolimus	2006
Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice. Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:11 Topics: Animals; Apolipoproteins E; Atherosclerosis; Fingolimod Hydrochloride; Hypercholesterolemia; Immunosuppressive Agents; Lipid Metabolism; Lymphocyte Subsets; Lymphocytes; Lymphopenia; Lysophospholipids; Male; Mice; Mice, Knockout; Propylene Glycols; Sphingosine; Spleen	2007
FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice. Diabetes, obesity & metabolism, 2008, Volume: 10, Issue:9 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Fingolimod Hydrochloride; Glucose Tolerance Test; Immunosuppressive Agents; Insulin; Insulin Resistance; Lymphopenia; Male; Mice; Mice, Inbred C57BL; Panniculitis; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Weight Gain	2008
Immunosuppressive effect of FTY 720 on autoimmune diabetes models. Transplantation proceedings, 1998, Volume: 30, Issue:7 Topics: Animals; Diabetes Mellitus, Type 1; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Islets of Langerhans; Lymphopenia; Male; Propylene Glycols; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Sphingosine; Thymectomy	1998
FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. Journal of immunology (Baltimore, Md. : 1950), 2000, Jun-01, Volume: 164, Issue:11 Topics: Animals; Antibodies, Viral; Autoimmune Diseases; Cell Movement; Cytotoxicity, Immunologic; Diabetes Mellitus, Experimental; Edema; Fingolimod Hydrochloride; Hypersensitivity, Delayed; Immunologic Memory; Immunosuppressive Agents; Lymphocyte Activation; Lymphocyte Count; Lymphocytic choriomeningitis virus; Lymphopenia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Propylene Glycols; Sphingosine; T-Lymphocytes, Cytotoxic	2000
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science (New York, N.Y.), 2002, Apr-12, Volume: 296, Issue:5566 Topics: Animals; B-Lymphocytes; Binding, Competitive; Calcium; CHO Cells; Cricetinae; Cyclic AMP; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Ligands; Lymph Nodes; Lymphocyte Count; Lymphopenia; Lysophospholipids; Mice; Organophosphates; Organophosphonates; Phosphorylation; Propylene Glycols; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Spleen; Stereoisomerism; T-Lymphocytes	2002
The immune modulator FTY720 targets sphingosine 1-phosphate receptors. The Journal of biological chemistry, 2002, Jun-14, Volume: 277, Issue:24 Topics: Animals; Apoptosis; Cell Line; Cell Membrane; Chemotaxis; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Insecta; Kidney; Lipid Metabolism; Lymphocytes; Lymphopenia; Mice; Models, Chemical; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats; Rats, Inbred Lew; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Recombinant Proteins; Signal Transduction; Sphingosine; Time Factors	2002