Page last updated: 2024-09-02

fingolimod hydrochloride and Disease Models, Animal

fingolimod hydrochloride has been researched along with Disease Models, Animal in 269 studies

*Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. [MeSH]

Research

Studies (269)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (0.37)	18.2507
2000's	54 (20.07)	29.6817
2010's	172 (63.94)	24.3611
2020's	42 (15.61)	2.80

Authors

Authors	Studies
Al-Shamma, H; Barden, J; Buzard, D; Edwards, J; Espinola, S; Fu, L; Gao, Y; Gatlin, J; Han, S; Jones, RM; Kawasaki, A; Le, M; Liu, L; Lopez, L; Moody, J; Sage, C; Schrader, T; Solomon, M; Thatte, J; Thoresen, L; Xing, C	1
Bechet, S; Dev, KK; Fagan, SG	1
Ahmadian, SR; Ghasemi-Kasman, M; Hashemian, M; Nosratiyan, N; Parsian, H; Rostami-Mansoor, S	1
Berkes, D; Bieberich, E; Crivelli, SM; De Vries, HE; Dehairs, J; den Hoedt, S; Derua, R; Giovagnoni, C; Kruining, DV; Losen, M; Luo, Q; Mané-Damas, M; Martinez-Martinez, P; Mulder, MT; Swinnen, JV; Waelkens, E; Walter, J; Wijnands, EPM	1
Akbari, M; Doerr, N; Kipp, KR; Marhamati, N; Rinschen, MM; Talbot, JJ; Vuong, S; Wang, Y; Weimbs, T; Wessely, O; West, JD	1
Esfandiary, E; Ghanadian, M; Ghasemi, N; Moradi, V; Rashidi, B	1
Deng, W; Guo, W; Hu, X; Li, T; Ma, X; Ni, P; Qi, X; Wang, Q; Wei, L; Yu, X; Zhao, L	1
Arai, K; Esposito, E; Lee, J; Li, W; Lizasoain, I; Lo, EH; Mandeville, ET; Mandeville, JB; Moro, MÁ; Nakano, T; Park, JH; Quinto-Alemany, D; Waeber, C; Zhang, F	1
Carreras, I; Dedeoglu, A; Jung, Y; Lopez-Benitez, J; Tognoni, CM	2
El-Sheakh, AR; Makled, MN	1
Çelik, H; Çetinkaya, A; Torun, İE; Türel, CA; Türel, İ	1
Bascuñana, P; Brackhan, M; Brüning, T; Eiriz, I; Jansone, B; Möhle, L; Pahnke, J; Wu, J	1
Ghasemi-Kasman, M; Hashemian, M; Parsian, H; Sadeghi, F	1
Camarillo, C; Chin, B; Herrera, GV; Perez, RG; Sarosiek, I; Vidal-Martinez, G; Yang, B	1
Basil, AH; Cai, Y; Chen, Z; Lim, KL; Lin, S; Sim, JPL; Zeng, L; Zhang, C; Ziyin, W	1
Barragan, JA; Chaparro, SA; De-Leon Esquivel, J; Diaz-Pacheco, V; Perez, RG; Segura-Ulate, I; Vargas-Medrano, J; Vidal-Martinez, G; Yang, B	1
Ahmed, N; Al-Masri, AA; AlBkhoor, B; Faggian, G; Fumagalli, G; Laghari, AH; Linardi, D; Luciani, GB; Meo, SA; Muhammad, N; Rungatscher, A; Tabassum, S	1
Cheng, H; Guo, RB; Guo, XD; Ji, J; Sun, XL; Sun, YQ; Xue, TF	1
Armida, M; Boirivant, M; Butera, A; De Simone, R; Pezzola, A; Potenza, RL; Ricceri, L	1
Angelopoulou, E; Gnatkovsky, V; Othman, I; Paudel, YN; Piperi, C; Shaikh, MF	1
Jęśko, H; Lukiw, WJ; Strosznajder, J; Strosznajder, RP; Wencel, PL; Wójtowicz, S	1
An, S; Gao, C; Huang, J; Jiang, R; Luo, H; Qian, Y; Song, Y; Zhang, J; Zhao, X	1
Carissimo, G; Chan, YH; Chee, RS; Cheng, P; Goggi, JL; Hartimath, SV; Khanapur, S; Lum, FM; Ng, LFP; Rajarethinam, R; Ramasamy, B; Rénia, L; Robins, EG; Teo, TH; Torres-Ruesta, A; Yong, FF	1
Bascuñana, P; Brackhan, M; Möhle, L; Pahnke, J	1
Asci, H; Eris Yalcin, S; Ozmen, O; Sezik, M; Yavuz, A	1
Engelhardt, B; Enzmann, G; Homann, T; Huwiler, A; Kleuser, B; Stark, H; Stepanovska, B; Tietz, S; Zivkovic, A	1
Choi, JW; Gaire, BP	1
Ishii, Y; Katsuda, Y; Kobayashi, K; Miyajima, K; Ohta, T; Sasase, T; Yamada, T	1
Feng, T; Gan, X; Guo, Y; Long, X; Pu, S; Ren, C; Tang, H; Zhou, H	1
Cohen, PL; McCulloch, A	1
Casarotto, P; Castrén, E; Delanoe, K; Edelmann, E; Endres, T; Gottmann, K; Kartalou, GI; Lesnikova, A; Lessmann, V; Marie, H; Pousinha, P; Salgueiro-Pereira, AR	1
Cao, P; Chai, S; Liu, J; Sun, S; Wang, Y; Wu, K; Xiao, X; Yan, H; Yang, C; Yuan, Y; Zhang, J; Zhao, M	1
Choudhury, SR; Karmakar, S; Sardoiwala, MN	1
Cheng, H; Di, G; Gao, CC; Han, YL; He, G; Jiang, X; Sun, LA; Wang, X; Zhou, ML	1
Diaz Diaz, AC; Malone, K; Moore, AC; Shearer, JA; Waeber, C	1
Edelmann, E; Garad, M; Leßmann, V	1
Ben-Zwi, M; Halimi, M; Karussis, D; Kassis, I; Petrou, P	1
Abe, K; Cui, Y; Feng, J; Fujiwara, A; Go, T; Hiraishi, K; Hirano, K; Inoue, R; Ishikawa, K; Kurahara, LH; Ohga, S; Okada, Y; Onitsuka, M; Satoh, T; Yahiro, E; Yamamura, A; Yokomise, H; Yokota, N; Yue, L	1
Asano, Y; Kamata, M; Mitsui, A; Okura, I; Sato, S; Shimizu, T; Tada, Y	1
Du, T; Duan, RS; Ge, MR; Li, H; Li, XL; Lian, Y; Liu, Y; Liu, YD; Yang, B; Yang, CL; Zhang, P	1
Dang, PT; Hale, MW; Kocovski, P; Marinis, S; Orian, JM; Tabassum-Sheikh, N	1
Bae, D; Baek, J; Ha, N; Kim, T; Ko, SM; Lee, JY; Lim, HS; Park, J; Som Jeong, D; Son, WC; Suh, D	1
Chen, J; Lai, X; Li, S; Li, Z; Xia, Q; Zhang, C	1
Blanchet, MR; Bossé, Y; Dion, G; Gendron, DR; Huppé, CA; Lecours, PB; Lemay, AM; Marsolais, D; Perreault-Vallières, V	1
Banik, NL; Dasgupta, S; Miller, LG; Purohit, S; Ray, SK; Wang, G; Young, JA	1
Buchwald, P; Frei, AW; Jiang, K; Li, Y; Stabler, CL	1
Hou, X; Pang, X	1
Berve, K; Groh, J; Martini, R	1
Chen, Z; Doyle, TM; Grenald, SA; Largent-Milnes, TM; Salvemini, D; Slosky, LM; Spiegel, S; Vanderah, TW; Zhang, H	1
Cantalupo, A; Dautaj, E; Di Lorenzo, A; Gargiulo, A; Hla, T; Liu, C; Zhang, Y	1
Cooper, JD; Nelvagal, HR	1
Arjmand, S; Asadi-Shekaari, M; Basiri, M; Dahmardeh, N; Kalantaripour, T; Shabani, M	1
Amodio, N; Citraro, R; Constanti, A; De Sarro, C; De Sarro, G; Gallo Cantafio, ME; Leo, A; Russo, E	1
Alshaker, H; Chao, Y; Cooper, C; Pchejetski, D; Srivats, S; Wang, Q	1
Bail, K; Bharti, R; Foerstner, KU; Kleinschnitz, C; Koeniger, T; Kuerten, S; Notz, Q; Rovituso, DM; Schampel, A; Scholz, CJ; Schropp, V; Wunsch, M	1
Asci, H; Ozmen, O; Sezik, M; Yavuz, A	1
Bieber, K; Hauenschild, E; Kalies, K; Kasperkiewicz, M; Ludwig, RJ; Maass, S; Niebuhr, M; Westermann, J	1
Donahue, RR; Doolen, S; Grachen, CM; Iannitti, T; Shaw, BC; Taylor, BK	1
Bielawski, J; Kim, S; Kong, Y; Li, J; Yang, H; Zhou, B	1
Feng, R; Fu, S; Sun, F; Xiao, W; Xu, K; Ye, W	1
Abe, M; Allegood, JC; Aoyagi, T; Hait, NC; Huang, WC; Katsuta, E; Milstien, S; Nagahashi, M; Nakajima, M; Sakimura, K; Spiegel, S; Takabe, K; Terracina, KP; Tsuchida, J; Wakai, T; Yamada, A; Yuza, K	1
Fu, J; Gao, F; Gao, Y; Li, Y; Meng, F; Yang, C	1
Chen, X; Ji, M; Jin, J; Lai, F; Wang, Y; Xue, N; Zhang, S; Zhang, X	1
Cao, LL; Chen, ZZ; Dong, YF; Guo, RB; Huang, JY; Ji, J; Lu, J; Sun, XL; Wu, J; Zhang, L	1
Cao, K; Li, L; Shi, D; Shi, M; Tian, T; Wen, S; Yao, S; Zhang, M; Zhou, H; Zhu, X	1
Campos, MM; da Costa, JC; Gomez, MV; Greggio, S; Silva, RBM; Venturin, GT	1
Jęśko, H; Lukiw, WJ; Strosznajder, RP; Wencel, PL	1
Kusnecov, AW	1
Aye, JM; Beierle, EA; Friedman, GK; Garner, EF; Moore, BP; Mroczek-Musulman, E; Stafman, LL; Stewart, JE; Williams, AP	1
Cho, SM; DeRosa, SG; Ferreira, NS; Furness, AM; Futerman, AH; Gao, D; Grishchuk, Y; Herron, SS; Medina, DL; Mepyans, ME; Sankar, SB; Scotto Rosato, A; Slaugenhaupt, SA; Smith, SS; Vardi, A; Weinstock, LD; Wood, LB	1
Cuzzone, DA; García Nores, GD; Gardenier, JC; Hespe, GE; Huang, JJ; Kataru, RP; Ly, CL; Mehrara, BJ; Nitti, MD; Rehal, S; Savetsky, IL; Torrisi, JS; Yu, JZ	1
Becker, AJ; de Curtis, M; Elger, CE; Gnatkovsky, V; Kuehn, JC; Müller, JA; Pitsch, J; Schoch, S; van Loo, KMJ; Vatter, H	1
Burston, JJ; Hauser, KF; Lichtman, AH; McLane, V; Selley, DE; Sim-Selley, LJ; Welch, SP; Wilkerson, JL	1
Chen, L; Feng, Z; Guan, X; Gui, H; Huang, J; Ma, S; Miao, X; Wang, J; Wang, JH; Yu, S; Zhou, H	1
Cuda, CM; Der, E; Gadhvi, GT; Gulinello, M; Makinde, HM; Mike, EV; Putterman, C; Stock, A; Winter, DR	1
Camps, MG; Fransen, MF; Hawinkels, LJ; Kneilling, M; Knopf, P; Ossendorp, F; Schoonderwoerd, M; van Hall, T	1
Aguilera-Albesa, S; Boespflug-Tanguy, O; Brady, L; Burmeister, M; Casasnovas, C; Cohen, JS; Colleaux, L; Cornet, C; Desguerre, I; Dorboz, I; Fatemi, A; Fourcade, S; Galehdari, H; Gleeson, JG; James, KN; Joya, J; Klee, EW; Lanpher, BC; Launay, N; Lesca, G; Maroofian, R; Mazaheri, N; Musaev, D; Pant, DC; Patterson, MC; Pinto E Vairo, F; Pujades, C; Pujol, A; Rodriguez, D; Rubbini, D; Ruiz, M; Schluter, A; Shariati, G; Siquier-Pernet, K; Sobreira, NLM; Tarnopolsky, M; Terriente, J; Ville, D; Wang, J; Willis, MJ; Wohler, E; Yan, H; Yoldi, ME; Zaki, MS	1
Chen, J; Chopp, M; Li, R; Venkat, P; Yan, T; Zhang, Q	1
Chen, R; Ge, J; Li, M; Liu, G; Wang, X; Yu, Y; Zou, Y	1
Bai, C; Chen, H; Huang, Z; Liu, G; Liu, H; Niu, W; Qin, Y; Wang, H; Wang, S; Zhang, X	1
Bradley, MJ; Clark, N; Davis, TA; Elster, EA; Foster, AD; Leonhardt, C; Vicente, D	1
Chen, Y; Dong, S; Tan, X; Yan, B; Yang, Z; Zhang, L; Zheng, Q; Zou, J	1
Ducruet, AF; Lawton, MT; Qiu, S; Sheth, KN; Shi, E; Shi, K	1
Bieber, K; Gupta, Y; Kalies, K; Ludwig, RJ; Mousavi, S; Sadik, CD; Sezin, T; Thieme, M; Wannick, M; Zillikens, D	1
Arumugam, TV; Chen, CLH; Choi, YK; Ihara, M; Kinoshita, H; Lim, YA; Maki, T; Saito, S; Takahashi, R; Wong, PT; Yamamoto, Y; Yasuda, K	1
Aytan, N; Carreras, I; Choi, JK; Dedeoglu, A; Jenkins, BG; Kowall, NW; Tognoni, CM	1
Ghasemi-Kasman, M; Javan, M; Yazdi, A	1
An, X; Goto, H; Kezuka, T; Matsuda, R; Matsunaga, Y; Usui, Y; Yamakawa, N	1
Bäumer, W; Dickhaut, J; Japtok, L; Kietzmann, M; Kleuser, B; Mischke, R; Schaper, K	1
Ebinuma, I; Isshiki, H; Iwatsubo, T; Osawa, S; Sasaki, T; Takasugi, N; Takeo, K; Tomita, T	1
Axelberg, H; Grände, PO; Lundblad, C	1
Ahmadiani, A; Chik, Z; Dargahi, L; Hemmati, F; Mohamed, Z; Naidu, M; Nasoohi, S; Omidbakhsh, R	1
Huwiler, A; Pfeilschifter, J; Schwalm, S	1
Chen, JF; Liu, BC; Liu, H; Ma, KL; Ni, HF; Pan, MM; Tang, RN; Zhang, JD; Zhang, MH	1
Chen, J; Chen, P; Liu, B; Ni, H; Pan, M; Zhang, J; Zhang, M	1
Banno, R; Fujita, T; Kohno, T; Matsushima, A; Matsushima, Y; Tsuji, T; Watanabe, S; Yoshida, Y	1
Altay, O; Hasegawa, Y; Rolland, W; Suzuki, H; Zhang, JH	1
Amico, E; Castrataro, R; Di Pardo, A; Favellato, M; Fucile, S; Maglione, V; Squitieri, F	1
Bittman, R; Camp, SM; Dudek, SM; Garcia, JG; Letsiou, E; Moreno-Vinasco, L; Sammani, S; Wang, L; Wang, T	1
Anthony, DC; Leppert, D; Losey, P; Meier, DP; Sibson, NR	1
Ayata, C; Barfejani, AH; Dong, Q; Lu, L; Qin, T; Waeber, C	1
Ching, D; Eberlé, D; Honbo, N; Imhof, I; Karliner, JS; Kim, RY; Kumar, N; Li, K; Luk, FS; Raffai, RL; Wang, G; Zhu, BQ	1
Akin, M; Arndt, T; Hedrich, HJ; Jörns, A; Lenzen, S; Terbish, T; Wedekind, D; Zu Vilsendorf, AM	1
Ferrer, FA; Hla, T; Shapiro, LH; Silva, C; Thangada, S; Yamase, H	1
Kong, Y; Tang, N; Wang, H; Wang, S	1
Al-Adawy, N; Graham, SL; Gupta, VK; Klistorner, A; Li, JC; You, Y	1
Khatri, M; Rajasagi, NK; Reddy, PB; Rouse, BT; Sehrawat, S; Suryawanshi, A	1
Dev, KK; Sheridan, GK	1
Lv, L; Qian, J; Ye, S; Ye, Y; Zhu, C	1
Dev, KK; Mir, AK; Pritchard, AJ	1
Cruz, VT; Fonseca, J	1
Albert-Weissenberger, C; Hennig, N; Hopp, S; Kleinschnitz, C; Mencl, S; Schuhmann, MK; Sirén, AL	1
Chen, Y; Cheng, Q; Gong, H; Hu, B; Lei, L; Lin, D; Liu, H; Ma, S; Mei, Y; Wu, Y; Yu, X; Zhao, L; Zhao, Y	1
Ahmadiani, A; Dargahi, L; Khallaghi, B; Mohamed, Z; Naidu, M; Nasoohi, S; Omidbakhsh, R; Rajabli, B	1
Blanc, CA; Lane, TE; Rosen, H	1
Arellano, B; Castro-Rojas, C; Cravens, PC; Deason, K; Eagar, TN; Hayardeny, L; Hussain, RZ; Stüve, O; Yarovinsky, F	1
Jiang, H; Liang, Y; Liu, L; Lu, Z; Pan, S; Pei, T; Song, R; Wang, J; Yin, D; Zheng, T	1
Harada, H; Hattori, K; Hirose, J; Kawato, Y; Koshika, T; Maeda, M; Morokata, T; Nagasaka, Y; Okada, Y; Saito, R; Yamamoto, R	1
Ding, LH; Liu, BC; Liu, D; Liu, H; Lv, LL; Ma, KL; Tang, RN; Wen, Y; Wu, M; Xu, M	1
Daneman, R; Frevert, U; Girgis, NM; Gundra, UM; Loke, P; Movila, A; Nacer, A; Sohet, F	1
Airas, L; Anthony, DC; Dickens, AM; Elo, P; Eskola, O; Haaparanta-Solin, M; Johansson, J; Jones, PA; Marjamäki, P; Rinne, J; Solin, O; Trigg, W	1
Paisansathan, C; Pelligrino, DA; Testai, FD; Xu, HL	1
Hla, T; Proia, RL	1
Chara, JC; Cipriani, R; Matute, C; Rodríguez-Antigüedad, A	1
Banno, R; Fujita, T; Kohno, T; Matsushima, Y; Mikami, N; Miyawaki, M; Otani, F; Takatsuji, M; Tsuji, T; Tsujikawa, K; Yoshida, Y	1
Dam, W; Hijmans, RS; Navis, G; Poosti, F; van den Born, J; van Goor, H; Yazdani, S	1
Botchwey, E; Das, A; Francis, MP; Huang, C; Krieger, J; Ogle, R; Wang, T	1
Chiba, K; Fukunari, A; Kataoka, H; Maeda, Y; Seki, N; Sugahara, K; Takemoto, K; Utsumi, H	1
Xiao, W; Xu, GT; Ye, W; Zhang, J; Zhang, Y	1
Alme, MN; Bø, L; Myhr, KM; Nystad, AE; Torkildsen, Ø; Vedeler, CA; Wergeland, S	1
Büttner, R; Diehl, L; Goltz, D; Huss, S; Meyer, R; Ramadori, E	1
Baharvand, H; Javan, M; Yazdi, A	1
Dhindsa, JS; Gill, GS; Grobelny, DW; Samuvel, DJ; Saxena, N; Singh, AK; Singh, I	1
Banno, R; Chikami, T; Fujita, T; Hamazaki, J; Kohno, T; Kuroda, A; Okuno, S; Sakurai, S; Tsuji, T; Yoshida, Y	1
Gao, Q; Jiang, Z; Liu, R; Lu, B; Ren, M; Wu, Y; Zhou, Y	1
Koch, M; Nashan, B; Poehnert, D	1
Arias, T; Badimon, JJ; Fuster, V; Goliasch, G; Hajjar, RJ; Ishikawa, K; Narula, J; Njerve, IU; Picatoste, B; Santos-Gallego, CG; Sanz, J; Sengupta, PP; Vahl, TP	1
Bak, EJ; Cha, JH; Choi, SH; Kim, JH; Lee, DE; Yoo, YJ	1
Bonder, CS; Dimasi, DP; Grimbaldeston, MA; Heddle, R; Pitman, MR; Pitson, SM; Sun, WY; Zhuang, Y	1
Bamias, G; Behrens, EH; Boyer, JD; Clark, D; Gima, L; González-Cabrera, P; Jedlicka, P; Karuppuchamy, T; Peach, R; Rivera-Nieves, J; Rosen, H; Sarkisyan, G; Scott, F; Veny, M	1
Haghani, M; Keshavarz, S; Namavar, MR; Nazari, M; Rafati, A	1
Aytan, N; Brinkmann, V; Carreras, I; Choi, JK; Dedeoglu, A; Jenkins, BG; Kowall, NW	1
Bauer, M; Benetti, E; Coldewey, SM; Collino, M; Huwiler, A; Pfeilschifter, J; Sponholz, C; Thiemermann, C	1
Daldrup, T; Derksen, A; Hartung, HP; Kieseier, BC; Meyer Zu Hörste, G; Steiner, I; Szepanowski, F	1
East, JE; Subrahmanyam, PB; Tiper, IV; Webb, TJ	1
Becker-Krail, D; Boger, HA; Farrand, AQ; Lavin, A	1
Armida, M; De Simone, R; Mazziotti, V; Minghetti, L; Pèzzola, A; Popoli, P; Potenza, RL	1
Joshi, A; Ratna, W; Stagni, G; Tamakuwala, M	1
Ader, I; Cuvillier, O; Gstalder, C	1
Fluri, F; Kleinschnitz, C; Krstic, M; Schuhmann, MK	1
Enderes, J; Heidecke, CD; Müller, J; Schulze, T; Tran, BT; van der Linde, J; von Bernstorff, W	1
Barr, SA; Brandt, C; Chen, B; Clare, S; Edinger, AL; Fallegger, D; Fransson, R; Hanessian, S; Huwiler, A; Keebaugh, A; Kim, SM; Kleinman, MT; Liu, G; McCracken, AN; McMonigle, RJ; Moitessier, N; Müschen, M; Perryman, MS; Roy, SG; Selwan, E; Sernissi, L; Snider, AJ; Tessier, J	1
Hasegawa, Y; Kawano, T; Kim-Mitsuyama, S; Suzuki, H; Uekawa, K	1
Hahn, JN; Kaushik, DK; Mishra, MK; Silva, C; Wang, J; Yong, VW	1
Huo, Z; Li, C; Wang, R; Wang, Z; Zhao, Z	1
Butts, M; Edison, J; Frattalone, S; Moratz, CM; Tracy, C; Woodard, GE	1
Sun, L; Xiao, W; Ye, W; Zhang, N	1
de Jong, GM; Slager, JJ; van Genderen, PJ; van Hellemond, JJ; Verbon, A	1
Guo, Y; Han, M; Lou, H; Perez, RG; Ren, M; Shi, H; Wei, X; Zhang, X	1
Hirsova, P; Maiers, JL; Malhi, H; Mauer, AS; Shah, VH	1
Jiménez-Altayó, F; Jurado, A; Meissner, A; Miro, F; Planas, AM; Vila, E	1
Furusawa, E; Irisa, M; Itoh, K; Kaizu, K; Kodama, T; Ogawa, Y; Oishi, K; Saito, T; Sakuraba, H; Sano, T; Togawa, T; Tsukimura, T; Yamanaka, S; Yanagi, Y	1
Ciric, B; Gran, B; Li, X; Ma, CG; Rostami, A; Zhang, GX; Zhang, Y	1
Cao, Y; Gao, J; Hao, Y; Liang, S; Sun, C; Wang, X; Wu, H; Wu, L; Xia, W	1
Chen, Z; Cui, K; Liu, J; Rao, K; Ruan, Y; Wang, S; Wang, T	1
Carbone, M; Furuya, H; Gaudino, G; Giorgi, C; Larson, D; Li, S; Napolitano, A; Pass, HI; Pastorino, S; Pellegrini, L; Pinton, P; Szymiczek, A; Takinishi, Y; Tanji, M; Xue, J; Yang, H	1
Balatoni, B; Baumruker, T; Bornancin, F; Foster, CA; Howard, LM; Kinnunen, A; Mechtcheriakova, D; Sobanov, J; Storch, MK; Wlachos, A	1
Antel, JP; Miron, VE; Schubart, A	1
Copland, DA; Dick, AD; Nicholson, LB; Raveney, BJ	1
Fauser, U; Schluesener, HJ; Zhang, Z; Zhang, ZY	2
Bueno, V; Lopes, CT; Oshima, CT; Palma, PV; Salinas, NR	1
Fukuda, K; Fukushima, A; Kumagai, N; Nishida, T; Nishino, K; Sumi, T; Ueno, H	1
Binder, E; Budde, K; Khadzhynov, D; Krämer, S; Loof, T; Martini, S; Neumayer, HH; Peters, H; Wang-Rosenke, Y	1
Dikow, R; Gross, ML; Hug, F; Schaier, M; Sommerer, C; Vorwalder, S; Waldherr, R; Zeier, M	1
Chow, WN; Colello, RJ; Graf, MR; Graham, RS; Lee, KD; Mathern, BE; Sato-Bigbee, C; Young, HF	1
Gidday, JM; Park, TS; Wacker, BK	1
Eaton, R; Gonzalez, MI; Marshall, I; Papadopoulos, D; Patel, R; Philpott, KL; Reynolds, R; Richardson, JC; Rundle, J; Stretton, J	1
Cartwright, E; Egom, EE; Ke, Y; Lei, M; Mohamed, TM; Musa, H; Solaro, RJ; Wang, T	1
Friedlander, RM; Lin, N	1
Hasegawa, Y; Rolland, W; Sozen, T; Suzuki, H; Zhang, JH	1
Adamowicz, JJ; Berdyshev, EV; Diab, KJ; Garrison, J; Gu, Y; Hubbard, WC; Kamocki, K; Petrache, I; Rajashekhar, G; Rush, NI; Schweitzer, KS; Skobeleva, A	1
Hendriks, RW; Hoogsteden, HC; KleinJan, A; Lambrecht, BN; Leman, K; van Nimwegen, M; Willart, M	1
Arslanian, C; Belfort, R; Bueno, V; Commodaro, AG; Lopes, CT; Peron, JP; Rizzo, LV	1
Li, F; Li, Q	1
Bajwa, A; Dondeti, KR; Haase, VH; Huang, L; Jo, SK; Lynch, KR; Macdonald, TL; Okusa, MD; Rosin, DL; Ye, H	1
Imado, T; Iwasaki, T; Kitano, S; Miyazawa, K; Sano, H; Tsunemi, S	1
Frey, O; Kamradt, T	1
Bauersachs, J; Bonz, A; Burkard, N; Ertl, G; Frantz, S; Hofmann, U; Hu, K; Ritter, O; Walter, F	1
Ley, K; McDuffie, M; Morris, MA; Nadler, JL	1
Kabashima, K; Sakabe, J; Sugita, K; Tanizaki, H; Tokura, Y; Yoshiki, R	1
Belfort, R; Bueno, V; Commodaro, AG; Rizzo, LV	1
Lai, WQ; Leung, BP; Wong, WS	1
Bode, C; Gräler, M; Heusch, G; Keul, P; Levkau, B; Lucke, S; von Wnuck Lipinski, K	1
Choi, JW; Chun, J; Gardell, SE; Herr, DR; Kennedy, G; Lee, CW; Lu, M; Noguchi, K; Rivera, R; Teo, ST; Yung, YC	1
Alsharif, N; Brinkmann, V; Guo, S; Hwang, SK; Kim, HH; Liao, JK; Lo, EH; Qin, T; Shin, HK; Waeber, C; Wei, Y; Yemisci, M; Yung, LM	1
Schluesener, HJ; Zhang, ZY; Zug, C	1
Benson, EL; Heuvelman, DM; Masferrer, JL; Radi, ZA	1
Bähr, M; Diem, R; Hein, K; Hillgruber, C; Kretzschmar, B; McRae, BL; Rau, CR; Sättler, MB	1
Chun, J; Cohen, JA	1
Chen, L; Di, J; Li, DJ; Li, W; Lin, Y; Ren, L; Shan, B; Sun, Y; Wang, W	1
Hasegawa, Y; Lekic, T; Manaenko, A; Ostrowski, R; Rolland, WB; Tang, J; Zhang, JH	1
Brinkman, V; Cojean, C; Li, L; Matsumoto, M; Pachner, AR; Seabrook, TJ	1
Apicco, D; Guckian, K; Hu, Y; Ji, B; Lee, X; Mi, S; Miller, RH; Pepinsky, RB	1
Böhler, T; Pchejetski, D; Stebbing, J; Waxman, J	1
Cahalan, SM; Cameron, MD; Gonzalez-Cabrera, PJ; Kago, T; Leaf, NB; Nguyen, N; Rosen, H; Sarkisyan, G	1
Cartwright, EJ; Gui, J; Jin, J; Ke, Y; Lei, M; Liu, W; Naumann, R; Neyses, L; Prehar, S; Solaro, RJ; Taglieri, DM; Tsui, H; Ulm, S; Wang, X; Xiao, RP; Zi, M	1
Bedoui, S; Carbone, FR; Eidsmo, L; Heath, WR; Stock, AT	1
Hagiya, H; Ito, T; Kurata, H; Mizuno, H; Song, J	1
Ruediger, R; Walter, G	1
Amor, S; Kipp, M	1
Bogen, B; Corthay, A; Lorvik, KB	1
Danilycheva, IV; Kryzhanovskiĭ, SM; Shmyrev, VI	1
Chiba, K; Yoshii, N	1
Armstrong, B; Deng, J; Forman, S; Kowolik, C; Lee, H; Liu, Y; Scuto, A; Wang, L; Weiss, LM; Yu, H	1
Chen, X; Li, J; Lu, Y; Wan, H; Ye, S; Zhang, S; Zheng, G; Zhu, H	1
Jeong, JK; Lee, JH; Lee, YJ; Moon, MH; Park, SY; Park, YG; Seol, JW	1
Barde, YA; Dekkers, MP; Deogracias, R; Guy, J; Ionescu, MC; Vogt, KE; Yazdani, M	1
Gao, F; Jiang, W; Li, X; Liu, Y; Wang, Y; Wei, D	1
Baer, K; Frevert, U; Kappe, SH; Mikolajczak, SA; Movila, A; Nacer, A	1
Bianco, R; Carlomagno, C; D'Amato, C; D'Amato, V; Damiano, V; De Placido, S; De Stefano, A; Del Vecchio, S; Formisano, L; Greco, A; Malapelle, U; Marciano, R; Marfè, G; Nappi, L; Rosa, R; Troncone, G; Veneziani, BM; Zannetti, A	1
Liu, J; Liu, M; Tao, W; Zhang, C	1
Hoogsteden, HC; Kleinjan, A; Lambrecht, BN; Leman, K; van Nimwegen, M	1
Altay, O; Hartman, R; Hasegawa, Y; Krafft, PR; Lekic, T; Manaenko, A; Ostrowski, R; Rolland, WB; Tang, J; Zhang, JH	1
Arai, K; Campos, F; Castillo, J; Lo, EH; Qin, T; Seo, JH; Waeber, C	1
Hof, RP; Matsumoto, Y	1
Amemiya, H; Fujino, M; Funeshima, N; Kimura, H; Kitazawa, Y; Li, XK; Suzuki, S	1
Kahan, BD; Ortiz, AM; Troncoso, P	1
Brinkmann, V; Kemeny, DM; Manlius, C; Sawicka, E; Trifilieff, A; Walker, C; Zuany-Amorim, C	1
Burne, MJ; Garcia, JG; Hassoun, PM; McVerry, BJ; Pearse, D; Peng, X; Rabb, H; Sammani, S; Tuder, RM	1
Borra, RC; Bueno, V; Franco, M; Oliveira, CM; Pestana, JO; Schor, N; Silva, HT	1
Chun, J; Hale, J; Lariosa-Willingham, K; Lin, FF; Mandala, S; Rao, TS; Tham, CS; Webb, M; Yu, N	1
Ito, T; Kai, Y; Kishi, D; Kiyono, H; Matsuda, H; Mizushima, T; Nezu, R; Tamagawa, H	1
Fujita, T; Hirayama, K; Kohno, T; Matsumoto, A; Tsuji, T; Watabe, K	1
Gottschalk, R; Maki, T; Monaco, AP; Ogawa, N	1
Chiba, K	1
Brinkmann, V; Gibb, DR; Ley, K; Morris, MA; Picard, F; Straume, M	1
Chu, AC; Fan, ST; Ho, JW; Lee, TK; Man, K; Ng, IO; Ng, KT; Poon, RT; Sun, CK; Sun, HC; Tang, ZY; Wang, XH; Xu, R; Xu, Y	1
Brinkmann, V; Clarkson, MR; Fernandes, S; Habicht, A; Henderson, J; Jurewicz, M; Sayegh, MH; Yang, J; Yuan, X	1
Domínguez, J; Kahan, BD; Ortiz, AM; Troncoso, P	1
Fan, ST; Ho, JW; Lam, KS; Lee, TK; Li, XL; Lo, CM; Man, K; Ng, KT; Sun, CK; Xu, A; Zhao, Y	1
Bergmann, S; Frink, M; Kaudel, CP; Klempnauer, J; Krettek, C; Pape, HC; Schmiddem, U; Winkler, M	1
Kaneko, T; Kawana, H; Kobayashi, E; Murakami, T; Takahashi, M; Yasue, T	1
Andoh, A; Bamba, S; Deguchi, Y; Fujiyama, Y; Inatomi, O; Tsujikawa, T; Yagi, Y	1
Hammad, H; Hijdra, D; Hoogsteden, HC; Idzko, M; Kool, M; Lambrecht, BN; Müller, T; Soullié, T; van Nimwegen, M; Willart, MA	1
Heusch, G; Keul, P; Levkau, B; Lucke, S; Schuchardt, M; Tölle, M; van der Giet, M; von Wnuck Lipinski, K	1
Assmann, G; Biessen, EA; Bot, M; Brinkmann, V; Brodde, M; Nofer, JR; Salm, P; Taylor, PJ; van Berkel, T	1
Daniel, C; Geisslinger, G; Radeke, HH; Sartory, N; Stein, JM; Zahn, N	1
Alperovich, G; Bolaños, N; Carrera, M; Cruzado, JM; Franquesa, M; Gomà, M; Grinyó, JM; Herrero-Fresneda, I; Lloberas, N; Poveda, R; Rama, I; Torras, J	1
Bergmann, S; Frink, M; Kaudel, CP; Klempnauer, J; Krettek, C; Probst, C; Schmiddem, U; van Griensven, M; Winkler, M	1
Daniel, C; Geisslinger, G; Radeke, HH; Sartory, NA; Schmidt, R; Stein, JM; Zahn, N	1
Bi, Y; He, X; Liu, L; Shang, W; Wang, C; Wang, D	1
Delbridge, MS; El Nahas, AM; Haylor, JL; Raftery, AT; Shrestha, BM	1
Frink, M; Hildebrand, F; Kaudel, CP; Klempnauer, J; Krettek, C; Pape, HC; van Griensven, M; Winkler, M	1
Balatoni, B; Foster, CA; Hiestand, PC; Koziel, A; Lambrou, GN; Schönborn, V; Storch, MK; Swoboda, EM; Weissert, R	1
del Rio, ML; Förster, R; Pabst, O; Penuelas-Rivas, G; Ramirez, P; Rodriguez-Barbosa, JI	1
Bueno, V; Cury, PM; da Silva, LB; Palma, PV	1
Hagiwara, N; Ikeda, T; Inoue, M; Koshinaga, T; Kusafuka, T; Sugito, K	1
Delbridge, MS; El Nahas, AM; Haylor, J; Raftery, AT; Shrestha, BM	1
Hao, Y; Xie, M; Zhou, JH; Zhu, GQ	1
Foster, CA; Hiestand, PC; Meier, DP; Rausch, M	1
Chiba, K; Kataoka, H	1
Bueno, V; Cordeiro, JA; Cury, PM; Lucas da Silva, LB; Ribeiro, DA	1
Mansoor, M; Melendez, AJ	1
Hamada, Y; Nagasawa, K; Sakano, Y; Toshima, T; Watanabe, H	1
Hwang, MW; Ito, H; Matsumori, A; Miyamoto, T; Nishio, R; Sasayama, S	1
Fujimura, A; Hirata, D; Iwamoto, M; Kamimura, T; Kano, S; Kobayashi, E; Masuyama, J; Minota, S; Okazaki, H; Sato, H; Yoshio, T	1
Inobe, M; Konishi, K; Murakami, M; Todo, S; Uede, T; Yamada, A	1

Reviews

22 review(s) available for fingolimod hydrochloride and Disease Models, Animal

Article	Year
From the Molecular Mechanism to Pre-clinical Results: Anti-epileptic Effects of Fingolimod. Current neuropharmacology, 2020, Volume: 18, Issue:11 Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Fingolimod Hydrochloride; Humans; Multiple Sclerosis; Seizures; Sphingosine 1 Phosphate Receptor Modulators	2020
Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis. Drugs in R&D, 2020, Volume: 20, Issue:3 Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Fingolimod Hydrochloride; Humans; Lymphocytes; Mice; Multiple Sclerosis; Nervous System Diseases; Neuroprotective Agents; Rats; Sphingosine 1 Phosphate Receptor Modulators	2020
Sphingosine 1-Phosphate Receptors in Cerebral Ischemia. Neuromolecular medicine, 2021, Volume: 23, Issue:1 Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Lysophospholipids; Neovascularization, Physiologic; Nerve Tissue Proteins; Neuroprotective Agents; Phosphotransferases (Alcohol Group Acceptor); Rats; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors	2021
Possible regenerative effects of fingolimod (FTY720) in multiple sclerosis disease: An overview on remyelination process. Journal of neuroscience research, 2020, Volume: 98, Issue:3 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Multiple Sclerosis; Oligodendroglia; Remyelination; Sphingosine-1-Phosphate Receptors	2020
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. Basic & clinical pharmacology & toxicology, 2014, Volume: 114, Issue:1 Topics: Animals; Cell Proliferation; Disease Models, Animal; Fibrosis; Fingolimod Hydrochloride; Glomerulonephritis; Humans; Inflammation; Kidney Failure, Chronic; Lysophospholipids; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine	2014
Central effects of fingolimod. Revista de neurologia, 2014, Aug-01, Volume: 59, Issue:3 Topics: Animals; Blood-Brain Barrier; Chemotaxis, Leukocyte; Clinical Trials as Topic; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immunologic Memory; Mice; Mice, Knockout; Mice, Neurologic Mutants; Multicenter Studies as Topic; Multiple Sclerosis, Relapsing-Remitting; Neurogenesis; Neuroglia; Neuroprotective Agents; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocyte Subsets	2014
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. The Journal of clinical investigation, 2015, Volume: 125, Issue:4 Topics: Acute Lung Injury; Anemia, Sickle Cell; Animals; Autoimmune Diseases; Cardiovascular Diseases; Cell Physiological Phenomena; Disease Models, Animal; Fingolimod Hydrochloride; Hematopoietic Stem Cell Mobilization; Humans; Influenza, Human; Lysophospholipids; Membrane Lipids; Mice; Multiple Sclerosis; Neoplasms; Neovascularization, Physiologic; Neurogenesis; Propylene Glycols; Receptors, Lysosphingolipid; Sphingolipids; Sphingosine	2015
Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection. Pathogens and disease, 2016, Volume: 74, Issue:6 Topics: Animals; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Hematologic Neoplasms; Host-Pathogen Interactions; Humans; Immune System; Immunosuppressive Agents; Infections; Inflammation; Lymphocytes; Lysophospholipids; Signal Transduction; Sphingosine; Transcription Factors	2016
Systematic review of the role of angiopoietin-1 and angiopoietin-2 in Plasmodium species infections: biomarkers or therapeutic targets? Malaria journal, 2016, Dec-01, Volume: 15, Issue:1 Topics: Angiopoietin-1; Angiopoietin-2; Animals; Biomarkers; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Malaria, Falciparum; Mice; Predictive Value of Tests; ROC Curve; Survival Analysis; Treatment Outcome	2016
Central nervous system-directed effects of FTY720 (fingolimod). Journal of the neurological sciences, 2008, Nov-15, Volume: 274, Issue:1-2 Topics: Animals; Blood-Brain Barrier; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Propylene Glycols; Sphingosine	2008
Autoimmune uveitis: the associated proinflammatory molecules and the search for immunoregulation. Autoimmunity reviews, 2011, Volume: 10, Issue:4 Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immunologic Factors; Immunomodulation; Inflammation Mediators; Propylene Glycols; Sphingosine; Uveitis	2011
Sphingosine kinase and sphingosine 1-phosphate in asthma. Bioscience reports, 2011, Volume: 31, Issue:2 Topics: Animals; Anti-Asthmatic Agents; Asthma; Cytokines; Disease Models, Animal; Epithelial Cells; Fingolimod Hydrochloride; Humans; Inflammation; Lung; Lysophospholipids; Mast Cells; Mice; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingolipids; Sphingosine	2011
Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. Annals of neurology, 2011, Volume: 69, Issue:5 Topics: Animals; Central Nervous System; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Disease Models, Animal; Fingolimod Hydrochloride; Heart Diseases; Humans; Immunosuppressive Agents; Infections; Liver Diseases; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Respiration Disorders; Sphingosine	2011
Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer. Nature reviews. Urology, 2011, Sep-13, Volume: 8, Issue:10 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Male; Mice; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Prostatic Neoplasms; Signal Transduction; Sphingosine	2011
FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination. Multiple sclerosis (Houndmills, Basingstoke, England), 2012, Volume: 18, Issue:3 Topics: Animals; Astrocytes; Axons; Central Nervous System; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Lysophospholipids; Mice; Microglia; Multiple Sclerosis; Myelin Sheath; Neurons; Oligodendroglia; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine	2012
[Sphingosine-1-phosphate signaling system and the innovative mechanism of action of fingolimod in treatment of multiple sclerosis: review of foreign literature]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:2 Pt 2 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immune System; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine	2012
[Pharmacological properties and clinical efficacy of fingolimod hydrochloride (Imusera®/Gilenya®) for the treatment of multiple sclerosis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2012, Volume: 139, Issue:6 Topics: Administration, Oral; Animals; Clinical Trials, Phase I as Topic; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Humans; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Secondary Prevention; Sphingosine; Th17 Cells	2012
Systematic review and meta-analysis of the efficacy of sphingosine-1-phosphate (S1P) receptor agonist FTY720 (fingolimod) in animal models of stroke. The International journal of neuroscience, 2013, Volume: 123, Issue:3 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Propylene Glycols; Receptors, Lysosphingolipid; Recovery of Function; Sphingosine; Stroke; Treatment Outcome	2013
FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. Pharmacology & therapeutics, 2005, Volume: 108, Issue:3 Topics: Animals; Autoimmune Diseases; Calcineurin Inhibitors; Clinical Trials as Topic; Disease Models, Animal; Drug Synergism; Fingolimod Hydrochloride; Graft vs Host Disease; Humans; Immunosuppressive Agents; Lymph Nodes; Lymphocytes; Peyer's Patches; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Spleen; T-Lymphocytes; Thymus Gland	2005
Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 2008, Volume: 66 Topics: Administration, Oral; Animals; Ascomycota; Biological Products; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Molecular Structure; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Treatment Outcome	2008
[Therapeutic effect of S1P receptor modifying drugs for autoimmune diseases]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2008, Volume: 131, Issue:3 Topics: Animals; Autoimmune Diseases; Clinical Trials, Phase II as Topic; Disease Models, Animal; Drug Design; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2008
Recent trials for FTY720 (fingolimod): a new generation of immunomodulators structurally similar to sphingosine. Reviews on recent clinical trials, 2008, Volume: 3, Issue:1 Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immune System Diseases; Immunosuppressive Agents; Propylene Glycols; Sphingosine	2008

Other Studies

247 other study(ies) available for fingolimod hydrochloride and Disease Models, Animal

Article	Year
Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P₁ agonists. Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19 Topics: Animals; Autoimmune Diseases; Butyrates; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Haplorhini; High-Throughput Screening Assays; Humans; Immunosuppressive Agents; Indoles; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Nerve Tissue Proteins; Oxadiazoles; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Structure-Activity Relationship; Substrate Specificity	2011
Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease. Molecular neurobiology, 2022, Volume: 59, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Fingolimod Hydrochloride; Mice; Mice, Transgenic; tau Proteins	2022
Intranasal administration of fingolimod (FTY720) attenuates demyelination area in lysolecithin-induced demyelination model of rat optic chiasm. Multiple sclerosis and related disorders, 2022, Volume: 59 Topics: Administration, Intranasal; Animals; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophosphatidylcholines; Male; Optic Chiasm; Rats; Rats, Wistar	2022
FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing APOE4. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 152 Topics: Alzheimer Disease; Animals; Apolipoprotein E4; Brain; Ceramides; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Memory Disorders; Mice; Sphingolipids	2022
Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression. Proceedings of the National Academy of Sciences of the United States of America, 2022, 07-26, Volume: 119, Issue:30 Topics: Animals; Disease Models, Animal; Disease Progression; Enzyme Activation; Fingolimod Hydrochloride; Humans; Mice; Polycystic Kidney, Autosomal Dominant; Protein Kinase C; TRPP Cation Channels	2022
The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis Iranian biomedical journal, 2022, 07-01, Volume: 26, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Rats; Rats, Wistar; Zingiber officinale	2022
Fingolimod ameliorates schizophrenia-like cognitive impairments induced by phencyclidine in male rats. British journal of pharmacology, 2023, Volume: 180, Issue:2 Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia	2023
Fingolimod Does Not Reduce Infarction After Focal Cerebral Ischemia in Mice During Active or Inactive Circadian Phases. Stroke, 2022, Volume: 53, Issue:12 Topics: Animals; Brain Edema; Brain Ischemia; Disease Models, Animal; Fingolimod Hydrochloride; Hemorrhage; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Sphingosine; Stroke	2022
Dysregulation of sphingosine-1-phosphate (S1P) and S1P receptor 1 signaling in the 5xFAD mouse model of Alzheimer's disease. Brain research, 2023, 01-15, Volume: 1799 Topics: Alzheimer Disease; Animals; Disease Models, Animal; Fingolimod Hydrochloride; Lysophospholipids; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-akt; Sphingosine; Sphingosine-1-Phosphate Receptors; TOR Serine-Threonine Kinases	2023
Fingolimod attenuates ovalbumin-induced airway inflammation via inhibiting MAPK/ERK signaling in mice. Journal of biochemical and molecular toxicology, 2023, Volume: 37, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Inflammation; Interleukin-13; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Ovalbumin	2023
The antiinflammatory and electrophysiological effects of fingolimod on penicillin-induced rats. Arquivos de neuro-psiquiatria, 2022, Volume: 80, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Contraindications, Drug; Diazepam; Disease Models, Animal; Electroencephalography; Fingolimod Hydrochloride; Interleukin-6; Male; Penicillins; Rats; Rats, Wistar; Seizures; Tumor Necrosis Factor-alpha	2022
Time- and Sex-Dependent Effects of Fingolimod Treatment in a Mouse Model of Alzheimer's Disease. Biomolecules, 2023, 02-09, Volume: 13, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Female; Fingolimod Hydrochloride; Male; Mice; Mice, Transgenic	2023
Fingolimod mitigates memory loss in a mouse model of Gulf War Illness amid decreasing the activation of microglia, protein kinase R, and NFκB. Neurotoxicology, 2023, Volume: 96 Topics: Amnesia; Animals; Disease Models, Animal; Fingolimod Hydrochloride; Gulf War; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Microglia; Neuroinflammatory Diseases; NF-kappa B; Persian Gulf Syndrome; Protein Kinases; Pyridostigmine Bromide	2023
Fingolimod (FTY720) improves the functional recovery and myelin preservation of the optic pathway in focal demyelination model of rat optic chiasm. Brain research bulletin, 2019, Volume: 153 Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Histone Deacetylase 1; Lysophosphatidylcholines; Male; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Optic Chiasm; Rats; Rats, Wistar; Recovery of Function; Remyelination; Sphingosine-1-Phosphate Receptors; Valproic Acid	2019
A Pilot Microbiota Study in Parkinson's Disease Patients versus Control Subjects, and Effects of FTY720 and FTY720-Mitoxy Therapies in Parkinsonian and Multiple System Atrophy Mouse Models. Journal of Parkinson's disease, 2020, Volume: 10, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Animals; Constipation; Disease Models, Animal; Dysbiosis; Female; Fingolimod Hydrochloride; Gastrointestinal Microbiome; Gastrointestinal Motility; Humans; Immunosuppressive Agents; Male; Mice; Mice, Transgenic; Microbiota; Middle Aged; Multiple System Atrophy; Parkinson Disease; Pilot Projects; RNA, Ribosomal, 16S	2020
Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity. Neuromolecular medicine, 2020, Volume: 22, Issue:2 Topics: Animals; Animals, Genetically Modified; Cell Line; Ceramides; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Drug Evaluation, Preclinical; Enzyme Activation; Fingolimod Hydrochloride; Gain of Function Mutation; Gene Knockdown Techniques; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Mutation, Missense; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Processing, Post-Translational; Recombinant Proteins; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; RNA, Small Interfering	2020
FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models. Experimental neurology, 2020, Volume: 325 Topics: alpha-Synuclein; Animals; Behavior, Animal; Disease Models, Animal; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Humans; Inflammation; Male; Mice; Mice, Transgenic; MicroRNAs; Multiple System Atrophy; Neuroprotective Agents; Proto-Oncogene Proteins c-ret	2020
Fingolimod Plays Role in Attenuation of Myocardial Injury Related to Experimental Model of Cardiac Arrest and Extracorporeal Life Support Resuscitation. International journal of molecular sciences, 2019, Dec-11, Volume: 20, Issue:24 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Cardiopulmonary Resuscitation; Collagen; Disease Models, Animal; Fingolimod Hydrochloride; Heart Arrest; Hemodynamics; Inflammation Mediators; Myocardium; Neutrophil Infiltration; Nitrosative Stress; Nucleotides; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Ventricular Function, Left	2019
FTY720 Exerts Anti-Glioma Effects by Regulating the Glioma Microenvironment Through Increased CXCR4 Internalization by Glioma-Associated Microglia. Frontiers in immunology, 2020, Volume: 11 Topics: Allografts; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Polarity; Disease Models, Animal; Fingolimod Hydrochloride; Glioblastoma; Macrophages; Male; Microglia; Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, CXCR4; Signal Transduction; Tumor Microenvironment	2020
Beneficial Effects of Fingolimod on Social Interaction, CNS and Peripheral Immune Response in the BTBR Mouse Model of Autism. Neuroscience, 2020, 05-21, Volume: 435 Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunity; Male; Mice; Mice, Inbred C57BL; Signal Transduction; Social Interaction	2020
Fingolimod Affects Transcription of Genes Encoding Enzymes of Ceramide Metabolism in Animal Model of Alzheimer's Disease. Molecular neurobiology, 2020, Volume: 57, Issue:6 Topics: Alzheimer Disease; Animals; Ceramidases; Ceramides; Disease Models, Animal; Down-Regulation; Female; Fingolimod Hydrochloride; Hippocampus; Humans; Lipid Metabolism; Membrane Proteins; Mice; Mice, Transgenic; Neocortex; Nerve Tissue Proteins; Oxidoreductases; Transcription, Genetic; Transferases (Other Substituted Phosphate Groups)	2020
Fingolimod Attenuates Lung Injury and Cardiac Dysfunction after Traumatic Brain Injury. Journal of neurotrauma, 2020, 10-01, Volume: 37, Issue:19 Topics: Acute Lung Injury; Animals; Brain Injuries, Traumatic; Cardiac Output; Cytokines; Disease Models, Animal; Echocardiography; Fingolimod Hydrochloride; Heart Diseases; Lung; Male; Mice; Mice, Inbred C57BL; Myocardium; Sphingosine 1 Phosphate Receptor Modulators	2020
Longitudinal [18F]FB-IL-2 PET Imaging to Assess the Immunopathogenicity of O'nyong-nyong Virus Infection. Frontiers in immunology, 2020, Volume: 11 Topics: Alphavirus Infections; Animals; CD4-Positive T-Lymphocytes; Disease Models, Animal; Drug Repositioning; Female; Fingolimod Hydrochloride; Humans; Immunocompetence; Longitudinal Studies; Male; Mice; Mice, Inbred C57BL; O'nyong-nyong Virus; Positron-Emission Tomography; Viremia	2020
Immunohistochemical analysis of protective effects of maternal fingolimod on the placenta and fetal lung and brain in chorioamnionitis-induced preterm birth rat model. Immunopharmacology and immunotoxicology, 2020, Volume: 42, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Brain; Chorioamnionitis; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunohistochemistry; Inflammation Mediators; Lipopolysaccharides; Lung; Placenta; Pregnancy; Premature Birth; Rats, Wistar	2020
Morpholino Analogues of Fingolimod as Novel and Selective S1P International journal of molecular sciences, 2020, Sep-04, Volume: 21, Issue:18 Topics: Animals; Central Nervous System; CHO Cells; Cricetulus; Disease Models, Animal; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Immunosuppressive Agents; Ligands; Lymphopenia; Lysophospholipids; Mice; Morpholinos; Multiple Sclerosis; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Spinal Cord; T-Lymphocytes	2020
The sphingosine-1-phosphate receptor modulator, FTY720, prevents the incidence of diabetes in Spontaneously Diabetic Torii rats. Clinical and experimental pharmacology & physiology, 2021, Volume: 48, Issue:6 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Fingolimod Hydrochloride; Incidence; Sphingosine-1-Phosphate Receptors	2021
Fingolimod suppressed the chronic unpredictable mild stress-induced depressive-like behaviors via affecting microglial and NLRP3 inflammasome activation. Life sciences, 2020, Dec-15, Volume: 263 Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Fingolimod Hydrochloride; Hippocampus; Inflammasomes; Male; Maze Learning; Microglia; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sphingosine 1 Phosphate Receptor Modulators; Stress, Psychological	2020
Fingolimod reduces salivary infiltrates and increases salivary secretion in a murine Sjögren's model. Journal of autoimmunity, 2020, Volume: 115 Topics: Administration, Oral; Animals; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Male; Mice; Mice, Transgenic; Saliva; Salivary Glands; Sjogren's Syndrome	2020
Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model. International journal of molecular sciences, 2020, Nov-25, Volume: 21, Issue:23 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents; Astrocytes; Disease Models, Animal; Fingolimod Hydrochloride; Hippocampus; Humans; Inflammation; Memory Disorders; Mice; Mice, Transgenic; Microglia; Presenilin-1; Synapses	2020
Curcumol and FTY720 synergistically induce apoptosis and differentiation in chronic myelomonocytic leukemia via multiple signaling pathways. Phytotherapy research : PTR, 2021, Volume: 35, Issue:4 Topics: Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Sesquiterpenes; Signal Transduction	2021
Chitosan nanocarrier for FTY720 enhanced delivery retards Parkinson's disease via PP2A-EzH2 signaling in vitro and ex vivo. Carbohydrate polymers, 2021, Feb-15, Volume: 254 Topics: alpha-Synuclein; Animals; Biological Availability; Cell Line, Tumor; Chitosan; Disease Models, Animal; Drug Carriers; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Fingolimod Hydrochloride; Humans; Mice; Mice, Inbred BALB C; Neurons; Neuroprotective Agents; Parkinson Disease; Phosphorylation; Protein Aggregates; Protein Phosphatase 2; Proteolysis; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators; Ubiquitination	2021
FTY720 Reduces Endothelial Cell Apoptosis and Remodels Neurovascular Unit after Experimental Traumatic Brain Injury. International journal of medical sciences, 2021, Volume: 18, Issue:2 Topics: Animals; Apoptosis; Astrocytes; Blood-Brain Barrier; Brain Injuries, Traumatic; Capillary Permeability; Disease Models, Animal; Endothelial Cells; Fingolimod Hydrochloride; Humans; Injections, Intraperitoneal; Mice; Mice, Inbred ICR	2021
The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia. Journal of neuroinflammation, 2021, Jan-30, Volume: 18, Issue:1 Topics: Aging; Animals; Brain Ischemia; Diet, High-Fat; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocytes, Regulatory	2021
Impairment of Spike-Timing-Dependent Plasticity at Schaffer Collateral-CA1 Synapses in Adult APP/PS1 Mice Depends on Proximity of Aβ Plaques. International journal of molecular sciences, 2021, Jan-30, Volume: 22, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Long-Term Potentiation; Male; Mice; Mice, Transgenic; Mutation; Patch-Clamp Techniques; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Synapses	2021
Synergistic neuroprotective effects of Fingolimod and mesenchymal stem cells (MSC) in experimental autoimmune encephalomyelitis. Immunology letters, 2021, Volume: 233 Topics: Animals; Apoptosis; Astrocytes; Biomarkers; Cell Differentiation; Cell Proliferation; Cytokines; Disease Management; Disease Models, Animal; Disease Susceptibility; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Humans; Immunomodulation; Immunophenotyping; Inflammation Mediators; Mesenchymal Stem Cells; Mice; Microglia; Neuroprotective Agents; Oxidative Stress	2021
Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension. Translational research : the journal of laboratory and clinical medicine, 2021, Volume: 233 Topics: Animals; Cell Proliferation; Cells, Cultured; Cordyceps; Disease Models, Animal; Fingolimod Hydrochloride; Gene Knockdown Techniques; Humans; Hypertension, Pulmonary; Male; Medicine, Chinese Traditional; Mice; Mice, Knockout; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Translational Research, Biomedical; TRPM Cation Channels; Vasodilation	2021
Fingolimod ameliorates imiquimod-induced psoriasiform dermatitis by sequestrating interleukin-17-producing ?d T cells in secondary lymph nodes. Journal of dermatological science, 2021, Volume: 102, Issue:2 Topics: Animals; Disease Models, Animal; Down-Regulation; Drug Evaluation, Preclinical; Female; Fingolimod Hydrochloride; Humans; Imiquimod; Interleukin-17; Intraepithelial Lymphocytes; Langerhans Cells; Lymph Nodes; Mice; Psoriasis; Skin; Up-Regulation	2021
Prophylactic administration of fingolimod (FTY720) ameliorated experimental autoimmune myasthenia gravis by reducing the number of dendritic cells, follicular T helper cells and antibody-secreting cells. International immunopharmacology, 2021, Volume: 96 Topics: Animals; Antibody-Producing Cells; Autoantigens; Dendritic Cells; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Immunity, Humoral; Immunosuppressive Agents; Myasthenia Gravis; Myasthenia Gravis, Autoimmune, Experimental; Peptides; Rats; Rats, Inbred Lew; Receptors, Cholinergic; T-Lymphocytes, Helper-Inducer	2021
Immunomodulation Eliminates Inflammation in the Hippocampus in Experimental Autoimmune Encephalomyelitis, but Does Not Ameliorate Anxiety-Like Behavior. Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Hippocampus; Immunomodulation; Inflammation; Mice; Mice, Inbred C57BL; Microglia; Signal Transduction; Sphingosine-1-Phosphate Receptors; Up-Regulation	2021
CKD-506: A novel HDAC6-selective inhibitor that exerts therapeutic effects in a rodent model of multiple sclerosis. Scientific reports, 2021, 07-14, Volume: 11, Issue:1 Topics: Animals; Antidepressive Agents; Blood-Brain Barrier; Cell Proliferation; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Macrophages; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Spinal Cord; T-Lymphocytes	2021
Exosomes Derived from Nerve Stem Cells Loaded with FTY720 Promote the Recovery after Spinal Cord Injury in Rats by PTEN/AKT Signal Pathway. Journal of immunology research, 2021, Volume: 2021 Topics: Animals; Apoptosis; Disease Models, Animal; Endothelial Cells; Exosomes; Fingolimod Hydrochloride; Humans; Male; Neural Stem Cells; Neurons; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators; Spinal Cord; Spinal Cord Injuries	2021
FTY720 promotes pulmonary fibrosis when administered during the remodelling phase following a bleomycin-induced lung injury. Pulmonary pharmacology & therapeutics, 2017, Volume: 44 Topics: Animals; Bleomycin; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Lung Injury; Male; Mice; Mice, Inbred C57BL; Neutrophils; Pulmonary Fibrosis; Time Factors	2017
Sphingosine Toxicity in EAE and MS: Evidence for Ceramide Generation via Serine-Palmitoyltransferase Activation. Neurochemical research, 2017, Volume: 42, Issue:10 Topics: Animals; Ceramides; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Humans; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Rats; Serine C-Palmitoyltransferase; Sphingosine; Spinal Cord	2017
Local delivery of fingolimod from three-dimensional scaffolds impacts islet graft efficacy and microenvironment in a murine diabetic model. Journal of tissue engineering and regenerative medicine, 2018, Volume: 12, Issue:2 Topics: Animals; Cellular Microenvironment; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Delivery Systems; Fingolimod Hydrochloride; Islets of Langerhans Transplantation; Male; Mice, Inbred C57BL; Time Factors; Tissue Scaffolds	2018
Synergistic protective effect of FTY720 and vitamin E against simulated cerebral ischemia in vitro. Molecular medicine reports, 2017, Volume: 16, Issue:1 Topics: Animals; Antioxidants; Astrocytes; Biomarkers; Brain Ischemia; Cell Survival; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Synergism; Fingolimod Hydrochloride; Inflammation Mediators; Neuroprotective Agents; Rats; Vitamin E	2017
Fingolimod and Teriflunomide Attenuate Neurodegeneration in Mouse Models of Neuronal Ceroid Lipofuscinosis. Molecular therapy : the journal of the American Society of Gene Therapy, 2017, 08-02, Volume: 25, Issue:8 Topics: Adolescent; Adult; Aminopeptidases; Animals; Axons; Brain; Child; Crotonates; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Hydroxybutyrates; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Molecular Chaperones; Neuronal Ceroid-Lipofuscinoses; Neurons; Nitriles; Serine Proteases; T-Lymphocyte Subsets; Thiolester Hydrolases; Toluidines; Tripeptidyl-Peptidase 1; Young Adult	2017
Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation. Pain, 2017, Volume: 158, Issue:9 Topics: Animals; Breast Neoplasms; Cancer Pain; Cell Line, Tumor; Disease Models, Animal; Female; Fingolimod Hydrochloride; Gene Expression Regulation, Neoplastic; Immunosuppressive Agents; Interleukin-10; Mice; Mice, Inbred C57BL; Neurogenic Inflammation; Proprotein Convertases; Receptors, Lysosphingolipid; Serine Endopeptidases; Signal Transduction; Sphingosine-1-Phosphate Receptors; Spinal Cord; Sulfones; Triazoles	2017
S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. Hypertension (Dallas, Tex. : 1979), 2017, Volume: 70, Issue:2 Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelial Cells; Fingolimod Hydrochloride; Hypertension; Immunosuppressive Agents; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine-1-Phosphate Receptors	2017
Progress toward Fulfilling the Potential of Immunomodulation in Childhood Neurodegeneration? Molecular therapy : the journal of the American Society of Gene Therapy, 2017, 08-02, Volume: 25, Issue:8 Topics: Animals; Crotonates; Disease Models, Animal; Fingolimod Hydrochloride; Hydroxybutyrates; Immunomodulation; Mice; Neurodegenerative Diseases; Neuronal Ceroid-Lipofuscinoses; Nitriles; Toluidines	2017
Modulation of sphingosine-1-phosphate receptor ameliorates harmaline-induced essential tremor in rat. Neuroscience letters, 2017, Jul-13, Volume: 653 Topics: Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Disease Models, Animal; Essential Tremor; Fingolimod Hydrochloride; Gait Disorders, Neurologic; Harmaline; Immunosuppressive Agents; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Lysosphingolipid	2017
Fingolimod Exerts only Temporary Antiepileptogenic Effects but Longer-Lasting Positive Effects on Behavior in the WAG/Rij Rat Absence Epilepsy Model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2017, Volume: 14, Issue:4 Topics: Animals; Anticonvulsants; Antidepressive Agents; Anxiety; Behavior, Animal; Brain; Depression; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Fingolimod Hydrochloride; Immunosuppressive Agents; Learning; Male; Memory; Rats, Transgenic; Rats, Wistar; Rotarod Performance Test; TOR Serine-Threonine Kinases	2017
New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth. Breast cancer research and treatment, 2017, Volume: 165, Issue:3 Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Docetaxel; Female; Fingolimod Hydrochloride; Humans; Lymphopenia; Mice; Nanoparticles; Neoplasm Metastasis; Neoplasm Staging; Taxoids; Tumor Burden; Xenograft Model Antitumor Assays	2017
Differential effects of FTY720 on the B cell compartment in a mouse model of multiple sclerosis. Journal of neuroinflammation, 2017, 07-24, Volume: 14, Issue:1 Topics: Animals; Antigens, CD19; B-Lymphocytes; Calcium-Binding Proteins; CD4-Positive T-Lymphocytes; Cell Aggregation; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunospot Assay; Female; Fingolimod Hydrochloride; Flow Cytometry; Freund's Adjuvant; Immunosuppressive Agents; Lymph Nodes; Mice; Myelin Basic Protein; Myelin Proteolipid Protein; Recombinant Fusion Proteins; Spleen; Time Factors	2017
Fingolimod against endotoxin-induced fetal brain injury in a rat model. The journal of obstetrics and gynaecology research, 2017, Volume: 43, Issue:11 Topics: Animals; Animals, Newborn; Apoptosis; Brain Injuries; Disease Models, Animal; Endotoxins; Female; Fetal Diseases; Fingolimod Hydrochloride; Inflammation; Neuroprotective Agents; Pregnancy; Rats; Rats, Wistar	2017
Evidence for a contributory role of a xenogeneic immune response in experimental epidermolysis bullosa acquisita. Experimental dermatology, 2017, Volume: 26, Issue:12 Topics: Animals; Antibodies, Heterophile; Collagen Type VII; Disease Models, Animal; Epidermolysis Bullosa Acquisita; Fingolimod Hydrochloride; Immunoglobulin G; Interferon-gamma; Lymph Nodes; Mice, Inbred C57BL; Rabbits; T-Lymphocytes	2017
Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn. Pain, 2018, Volume: 159, Issue:2 Topics: Anilides; Animals; Central Nervous System Sensitization; Disease Models, Animal; eIF-2 Kinase; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuralgia; Organophosphonates; Oxadiazoles; Pain Threshold; Peptide Fragments; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Spinal Cord; Spinal Nerve Roots; Subcellular Fractions; Thiophenes	2018
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination. Glia, 2018, Volume: 66, Issue:3 Topics: Animals; Apoptosis; Brain; Chimera; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression; Gliosis; Indans; Inflammation; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Neuroprotective Agents; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; White Matter	2018
Fingolimod Suppresses a Cascade of Core Vicious Cycle in Dry Eye NOD Mouse Model: Involvement of Sphingosine-1-Phosphate Receptors in Infiltrating Leukocytes. Investigative ophthalmology & visual science, 2017, 12-01, Volume: 58, Issue:14 Topics: Animals; Blotting, Western; Disease Models, Animal; Dry Eye Syndromes; Fingolimod Hydrochloride; Immunohistochemistry; Immunosuppressive Agents; Leukocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Receptors, Lysosphingolipid; Sphingosine	2017
Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis. Cancer research, 2018, 04-01, Volume: 78, Issue:7 Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Animals; Breast Neoplasms; Cell Line, Tumor; Culture Media, Conditioned; Cytokines; Diet, High-Fat; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Interleukin-6; Lung; Lysophospholipids; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Obesity; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors	2018
The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus. Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:1 Topics: Anilides; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclooxygenase 2; Disease Models, Animal; Drug Resistant Epilepsy; Fingolimod Hydrochloride; Hippocampus; Humans; Immunosuppressive Agents; Injections, Intraperitoneal; Lysophospholipids; Male; Organophosphonates; Phenytoin; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Up-Regulation	2018
Validating a Selective S1P Biological & pharmaceutical bulletin, 2018, Apr-01, Volume: 41, Issue:4 Topics: Administration, Oral; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fingolimod Hydrochloride; Guinea Pigs; Mice; Mitotic Index; Mucous Membrane; Oxazoles; Propanolamines; Psoriasis; Random Allocation; Receptors, Lysosphingolipid; Reproducibility of Results; Skin; Specific Pathogen-Free Organisms; Sphingosine-1-Phosphate Receptors; Vagina	2018
S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFκB signalling. Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:6 Topics: Animals; Astrocytes; Cultural Deprivation; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; HMGB1 Protein; Humans; Immunosuppressive Agents; Inflammation; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Primary Cell Culture; Rats; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine-1-Phosphate Receptors; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha	2018
FTY720 attenuates behavioral deficits in a murine model of systemic lupus erythematosus. Brain, behavior, and immunity, 2018, Volume: 70 Topics: Animals; Brain; Cytokines; Depression; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunologic Factors; Lupus Erythematosus, Systemic; Lymphocytes; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Quality of Life; Signal Transduction; T-Lymphocytes	2018
Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Molecular neurobiology, 2018, Volume: 55, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Calcium Channel Blockers; Chemokines; Cognition Disorders; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Hyperalgesia; Inflammation; Inflammation Mediators; Injections, Spinal; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Nociception; omega-Conotoxins; Peptide Fragments	2018
Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer's Disease. Molecular neurobiology, 2019, Volume: 56, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Humans; Mice; RNA, Messenger; Sphingolipids	2019
From the head of a caterpillar: A possible treatment for neuropsychiatric sequelae of autoimmune disease. Brain, behavior, and immunity, 2018, Volume: 71 Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Lupus Erythematosus, Systemic; Mice	2018
FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts. Scientific reports, 2018, 05-02, Volume: 8, Issue:1 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Humans; Medulloblastoma; Mice; Xenograft Model Antitumor Assays	2018
Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV. Human molecular genetics, 2018, 08-01, Volume: 27, Issue:15 Topics: Animals; Astrocytes; Brain; Cells, Cultured; Cytokines; Disease Models, Animal; Encephalitis; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Lysosomal Membrane Proteins; Male; Mice, Knockout; Mucolipidoses; Phosphatidylinositol 3-Kinases; Phosphoproteins; Proto-Oncogene Proteins c-akt; Transient Receptor Potential Channels	2018
CD4 Nature communications, 2018, 05-17, Volume: 9, Issue:1 Topics: Adoptive Transfer; Animals; CD4 Antigens; CD4-Positive T-Lymphocytes; Cell Differentiation; Dendritic Cells; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymph Nodes; Lymphangiogenesis; Lymphatic Vessels; Lymphedema; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Lysosphingolipid; Skin	2018
Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy. Molecular neurobiology, 2019, Volume: 56, Issue:3 Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Fingolimod Hydrochloride; Kainic Acid; Male; Mice; Pilocarpine; Seizures	2019
Differential Tolerance to FTY720-Induced Antinociception in Acute Thermal and Nerve Injury Mouse Pain Models: Role of Sphingosine-1-Phosphate Receptor Adaptation. The Journal of pharmacology and experimental therapeutics, 2018, Volume: 366, Issue:3 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Male; Mice; Mice, Inbred ICR; Neuralgia; Nociceptin; Opioid Peptides; Receptors, Lysosphingolipid; Temperature	2018
FTY720 attenuates intestinal injury and suppresses inflammation in experimental necrotizing enterocolitis via modulating CXCL5/CXCR2 axis. Biochemical and biophysical research communications, 2018, 11-10, Volume: 505, Issue:4 Topics: Animals; Chemokine CXCL5; Disease Models, Animal; Enterocolitis, Necrotizing; Female; Fingolimod Hydrochloride; Inflammation; Intestines; Male; Mice; Mice, Inbred C57BL; Receptors, Interleukin-8B	2018
Neuropsychiatric Systemic Lupus Erythematosus Is Dependent on Sphingosine-1-Phosphate Signaling. Frontiers in immunology, 2018, Volume: 9 Topics: Animals; Astrocytes; Autoantibodies; Behavior Observation Techniques; Behavior, Animal; Brain; Cognition; Cytokines; Depression; Disease Models, Animal; Endothelial Cells; Female; Fingolimod Hydrochloride; Humans; Lupus Vasculitis, Central Nervous System; Lysophospholipids; Mice; Mice, Inbred MRL lpr; Microglia; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Treatment Outcome	2018
Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy. JCI insight, 2018, 12-06, Volume: 3, Issue:23 Topics: Animals; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immunotherapy; Lymph Nodes; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Tumor Microenvironment	2018
Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy. The Journal of clinical investigation, 2019, 03-01, Volume: 129, Issue:3 Topics: Animals; Animals, Genetically Modified; Brain; Disease Models, Animal; Fatty Acid Desaturases; Fingolimod Hydrochloride; Hereditary Central Nervous System Demyelinating Diseases; Humans; Locomotion; Oligodendroglia; Zebrafish; Zebrafish Proteins	2019
RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage. Journal of the neurological sciences, 2019, Apr-15, Volume: 399 Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain; Disease Models, Animal; Fingolimod Hydrochloride; Heart Rate; Inflammation; Male; Mice; Neurons; Recovery of Function; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Subarachnoid Hemorrhage	2019
FTY720 alleviates coxsackievirus B3-induced myocarditis and inhibits viral replication through regulating sphingosine 1-phosphate receptors and AKT/caspase-3 pathways. Journal of cellular physiology, 2019, Volume: 234, Issue:10 Topics: Animals; Antiviral Agents; Apoptosis; Caspase 3; Cells, Cultured; Coxsackievirus Infections; Disease Models, Animal; Enterovirus B, Human; Fingolimod Hydrochloride; Host-Pathogen Interactions; Male; Mice, Inbred BALB C; Myocarditis; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Time Factors; Virus Replication	2019
LncRNA analysis of lung tissues after hUC-MSCs and FTY720 treatment of lipopolysaccharide-induced acute lung injury in mouse models. International immunopharmacology, 2019, Volume: 71 Topics: Acute Lung Injury; Animals; Combined Modality Therapy; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression Regulation; Gene Ontology; Humans; Immunosuppressive Agents; Lipopolysaccharides; Lung; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Pneumonia; RNA, Long Noncoding; Signal Transduction; Umbilical Cord	2019
FTY720 Effects on Inflammation and Liver Damage in a Rat Model of Renal Ischemia-Reperfusion Injury. Mediators of inflammation, 2019, Volume: 2019 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Inflammation; Kidney; Kidney Diseases; Liver; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Transcription Factor AP-1	2019
FTY720 attenuates iron deposition and glial responses in improving delayed lesion and long-term outcomes of collagenase-induced intracerebral hemorrhage. Brain research, 2019, 09-01, Volume: 1718 Topics: Animals; Brain; Brain Injuries; Cerebral Hemorrhage; Disease Models, Animal; Fingolimod Hydrochloride; Gliosis; Inflammation; Iron; Male; Mice; Mice, Inbred ICR; Neuroglia; Neuroprotective Agents	2019
Chronic inflammation, cognitive impairment, and distal brain region alteration following intracerebral hemorrhage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:8 Topics: Aminopyridines; Animals; Brain; Cerebral Hemorrhage; Cognition; Cognitive Dysfunction; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroimaging; Neuronal Plasticity; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2019
The Sphingosine-1-Phosphate Receptor Modulator Fingolimod Aggravates Murine Epidermolysis Bullosa Acquisita. The Journal of investigative dermatology, 2019, Volume: 139, Issue:11 Topics: Animals; Autoantibodies; Autoimmune Diseases; Cells, Cultured; Collagen Type VII; Disease Models, Animal; Epidermolysis Bullosa Acquisita; Fingolimod Hydrochloride; Forkhead Transcription Factors; Humans; Inflammation; Interleukin-10; Intraepithelial Lymphocytes; Mice; Neutrophils; Skin; Sphingosine-1-Phosphate Receptors; T-Lymphocytes, Regulatory	2019
Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion. Brain research, 2019, 10-01, Volume: 1720 Topics: Animals; Brain Ischemia; Cell Differentiation; Disease Models, Animal; Female; Fingolimod Hydrochloride; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Oligodendrocyte Precursor Cells; Oligodendroglia; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; White Matter	2019
Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease. Scientific reports, 2019, 07-29, Volume: 9, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Disease Models, Animal; Drug Repositioning; Female; Fingolimod Hydrochloride; gamma-Aminobutyric Acid; Mice; Mice, Transgenic; Microglia; Neuroprotective Agents	2019
Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2013, Volume: 33, Issue:2 Topics: Animals; Disease Models, Animal; Female; Fingolimod Hydrochloride; Freund's Adjuvant; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Neuritis, Autoimmune, Experimental; Optic Nerve; Peptide Fragments; Pertussis Toxin; Propylene Glycols; Sphingosine; Statistics, Nonparametric; Visual Acuity	2013
Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. Journal of dermatological science, 2013, Volume: 71, Issue:1 Topics: Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Cell Differentiation; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Imiquimod; Keratinocytes; Local Lymph Node Assay; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, SCID; Propylene Glycols; Psoriasis; Receptors, Lysosphingolipid; Skin; Skin Transplantation; Sphingosine; Sphingosine-1-Phosphate Receptors; Time Factors	2013
FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. PloS one, 2013, Volume: 8, Issue:5 Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Brain; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Mice; Mice, Inbred BALB C; Neurons; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Signal Transduction; Sphingosine; Sulfhydryl Compounds	2013
Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat. Acta anaesthesiologica Scandinavica, 2013, Volume: 57, Issue:6 Topics: Animals; Capillary Leak Syndrome; Capillary Permeability; Cecum; Disease Models, Animal; Diuresis; Drug Evaluation, Preclinical; Edema; Endothelium, Vascular; Fingolimod Hydrochloride; Hematocrit; Hemodynamics; Hemoglobins; Intestinal Perforation; Lysophospholipids; Male; Plasma Volume; Propylene Glycols; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis; Sphingosine	2013
Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: comparison with memantine. Behavioural brain research, 2013, Sep-01, Volume: 252 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fingolimod Hydrochloride; Gene Expression Profiling; Gene Expression Regulation; Hippocampus; Male; Memantine; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neuroprotective Agents; Peptide Fragments; Propylene Glycols; Rats; Rats, Sprague-Dawley; Sex Factors; Sphingosine	2013
FTY720 attenuates tubulointerstitial inflammation and fibrosis in subtotally nephrectomized rats. Renal failure, 2013, Volume: 35, Issue:7 Topics: Animals; Cell Movement; Chemokine CCL2; Disease Models, Animal; Fibrosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Interleukin-6; Kidney Tubules; Lymphocytes; Male; Nephrectomy; Nephritis, Interstitial; Propylene Glycols; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Sphingosine; Transforming Growth Factor beta1; Treatment Outcome; Tumor Necrosis Factor-alpha	2013
FTY720 prevents progression of renal fibrosis by inhibiting renal microvasculature endothelial dysfunction in a rat model of chronic kidney disease. Journal of molecular histology, 2013, Volume: 44, Issue:6 Topics: Animals; Collagen Type IV; Disease Models, Animal; Disease Progression; Endothelial Cells; Fibronectins; Fibrosis; Fingolimod Hydrochloride; Gene Expression Regulation; Kidney; Kidney Glomerulus; Male; Microvessels; Nitric Oxide; Nitric Oxide Synthase Type III; Propylene Glycols; Rats; Renal Insufficiency, Chronic; Sphingosine; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A	2013
Efficacy of combination treatment with fingolimod (FTY720) plus pathogenic autoantigen in a glucose-6-phosphate isomerase peptide (GPI325-339)-induced arthritis mouse model. Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:11 Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Disease Models, Animal; Drug Therapy, Combination; Fingolimod Hydrochloride; Glucose-6-Phosphate Isomerase; Immunoglobulin G; Immunosuppressive Agents; Joints; Male; Mice; Mice, Inbred DBA; Peptides; Propylene Glycols; Sphingosine; Treatment Outcome	2013
Role of the sphingosine metabolism pathway on neurons against experimental cerebral ischemia in rats. Translational stroke research, 2013, Volume: 4, Issue:5 Topics: Animals; Brain Ischemia; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Male; Neurons; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats; Rats, Sprague-Dawley; Sphingosine	2013
FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease. Human molecular genetics, 2014, May-01, Volume: 23, Issue:9 Topics: Animals; Brain; Cell Line; Disease Models, Animal; Fingolimod Hydrochloride; Huntington Disease; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Transgenic; Neurodegenerative Diseases; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Real-Time Polymerase Chain Reaction; Sphingosine	2014
FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Critical care medicine, 2014, Volume: 42, Issue:3 Topics: Acute Lung Injury; Animals; Arrestins; beta-Arrestins; Bleomycin; Blotting, Western; Capillary Permeability; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Fingolimod Hydrochloride; Fluorescent Antibody Technique; Humans; Mice; Mice, Inbred C57BL; Propylene Glycols; Random Allocation; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Sensitivity and Specificity; Sphingosine	2014
Investigation of immune and CNS-mediated effects of fingolimod in the focal delayed-type hypersensitivity multiple sclerosis model. Neuropharmacology, 2014, Volume: 79 Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Disease Models, Animal; Disease Progression; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocytes; Macrophages; Male; Microglia; Multiple Sclerosis; Propylene Glycols; Rats; Rats, Inbred Lew; Sphingosine	2014
Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage. Brain research, 2014, Mar-25, Volume: 1555 Topics: Animals; Apoptosis; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Fingolimod Hydrochloride; Hematoma; Male; Mice; Neuroprotective Agents; Propylene Glycols; Sphingosine; Weight Loss	2014
The immunosuppressant FTY720 prolongs survival in a mouse model of diet-induced coronary atherosclerosis and myocardial infarction. Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:2 Topics: Animals; Apolipoproteins E; Cardiotonic Agents; Coronary Artery Disease; Diet, High-Fat; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Propylene Glycols; Sphingosine; Survival Rate; T-Lymphocytes, Regulatory; Time Factors; Transforming Growth Factor beta; Ventricular Function, Left	2014
Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes. Journal of molecular medicine (Berlin, Germany), 2014, Volume: 92, Issue:7 Topics: Animals; Antibodies; Cell Proliferation; Cytokines; Diabetes Mellitus, Type 1; Disease Models, Animal; Drug Therapy, Combination; Fingolimod Hydrochloride; Hyperglycemia; Immunosuppressive Agents; Insulin-Secreting Cells; Lymph Nodes; Macrophages; Microscopy, Electron, Transmission; Propylene Glycols; Rats; Receptors, Antigen, T-Cell; Sphingosine; T-Lymphocytes	2014
Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction. The Journal of urology, 2014, Volume: 191, Issue:5 Suppl Topics: Animals; Blotting, Western; Disease Models, Animal; Female; Fibrosis; Fingolimod Hydrochloride; Immunohistochemistry; Immunosuppressive Agents; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Propylene Glycols; Sphingosine; Transforming Growth Factor beta1; Ureteral Obstruction	2014
FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells. Inflammation, 2014, Volume: 37, Issue:4 Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Movement; Disease Models, Animal; Fibrosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Liver Cirrhosis; Mesenchymal Stem Cells; Mice; Mice, Inbred ICR; Mice, SCID; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Wound Healing	2014
FTY720 protects retinal ganglion cells in experimental glaucoma. Investigative ophthalmology & visual science, 2014, Apr-17, Volume: 55, Issue:5 Topics: Animals; Blotting, Western; Disease Models, Animal; Fingolimod Hydrochloride; Glaucoma; Immunohistochemistry; Injections, Intraperitoneal; Male; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Night Vision; Ocular Hypertension; Optic Disk; Phosphatidylinositol 3-Kinase; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Retina; Retinal Ganglion Cells; Sensory Thresholds; Sphingosine	2014
An approach to control relapse of inflammatory lesions after discontinuation of primary therapy. PloS one, 2014, Volume: 9, Issue:5 Topics: Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Cell Differentiation; Disease Models, Animal; Female; Fingolimod Hydrochloride; Herpesvirus 1, Human; Immunosuppressive Agents; Interleukin-6; Keratitis, Herpetic; Mice; Mice, Knockout; Propylene Glycols; Receptors, Lysosphingolipid; Recurrence; Secondary Prevention; Sphingosine; T-Lymphocyte Subsets	2014
Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations. Scientific reports, 2014, May-23, Volume: 4 Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Inbred C57BL; Motor Activity; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Vocalization, Animal	2014
FTY720 attenuates paraquat-induced lung injury in mice. International immunopharmacology, 2014, Volume: 21, Issue:2 Topics: Actins; Acute Lung Injury; Animals; Body Weight; Bronchoalveolar Lavage Fluid; Collagen Type I; Collagen Type III; Disease Models, Animal; Fingolimod Hydrochloride; Interleukin-1beta; Interleukin-6; Lung; Lung Injury; Mice; Mice, Inbred C57BL; Paraquat; Propylene Glycols; Pulmonary Edema; Pulmonary Fibrosis; Sphingosine; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A	2014
Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures. PloS one, 2014, Volume: 9, Issue:6 Topics: Animals; Cerebellum; Coculture Techniques; Cytokines; Demyelinating Diseases; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation Mediators; Mice; Mice, Transgenic; Myelin-Oligodendrocyte Glycoprotein; Phenotype; Propylene Glycols; Sphingosine; Spleen; T-Lymphocytes; Tissue Culture Techniques	2014
FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation. Journal of neuroimmunology, 2014, Sep-15, Volume: 274, Issue:1-2 Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Disease Models, Animal; Encephalitis; Fingolimod Hydrochloride; Flow Cytometry; Immunosuppressive Agents; Lymphopenia; Mice; Mice, Inbred C57BL; Propylene Glycols; Signal Transduction; Sphingosine; T-Lymphocytes; Treatment Outcome	2014
The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. Cellular & molecular immunology, 2015, Volume: 12, Issue:6 Topics: Animals; Bone Marrow Transplantation; Cell Movement; Chemokine CCL2; Chemokine CCL7; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression Regulation; Graft vs Host Disease; Human Umbilical Vein Endothelial Cells; Humans; Immunosuppressive Agents; Indans; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Monocytes; Oxadiazoles; Receptors, Lysosphingolipid; Severity of Illness Index; Signal Transduction; T-Lymphocytes; Whole-Body Irradiation	2015
Fingolimod affects gene expression profile associated with LPS-induced memory impairment. Experimental brain research, 2014, Volume: 232, Issue:11 Topics: Animals; Avoidance Learning; Brain; Caspase 3; Dark Adaptation; Disease Models, Animal; Drug Administration Routes; Drug Administration Schedule; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Immunosuppressive Agents; Interleukin-1beta; Lipopolysaccharides; Male; Memory Disorders; Nerve Tissue Proteins; Propylene Glycols; Rats; Rats, Wistar; Sphingosine; Transcriptome; Tumor Necrosis Factor-alpha	2014
FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. Journal of neuroinflammation, 2014, Aug-20, Volume: 11 Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Central Nervous System; Demyelinating Diseases; Disease Models, Animal; Encephalitis, Viral; Fingolimod Hydrochloride; Green Fluorescent Proteins; Immunosuppressive Agents; Lymph Nodes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Murine hepatitis virus; Nerve Tissue Proteins; Propylene Glycols; Severity of Illness Index; Sphingosine; T-Lymphocytes, Cytotoxic; Virus Replication	2014
Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance. Journal of neuroimmunology, 2014, Nov-15, Volume: 276, Issue:1-2 Topics: Animals; Antigens, CD; Central Nervous System; Disease Models, Animal; Fingolimod Hydrochloride; Glatiramer Acetate; Immunologic Surveillance; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Peptides; Propylene Glycols; Sphingosine; Toxoplasmosis	2014
FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling. BMC cancer, 2014, Oct-25, Volume: 14 Topics: Animals; Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Fingolimod Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Metastasis; Phosphorylation; Propylene Glycols; Signal Transduction; Sphingosine; STAT3 Transcription Factor; Tumor Burden; Xenograft Model Antitumor Assays	2014
ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. PloS one, 2014, Volume: 9, Issue:10 Topics: Animals; Benzimidazoles; Blood Pressure; Bronchoconstriction; Cell Line; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Heart Rate; Lymphocytes; Male; Mice; Oxadiazoles; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine	2014
FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. Acta pharmacologica Sinica, 2014, Volume: 35, Issue:12 Topics: Acetylglucosaminidase; Albuminuria; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Down-Regulation; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation Mediators; Kidney Tubules; Lymphocytes; Lysophospholipids; Macrophages; Male; Nephritis, Interstitial; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats, Wistar; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Time Factors	2014
Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier. PLoS pathogens, 2014, Volume: 10, Issue:12 Topics: Animals; Blood-Brain Barrier; CD8-Positive T-Lymphocytes; Cerebral Cortex; Claudin-5; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Macrophages; Malaria, Cerebral; Mice; Neutrophils; Occludin; Plasmodium berghei; Plasmodium yoelii; Propylene Glycols; Sphingosine; Zonula Occludens-1 Protein	2014
In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015, Volume: 56, Issue:2 Topics: Animals; Autoradiography; BCG Vaccine; Carrier Proteins; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Freund's Adjuvant; Immunohistochemistry; Immunosuppressive Agents; Inflammation; Ligands; Male; Microglia; Multiple Sclerosis; Positron-Emission Tomography; Propylene Glycols; Rats; Rats, Inbred Lew; Receptors, GABA-A; Sphingosine; Time Factors	2015
Protective role of fingolimod (FTY720) in rats subjected to subarachnoid hemorrhage. Journal of neuroinflammation, 2015, Jan-27, Volume: 12 Topics: Analysis of Variance; Animals; Brain; Cell Count; Cerebrovascular Circulation; Disease Models, Animal; Fingolimod Hydrochloride; Leukocytes; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Time Factors	2015
FTY720 attenuates excitotoxicity and neuroinflammation. Journal of neuroinflammation, 2015, May-08, Volume: 12 Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Brain Diseases; Cell Death; Cells, Cultured; Cerebellum; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fingolimod Hydrochloride; In Vitro Techniques; Kainic Acid; L-Lactate Dehydrogenase (Cytochrome); Male; N-Methylaspartate; Neurons; Organ Culture Techniques; Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors	2015
Functional Mechanism(s) of the Inhibition of Disease Progression by Combination Treatment with Fingolimod Plus Pathogenic Antigen in a Glucose-6-phosphate Isomerase Peptide-Induced Arthritis Mouse Model. Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:8 Topics: Animals; Antigens; Arthritis, Experimental; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Combined Modality Therapy; Disease Models, Animal; Disease Progression; Fingolimod Hydrochloride; Glucose-6-Phosphate Isomerase; Immune Tolerance; Immunosuppressive Agents; Male; Mice, Inbred DBA; Peptides; T-Lymphocytes, Regulatory	2015
Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats. Disease models & mechanisms, 2015, Aug-01, Volume: 8, Issue:8 Topics: Animals; Antibodies; Biomarkers; Clodronic Acid; Collagen Type III; Disease Models, Animal; Doxorubicin; Fibrosis; Fingolimod Hydrochloride; Inflammation; Kidney Diseases; Kidney Tubules; Leukocyte Count; Liposomes; Lymphangiogenesis; Lymphatic Vessels; Macrophages; Male; Myofibroblasts; Proteinuria; Rats, Wistar; RNA, Messenger; T-Lymphocytes; Vascular Endothelial Growth Factor Receptor-3	2015
Enhanced osseous integration of human trabecular allografts following surface modification with bioactive lipids. Drug delivery and translational research, 2016, Volume: 6, Issue:2 Topics: Animals; Bone Regeneration; Bone Transplantation; Cancellous Bone; Disease Models, Animal; Extracellular Matrix; Fingolimod Hydrochloride; Fractures, Bone; Humans; Mice; Rats; Skull; Tibia; Transplantation, Homologous	2016
IL-17-Producing Vγ4+ γδ T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions. Journal of immunology (Baltimore, Md. : 1950), 2015, Aug-15, Volume: 195, Issue:4 Topics: Animals; Cell Movement; Dermatitis; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Homeostasis; Immunosuppressive Agents; Inflammation; Interleukin-17; Lymph Nodes; Male; Mice; Proprotein Convertases; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Lysosphingolipid; Serine Endopeptidases; T-Lymphocyte Subsets; Toll-Like Receptor 7; Toll-Like Receptor 8	2015
FTY720 ameliorates Dry Eye Disease in NOD mice: Involvement of leukocytes inhibition and goblet cells regeneration in ocular surface tissue. Experimental eye research, 2015, Volume: 138 Topics: Animals; Cell Count; Conjunctiva; Cyclosporine; Disease Models, Animal; Dry Eye Syndromes; Enzyme-Linked Immunosorbent Assay; Fingolimod Hydrochloride; Goblet Cells; Immunohistochemistry; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lacrimal Apparatus; Leukocytes; Male; Mice; Mice, Inbred NOD; Real-Time Polymerase Chain Reaction; Regeneration; RNA, Messenger; Tears; Tumor Necrosis Factor-alpha	2015
Fingolimod does not enhance cerebellar remyelination in the cuprizone model. Journal of neuroimmunology, 2015, Aug-15, Volume: 285 Topics: Animals; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Propylene Glycols; Sphingosine	2015
Immunomodulation by splenectomy or by FTY720 protects the heart against ischemia reperfusion injury. Clinical and experimental pharmacology & physiology, 2015, Volume: 42, Issue:11 Topics: Animals; Chemotaxis; Cytoprotection; Disease Models, Animal; Fingolimod Hydrochloride; Hemodynamics; Immunity, Innate; Immunosuppressive Agents; Male; Mice, Inbred C57BL; Monocytes; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phagocytosis; Splenectomy; Time Factors	2015
Enhanced remyelination following lysolecithin-induced demyelination in mice under treatment with fingolimod (FTY720). Neuroscience, 2015, Dec-17, Volume: 311 Topics: Animals; Corpus Callosum; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophosphatidylcholines; Male; Mice, Inbred C57BL; Myelin Sheath; Neural Stem Cells; Neuroprotective Agents; Oligodendroglia	2015
AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis. PloS one, 2015, Volume: 10, Issue:10 Topics: Animals; Capillary Permeability; Cell Membrane; CHO Cells; Cricetulus; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Extracellular Signal-Regulated MAP Kinases; Female; Fingolimod Hydrochloride; Heart Rate; Lymphocyte Count; Multiple Sclerosis; Proteolysis; Proto-Oncogene Proteins c-akt; Rats; Receptors, Lysosphingolipid; T-Lymphocyte Subsets	2015
Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice. Allergology international : official journal of the Japanese Society of Allergology, 2016, Volume: 65, Issue:2 Topics: Animals; Dermatitis, Atopic; Dermatophagoides farinae; Disease Models, Animal; Female; Filaggrin Proteins; Fingolimod Hydrochloride; Immunoglobulin E; Immunologic Factors; Immunosuppressive Agents; Intermediate Filament Proteins; Mice; Ointments; Tacrolimus	2016
Effect of a new drug releasing system on microencapsulated islet transplantation. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:10 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Carriers; Fingolimod Hydrochloride; Flow Cytometry; Graft Survival; Graphite; Immunohistochemistry; Immunosuppressive Agents; Islets of Langerhans Transplantation; Lymphocyte Count; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; T-Lymphocytes; Transplantation, Heterologous	2015
Effects of FTY720 on peripheral blood lymphocytes and graft infiltrating cells in a rat model of chronic renal allograft rejection. Transplant immunology, 2016, Volume: 35 Topics: Animals; B-Lymphocytes; Chronic Disease; Disease Models, Animal; Fingolimod Hydrochloride; Graft Rejection; Immunity, Cellular; Immunity, Humoral; Kidney Transplantation; Rats; T-Lymphocytes	2016
Sphingosine-1-Phosphate Receptor Agonist Fingolimod Increases Myocardial Salvage and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Porcine Model of Ischemia/Reperfusion. Circulation, 2016, Mar-08, Volume: 133, Issue:10 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Myocardial Infarction; Myocardial Reperfusion Injury; Receptors, Lysosphingolipid; Salvage Therapy; Swine; Ventricular Remodeling	2016
The sphingosine-1-phosphate receptor 1 binding molecule FTY720 inhibits osteoclast formation in rats with ligature-induced periodontitis. Journal of periodontal research, 2017, Volume: 52, Issue:1 Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Furcation Defects; Immunosuppressive Agents; Ligation; Male; Osteoclasts; Periodontitis; Rats; Rats, Sprague-Dawley; T-Lymphocytes	2017
Topical Application of Fingolimod Perturbs Cutaneous Inflammation. Journal of immunology (Baltimore, Md. : 1950), 2016, 05-01, Volume: 196, Issue:9 Topics: Administration, Topical; Animals; Capillary Permeability; Cell Movement; Cells, Cultured; Cytokines; Dermatitis; Disease Models, Animal; Fingolimod Hydrochloride; Histamine; Humans; Immunoglobulin E; Inflammation Mediators; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Neutrophils; Phosphotransferases (Alcohol Group Acceptor); Skin	2016
Sphingosine-1-phosphate receptor-1 (S1P Mucosal immunology, 2017, Volume: 10, Issue:1 Topics: Animals; Cell Movement; Cells, Cultured; Colitis; Dendritic Cells; Dextran Sulfate; Disease Models, Animal; Endothelium; Fingolimod Hydrochloride; Humans; Immunologic Factors; Immunologic Memory; Indans; Inflammatory Bowel Diseases; Intestines; Lymphocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxadiazoles; Receptors, Lysosphingolipid	2017
Fingolimod (FTY720) improves hippocampal synaptic plasticity and memory deficit in rats following focal cerebral ischemia. Brain research bulletin, 2016, Volume: 124 Topics: Animals; Avoidance Learning; Brain Infarction; Disease Models, Animal; Fingolimod Hydrochloride; Hippocalcin; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Long-Term Potentiation; Lymphocytes; Male; Memory Disorders; Neurologic Examination; Neuronal Plasticity; Neutrophils; Rats; Rats, Sprague-Dawley; Reperfusion; Time Factors	2016
Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer's disease. Scientific reports, 2016, 04-27, Volume: 6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Brain; Disease Models, Animal; Fingolimod Hydrochloride; Mice; Treatment Outcome	2016
Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Scientific reports, 2016, 06-09, Volume: 6 Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Fingolimod Hydrochloride; Heart; Humans; Inflammation; Lipopolysaccharides; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocardium; Peptidoglycan; Phosphatidylinositol 3-Kinases; Phosphorylation; Pilot Projects; Receptors, Lysosphingolipid; Sepsis; Sphingosine	2016
Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling. Journal of neuroinflammation, 2016, 06-10, Volume: 13, Issue:1 Topics: Animals; Benzoxazoles; Cyclic AMP; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Forkhead Transcription Factors; Gene Expression Regulation; Homeodomain Proteins; Immunosuppressive Agents; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Regeneration; Neural Conduction; Neurofilament Proteins; Piperazines; Sciatic Neuropathy; Signal Transduction	2016
Effects of fingolimod administration in a genetic model of cognitive deficits. Journal of neuroscience research, 2017, Volume: 95, Issue:5 Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Dysbindin; Enzyme-Linked Immunosorbent Assay; Fingolimod Hydrochloride; Gene Expression Regulation; Immunosuppressive Agents; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Social Behavior; Synaptosomes	2017
Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2016, Volume: 13, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Animals; Body Weight; Brain; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Mice, Transgenic; Movement Disorders; Mutation; Nitric Oxide Synthase Type II; Spinal Cord; Superoxide Dismutase	2016
Fingolimod hydrochloride gel shows promising therapeutic effects in a mouse model of atopic dermatitis. The Journal of pharmacy and pharmacology, 2016, Volume: 68, Issue:10 Topics: Administration, Cutaneous; Animals; Dermatitis, Atopic; Disease Models, Animal; Female; Fingolimod Hydrochloride; Gels; Mice; Mice, Hairless; Severity of Illness Index; Skin	2016
FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. Molecular cancer therapeutics, 2016, Volume: 15, Issue:10 Topics: Animals; Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Fingolimod Hydrochloride; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Mice; Neovascularization, Pathologic; Oxygen Consumption; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Vascular Endothelial Growth Factor A; Vascular Remodeling; Xenograft Model Antitumor Assays	2016
Fingolimod (FTY720) Reduces Cortical Infarction and Neurological Deficits During Ischemic Stroke Through Potential Maintenance of Microvascular Patency. Current neurovascular research, 2016, Volume: 13, Issue:4 Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Fingolimod Hydrochloride; Infarction, Middle Cerebral Artery; Male; Mice, Inbred C57BL; Microvessels; Stroke	2016
FTY720-Induced Lymphopenia Does Not Aggravate Mortality in a Murine Model of Polymicrobial Abdominal Sepsis. Shock (Augusta, Ga.), 2017, Volume: 47, Issue:3 Topics: Animals; Disease Models, Animal; Female; Fingolimod Hydrochloride; Flow Cytometry; Lymphopenia; Mice; Mice, Inbred C57BL; Peritonitis; Sepsis	2017
Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia, 2017, Volume: 31, Issue:3 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Fingolimod Hydrochloride; Humans; Leukemia; Mice; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Xenograft Model Antitumor Assays	2017
Blockage of Central Sphingosine-1-phosphate Receptor does not Abolish the Protective Effect of FTY720 in Early Brain Injury after Experimental Subarachnoid Hemorrhage. Current drug delivery, 2017, Sep-06, Volume: 14, Issue:6 Topics: Animals; Brain; Brain Edema; Disease Models, Animal; Fingolimod Hydrochloride; Male; Neuroprotective Agents; Phosphoserine; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Subarachnoid Hemorrhage	2017
Impact of Minocycline on Extracellular Matrix Metalloproteinase Inducer, a Factor Implicated in Multiple Sclerosis Immunopathogenesis. Journal of immunology (Baltimore, Md. : 1950), 2016, 11-15, Volume: 197, Issue:10 Topics: Animals; Anti-Bacterial Agents; Basigin; Central Nervous System; Clinical Trials, Phase III as Topic; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Fumarates; Humans; Interferon-beta; Lymphocyte Activation; Maleates; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Minocycline; Monocytes; Multiple Sclerosis; T-Lymphocytes; Tissue Inhibitor of Metalloproteinase-1	2016
Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. Acta haematologica, 2017, Volume: 137, Issue:1 Topics: Adenosine Diphosphate; Animals; Anticoagulants; Arteriovenous Shunt, Surgical; Biomimetic Materials; Blood Platelets; Carotid Artery, Common; Chlorides; Disease Models, Animal; Ferric Compounds; Fibrinolytic Agents; Fingolimod Hydrochloride; Humans; Lysophospholipids; Male; Platelet Aggregation; Platelet Function Tests; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thrombosis; Vena Cava, Inferior	2017
Inhibition of Sphingosine-1-phosphate receptors in ischemia reperfusion injured autoimmunity-prone mice. Cellular immunology, 2017, Volume: 311 Topics: Animals; Autoimmunity; Blood Vessels; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cultured; Cytokines; Disease Models, Animal; Disease Susceptibility; Fingolimod Hydrochloride; Gene Expression Regulation; Humans; Immunosuppressive Agents; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Neutrophils; Receptors, Lysosphingolipid; Reperfusion Injury; Sphingosine-1-Phosphate Receptors	2017
Adverse Effect Profile of Topical Ocular Administration of Fingolimod for Treatment of Dry Eye Disease. Basic & clinical pharmacology & toxicology, 2017, Volume: 120, Issue:4 Topics: Animals; Cornea; Corneal Neovascularization; Disease Models, Animal; Dose-Response Relationship, Drug; Dry Eye Syndromes; Fingolimod Hydrochloride; Leukocytes; Mice, Inbred BALB C; Ophthalmic Solutions; Retina	2017
FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models. Neurochemical research, 2017, Volume: 42, Issue:2 Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Humans; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Oxidopamine; Parkinsonian Disorders	2017
Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis. American journal of physiology. Gastrointestinal and liver physiology, 2017, Mar-01, Volume: 312, Issue:3 Topics: Animals; Diet, High-Fat; Disease Models, Animal; Fingolimod Hydrochloride; Hepatocytes; Hepatomegaly; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Receptors, Lysosphingolipid; Signal Transduction; Triglycerides	2017
Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension. Cardiovascular research, 2017, Volume: 113, Issue:2 Topics: Adoptive Transfer; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Bone Marrow Transplantation; Cell Movement; Disease Models, Animal; Fingolimod Hydrochloride; Genetic Predisposition to Disease; Hypertension; Inflammation Mediators; Lymph Nodes; Lysophospholipids; Mesenteric Arteries; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; T-Lymphocytes; Time Factors; Vascular Remodeling	2017
FcRγ-dependent immune activation initiates astrogliosis during the asymptomatic phase of Sandhoff disease model mice. Scientific reports, 2017, 01-13, Volume: 7 Topics: Animals; Astrocytes; beta-Hexosaminidase beta Chain; Cerebral Cortex; Disease Models, Animal; Fingolimod Hydrochloride; G(M2) Ganglioside; Gliosis; Heterozygote; Immunity; Immunosuppressive Agents; Mice, Inbred C57BL; Motor Activity; Phenotype; Receptors, Fc; Sandhoff Disease; Up-Regulation; Walking	2017
Effect of Fingolimod on Neural Stem Cells: A Novel Mechanism and Broadened Application for Neural Repair. Molecular therapy : the journal of the American Society of Gene Therapy, 2017, 02-01, Volume: 25, Issue:2 Topics: Animals; Cell Differentiation; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Extracellular Signal-Regulated MAP Kinases; Fingolimod Hydrochloride; Humans; Mice; Multiple Sclerosis; Myelin Sheath; Nerve Regeneration; Neural Stem Cells; Oligodendroglia; Receptors, Lysosphingolipid; Signal Transduction; Stem Cell Transplantation; Treatment Outcome	2017
Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism. Life sciences, 2017, Mar-15, Volume: 173 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autistic Disorder; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Inflammation; Interleukin-1beta; Interleukin-6; Learning; Male; Malondialdehyde; Memory Disorders; Oxidative Stress; Oxidoreductases; Pyramidal Cells; Rats; Rats, Wistar; Social Behavior	2017
FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis. The journal of sexual medicine, 2017, Volume: 14, Issue:3 Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Erectile Dysfunction; Fibrosis; Fingolimod Hydrochloride; Male; Penile Erection; Random Allocation; Rats; Rats, Sprague-Dawley; Streptozocin	2017
FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model. Journal of translational medicine, 2017, 03-15, Volume: 15, Issue:1 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Fingolimod Hydrochloride; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mice; Protein Phosphatase 2; Tumor Suppressor Proteins	2017
FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage. Brain pathology (Zurich, Switzerland), 2009, Volume: 19, Issue:2 Topics: Animals; Antigens; Blood-Brain Barrier; Blotting, Western; Brain; Capillary Permeability; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Immunization; Immunosuppressive Agents; Myelin Proteins; Phospholipases A2, Cytosolic; Polymerase Chain Reaction; Propylene Glycols; Random Allocation; Rats; Sphingosine; Spinal Cord	2009
Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease. Archives of ophthalmology (Chicago, Ill. : 1960), 2008, Volume: 126, Issue:10 Topics: Administration, Oral; Animals; Autoimmune Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Emergency Treatment; Female; Fingolimod Hydrochloride; Immunohistochemistry; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Propylene Glycols; Random Allocation; Reference Values; Retinitis; Sensitivity and Specificity; Sphingosine; Treatment Outcome; Uveitis	2008
Distribution of Foxp3(+) T-regulatory cells in experimental autoimmune neuritis rats. Experimental neurology, 2009, Volume: 216, Issue:1 Topics: Animals; Cell Proliferation; Disease Models, Animal; Down-Regulation; Fingolimod Hydrochloride; Forkhead Transcription Factors; Immunity, Cellular; Immunosuppressive Agents; Lymph Nodes; Lymphocyte Activation; Lymphocyte Count; Lymphoid Tissue; Male; Neuritis, Autoimmune, Experimental; Polyradiculoneuropathy; Propylene Glycols; Rats; Rats, Inbred Lew; Sciatic Nerve; Sphingosine; Spleen; T-Lymphocytes, Regulatory	2009
Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720. Pathology oncology research : POR, 2009, Volume: 15, Issue:4 Topics: Adenoma; Animals; Apoptosis; Caspase 3; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Lung; Lung Neoplasms; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Proliferating Cell Nuclear Antigen; Propylene Glycols; Sphingosine; Urethane	2009
Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice. Cell biology international, 2009, Volume: 33, Issue:4 Topics: Allergens; Ambrosia; Animals; Conjunctivitis, Allergic; Disease Models, Animal; Eosinophils; Fingolimod Hydrochloride; Immunosuppressive Agents; Macrophages; Mice; Mice, Inbred BALB C; Propylene Glycols; Sphingosine; T-Lymphocytes	2009
The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy. American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:1 Topics: Animals; Blood Pressure; Cell Movement; Cell Proliferation; Disease Models, Animal; Extracellular Matrix; Fibrosis; Fingolimod Hydrochloride; Hypertension; Immunosuppressive Agents; Kidney; Kidney Diseases; Lymphocytes; Macrophages; Male; Nephrectomy; Propylene Glycols; Proteinuria; Rats; Rats, Wistar; Sphingosine; Transforming Growth Factor beta	2009
Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:3 Topics: Administration, Oral; Albuminuria; Animals; Blood Pressure; Body Weight; Chemokine CCL2; Chemokine CCL5; Chemokines; Creatinine; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Fibronectins; Fibrosis; Fingolimod Hydrochloride; Gene Expression Regulation; Immunosuppressive Agents; Inflammation Mediators; Kidney; Kidney Failure, Chronic; Lymphocytes; Macrophages; Male; Nephrectomy; Nephritis; Phenotype; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, CCR1; Receptors, CCR2; Receptors, CCR5; Sphingosine; Time Factors; Transforming Growth Factor beta1	2009
FTY720 reduces inflammation and promotes functional recovery after spinal cord injury. Journal of neurotrauma, 2009, Volume: 26, Issue:12 Topics: Animals; Autoimmunity; Chemotaxis, Leukocyte; Demyelinating Autoimmune Diseases, CNS; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Immunosuppressive Agents; Lymphocyte Activation; Myelitis; Nerve Fibers, Myelinated; Nerve Regeneration; Paralysis; Propylene Glycols; Rats; Rats, Long-Evans; Recovery of Function; Sphingosine; Spinal Cord Injuries; T-Lymphocytes; Treatment Outcome; Urinary Bladder, Neurogenic; Wallerian Degeneration	2009
Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2. Stroke, 2009, Volume: 40, Issue:10 Topics: Animals; Arterioles; Brain Edema; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Fingolimod Hydrochloride; Hypoxia-Ischemia, Brain; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Lysophospholipids; Male; Mice; Microcirculation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Reperfusion Injury; RNA, Messenger; Sphingosine	2009
FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses. Journal of neuroscience research, 2010, Feb-01, Volume: 88, Issue:2 Topics: Animals; Autoantibodies; Axons; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Gene Expression; Immunosuppressive Agents; Lymphocytes; Multiple Sclerosis; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Propylene Glycols; Rats; Rats, Inbred Strains; Recombinant Proteins; Severity of Illness Index; Sphingosine; Spinal Cord; Time Factors	2010
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. Journal of molecular and cellular cardiology, 2010, Volume: 48, Issue:2 Topics: Animals; Animals, Newborn; Arrhythmias, Cardiac; Disease Models, Animal; Enzyme Activation; Fingolimod Hydrochloride; Gene Expression Regulation; In Vitro Techniques; Intracellular Space; Male; p21-Activated Kinases; Pertussis Toxin; Phosphorylation; Propylene Glycols; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Reperfusion Injury; RNA, Messenger; Signal Transduction; Sinoatrial Node; Sphingosine; Time Factors; Ultrasonography	2010
T-cell activation in ischemic stroke: a new therapeutic target for delayed infarct expansion? Neurosurgery, 2009, Volume: 65, Issue:6 Topics: Animals; Brain Infarction; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Interleukin-17; Interleukin-23; Mice; Mice, Knockout; Propylene Glycols; Sphingosine; T-Lymphocytes	2009
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke, 2010, Volume: 41, Issue:2 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Fingolimod Hydrochloride; Immunosuppressive Agents; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Nerve Degeneration; Neuroprotective Agents; Oxadiazoles; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Stroke; Thiophenes; Treatment Outcome	2010
Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. American journal of respiratory and critical care medicine, 2010, Feb-15, Volume: 181, Issue:4 Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Ceramides; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Indoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Propylene Glycols; Pulmonary Alveoli; Pulmonary Emphysema; Pyrroles; Receptors, Lysosphingolipid; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sphingosine	2010
United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2010, Volume: 40, Issue:3 Topics: Animals; Asthma; Disease Models, Animal; Female; Fingolimod Hydrochloride; Inflammation; Mice; Mice, Inbred BALB C; Ovalbumin; Propylene Glycols; Rhinitis, Allergic, Perennial; Sphingosine; Th2 Cells	2010
Evaluation of experimental autoimmune uveitis in mice treated with FTY720. Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:5 Topics: Animals; Autoimmune Diseases; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cell Movement; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Proteins; Fingolimod Hydrochloride; Flow Cytometry; Immunoglobulin G; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Intubation, Gastrointestinal; Lymph Nodes; Mice; Peptide Fragments; Propylene Glycols; Retinol-Binding Proteins; Sphingosine; T-Lymphocytes, Regulatory; Uveitis, Posterior	2010
Effects of different dose of FTY720 on lymphocyte cell cycle arrest in cardiac transplantation model of rats. Immunopharmacology and immunotoxicology, 2010, Volume: 32, Issue:4 Topics: Animals; Blood; Cell Cycle; Cell Division; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Interphase; Lymph Nodes; Lymphocyte Count; Lymphocytes; Lymphopenia; Male; Propylene Glycols; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sphingosine; Thymus Gland	2010
Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. Journal of the American Society of Nephrology : JASN, 2010, Volume: 21, Issue:6 Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Movement; Disease Models, Animal; Epithelial Cells; Fingolimod Hydrochloride; Homeodomain Proteins; Kidney Tubules, Proximal; Leukocytes; Lipopolysaccharides; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Reperfusion Injury; RNA, Messenger; Signal Transduction; Sphingosine; Thiophenes	2010
Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model. Clinical immunology (Orlando, Fla.), 2010, Volume: 136, Issue:2 Topics: Administration, Oral; Animals; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cell Line; Cytokines; Dinoprostone; Disease Models, Animal; Female; Fingolimod Hydrochloride; Glucans; Humans; Immunosuppressive Agents; Interleukin-4; Mice; Mice, Inbred Strains; Polysaccharides; Propylene Glycols; Specific Pathogen-Free Organisms; Sphingosine; Spleen; Thymus Gland	2010
Arthritis: where are the T cells? Arthritis research & therapy, 2010, Volume: 12, Issue:3 Topics: Animals; Antigens; Arthritis; Arthritis, Experimental; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Joints; Lysophospholipids; Mice; Propylene Glycols; Sphingosine; T-Lymphocytes, Helper-Inducer	2010
Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusion. British journal of pharmacology, 2010, Volume: 160, Issue:5 Topics: Animals; Arrhythmias, Cardiac; Calcium; Disease Models, Animal; Down-Regulation; Fingolimod Hydrochloride; Ischemic Preconditioning, Myocardial; Lymphocyte Count; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Tumor Necrosis Factor-alpha	2010
Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells. Autoimmunity, 2011, Volume: 44, Issue:2 Topics: Adoptive Transfer; Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Fingolimod Hydrochloride; Immunomodulation; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Propylene Glycols; Sphingosine; T-Lymphocytes	2011
FTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in mice. The American journal of pathology, 2010, Volume: 177, Issue:4 Topics: Animals; Blotting, Western; Bone Marrow; Cell Movement; Chemotaxis; Disease Models, Animal; Eosinophils; Female; Fingolimod Hydrochloride; Flow Cytometry; Humans; Immunosuppressive Agents; Inflammation; Interleukin-5; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Propylene Glycols; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin; Skin Diseases; Sphingosine	2010
Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis. Circulation research, 2011, Feb-04, Volume: 108, Issue:3 Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Movement; Cell Proliferation; Disease Models, Animal; Fingolimod Hydrochloride; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Peritonitis; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Thioglycolates	2011
FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proceedings of the National Academy of Sciences of the United States of America, 2011, Jan-11, Volume: 108, Issue:2 Topics: Animals; Astrocytes; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Immunosuppressive Agents; Lymphocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Propylene Glycols; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine	2011
Fingolimod provides long-term protection in rodent models of cerebral ischemia. Annals of neurology, 2011, Volume: 69, Issue:1 Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; In Vitro Techniques; Inflammation; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine; Stroke	2011
Sphingosine 1-phosphate receptor modulator FTY720 suppresses rat experimental autoimmune prostatitis. Scandinavian journal of immunology, 2011, Volume: 73, Issue:6 Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Immunohistochemistry; Immunosuppressive Agents; Male; Propylene Glycols; Prostatitis; Rats; Rats, Inbred Lew; Receptors, Lysosphingolipid; Specific Pathogen-Free Organisms; Sphingosine	2011
Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model. Digestive diseases and sciences, 2011, Volume: 56, Issue:8 Topics: Animals; Antibodies, Monoclonal; Crohn Disease; Diarrhea; Disease Models, Animal; Female; Fingolimod Hydrochloride; Gastrointestinal Agents; Interleukin-12; Interleukin-23; Mice; Mice, Inbred BALB C; Organ Size; Propylene Glycols; Sphingosine; Sulfasalazine; Trinitrobenzenesulfonic Acid; Weight Loss	2011
Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis. The American journal of pathology, 2011, Volume: 178, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cytokines; Disease Models, Animal; Electrophysiology; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Glycoproteins; Immunosuppressive Agents; Myelin Sheath; Neurons; Oligodendroglia; Optic Neuritis; Propylene Glycols; Rats; Sphingosine	2011
FTY720-induced conversion of conventional Foxp3- CD4+ T cells to Foxp3+ regulatory T cells in NOD mice. American journal of reproductive immunology (New York, N.Y. : 1989), 2011, Volume: 66, Issue:5 Topics: Animals; CD4-Positive T-Lymphocytes; Disease Models, Animal; Embryo Loss; Female; Fingolimod Hydrochloride; Forkhead Transcription Factors; Humans; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Pregnancy; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes, Regulatory	2011
FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice. Acta neurochirurgica. Supplement, 2011, Volume: 111 Topics: Analysis of Variance; Animals; Brain Edema; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Fingolimod Hydrochloride; Functional Laterality; Immunosuppressive Agents; Mice; Nervous System Diseases; Neurologic Examination; Propylene Glycols; Psychomotor Performance; Sphingosine; Time Factors	2011
The effect of FTY720 in the Theiler's virus model of multiple sclerosis. Journal of the neurological sciences, 2011, Sep-15, Volume: 308, Issue:1-2 Topics: Animals; Cardiovirus Infections; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Injections, Intraperitoneal; Mice; Multiple Sclerosis; Propylene Glycols; Sphingosine; Theilovirus; Viral Load	2011
Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo. Molecular and cellular neurosciences, 2011, Volume: 48, Issue:1 Topics: Animals; Chelating Agents; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Regeneration; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine	2011
S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis. Molecular pharmacology, 2012, Volume: 81, Issue:2 Topics: Animals; Central Nervous System; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Immunosuppressive Agents; Indans; Lymphopenia; Mice; Multiple Sclerosis; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2012
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation, 2011, Dec-13, Volume: 124, Issue:24 Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Female; Fingolimod Hydrochloride; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; NFATC Transcription Factors; p21-Activated Kinases; Propylene Glycols; Rats; Signal Transduction; Sphingosine; Stress, Physiological	2011
Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics. The Journal of pathology, 2012, Volume: 226, Issue:5 Topics: Adoptive Transfer; Animals; Chemotaxis, Leukocyte; Disease Models, Animal; Fingolimod Hydrochloride; Genes, T-Cell Receptor; Herpes Simplex; Herpesvirus 1, Human; Immunosuppressive Agents; Lymph Nodes; Lymphatic Vessels; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Propylene Glycols; Skin; Sphingosine; T-Lymphocytes; Time Factors	2012
Prevention of GVHD and graft rejection by a new S1P receptor agonist, W-061, in rat small bowel transplantation. Transplant immunology, 2012, Volume: 26, Issue:2-3 Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Intestine, Small; Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes; Time Factors; Transplantation, Homologous	2012
Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways. Cell cycle (Georgetown, Tex.), 2012, Feb-01, Volume: 11, Issue:3 Topics: Animals; Benzopyrenes; Disease Models, Animal; Fingolimod Hydrochloride; Gene Knock-In Techniques; Humans; Immunosuppressive Agents; Lung Neoplasms; Mice; Mice, Knockout; Point Mutation; Propylene Glycols; Protein Phosphatase 2; ras Proteins; Signal Transduction; Sphingosine; Tumor Suppressor Protein p53	2012
Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice. Blood, 2012, Mar-01, Volume: 119, Issue:9 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Immunologic Surveillance; Immunosuppressive Agents; Lymphoma, B-Cell; Mice; Mice, SCID; Mice, Transgenic; Multiple Myeloma; Propylene Glycols; Sphingosine	2012
S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma. Blood, 2012, Aug-16, Volume: 120, Issue:7 Topics: Animals; Apoptosis; B-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Fingolimod Hydrochloride; Gene Silencing; Humans; Lymphocyte Activation; Lymphoma, Large B-Cell, Diffuse; Mice; Neoplasm Invasiveness; Phosphorylation; Propylene Glycols; Receptors, Lysosphingolipid; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; STAT3 Transcription Factor	2012
Effect of FTY720 on some physiological indexes of Non-Obese Diabetic (NOD) Mice. International journal of molecular sciences, 2012, Volume: 13, Issue:5 Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Fingolimod Hydrochloride; Glutamate Decarboxylase; Immunosuppressive Agents; Kidney; Liver; Mice; Mice, Inbred NOD; Propylene Glycols; Sphingosine; Spleen	2012
Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model. Experimental & molecular medicine, 2012, Oct-31, Volume: 44, Issue:10 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Antigens, Differentiation; Carrier Proteins; Cell Size; Diet, High-Fat; Disease Models, Animal; Enzyme Activation; Fingolimod Hydrochloride; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Lipase; Lipolysis; Male; Mice; Mice, Inbred C57BL; Obesity; Perilipin-1; Phosphoproteins; Phosphorylation; Propylene Glycols; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Sphingosine; Sterol Esterase	2012
Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome. Proceedings of the National Academy of Sciences of the United States of America, 2012, Aug-28, Volume: 109, Issue:35 Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cell Death; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; MAP Kinase Signaling System; Methyl-CpG-Binding Protein 2; Mice; Motor Activity; N-Methylaspartate; Neurons; Organ Culture Techniques; Pregnancy; Propylene Glycols; Receptors, Lysosphingolipid; Rett Syndrome; Sphingosine	2012
Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model. Pharmacology, biochemistry, and behavior, 2012, Volume: 103, Issue:2 Topics: Animals; Astrocytes; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Fingolimod Hydrochloride; Hippocampus; Immunohistochemistry; Interleukin-1beta; Lithium Compounds; Male; Pilocarpine; Propylene Glycols; Rats; Rats, Sprague-Dawley; Sphingosine; Status Epilepticus; Tumor Necrosis Factor-alpha	2012
Neuroimmunological blood brain barrier opening in experimental cerebral malaria. PLoS pathogens, 2012, Volume: 8, Issue:10 Topics: Animals; Benzamides; Blood-Brain Barrier; Cerebral Hemorrhage; Disease Models, Animal; Fingolimod Hydrochloride; Imatinib Mesylate; Lipopolysaccharide Receptors; Lymphocyte Function-Associated Antigen-1; Malaria, Cerebral; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Neuroimmunomodulation; Parasitemia; Piperazines; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Propylene Glycols; Pyrimidines; Sphingosine	2012
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models. Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jan-01, Volume: 19, Issue:1 Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Line, Tumor; Cetuximab; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Fingolimod Hydrochloride; Gene Expression; Humans; Mice; Mice, Nude; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Treatment Outcome; Xenograft Model Antitumor Assays	2013
Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model. Allergy, 2013, Volume: 68, Issue:2 Topics: Administration, Topical; Animals; Apoptosis; Disease Models, Animal; Drug Delivery Systems; Eosinophils; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Mast Cells; Mice; Mice, Inbred Strains; Ovalbumin; Propylene Glycols; Random Allocation; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Sensitivity and Specificity; Sphingosine; Th2 Cells	2013
Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage. Experimental neurology, 2013, Volume: 241 Topics: Analysis of Variance; Animals; Basal Ganglia; Behavior, Animal; Blood Transfusion, Autologous; Brain Edema; CD3 Complex; Cell Count; Cerebral Cortex; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Fingolimod Hydrochloride; Forelimb; Functional Laterality; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-17; Leukocytes; Lymphocytes; Male; Maze Learning; Mice; Nervous System Diseases; Propylene Glycols; Psychomotor Disorders; Rats; Rats, Sprague-Dawley; Space Perception; Sphingosine; Time Factors	2013
Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model. Stroke, 2013, Volume: 44, Issue:2 Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Fingolimod Hydrochloride; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Propylene Glycols; Sphingosine; Thromboembolism; Time Factors; Tissue Plasminogen Activator; Treatment Outcome	2013
Effects of mycophenolate sodium with or without FTY720 in a DA-to-Lewis rat heart transplantation model. Transplantation proceedings, 2002, Volume: 34, Issue:7 Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Mycophenolic Acid; Propylene Glycols; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Sphingosine; Time Factors; Transplantation, Homologous	2002
Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:1 Topics: Animals; Apoptosis; Central Nervous System; Central Nervous System Diseases; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Propylene Glycols; Rats; Rats, Inbred Lew; Sphingosine; T-Lymphocytes	2003
Prevention of renal ischemic reperfusion injury using FTY 720 and ICAM-1 antisense oligonucleotides. Transplantation proceedings, 2003, Volume: 35, Issue:4 Topics: Analysis of Variance; Animals; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Kidney Transplantation; Male; Oligonucleotides, Antisense; Propylene Glycols; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Sphingosine; Thionucleotides; Transplantation, Isogeneic	2003
Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720. Journal of immunology (Baltimore, Md. : 1950), 2003, Dec-01, Volume: 171, Issue:11 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bystander Effect; Cell Movement; Disease Models, Animal; Epitopes, T-Lymphocyte; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mice, Transgenic; Propylene Glycols; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Th1 Cells; Th2 Cells	2003
Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. American journal of respiratory and critical care medicine, 2004, Jun-01, Volume: 169, Issue:11 Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Disease Models, Animal; Endothelial Cells; Endotoxins; Fingolimod Hydrochloride; Immunosuppressive Agents; Kidney; Kidney Diseases; Lipopolysaccharides; Lung; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Neutrophils; Organ Size; Perfusion; Peroxidase; Pneumonia; Propylene Glycols; Respiratory Distress Syndrome; Sphingosine; Time Factors	2004
FTY720 impairs necrosis development after ischemia-reperfusion injury. Transplantation proceedings, 2004, Volume: 36, Issue:4 Topics: Analysis of Variance; Animals; Creatinine; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Liver; Mice; Necrosis; Propylene Glycols; Reperfusion Injury; Sphingosine; Urea	2004
Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. Journal of neuroimmunology, 2004, Volume: 153, Issue:1-2 Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Immunosuppressive Agents; Interferon-gamma; Lymphocytes; Lymphopenia; Mice; Mice, Inbred Strains; Mitoxantrone; Molecular Sequence Data; Myelin Proteins; Myelin Proteolipid Protein; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Propylene Glycols; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Time Factors	2004
Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis. Inflammatory bowel diseases, 2004, Volume: 10, Issue:3 Topics: Animals; Apoptosis; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colitis; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Immunosuppressive Agents; Interferon-gamma; Interleukin-10; Lymphocytes; Mice; Mice, Inbred C57BL; Propylene Glycols; Sphingosine; Tissue Distribution	2004
A novel immunomodulator, FTY720, prevents spontaneous dermatitis in NC/Nga mice. Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:9 Topics: Animals; Dermatitis, Atopic; Disease Models, Animal; Epidermis; Fingolimod Hydrochloride; Immunoglobulin E; Immunosuppressive Agents; Male; Mice; Mice, Inbred Strains; Propylene Glycols; Specific Pathogen-Free Organisms; Sphingosine; Time Factors	2004
Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720. Transplantation, 2005, May-15, Volume: 79, Issue:9 Topics: Administration, Oral; Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Mice; Mice, Inbred NOD; Propylene Glycols; Sphingosine	2005
Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720. European journal of immunology, 2005, Volume: 35, Issue:12 Topics: Animals; Cell Movement; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymph Nodes; Lymphoid Tissue; Lymphopenia; Male; Mice; Mice, Inbred C57BL; Models, Biological; Propylene Glycols; Sphingosine; T-Lymphocytes	2005
FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Dec-01, Volume: 11, Issue:23 Topics: Animals; Antigens, CD34; Carcinoma, Hepatocellular; Disease Models, Animal; Down-Regulation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Liver Neoplasms, Experimental; Mice; Mice, Nude; Microcirculation; Neovascularization, Pathologic; Propylene Glycols; rac GTP-Binding Proteins; Sphingosine; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Wound Healing	2005
Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection. Journal of immunology (Baltimore, Md. : 1950), 2006, Jan-01, Volume: 176, Issue:1 Topics: Adoptive Transfer; Animals; Apoptosis; CD4-Positive T-Lymphocytes; Chemotaxis, Leukocyte; Chronic Disease; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Graft Rejection; Heart Transplantation; Immunohistochemistry; Immunologic Memory; Immunosuppressive Agents; Lymphocyte Activation; Mice; Mice, Transgenic; Propylene Glycols; Receptors, Antigen, T-Cell; Skin Transplantation; Sphingosine; Transplantation, Homologous	2006
Use of FTY 720 and ICAM-1 antisense oligonucleotides for attenuating chronic renal damage secondary to ischemia-reperfusion injury. Transplantation proceedings, 2005, Volume: 37, Issue:10 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Intercellular Adhesion Molecule-1; Inulin; Kidney; Kidney Function Tests; Male; Oligonucleotides, Antisense; Propylene Glycols; Rats; Rats, Inbred Lew; Reperfusion Injury; Sphingosine	2005
Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2006, Volume: 6, Issue:3 Topics: Adiponectin; Animals; Disease Models, Animal; Drug Therapy, Combination; Fatty Liver; Fingolimod Hydrochloride; Follow-Up Studies; Graft Rejection; Graft Survival; Immunosuppressive Agents; Liver Transplantation; Male; Propylene Glycols; Rats; Rats, Zucker; Sphingosine; Treatment Outcome	2006
FTY720 for treatment of ischemia-reperfusion injury following complete renal ischemia in C57/BL6 mice. Transplantation proceedings, 2006, Volume: 38, Issue:3 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Injections, Intraperitoneal; Ischemia; Male; Mice; Mice, Inbred C57BL; Propylene Glycols; Renal Circulation; Reperfusion Injury; Sphingosine	2006
Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice. Biochemical and biophysical research communications, 2006, Jun-23, Volume: 345, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Liver; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Sulfhydryl Compounds; Treatment Outcome	2006
The S1P receptor modulator FTY720 prevents the development of experimental colitis in mice. Oncology reports, 2006, Volume: 16, Issue:4 Topics: Animals; CD4-Positive T-Lymphocytes; Cell Transplantation; Colitis; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammatory Bowel Diseases; L-Selectin; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Spleen	2006
Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. The Journal of clinical investigation, 2006, Volume: 116, Issue:11 Topics: Administration, Inhalation; Allergens; Animals; Asthma; Cell Differentiation; Cell Movement; Cell Polarity; Dendritic Cells; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression Regulation; Heart; Lymph Nodes; Lymphocytes; Lysophospholipids; Mice; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2006
The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:3 Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Movement; Cells, Cultured; Cholesterol, Dietary; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression Regulation; Immunohistochemistry; Lysophospholipids; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Probability; Propylene Glycols; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Statistics, Nonparametric	2007
FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation, 2007, Jan-30, Volume: 115, Issue:4 Topics: Animals; Atherosclerosis; Cell Division; Cholesterol, HDL; Cytokines; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocyte Count; Lymphocytes; Lysophospholipids; Macrophages; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Propylene Glycols; Receptors, LDL; Signal Transduction; Sphingosine; Triglycerides	2007
FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells. Journal of immunology (Baltimore, Md. : 1950), 2007, Feb-15, Volume: 178, Issue:4 Topics: Animals; Antigens, CD; Antigens, Differentiation; Aziridines; Cell Differentiation; Choline; Colitis; CTLA-4 Antigen; Cytokines; Disease Models, Animal; Down-Regulation; Fingolimod Hydrochloride; Forkhead Transcription Factors; Immunosuppressive Agents; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Neuromuscular Blocking Agents; Propylene Glycols; Sphingosine; T-Lymphocytes, Regulatory; Th1 Cells	2007
New immunosuppresor strategies in the treatment of murine lupus nephritis. Lupus, 2007, Volume: 16, Issue:1 Topics: Administration, Oral; Animals; Antibodies, Antinuclear; Apoptosis; Autoantigens; Cell Movement; Chromatin; Complement C3; Complement C3 Nephritic Factor; Cyclophosphamide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fingolimod Hydrochloride; Glomerular Mesangium; Immunoglobulin G; Immunosuppressive Agents; Injections, Intraperitoneal; Kidney Glomerulus; Lupus Nephritis; Lymphocytes; Mice; Mice, Inbred NZB; Nucleosomes; Propylene Glycols; Proteinuria; Receptors, Lysosphingolipid; Sirolimus; Sphingosine	2007
FTY720 for treatment of ischemia-reperfusion injury following complete renal ischemia; impact on long-term survival and T-lymphocyte tissue infiltration. Transplantation proceedings, 2007, Volume: 39, Issue:2 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Propylene Glycols; Renal Circulation; Reperfusion Injury; Sphingosine; Survival Analysis; T-Lymphocytes	2007
FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions. Molecular immunology, 2007, Volume: 44, Issue:13 Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Colitis, Ulcerative; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Oxazolone; Propylene Glycols; Sphingosine; Th2 Cells	2007
Long-term effect of FTY720 on lymphocyte count and islet allograft survival in mice. Microsurgery, 2007, Volume: 27, Issue:4 Topics: Animals; Blood Glucose; Cell Movement; Diabetes Mellitus, Experimental; Disease Models, Animal; Fingolimod Hydrochloride; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Lymphocyte Count; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Propylene Glycols; Random Allocation; Sphingosine; Time Factors	2007
Reduction of ischemia-reperfusion injury in the rat kidney by FTY720, a synthetic derivative of sphingosine. Transplantation, 2007, Jul-27, Volume: 84, Issue:2 Topics: Animals; Apoptosis; Cell Proliferation; Creatinine; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Follow-Up Studies; Immunohistochemistry; Immunosuppressive Agents; Kidney; Kidney Transplantation; Male; Proliferating Cell Nuclear Antigen; Propylene Glycols; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sphingosine; Treatment Outcome	2007
FTY720 improves survival after transient ischemia and reperfusion of the hind limbs. The Journal of trauma, 2007, Volume: 63, Issue:2 Topics: Analysis of Variance; Animals; Biomarkers; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Hindlimb; Immunosuppressive Agents; Interleukin-1; Ischemia; Male; Mice; Mice, Inbred C57BL; Peroxidase; Probability; Propylene Glycols; Random Allocation; Reference Values; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Sphingosine; Survival Rate	2007
FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis. Brain research bulletin, 2007, Oct-19, Volume: 74, Issue:5 Topics: Analysis of Variance; Animals; Body Weight; Disease Models, Animal; Electric Stimulation; Encephalomyelitis, Autoimmune, Experimental; Evoked Potentials, Somatosensory; Evoked Potentials, Visual; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Longitudinal Studies; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neural Conduction; Propylene Glycols; Rats; Reaction Time; Sphingosine; Spinal Cord; Time Factors	2007
The thymus is required for the ability of FTY720 to prolong skin allograft survival across different histocompatibility MHC barriers. Transplant international : official journal of the European Society for Organ Transplantation, 2007, Volume: 20, Issue:10 Topics: Animals; Disease Models, Animal; Female; Fingolimod Hydrochloride; Flow Cytometry; Graft Rejection; Graft Survival; Immunosuppressive Agents; Major Histocompatibility Complex; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Propylene Glycols; Skin Transplantation; Sphingosine; Thymus Gland; Transplantation, Homologous; Treatment Outcome	2007
Evaluation of stem cell administration in a model of kidney ischemia-reperfusion injury. International immunopharmacology, 2007, Dec-15, Volume: 7, Issue:13 Topics: Animals; Creatinine; Disease Models, Animal; Fingolimod Hydrochloride; Hematopoietic Stem Cell Transplantation; Kidney; Male; Mice; Mice, Inbred C57BL; Necrosis; Propylene Glycols; Reperfusion Injury; Sphingosine	2007
Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1. Surgery today, 2008, Volume: 38, Issue:1 Topics: Animals; Cell Adhesion Molecules; Disease Models, Animal; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Immunosuppressive Agents; Intestinal Mucosa; Intestine, Small; Mucoproteins; Organ Transplantation; Propylene Glycols; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sphingosine; Transplantation, Homologous	2008
FTY720 reduces extracellular matrix expansion associated with ischemia-reperfusion induced injury. Transplantation proceedings, 2007, Volume: 39, Issue:10 Topics: Animals; Creatinine; Cyclosporine; Disease Models, Animal; Extracellular Matrix; Fingolimod Hydrochloride; Immunosuppressive Agents; Kidney Transplantation; Male; Propylene Glycols; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sphingosine; Transplantation, Homologous	2007
FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves. Experimental neurology, 2008, Volume: 210, Issue:2 Topics: Animals; Body Weight; CD3 Complex; Disease Models, Animal; Ectodysplasins; Fingolimod Hydrochloride; Flow Cytometry; Immunosuppressive Agents; Lymphocytes; Macrophages; Male; Neuritis, Autoimmune, Experimental; Propylene Glycols; Rats; Rats, Inbred Lew; Sciatic Nerve; Sphingosine; Sulfonamides	2008
[Effect of FTY720 on glomerulosclerosis and expression of cell cycle regulatory proteins in subtotally nephrectomized rats]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2007, Volume: 45, Issue:12 Topics: Animals; Cell Cycle Proteins; Disease Models, Animal; Fingolimod Hydrochloride; Glomerulosclerosis, Focal Segmental; Immunosuppressive Agents; Kidney; Male; Nephrectomy; Postoperative Period; Propylene Glycols; Rats; Rats, Sprague-Dawley; Sphingosine	2007
FTY720 treatment in experimentally urethane-induced lung tumors. Journal of experimental therapeutics & oncology, 2008, Volume: 7, Issue:1 Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Anticarcinogenic Agents; Carcinogens; Disease Models, Animal; Fingolimod Hydrochloride; Leukocytes, Mononuclear; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Propylene Glycols; Sphingosine; Spleen; Urethane	2008
Effect of a new immunosuppressant, FTY720, on joint allografts. Journal of reconstructive microsurgery, 1999, Volume: 15, Issue:4 Topics: Anastomosis, Surgical; Animals; Disease Models, Animal; Fingolimod Hydrochloride; Graft Rejection; Immunosuppressive Agents; Knee Joint; Male; Propylene Glycols; Rats; Rats, Inbred BN; Rats, Inbred F344; Sphingosine; Statistics, Nonparametric; Transplantation, Homologous; Treatment Outcome	1999
Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis. Journal of the American College of Cardiology, 2001, Volume: 37, Issue:6 Topics: Acute Disease; Animals; Cardiovirus Infections; Disease Models, Animal; Drug Evaluation, Preclinical; Encephalomyocarditis virus; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-12; Interleukin-2; Male; Mice; Mice, Inbred DBA; Myocarditis; Nitric Oxide; Proportional Hazards Models; Propylene Glycols; Severity of Illness Index; Sphingosine; Survival Analysis; Treatment Outcome; Tumor Necrosis Factor-alpha	2001
Effects of FTY720 in MRL-lpr/lpr mice: therapeutic potential in systemic lupus erythematosus. The Journal of rheumatology, 2002, Volume: 29, Issue:4 Topics: Administration, Oral; Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Apoptosis; Bone Marrow Cells; Cells, Cultured; Disease Models, Animal; DNA; Female; Fingolimod Hydrochloride; Flow Cytometry; Immunoglobulin G; Immunosuppressive Agents; Interleukin-2; Kidney Glomerulus; Longevity; Lupus Erythematosus, Systemic; Lymphoid Tissue; Methylprednisolone; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; Propylene Glycols; Sphingosine; T-Lymphocytes	2002
Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative disease in a murine airway model. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2002, Volume: 21, Issue:6 Topics: Abatacept; Animals; Antigens, CD; Antigens, Differentiation; Bronchiolitis Obliterans; CTLA-4 Antigen; Disease Models, Animal; Fingolimod Hydrochloride; Immunoconjugates; Immunoglobulin G; Immunosuppressive Agents; Lung Transplantation; Mice; Postoperative Complications; Propylene Glycols; Respiratory Mucosa; Sphingosine; Trachea	2002