Compounds > fingolimod hydrochloride
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fingolimod hydrochloride and Inflammation

fingolimod hydrochloride has been researched along with Inflammation in 106 studies

Research

Studies (106)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (0.94)18.2507
2000's13 (12.26)29.6817
2010's62 (58.49)24.3611
2020's30 (28.30)2.80

Authors

AuthorsStudies
Bandela, M; Belvitch, P; Brown, ME; Chen, J; Dudek, SM; Garcia, JGN; Letsiou, E; Meliton, LN; Wang, H; Wang, L1
Darjatmoko, SR; Farnoodian, M; Polans, AS; Sheibani, N; Song, YS; Sorenson, CM; Wang, S1
Bittman, R; Goel, K; Petrache, I; Schweitzer, KS; Serban, KA1
Aliomrani, M; Dayani, L; Dinani, MS; Hashempour, H; Taheri, A; Varshosaz, J1
Camacho-Muñoz, D; Certo, M; Cucchi, D; Fischer, DP; Jones, SW; Kucuk, S; Mauro, C; Nicolaou, A; Niven, J1
El-Sheakh, AR; Makled, MN1
Feng, F; Feng, Y; Li, W; Pan, S; Zhang, J1
Baweja, S; Bihari, C; Kumar, G; Kumar, J; Kumari, A; Maiwall, R; Mourya, AK; Negi, P; Rastogi, A; Reddy, GS; Sarin, SK; Sarohi, V; Sood, AK; Subudhi, PD; Thangariyal, S; Tomar, A; Tripathi, DM; Vashistha, C1
Endres, T; Gottmann, K; Kartalou, GI; Leßmann, V; Pawlitzki, M1
Jin, Z; Sun, M; Weng, H; Ye, H; Yuan, Y1
Chang, S; Chen, J; Fan, W; Huang, T; Kang, J; Tian, J; Wang, J; Wang, Y; Xu, H1
Blecharz-Klin, K; Mirowska-Guzel, D; Piechal, A; Pyrzanowska, J; Strosznajder, RP; Wencel, PL1
Barragan, JA; Chaparro, SA; De-Leon Esquivel, J; Diaz-Pacheco, V; Perez, RG; Segura-Ulate, I; Vargas-Medrano, J; Vidal-Martinez, G; Yang, B1
Emming, S; Gobbi, C; Monticelli, S; Sacco, R; Zecca, C1
Bishayee, A; Lukina, E; McGowan, E; Sukocheva, OA1
Higashikawa, K; Houkin, K; Kawabori, M; Kihara, A; Kuge, Y; Midori, YA; Ohno, Y; Wang, Z; Yasui, H1
Bar-Klein, G; Friedman, A; Hameed, MQ; Jozwiak, S; Kaminski, RM; Klein, P; Klitgaard, H; Koepp, M; Löscher, W; Prince, DA; Rotenberg, A; Twyman, R; Vezzani, A; Wong, M1
Houkin, K; Kawabori, M; Konno, K; Seki, T; Takamiya, S; Tateno, T; Watanabe, M; Yamazaki, K1
Chen, M; Hu, ZW; Qin, C; Tao, R; Tian, DS; Wang, W; Wu, LJ; Yang, S; Yu, HH; Zhang, Q; Zhou, LQ1
Gomez-Mayordomo, V; González-García, N; Matías-Guiu, J; Matías-Guiu, JA; Montero-Escribano, P; Porta-Etessam, J1
Han, Z; Luo, Y; Tian, Y; Wang, Y; Wang, Z; Yin, D; Zhang, J; Zhou, S1
Choi, JW; Gaire, BP1
Chen, CP; Chew, WS; Chua, XY; Herr, DR; Ho, LTY; Lai, MKP; Lam, BWS; Ong, WY; Xiang, P1
Casarotto, P; Castrén, E; Delanoe, K; Edelmann, E; Endres, T; Gottmann, K; Kartalou, GI; Lesnikova, A; Lessmann, V; Marie, H; Pousinha, P; Salgueiro-Pereira, AR1
Farbood, Y; Ghafouri, S; Najafian, SA; Sarkaki, A1
Li, J; Meng, H; Wang, L; Wen, S; Zhang, J; Zhang, Y; Zhao, K; Zhu, C1
Dang, PT; Hale, MW; Kocovski, P; Marinis, S; Orian, JM; Tabassum-Sheikh, N1
Asci, H; Ozmen, O; Savran, M; Sezik, M; Yalcin, SE; Yavuz, A1
Kang, DL; Li, TT; Shi, ZA; Su, H; Tu, FP1
Chen, H; Chen, Q; Chu, Y; Guo, Q; Jiang, C; Li, C; Li, X; Liu, P; Luo, Y; Ning, T; Song, H; Su, B; Sun, T; Wang, Y; You, H; Zhang, T; Zhang, Y; Zhao, Z; Zhou, W; Zhou, Z1
Blanchet, MR; Bossé, Y; Dion, G; Gendron, DR; Huppé, CA; Lecours, PB; Lemay, AM; Marsolais, D; Perreault-Vallières, V1
Asci, H; Ozmen, O; Sezik, M; Yavuz, A1
Bettelli, E; Buckner, JH; Duhen, R; Eken, A; Fry, M; Kita, M; Oukka, M; Singh, AK1
Conlon, EG; Hla, T; Kono, M; Lux, SY; Proia, RL; Yanagida, K1
Bielawski, J; Kim, S; Kong, Y; Li, J; Yang, H; Zhou, B1
Cao, K; Liu, L; Shi, D; Wen, S; Wu, F; You, Q; Zhang, K; Zhao, Y; Zhou, H; Zhu, X1
Abe, M; Allegood, JC; Aoyagi, T; Hait, NC; Huang, WC; Katsuta, E; Milstien, S; Nagahashi, M; Nakajima, M; Sakimura, K; Spiegel, S; Takabe, K; Terracina, KP; Tsuchida, J; Wakai, T; Yamada, A; Yuza, K1
Dev, KK; Healy, LM; O'Sullivan, C; O'Sullivan, SA; Sheridan, GK1
Cao, LL; Chen, ZZ; Dong, YF; Guo, RB; Huang, JY; Ji, J; Lu, J; Sun, XL; Wu, J; Zhang, L1
Campos, MM; da Costa, JC; Gomez, MV; Greggio, S; Silva, RBM; Venturin, GT1
Abberger, H; Bendix, I; Crasmöller, M; Felderhoff-Müser, U; Hansen, W; Herz, J; Köster, C1
Chen, L; Feng, Z; Guan, X; Gui, H; Huang, J; Ma, S; Miao, X; Wang, J; Wang, JH; Yu, S; Zhou, H1
Bellón, JM; Cebrián, D; García-Moreno, F; Ginestal, R; Pascual, G; Pérez-Köhler, B; Pérez-López, P; Rodríguez, M1
Bieberich, E; Dinkins, MB; Elsherbini, A; Jiang, X; Kong, JN; Leanhart, S; Qin, H; Wang, G; Wang, R; Zhao, Y; Zhong, L; Zhu, Z1
Miš, K; Pirkmajer, S; Stenovec, M; Trkov Bobnar, S; Zorec, R1
Chen, J; Chopp, M; Li, R; Venkat, P; Yan, T; Zhang, Q1
Bradley, MJ; Clark, N; Davis, TA; Elster, EA; Foster, AD; Leonhardt, C; Vicente, D1
Chen, Y; Dong, S; Tan, X; Yan, B; Yang, Z; Zhang, L; Zheng, Q; Zou, J1
Ducruet, AF; Lawton, MT; Qiu, S; Sheth, KN; Shi, E; Shi, K1
Bieber, K; Gupta, Y; Kalies, K; Ludwig, RJ; Mousavi, S; Sadik, CD; Sezin, T; Thieme, M; Wannick, M; Zillikens, D1
Blumenfeld-Kan, S; Miller, A; Staun-Ram, E1
Angelopoulou, E; Piperi, C1
Antel, JP; Bar-Or, A; Bernier, LP; Cui, QL; Gris, P; Johnson, TA; Kennedy, TE; Leong, SY; Moore, CS; Séguéla, P; Wu, C1
Huwiler, A; Pfeilschifter, J; Schwalm, S1
Brede, M; Deppermann, C; Göb, E; Göbel, K; Herrmann, AM; Kleinschnitz, C; Kraft, P; Lorenz, K; Meuth, SG; Nieswandt, B; Pfeilschifter, W; Schuhmann, MK; Stoll, G; Thielmann, I1
Ching, D; Eberlé, D; Honbo, N; Imhof, I; Karliner, JS; Kim, RY; Kumar, N; Li, K; Luk, FS; Raffai, RL; Wang, G; Zhu, BQ1
Murayama, T; Nakamura, H1
Amino, I; Doi, S; Fujiki, N; Fukazawa, T; Kikuchi, S; Minami, N; Miyazaki, Y; Niino, M; Nonaka, T; Takahashi, E; Tashiro, J1
Ferrer, FA; Hla, T; Shapiro, LH; Silva, C; Thangada, S; Yamase, H1
Fichman-Horn, S; Hellmann, MA; Inbar, E; Lev, N; Lotan, I; Luckman, J; Mosberg-Galili, R; Steiner, I; Yakimov, M1
Crespo, MI; García, IA; Gorlino, CV; Harman, MF; Maletto, BA; Morón, G; Pistoresi-Palencia, MC; Ranocchia, RP1
Awojoodu, AO; Botchwey, EA; Chiappa, NF; Lynch, K; Ogle, ME; Peirce-Cottler, S; Sefcik, LS1
Gao, M; Han, G; Huang, Y; Jia, L; Lei, T; Liu, Y; Wang, L; Xiao, Y1
Baumann, JM; Bhaumik, SK; Chougnet, CA; Dunn, RS; Kallapur, SG; Kuan, CY; Lee, YH; Lewkowich, IP; Li, Y; Lin, SH; Lin, X; Lindquist, DM; Liu, CY; Murali-Krishna, K; Shie, FS; Sun, YY; Wills-Karp, M; Yang, D; Zhang, Y1
Airas, L; Anthony, DC; Dickens, AM; Elo, P; Eskola, O; Haaparanta-Solin, M; Johansson, J; Jones, PA; Marjamäki, P; Rinne, J; Solin, O; Trigg, W1
Ahmadiani, A; Asle-Rousta, M; Dargahi, L; Kolahdooz, Z; Nasoohi, S1
Chiu, AW; Chow, YC; Huang, CJ; Pan, WH; Shih, HJ; Wang, TY; Yen, JC1
Dam, W; Hijmans, RS; Navis, G; Poosti, F; van den Born, J; van Goor, H; Yazdani, S1
Blaho, VA; Engelbrecht, E; Galvani, S; Han, MH; Hla, T; Kono, M; Liu, C; Proia, RL; Steinman, L; Swendeman, SL1
Alberch, J; Brito, V; Canals, JM; García-Díaz Barriga, G; Ginés, S; Giralt, A; Miguez, A; Straccia, M1
Chiba, K; Fukunari, A; Kataoka, H; Maeda, Y; Seki, N; Sugahara, K; Takemoto, K; Utsumi, H1
Cotleur, A; Kanda, T; Love, A; Obermeier, B; Ransohoff, RM; Sano, Y; Spampinato, SF; Takeshita, Y1
Guerrero, M; Roberts, E; Urbano, M1
Axelsson, M; Blennow, K; Khademi, M; Lycke, J; Malmeström, C; Novakova, L; Olsson, T; Piehl, F; Zetterberg, H1
Beretta, M; Berno, V; Campanella, R; Fassina, L; Geginat, J; Gualtierotti, R; Hadi, LA; Ingegnoli, F; Levi, V; Marfia, G; Miozzo, M; Navone, SE; Paroni, M; Rampini, P; Riboni, L; Tremolada, C1
Bauer, M; Benetti, E; Coldewey, SM; Collino, M; Huwiler, A; Pfeilschifter, J; Sponholz, C; Thiemermann, C1
Han, MH; Tsai, HC1
East, JE; Subrahmanyam, PB; Tiper, IV; Webb, TJ1
Adamczyk-Sowa, M; Gąsior, M; Kluczewska, E; Mazur, B; Niedziela, JT; Niedziela, N; Sowa, P1
Cao, Y; Gao, J; Hao, Y; Liang, S; Sun, C; Wang, X; Wu, H; Wu, L; Xia, W1
Brecht, L; Huhn, K; Klausmeyer, A; Lee, DH; Linker, RA; Melms, A; Rötger, C; Schlachetzki, J; Seubert, S; Waschbisch, A; Wiese, S; Winkler, J1
Aoki, J; Arima, N; Kano, K; Kitamura, H; Makide, K1
Brinkmann, V1
Hendriks, RW; Hoogsteden, HC; KleinJan, A; Lambrecht, BN; Leman, K; van Nimwegen, M; Willart, M1
Dragun, D; Fuller, TF; Hegner, B; Hoff, U; Kong, L; Luft, FC; Naether, M; Nieminen-Kelhä, M; Nolting, J; Wagner, P1
Kabashima, K; Sakabe, J; Sugita, K; Tanizaki, H; Tokura, Y; Yoshiki, R1
Chun, J; Noguchi, K1
Chiang, ET; Dudek, SM; Garcia, JG; Simmons, JT; Wang, L1
Lai, WQ; Leung, BP; Wong, WS1
Bode, C; Gräler, M; Heusch, G; Keul, P; Levkau, B; Lucke, S; von Wnuck Lipinski, K1
Alsharif, N; Brinkmann, V; Guo, S; Hwang, SK; Kim, HH; Liao, JK; Lo, EH; Qin, T; Shin, HK; Waeber, C; Wei, Y; Yemisci, M; Yung, LM1
Hla, T; Obinata, H1
Hoshino, Y; Kimura, A; Madoiwa, S; Mimuro, J; Norimatsu, Y; Ohmori, T; Sakata, Y; Seichi, A; Yatomi, Y1
Graham-Rowe, D1
Brinkmann, V; Kemeny, DM; Manlius, C; Sawicka, E; Trifilieff, A; Walker, C; Zuany-Amorim, C1
Brinkmann, V; Cyster, JG; Hla, T1
Fan, ST; Ho, JW; Lee, TK; Li, XL; Lo, CM; Man, K; Ng, KT; Sun, CK; Zhao, Y1
Albert, R; Brinkmann, V; Dubois, G; Edwards, M; Jarai, G; Newson, C; Nicholls, A; Sawicka, E; Thomas, M; Walker, C1
Senior, K1
Baumruker, T; Brinkmann, V1
El Alwani, M; Hannun, YA; Obeid, LM; Wu, BX1
Daniel, C; Geisslinger, G; Radeke, HH; Sartory, N; Stein, JM; Zahn, N1
Guo, D; He, S; Tan, W; Wang, F1
Allende, ML; Bromberg, JS; Ding, Y; Esses, SJ; Garin, A; Ginhoux, F; He, X; Lal, G; Ledgerwood, LG; Lira, SA; Merad, M; Ochando, JC; Peche, H; Schuchman, EH; Yang, Y; Zhang, N1
Amemiya, H; Hiromitsu, K; Li, XK; Suzuki, K; Suzuki, S; Yan, H1
Brinkmann, V; Chen, S; Feng, L; Pinschewer, DD1

Reviews

20 review(s) available for fingolimod hydrochloride and Inflammation

ArticleYear
Repurposing drugs against Alzheimer's disease: can the anti-multiple sclerosis drug fingolimod (FTY720) effectively tackle inflammation processes in AD?
    Journal of neural transmission (Vienna, Austria : 1996), 2023, Volume: 130, Issue:8

    Topics: Aged; Alzheimer Disease; Animals; Drug Repositioning; Fingolimod Hydrochloride; Humans; Inflammation; Mice; Multiple Sclerosis; Sclerosis

2023
Sphingolipids as mediators of inflammation and novel therapeutic target in inflammatory bowel disease.
    Advances in protein chemistry and structural biology, 2020, Volume: 120

    Topics: Animals; Anti-Inflammatory Agents; Fingolimod Hydrochloride; Humans; Inflammation; Inflammatory Bowel Diseases; Protein Kinase Inhibitors; Signal Transduction; Sphingolipids

2020
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
    Epilepsia, 2020, Volume: 61, Issue:3

    Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Atorvastatin; Brain Injuries, Traumatic; Ceftriaxone; Dibenzazepines; Drug Repositioning; Epilepsy; Epilepsy, Post-Traumatic; Erythropoietin; Fingolimod Hydrochloride; GABA Agents; Gabapentin; Humans; Immunologic Factors; Inflammation; Interleukin 1 Receptor Antagonist Protein; Isoflurane; Levetiracetam; Losartan; Neuroprotective Agents; Oxidative Stress; Pregabalin; Pyrrolidinones; Sirolimus; Stroke; Topiramate; Translational Research, Biomedical; Vigabatrin

2020
Sphingosine 1-Phosphate Receptors in Cerebral Ischemia.
    Neuromolecular medicine, 2021, Volume: 23, Issue:1

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Lysophospholipids; Neovascularization, Physiologic; Nerve Tissue Proteins; Neuroprotective Agents; Phosphotransferases (Alcohol Group Acceptor); Rats; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors

2021
Preclinical and Clinical Evidence for the Involvement of Sphingosine 1-Phosphate Signaling in the Pathophysiology of Vascular Cognitive Impairment.
    Neuromolecular medicine, 2021, Volume: 23, Issue:1

    Topics: Aldehyde-Lyases; Alzheimer Disease; Animals; Cerebrovascular Disorders; Clinical Trials as Topic; Dementia, Vascular; Drug Delivery Systems; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Lysophospholipids; Mice; Mice, Knockout; Neurodegenerative Diseases; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors

2021
Beneficial Effects of Fingolimod in Alzheimer's Disease: Molecular Mechanisms and Therapeutic Potential.
    Neuromolecular medicine, 2019, Volume: 21, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, Neoplasm; Apoptosis; Blood-Brain Barrier; Brain-Derived Neurotrophic Factor; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Immunologic Factors; Inflammation; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Models, Biological; N-Methylaspartate; Nerve Tissue Proteins; Neuroimmunomodulation; Neuroprotective Agents; Phosphotransferases (Alcohol Group Acceptor); Rats; Signal Transduction; Species Specificity; Sphingolipids; Sphingosine-1-Phosphate Receptors

2019
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases.
    Basic & clinical pharmacology & toxicology, 2014, Volume: 114, Issue:1

    Topics: Animals; Cell Proliferation; Disease Models, Animal; Fibrosis; Fingolimod Hydrochloride; Glomerulonephritis; Humans; Inflammation; Kidney Failure, Chronic; Lysophospholipids; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine

2014
Role of sphingolipids in arachidonic acid metabolism.
    Journal of pharmacological sciences, 2014, Volume: 124, Issue:3

    Topics: Active Transport, Cell Nucleus; Animals; Arachidonic Acid; Cells, Cultured; Ceramides; Cyclooxygenase 2; Fingolimod Hydrochloride; Golgi Apparatus; Group IV Phospholipases A2; Humans; Inflammation; Lactosylceramides; Lysophospholipids; Propylene Glycols; Sphingolipids; Sphingomyelins; Sphingosine

2014
Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015).
    Expert opinion on therapeutic patents, 2016, Volume: 26, Issue:4

    Topics: Animals; Autoimmune Diseases; Drug Design; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Lysophospholipids; Multiple Sclerosis, Relapsing-Remitting; Patents as Topic; Receptors, Lysosphingolipid; Sphingosine

2016
Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation.
    Drugs, 2016, Volume: 76, Issue:11

    Topics: Animals; Autoimmune Diseases; Fingolimod Hydrochloride; Humans; Inflammation; Lymphocytes; Lysophospholipids; Molecular Targeted Therapy; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine

2016
Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection.
    Pathogens and disease, 2016, Volume: 74, Issue:6

    Topics: Animals; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Hematologic Neoplasms; Host-Pathogen Interactions; Humans; Immune System; Immunosuppressive Agents; Infections; Inflammation; Lymphocytes; Lysophospholipids; Signal Transduction; Sphingosine; Transcription Factors

2016
[Lysophospholipid mediators].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2009, Volume: 54, Issue:1

    Topics: Animals; Cell Physiological Phenomena; Drug Design; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Insulin; Insulin Secretion; Lysophospholipids; Neurotransmitter Agents; Propylene Glycols; Receptors, G-Protein-Coupled; Sphingosine

2009
FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.
    British journal of pharmacology, 2009, Volume: 158, Issue:5

    Topics: Animals; Astrocytes; Brain; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Gap Junctions; Humans; Immune System; Inflammation; Lymph Nodes; Lysophospholipids; Multiple Sclerosis; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes

2009
Roles for lysophospholipid S1P receptors in multiple sclerosis.
    Critical reviews in biochemistry and molecular biology, 2011, Volume: 46, Issue:1

    Topics: Animals; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Humans; Inflammation; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Phosphorylation; Propylene Glycols; Receptors, Lysophospholipid; Signal Transduction; Sphingosine

2011
Sphingosine kinase and sphingosine 1-phosphate in asthma.
    Bioscience reports, 2011, Volume: 31, Issue:2

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Cytokines; Disease Models, Animal; Epithelial Cells; Fingolimod Hydrochloride; Humans; Inflammation; Lung; Lysophospholipids; Mast Cells; Mice; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingolipids; Sphingosine

2011
Sphingosine 1-phosphate in coagulation and inflammation.
    Seminars in immunopathology, 2012, Volume: 34, Issue:1

    Topics: Animals; Atherosclerosis; Blood Coagulation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Lymph Nodes; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha

2012
FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2004, Volume: 4, Issue:7

    Topics: Animals; Cell Proliferation; Clinical Trials as Topic; Endothelium, Vascular; Fingolimod Hydrochloride; Heart Rate; Humans; Immunosuppressive Agents; Inflammation; Lymphocytes; Lysophospholipids; Models, Biological; Models, Chemical; Phosphorylation; Propylene Glycols; Protein Binding; Rats; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Sphingosine; Thymus Gland

2004
Pulmonary and vascular pharmacology of sphingosine 1-phosphate.
    Current opinion in pharmacology, 2006, Volume: 6, Issue:3

    Topics: Animals; Asthma; Capillary Permeability; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Lung; Lysophospholipids; Mast Cells; Muscle, Smooth, Vascular; Propylene Glycols; Receptors, Lysosphingolipid; Respiratory Mucosa; Signal Transduction; Sphingosine; T-Lymphocytes; Vasoconstriction

2006
Bioactive sphingolipids in the modulation of the inflammatory response.
    Pharmacology & therapeutics, 2006, Volume: 112, Issue:1

    Topics: Animals; Cyclooxygenase 2; Cytokines; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Lipopolysaccharides; Phospholipases A; Propylene Glycols; Prostaglandins; Sphingolipids; Sphingosine

2006
FTY720: altered lymphocyte traffic results in allograft protection.
    Transplantation, 2001, Sep-15, Volume: 72, Issue:5

    Topics: Animals; Autoimmune Diseases; Cell Movement; Chemokines; Clinical Trials as Topic; Cyclosporine; Diabetes Mellitus, Type 1; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Humans; Immunologic Memory; Immunosuppressive Agents; Inflammation; Islets of Langerhans Transplantation; Lymphocyte Activation; Lymphocytes; Models, Animal; Propylene Glycols; Safety; Sphingosine; Transplantation, Homologous

2001

Other Studies

86 other study(ies) available for fingolimod hydrochloride and Inflammation

ArticleYear
MRSA-induced endothelial permeability and acute lung injury are attenuated by FTY720 S-phosphonate.
    American journal of physiology. Lung cellular and molecular physiology, 2022, 01-01, Volume: 322, Issue:1

    Topics: Acute Lung Injury; Animals; Antigens, CD; Cadherins; Cell Membrane Permeability; Cytoprotection; Cytoskeleton; Endothelial Cells; Enzyme Activation; Fingolimod Hydrochloride; Humans; Inflammation; Methicillin-Resistant Staphylococcus aureus; Mice; Myosin Light Chains; Organophosphonates; Phosphorylation; rhoA GTP-Binding Protein; Signal Transduction

2022
Fingolimod (FTY720), a Sphinogosine-1-Phosphate Receptor Agonist, Mitigates Choroidal Endothelial Proangiogenic Properties and Choroidal Neovascularization.
    Cells, 2022, 03-11, Volume: 11, Issue:6

    Topics: Choroid; Choroidal Neovascularization; Endothelial Cells; Fingolimod Hydrochloride; Humans; Inflammation; Phosphates; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2022
Pharmacological sphingosine-1 phosphate receptor 1 targeting in cigarette smoke-induced emphysema in mice.
    American journal of physiology. Lung cellular and molecular physiology, 2022, 06-01, Volume: 322, Issue:6

    Topics: Animals; Cigarette Smoking; Fingolimod Hydrochloride; Inflammation; Mice; Mice, Inbred C57BL; Pulmonary Emphysema; Sphingosine-1-Phosphate Receptors

2022
Immunomodulatory effects of cyclotides isolated from Viola odorata in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis.
    Multiple sclerosis and related disorders, 2022, Volume: 64

    Topics: Amino Acid Sequence; Animals; Cyclotides; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Viola; Water

2022
Omega-3 polyunsaturated fatty acids reverse the impact of western diets on regulatory T cell responses through averting ceramide-mediated pathways.
    Biochemical pharmacology, 2022, Volume: 204

    Topics: Animals; Ceramides; Diet, Western; Fatty Acids, Omega-3; Fingolimod Hydrochloride; Fish Oils; Forkhead Transcription Factors; Humans; Inflammation; Interleukin-10; Interleukin-17; Proto-Oncogene Proteins c-akt; Sugars; T-Lymphocytes, Regulatory

2022
Fingolimod attenuates ovalbumin-induced airway inflammation via inhibiting MAPK/ERK signaling in mice.
    Journal of biochemical and molecular toxicology, 2023, Volume: 37, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Inflammation; Interleukin-13; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Ovalbumin

2023
Fingolimod ameliorates chronic experimental autoimmune neuritis by modulating inflammatory cytokines and Akt/mTOR/NF-κB signaling.
    Brain and behavior, 2023, Volume: 13, Issue:4

    Topics: Animals; Cytokines; Fingolimod Hydrochloride; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-6; Neuritis, Autoimmune, Experimental; NF-kappa B; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred Lew; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha

2023
Hepatopulmonary syndrome is associated with low sphingosine-1-phosphate levels and can be ameliorated by the functional agonist fingolimod.
    Journal of hepatology, 2023, Volume: 79, Issue:1

    Topics: Animals; Fingolimod Hydrochloride; Hepatopulmonary Syndrome; Inflammation; Liver Cirrhosis; Mice; Niacinamide; Rats; Rats, Sprague-Dawley

2023
FTY-720 alleviates diabetes-induced liver injury by inhibiting oxidative stress and inflammation.
    Fundamental & clinical pharmacology, 2023, Volume: 37, Issue:5

    Topics: Animals; Chemical and Drug Induced Liver Injury, Chronic; Diabetes Mellitus, Experimental; Fingolimod Hydrochloride; Glucose; Inflammation; Liver; Mice; NF-kappa B; Oxidative Stress; Toll-Like Receptor 4

2023
S1P/S1PR1 axis promotes macrophage M1 polarization through NLRP3 inflammasome activation in Lupus nephritis.
    Molecular immunology, 2023, Volume: 160

    Topics: Animals; Fingolimod Hydrochloride; Inflammasomes; Inflammation; Lupus Erythematosus, Systemic; Lupus Nephritis; Macrophages; Mice; Mice, Inbred MRL lpr; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Sphingosine-1-Phosphate Receptors

2023
Fingolimod Modulates the Gene Expression of Proteins Engaged in Inflammation and Amyloid-Beta Metabolism and Improves Exploratory and Anxiety-Like Behavior in Obese Mice.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2023, Volume: 20, Issue:5

    Topics: Amyloid Precursor Protein Secretases; Animals; Anxiety; Aspartic Acid Endopeptidases; bcl-2-Associated X Protein; Cytokines; Diabetes Mellitus, Type 2; Fingolimod Hydrochloride; Gene Expression; Inflammation; Mice; Mice, Obese; Obesity; Receptors, Lysosphingolipid; RNA, Messenger

2023
FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models.
    Experimental neurology, 2020, Volume: 325

    Topics: alpha-Synuclein; Animals; Behavior, Animal; Disease Models, Animal; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Humans; Inflammation; Male; Mice; Mice, Transgenic; MicroRNAs; Multiple System Atrophy; Neuroprotective Agents; Proto-Oncogene Proteins c-ret

2020
Rebound of disease activity after fingolimod withdrawal: Immunological and gene expression profiling.
    Multiple sclerosis and related disorders, 2020, Volume: 40

    Topics: Adult; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Magnetic Resonance Imaging; Multiple Sclerosis, Relapsing-Remitting; Recurrence; Rituximab; T-Lymphocytes; Transcriptome

2020
FTY720 Protects Against Ischemia-Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model.
    Translational stroke research, 2020, Volume: 11, Issue:5

    Topics: Animals; Apoptosis; Brain Ischemia; Endothelial Cells; Fingolimod Hydrochloride; Inflammation; Organophosphates; Rats, Sprague-Dawley; Sphingosine; Tight Junction Proteins

2020
FTY720 Attenuates Neuropathic Pain after Spinal Cord Injury by Decreasing Systemic and Local Inflammation in a Rat Spinal Cord Compression Model.
    Journal of neurotrauma, 2020, 08-01, Volume: 37, Issue:15

    Topics: Animals; Female; Fingolimod Hydrochloride; Inflammation; Injections, Intraperitoneal; Neuralgia; Rats; Rats, Sprague-Dawley; Sphingosine 1 Phosphate Receptor Modulators; Spinal Cord Compression; Spinal Cord Injuries; Thoracic Vertebrae

2020
FTY720 Modulates Microglia Toward Anti-inflammatory Phenotype by Suppressing Autophagy via STAT1 Pathway.
    Cellular and molecular neurobiology, 2021, Volume: 41, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Autophagy; Cells, Cultured; Fingolimod Hydrochloride; Inflammation; Lipopolysaccharides; Mice, Inbred C57BL; Microglia; Models, Biological; Phenotype; Signal Transduction; STAT1 Transcription Factor

2021
Clinical exacerbation of SARS-CoV2 infection after fingolimod withdrawal.
    Journal of medical virology, 2021, Volume: 93, Issue:1

    Topics: COVID-19; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; RNA, Viral; SARS-CoV-2

2021
Fingolimod administration improves neurological functions of mice with subarachnoid hemorrhage.
    Neuroscience letters, 2020, 09-25, Volume: 736

    Topics: Animals; Brain; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Killer Cells, Natural; Male; Mice; Mice, Inbred C57BL; Recovery of Function; Subarachnoid Hemorrhage; T-Lymphocytes

2020
Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model.
    International journal of molecular sciences, 2020, Nov-25, Volume: 21, Issue:23

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents; Astrocytes; Disease Models, Animal; Fingolimod Hydrochloride; Hippocampus; Humans; Inflammation; Memory Disorders; Mice; Mice, Transgenic; Microglia; Presenilin-1; Synapses

2020
FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation.
    Neuroscience letters, 2021, 03-23, Volume: 748

    Topics: Aging; Animals; Animals, Newborn; Cognitive Dysfunction; Epilepsy; Female; Fingolimod Hydrochloride; Hippocampus; Hypoxia; Inflammation; Male; Neuroprotective Agents; Pentylenetetrazole; Rats; Seizures; Severity of Illness Index

2021
FTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4
    Drug design, development and therapy, 2021, Volume: 15

    Topics: Animals; Arthritis, Experimental; CD4-Positive T-Lymphocytes; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Male; Mice; Mice, Inbred DBA; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Synoviocytes; Time Factors; Tumor Necrosis Factor-alpha

2021
Immunomodulation Eliminates Inflammation in the Hippocampus in Experimental Autoimmune Encephalomyelitis, but Does Not Ameliorate Anxiety-Like Behavior.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Hippocampus; Immunomodulation; Inflammation; Mice; Mice, Inbred C57BL; Microglia; Signal Transduction; Sphingosine-1-Phosphate Receptors; Up-Regulation

2021
Combined Use of Magnesium Sulfate and Fingolimod for Antenatal Neuroprotection against Inflammation-Mediated Experimental Preterm Brain Injury in a Rat Model.
    Fetal and pediatric pathology, 2022, Volume: 41, Issue:4

    Topics: Animals; Brain Injuries; Endotoxins; Female; Fingolimod Hydrochloride; Humans; Inflammation; Interleukin-10; Interleukin-6; Magnesium Sulfate; Neuroprotection; Neuroprotective Agents; Pregnancy; Rats

2022
Fingolimod attenuates renal ischemia/reperfusion-induced acute lung injury by inhibiting inflammation and apoptosis and modulating S1P metabolism.
    The Journal of international medical research, 2021, Volume: 49, Issue:8

    Topics: Acute Lung Injury; Animals; Apoptosis; Fingolimod Hydrochloride; Inflammation; Ischemia; Lysophospholipids; Rats; Reperfusion; Reperfusion Injury; Sphingosine

2021
Macrophage-Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021, Volume: 8, Issue:20

    Topics: Animals; Cell Line, Tumor; Cellular Microenvironment; Fingolimod Hydrochloride; Humans; Hydrogen Peroxide; Inflammation; Ischemic Stroke; Lysosomes; Macrophages; Manganese Compounds; Nanoparticles; Nanospheres; Neurons; Neuroprotection; Oxidative Stress; Oxides; Oxygen; Primary Cell Culture; Rats; Reperfusion Injury

2021
FTY720 promotes pulmonary fibrosis when administered during the remodelling phase following a bleomycin-induced lung injury.
    Pulmonary pharmacology & therapeutics, 2017, Volume: 44

    Topics: Animals; Bleomycin; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Lung Injury; Male; Mice; Mice, Inbred C57BL; Neutrophils; Pulmonary Fibrosis; Time Factors

2017
Fingolimod against endotoxin-induced fetal brain injury in a rat model.
    The journal of obstetrics and gynaecology research, 2017, Volume: 43, Issue:11

    Topics: Animals; Animals, Newborn; Apoptosis; Brain Injuries; Disease Models, Animal; Endotoxins; Female; Fetal Diseases; Fingolimod Hydrochloride; Inflammation; Neuroprotective Agents; Pregnancy; Rats; Rats, Wistar

2017
S1P
    Scientific reports, 2017, 10-10, Volume: 7, Issue:1

    Topics: Animals; Autoimmunity; Case-Control Studies; Disease Susceptibility; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Gene Deletion; Humans; Inflammation; Lymphadenopathy; Lymphoid Tissue; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Organ Specificity; Phenotype; Receptors, Lysosphingolipid; T-Lymphocytes, Regulatory; Th17 Cells; Transcription, Genetic

2017
Bioluminescence imaging of G protein-coupled receptor activation in living mice.
    Nature communications, 2017, 10-27, Volume: 8, Issue:1

    Topics: Alleles; Animals; beta-Arrestin 2; Cell Membrane; Embryonic Stem Cells; Fibroblasts; Fingolimod Hydrochloride; Genetic Complementation Test; Green Fluorescent Proteins; Heterozygote; Homozygote; Inflammation; Ligands; Luciferases; Luminescence; Mice; Receptors, Lysosphingolipid; Signal Transduction; Sphingolipids

2017
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.
    Glia, 2018, Volume: 66, Issue:3

    Topics: Animals; Apoptosis; Brain; Chimera; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression; Gliosis; Indans; Inflammation; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Neuroprotective Agents; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; White Matter

2018
Fingolimod targets cerebral endothelial activation to block leukocyte recruitment in the central nervous system.
    Journal of leukocyte biology, 2018, Volume: 103, Issue:1

    Topics: Animals; Cells, Cultured; Central Nervous System; Cerebrovascular Circulation; Cerebrum; Cytokines; Endothelium, Vascular; Fingolimod Hydrochloride; Inflammation; Leukocytes; Male; Mice; Mice, Inbred C57BL; Microvessels; Nerve Tissue Proteins; T-Lymphocytes

2018
Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.
    Cancer research, 2018, 04-01, Volume: 78, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Animals; Breast Neoplasms; Cell Line, Tumor; Culture Media, Conditioned; Cytokines; Diet, High-Fat; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Interleukin-6; Lung; Lysophospholipids; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Obesity; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors

2018
Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia.
    Journal of neurochemistry, 2018, Volume: 144, Issue:6

    Topics: Animals; Astrocytes; Chemokine CXCL5; Female; Fingolimod Hydrochloride; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microglia; Rats, Wistar; Receptors, Lysosphingolipid; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4

2018
S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFκB signalling.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:6

    Topics: Animals; Astrocytes; Cultural Deprivation; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; HMGB1 Protein; Humans; Immunosuppressive Agents; Inflammation; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Primary Cell Culture; Rats; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine-1-Phosphate Receptors; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2018
Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis.
    Molecular neurobiology, 2018, Volume: 55, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Calcium Channel Blockers; Chemokines; Cognition Disorders; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Hyperalgesia; Inflammation; Inflammation Mediators; Injections, Spinal; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Nociception; omega-Conotoxins; Peptide Fragments

2018
Peripheral T Cell Depletion by FTY720 Exacerbates Hypoxic-Ischemic Brain Injury in Neonatal Mice.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Animals; Animals, Newborn; Brain; Female; Fingolimod Hydrochloride; Hypoxia-Ischemia, Brain; Immunosuppressive Agents; Inflammation; Lymphocyte Depletion; Lymphocyte Subsets; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Receptors, Lysosphingolipid; T-Lymphocytes; T-Lymphocytes, Regulatory

2018
FTY720 attenuates intestinal injury and suppresses inflammation in experimental necrotizing enterocolitis via modulating CXCL5/CXCR2 axis.
    Biochemical and biophysical research communications, 2018, 11-10, Volume: 505, Issue:4

    Topics: Animals; Chemokine CXCL5; Disease Models, Animal; Enterocolitis, Necrotizing; Female; Fingolimod Hydrochloride; Inflammation; Intestines; Male; Mice; Mice, Inbred C57BL; Receptors, Interleukin-8B

2018
Comparing the influence of two immunosuppressants (fingolimod, azathioprine) on wound healing in a rat model of primary and secondary intention wound closure.
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2019, Volume: 27, Issue:1

    Topics: Animals; Azathioprine; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Male; Models, Animal; Rats; Rats, Sprague-Dawley; Wound Closure Techniques; Wound Healing

2019
Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide.
    Glia, 2019, Volume: 67, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Anion Transport Proteins; Cytokines; Fingolimod Hydrochloride; Inflammation; Lipopolysaccharides; Lysophospholipids; Maze Learning; Memory, Short-Term; Mice; Mice, Knockout; Microglia; NF-kappa B; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine

2019
Fingolimod Suppresses the Proinflammatory Status of Interferon-γ-Activated Cultured Rat Astrocytes.
    Molecular neurobiology, 2019, Volume: 56, Issue:9

    Topics: Adenosine Triphosphate; Animals; Astrocytes; Cell Count; Cells, Cultured; Cytoplasmic Vesicles; Dextrans; Female; Fingolimod Hydrochloride; Histocompatibility Antigens Class II; Inflammation; Interferon-gamma; Rats, Wistar; Receptors, Adrenergic, beta-2; Transcription Factor RelA

2019
RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage.
    Journal of the neurological sciences, 2019, Apr-15, Volume: 399

    Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain; Disease Models, Animal; Fingolimod Hydrochloride; Heart Rate; Inflammation; Male; Mice; Neurons; Recovery of Function; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Subarachnoid Hemorrhage

2019
FTY720 Effects on Inflammation and Liver Damage in a Rat Model of Renal Ischemia-Reperfusion Injury.
    Mediators of inflammation, 2019, Volume: 2019

    Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Inflammation; Kidney; Kidney Diseases; Liver; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Transcription Factor AP-1

2019
FTY720 attenuates iron deposition and glial responses in improving delayed lesion and long-term outcomes of collagenase-induced intracerebral hemorrhage.
    Brain research, 2019, 09-01, Volume: 1718

    Topics: Animals; Brain; Brain Injuries; Cerebral Hemorrhage; Disease Models, Animal; Fingolimod Hydrochloride; Gliosis; Inflammation; Iron; Male; Mice; Mice, Inbred ICR; Neuroglia; Neuroprotective Agents

2019
Chronic inflammation, cognitive impairment, and distal brain region alteration following intracerebral hemorrhage.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:8

    Topics: Aminopyridines; Animals; Brain; Cerebral Hemorrhage; Cognition; Cognitive Dysfunction; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroimaging; Neuronal Plasticity; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

2019
The Sphingosine-1-Phosphate Receptor Modulator Fingolimod Aggravates Murine Epidermolysis Bullosa Acquisita.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:11

    Topics: Animals; Autoantibodies; Autoimmune Diseases; Cells, Cultured; Collagen Type VII; Disease Models, Animal; Epidermolysis Bullosa Acquisita; Fingolimod Hydrochloride; Forkhead Transcription Factors; Humans; Inflammation; Interleukin-10; Intraepithelial Lymphocytes; Mice; Neutrophils; Skin; Sphingosine-1-Phosphate Receptors; T-Lymphocytes, Regulatory

2019
Fingolimod reduces CXCR4-mediated B cell migration and induces regulatory B cells-mediated anti-inflammatory immune repertoire.
    Multiple sclerosis and related disorders, 2019, Volume: 34

    Topics: Adult; B-Lymphocytes; Brain-Derived Neurotrophic Factor; Cell Movement; Cell Proliferation; Chemokine CXCL12; Female; Fingolimod Hydrochloride; Follow-Up Studies; Humans; Immunosuppressive Agents; Inflammation; Interleukin-2; Male; Multiple Sclerosis, Relapsing-Remitting; Receptors, CXCR4; T-Lymphocytes; Transforming Growth Factor beta; Treatment Outcome

2019
Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation.
    Journal of neuroinflammation, 2013, Mar-19, Volume: 10

    Topics: Astrocytes; Cells, Cultured; Drug Administration Schedule; Fetus; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; MAP Kinase Signaling System; Propylene Glycols; Sphingosine

2013
FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection.
    Stroke, 2013, Volume: 44, Issue:11

    Topics: Animals; Brain Ischemia; Enzyme Inhibitors; Fingolimod Hydrochloride; Homeodomain Proteins; Hypoxia; Immunosuppressive Agents; Inflammation; Lymphocytes; Lymphopenia; Male; Mice; Mice, Transgenic; Middle Cerebral Artery; Neurons; Neuroprotective Agents; Propylene Glycols; Sphingosine; Stroke; Thrombosis

2013
The immunosuppressant FTY720 prolongs survival in a mouse model of diet-induced coronary atherosclerosis and myocardial infarction.
    Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:2

    Topics: Animals; Apolipoproteins E; Cardiotonic Agents; Coronary Artery Disease; Diet, High-Fat; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Propylene Glycols; Sphingosine; Survival Rate; T-Lymphocytes, Regulatory; Time Factors; Transforming Growth Factor beta; Ventricular Function, Left

2014
Suppressed pro-inflammatory properties of circulating B cells in patients with multiple sclerosis treated with fingolimod, based on altered proportions of B-cell subpopulations.
    Clinical immunology (Orlando, Fla.), 2014, Volume: 151, Issue:2

    Topics: Adult; B-Lymphocyte Subsets; B7-1 Antigen; Case-Control Studies; Chemotaxis, Leukocyte; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Interleukin-10; Male; Middle Aged; Multiple Sclerosis; Propylene Glycols; Receptors, CCR7; Sphingosine; Tumor Necrosis Factor-alpha

2014
Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction.
    The Journal of urology, 2014, Volume: 191, Issue:5 Suppl

    Topics: Animals; Blotting, Western; Disease Models, Animal; Female; Fibrosis; Fingolimod Hydrochloride; Immunohistochemistry; Immunosuppressive Agents; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Propylene Glycols; Sphingosine; Transforming Growth Factor beta1; Ureteral Obstruction

2014
Tumefactive demyelination and a malignant course in an MS patient during and following fingolimod therapy.
    Journal of the neurological sciences, 2014, Sep-15, Volume: 344, Issue:1-2

    Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain Injuries; Encephalitis; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Magnetic Resonance Imaging; Multiple Sclerosis; Occipital Lobe; Propylene Glycols; Sphingosine

2014
Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Aug-15, Volume: 193, Issue:4

    Topics: Adoptive Transfer; Animals; Antigen-Antibody Complex; Cell Movement; Female; Fingolimod Hydrochloride; Immune System Diseases; Immunosuppressive Agents; Inflammation; L-Selectin; Leukocyte Disorders; Lymph Nodes; Lymphatic Vessels; Lymphocyte Function-Associated Antigen-1; Lysophospholipids; Macrophage-1 Antigen; Mice; Mice, Inbred BALB C; Neutrophils; P-Selectin; Propylene Glycols; Receptors, CXCR4; Receptors, Lysosphingolipid; Sphingosine

2014
Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning.
    Acta biomaterialia, 2014, Volume: 10, Issue:11

    Topics: Animals; Fingolimod Hydrochloride; Inflammation; Kinetics; Lactic Acid; Ligands; Lymphocytes; Lysophospholipids; Male; Mice, Inbred C57BL; Microvessels; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Propylene Glycols; Prostheses and Implants; Receptors, Lysosphingolipid; Sphingolipids; Sphingosine; Tissue Engineering; Vascular Remodeling

2014
Prolonging survival of corneal transplantation by selective sphingosine-1-phosphate receptor 1 agonist.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Animals; Corneal Transplantation; Cytokines; Fingolimod Hydrochloride; Gene Expression Regulation; Graft Survival; Inflammation; Kidney; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Time Factors

2014
Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Dec-03, Volume: 34, Issue:49

    Topics: Animals; Animals, Newborn; Atrophy; Blood-Brain Barrier; Brain; Cell Movement; Chorioamnionitis; Cytokines; Dose-Response Relationship, Drug; Female; Fingolimod Hydrochloride; Humans; Hypoxia-Ischemia, Brain; Immunosuppressive Agents; Infant, Newborn; Inflammation; Lipopolysaccharides; Lymphocyte Activation; Lymphocytes; NF-kappa B; Pregnancy; Propylene Glycols; Rats; Receptors, Interleukin; Sphingosine; T-Lymphocytes; White Matter

2014
In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015, Volume: 56, Issue:2

    Topics: Animals; Autoradiography; BCG Vaccine; Carrier Proteins; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Freund's Adjuvant; Immunohistochemistry; Immunosuppressive Agents; Inflammation; Ligands; Male; Microglia; Multiple Sclerosis; Positron-Emission Tomography; Propylene Glycols; Rats; Rats, Inbred Lew; Receptors, GABA-A; Sphingosine; Time Factors

2015
Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2015, Volume: 42, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Fingolimod Hydrochloride; Inflammation; Lipopolysaccharides; Lysophospholipids; Male; Maze Learning; Memory Disorders; Oxadiazoles; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Tumor Necrosis Factor-alpha

2015
FTY720 mitigates torsion/detorsion-induced testicular injury in rats.
    The Journal of surgical research, 2015, Jun-15, Volume: 196, Issue:2

    Topics: Animals; Drug Evaluation, Preclinical; Edema; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Lipid Metabolism; Male; Neutrophil Infiltration; Propylene Glycols; Random Allocation; Rats, Sprague-Dawley; Spermatic Cord Torsion; Sphingosine; Testis

2015
Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats.
    Disease models & mechanisms, 2015, Aug-01, Volume: 8, Issue:8

    Topics: Animals; Antibodies; Biomarkers; Clodronic Acid; Collagen Type III; Disease Models, Animal; Doxorubicin; Fibrosis; Fingolimod Hydrochloride; Inflammation; Kidney Diseases; Kidney Tubules; Leukocyte Count; Liposomes; Lymphangiogenesis; Lymphatic Vessels; Macrophages; Male; Myofibroblasts; Proteinuria; Rats, Wistar; RNA, Messenger; T-Lymphocytes; Vascular Endothelial Growth Factor Receptor-3

2015
HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.
    Nature, 2015, Jul-16, Volume: 523, Issue:7560

    Topics: Animals; Apolipoproteins; Apolipoproteins M; Blood-Brain Barrier; Cell Movement; Cell Proliferation; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Hematopoietic Stem Cells; Inflammation; Lipoproteins, HDL; Lymphocytes; Lymphoid Progenitor Cells; Lymphopoiesis; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Protein Binding; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine

2015
Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.
    Human molecular genetics, 2015, Sep-01, Volume: 24, Issue:17

    Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cyclic AMP; Dendritic Spines; Fingolimod Hydrochloride; Gene Expression; Hippocampus; Huntington Disease; Inflammation; Memory; Mice; Neuronal Plasticity; Receptor, trkB; Receptors, Nerve Growth Factor; RNA, Messenger; Up-Regulation

2015
IL-17-Producing Vγ4+ γδ T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions.
    Journal of immunology (Baltimore, Md. : 1950), 2015, Aug-15, Volume: 195, Issue:4

    Topics: Animals; Cell Movement; Dermatitis; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Homeostasis; Immunosuppressive Agents; Inflammation; Interleukin-17; Lymph Nodes; Male; Mice; Proprotein Convertases; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Lysosphingolipid; Serine Endopeptidases; T-Lymphocyte Subsets; Toll-Like Receptor 7; Toll-Like Receptor 8

2015
Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Adult; Astrocytes; Blood-Brain Barrier; Cell Movement; Cell Survival; Cytokines; Endothelial Cells; Fingolimod Hydrochloride; Granulocyte-Macrophage Colony-Stimulating Factor; Healthy Volunteers; Humans; Inflammation; Leukocytes; Lysophospholipids; Microcirculation; Middle Aged; Multiple Sclerosis; Receptors, Lysosphingolipid; Signal Transduction; Sphingolipids; Sphingosine; Stress, Mechanical; Young Adult

2015
Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2017, Volume: 23, Issue:1

    Topics: Adult; Biomarkers; Chemokine CXCL13; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Fingolimod Hydrochloride; Glial Fibrillary Acidic Protein; Humans; Inflammation; Male; Middle Aged; Multiple Sclerosis; Neurofilament Proteins; Treatment Outcome; Young Adult

2017
The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling.
    Stem cells and development, 2016, 07-15, Volume: 25, Issue:14

    Topics: Adipose Tissue; Adult; Cell Proliferation; Cell Separation; Chemotaxis; Culture Media, Conditioned; Cytokines; Down-Regulation; Female; Fingolimod Hydrochloride; Humans; Inflammation; Lipopolysaccharides; Lysophospholipids; Male; Mesenchymal Stem Cells; Microglia; Middle Aged; Phenotype; Proteome; Signal Transduction; Sphingosine

2016
Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis.
    Scientific reports, 2016, 06-09, Volume: 6

    Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Fingolimod Hydrochloride; Heart; Humans; Inflammation; Lipopolysaccharides; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocardium; Peptidoglycan; Phosphatidylinositol 3-Kinases; Phosphorylation; Pilot Projects; Receptors, Lysosphingolipid; Sepsis; Sphingosine

2016
Assessment of Serum Nitrogen Species and Inflammatory Parameters in Relapsing-Remitting Multiple Sclerosis Patients Treated with Different Therapeutic Approaches.
    BioMed research international, 2016, Volume: 2016

    Topics: Adolescent; Adult; Biomarkers; Fingolimod Hydrochloride; Humans; Inflammation; Interferon beta-1a; Interferon beta-1b; Middle Aged; Multiple Sclerosis; Natalizumab; Nitric Oxide; Reactive Nitrogen Species

2016
Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism.
    Life sciences, 2017, Mar-15, Volume: 173

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autistic Disorder; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Inflammation; Interleukin-1beta; Interleukin-6; Learning; Male; Malondialdehyde; Memory Disorders; Oxidative Stress; Oxidoreductases; Pyramidal Cells; Rats; Rats, Wistar; Social Behavior

2017
Fingolimod effects in neuroinflammation: Regulation of astroglial glutamate transporters?
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Animals; Astrocytes; Cells, Cultured; Down-Regulation; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; PC12 Cells; Rats; RNA, Messenger; Tumor Necrosis Factor-alpha

2017
United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2010, Volume: 40, Issue:3

    Topics: Animals; Asthma; Disease Models, Animal; Female; Fingolimod Hydrochloride; Inflammation; Mice; Mice, Inbred BALB C; Ovalbumin; Propylene Glycols; Rhinitis, Allergic, Perennial; Sphingosine; Th2 Cells

2010
Cytoprotective Actions of FTY720 Modulate Severe Preservation Reperfusion Injury in Rat Renal Transplants.
    Transplantation, 2010, Feb-27, Volume: 89, Issue:4

    Topics: Adenosine; Allopurinol; Animals; Cell Culture Techniques; Cell Division; Cell Survival; Fingolimod Hydrochloride; Flow Cytometry; Glutathione; Immunohistochemistry; Immunosuppressive Agents; Inflammation; Insulin; Kidney Transplantation; Male; Organ Preservation Solutions; Propylene Glycols; Raffinose; Rats; Rats, Inbred Lew; Reperfusion Injury; Sphingosine

2010
FTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in mice.
    The American journal of pathology, 2010, Volume: 177, Issue:4

    Topics: Animals; Blotting, Western; Bone Marrow; Cell Movement; Chemotaxis; Disease Models, Animal; Eosinophils; Female; Fingolimod Hydrochloride; Flow Cytometry; Humans; Immunosuppressive Agents; Inflammation; Interleukin-5; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Propylene Glycols; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin; Skin Diseases; Sphingosine

2010
FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl.
    The European respiratory journal, 2011, Volume: 38, Issue:1

    Topics: Adherens Junctions; Cells, Cultured; Endothelial Cells; Fingolimod Hydrochloride; Gene Expression Regulation; Humans; Inflammation; Lung; Lysophospholipids; Permeability; Phosphorylation; Propylene Glycols; Proto-Oncogene Proteins c-abl; Pulmonary Artery; RNA, Small Interfering; Signal Transduction; Sphingosine; Subcellular Fractions; Tight Junctions

2011
Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis.
    Circulation research, 2011, Feb-04, Volume: 108, Issue:3

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Movement; Cell Proliferation; Disease Models, Animal; Fingolimod Hydrochloride; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Peritonitis; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Thioglycolates

2011
Fingolimod provides long-term protection in rodent models of cerebral ischemia.
    Annals of neurology, 2011, Volume: 69, Issue:1

    Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; In Vitro Techniques; Inflammation; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine; Stroke

2011
FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms.
    The American journal of pathology, 2012, Volume: 180, Issue:4

    Topics: Animals; Astrocytes; Capillary Permeability; Cell Movement; Cytokines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Inflammation Mediators; Locomotion; Mice; Mice, Inbred C57BL; Mice, SCID; Microglia; Neutrophils; Propylene Glycols; Receptors, Lysosphingolipid; Recovery of Function; Sphingosine; Spinal Cord Injuries; T-Lymphocytes; Treatment Outcome

2012
Drugs: An injection of hope.
    Nature, 2012, Apr-12, Volume: 484, Issue:7393

    Topics: Alemtuzumab; Animals; Antibodies, Monoclonal, Humanized; Cladribine; Clinical Trials, Phase III as Topic; Crotonates; Dimethyl Fumarate; Disease Progression; Drug-Related Side Effects and Adverse Reactions; Fingolimod Hydrochloride; Fumarates; Humans; Hydroxybutyrates; Inflammation; Multiple Sclerosis; Natalizumab; Nitriles; Propylene Glycols; Quinolones; Risk Assessment; Sphingosine; Toluidines; United States; United States Food and Drug Administration

2012
Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Dec-01, Volume: 171, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bystander Effect; Cell Movement; Disease Models, Animal; Epitopes, T-Lymphocyte; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mice, Transgenic; Propylene Glycols; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Th1 Cells; Th2 Cells

2003
FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005, Volume: 5, Issue:1

    Topics: Animals; Apoptosis; Blotting, Western; Chemokine CXCL2; Chemokines, CXC; DNA Primers; Down-Regulation; Endothelin-1; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Fingolimod Hydrochloride; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hepatocytes; HSP70 Heat-Shock Proteins; Immunosuppressive Agents; In Situ Nick-End Labeling; Inflammation; Intercellular Signaling Peptides and Proteins; Interleukin-10; Liver; Male; MAP Kinase Signaling System; Microscopy, Electron; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Propylene Glycols; Proteins; raf Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine; Time Factors; Up-Regulation

2005
The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.
    Journal of immunology (Baltimore, Md. : 1950), 2005, Dec-15, Volume: 175, Issue:12

    Topics: Animals; Cell Proliferation; Chemotaxis, Leukocyte; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Lymph Nodes; Lymphocyte Activation; Lymphocyte Count; Mice; Mice, Inbred C57BL; Organ Specificity; Ovalbumin; Propylene Glycols; Receptors, Interleukin-2; Receptors, Lysosphingolipid; Respiratory System; Sphingosine; T-Lymphocytes, Regulatory

2005
Multiple sclerosis poses tough drug development challenges.
    Drug discovery today, 2005, Volume: 10, Issue:23-24

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Clinical Trials as Topic; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Integrin alpha2; Multiple Sclerosis; Natalizumab; Propylene Glycols; Sphingosine

2005
FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Feb-15, Volume: 178, Issue:4

    Topics: Animals; Antigens, CD; Antigens, Differentiation; Aziridines; Cell Differentiation; Choline; Colitis; CTLA-4 Antigen; Cytokines; Disease Models, Animal; Down-Regulation; Fingolimod Hydrochloride; Forkhead Transcription Factors; Immunosuppressive Agents; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Neuromuscular Blocking Agents; Propylene Glycols; Sphingosine; T-Lymphocytes, Regulatory; Th1 Cells

2007
Reduction of CD4 positive T cells and improvement of pathological changes of collagen-induced arthritis by FTY720.
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Animals; Ankle Joint; Arthritis, Experimental; Bone Density; CD4 Antigens; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; CD8 Antigens; CD8-Positive T-Lymphocytes; Chickens; Collagen Type II; Female; Fingolimod Hydrochloride; Flow Cytometry; Forelimb; Immunohistochemistry; Immunosuppressive Agents; Inflammation; Prednisone; Propylene Glycols; Rats; Rats, Wistar; Sphingosine; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Weight Loss

2007
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.
    Nature immunology, 2008, Volume: 9, Issue:1

    Topics: Animals; Cell Movement; Endothelium, Lymphatic; Fingolimod Hydrochloride; Homeostasis; Inflammation; Integrin alpha4beta1; Intercellular Adhesion Molecule-1; Lymph Nodes; Lymphatic Vessels; Lymphocyte Function-Associated Antigen-1; Lysophospholipids; Mice; Mice, Inbred C57BL; Models, Immunological; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; T-Lymphocytes; Vascular Cell Adhesion Molecule-1

2008
Immunosuppressive effect of FTY 720 on autoimmune diabetes models.
    Transplantation proceedings, 1998, Volume: 30, Issue:7

    Topics: Animals; Diabetes Mellitus, Type 1; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Islets of Langerhans; Lymphopenia; Male; Propylene Glycols; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Sphingosine; Thymectomy

1998