fingolimod hydrochloride has been researched along with Cirrhosis in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 13 (56.52) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Ghobrial, RM; Kloc, M; Subuddhi, A; Ubelaker, HV; Uosef, A; Zou, D | 1 |
| Baek, JA; Cho, KH; Cho, ML; Choi, JW; Choi, JY; Jhun, J; Kim, SY; Park, MJ; Park, SH; Ryu, J | 1 |
| Amargant, F; Duncan, FE; Johnson, BW; Larmore, MJ; Lawson, M; Manuel, SL; Pritchard, MT; Zelinski, MB | 1 |
| Genovese, F; Hijmans, RS; Karsdal, MA; Navis, G; Rasmussen, DG; van den Born, J; van Goor, H; Yazdani, S | 1 |
| Shi, D; Tian, T; Wen, S; Zhang, J; Zhou, H; Zhu, X | 1 |
| Cui, L; Cui, N; Gao, G; Li, C; Yang, L; Zhang, S; Zhuo, Y | 1 |
| Berry, A; Cartwright, EJ; Chowdhury, SK; Hanley, NA; Ke, Y; Lei, M; Liu, W; Meng, QJ; Neyses, L; Oceandy, D; Prehar, S; Solaro, RJ; Travis, M; Tsui, H; Wang, X; Xiao, RP; Zeef, L; Zi, M | 1 |
| Huwiler, A; Pfeilschifter, J; Schwalm, S | 1 |
| Chen, JF; Liu, BC; Liu, H; Ma, KL; Ni, HF; Pan, MM; Tang, RN; Zhang, JD; Zhang, MH | 1 |
| Chen, J; Chen, P; Liu, B; Ni, H; Pan, M; Zhang, J; Zhang, M | 1 |
| Ferrer, FA; Hla, T; Shapiro, LH; Silva, C; Thangada, S; Yamase, H | 1 |
| Kong, Y; Tang, N; Wang, H; Wang, S | 1 |
| Dam, W; Hijmans, RS; Navis, G; Poosti, F; van den Born, J; van Goor, H; Yazdani, S | 1 |
| Abdullah, CS; Jin, ZQ; Li, Z; Wang, X | 1 |
| Chen, Z; Cui, K; Liu, J; Rao, K; Ruan, Y; Wang, S; Wang, T | 1 |
| Binder, E; Budde, K; Khadzhynov, D; Krämer, S; Loof, T; Martini, S; Neumayer, HH; Peters, H; Wang-Rosenke, Y | 1 |
| Dikow, R; Gross, ML; Hug, F; Schaier, M; Sommerer, C; Vorwalder, S; Waldherr, R; Zeier, M | 1 |
| Xie, M; Zhou, JH | 1 |
| Brooks, SF; Chun, J; Fontaine, BA; Luster, AD; Shea, BS; Tager, AM | 1 |
| Kawachi, H; Krämer, S; Martini, S; Neumayer, HH; Peters, H; Shimizu, F; Wang, Y | 1 |
| Fan, ST; Ho, JW; Lee, TK; Li, XL; Lo, CM; Man, K; Ng, KT; Sun, CK; Zhao, Y | 1 |
| Eberhardt, W; Huwiler, A; Pfeilschifter, J; Ren, S; Xin, C | 1 |
| Ahn, KO; Bang, BK; Choi, BS; Kim, J; Kim, JS; Kim, JY; Kim, YS; Li, C; Lim, SW; Yang, CW; Yang, HJ | 1 |
1 review(s) available for fingolimod hydrochloride and Cirrhosis
| Article | Year |
|---|---|
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Fibrosis; Fingolimod Hydrochloride; Glomerulonephritis; Humans; Inflammation; Kidney Failure, Chronic; Lysophospholipids; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2014 |
22 other study(ies) available for fingolimod hydrochloride and Cirrhosis
| Article | Year |
|---|---|
Comparative transcriptome profile of mouse macrophages treated with the RhoA/Rock pathway inhibitors Y27632, Fingolimod (Gilenya), and Rezurock (Belumosudil, SLx-2119).
Topics: Actins; Animals; Fibrosis; Fingolimod Hydrochloride; Graft vs Host Disease; Humans; Macrophages; Mice; rho-Associated Kinases; rhoA GTP-Binding Protein; Transcriptome | 2023 |
FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition.
Topics: Animals; Fibrosis; Fingolimod Hydrochloride; Graft vs Host Disease; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Propylene Glycols | 2020 |
Sphingosine-1-phosphate and its mimetic FTY720 do not protect against radiation-induced ovarian fibrosis in the nonhuman primate†.
Topics: Animals; Female; Fibrosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Macaca mulatta; Ovarian Diseases; Sphingosine; Sphingosine 1 Phosphate Receptor Modulators | 2021 |
Urinary collagen degradation products as early markers of progressive renal fibrosis.
Topics: Animals; Biomarkers; Collagen Type I; Collagen Type III; Disease Progression; Doxorubicin; Fibrosis; Fingolimod Hydrochloride; Kidney; Male; Proteinuria; Proteolysis; Rats, Wistar | 2017 |
FTY720 ameliorates renal fibrosis by simultaneously affecting leucocyte recruitment and TGF-β signalling in fibroblasts.
Topics: Animals; Cell Adhesion; Cell Line; Cell Movement; Creatinine; Extracellular Matrix; Fibroblasts; Fibrosis; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Kidney; Leukocytes; Male; Mice; Mice, Inbred C57BL; Rats; Receptors, Lysosphingolipid; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta; Ureteral Obstruction | 2017 |
FTY720 inhibits the activation of pancreatic stellate cells by promoting apoptosis and suppressing autophagy via the AMPK/mTOR pathway.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cells, Cultured; Fibrosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Membrane Potential, Mitochondrial; Pancreas; Pancreatic Stellate Cells; Rats; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cell Adhesion Molecules; Cells, Cultured; Fibroblasts; Fibrosis; Fingolimod Hydrochloride; Hemodynamics; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Myocardium; NFATC Transcription Factors; Propylene Glycols; Rats; Rats, Sprague-Dawley; Sphingosine; Ventricular Pressure | 2013 |
FTY720 attenuates tubulointerstitial inflammation and fibrosis in subtotally nephrectomized rats.
Topics: Animals; Cell Movement; Chemokine CCL2; Disease Models, Animal; Fibrosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Interleukin-6; Kidney Tubules; Lymphocytes; Male; Nephrectomy; Nephritis, Interstitial; Propylene Glycols; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Sphingosine; Transforming Growth Factor beta1; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
FTY720 prevents progression of renal fibrosis by inhibiting renal microvasculature endothelial dysfunction in a rat model of chronic kidney disease.
Topics: Animals; Collagen Type IV; Disease Models, Animal; Disease Progression; Endothelial Cells; Fibronectins; Fibrosis; Fingolimod Hydrochloride; Gene Expression Regulation; Kidney; Kidney Glomerulus; Male; Microvessels; Nitric Oxide; Nitric Oxide Synthase Type III; Propylene Glycols; Rats; Renal Insufficiency, Chronic; Sphingosine; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2013 |
Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction.
Topics: Animals; Blotting, Western; Disease Models, Animal; Female; Fibrosis; Fingolimod Hydrochloride; Immunohistochemistry; Immunosuppressive Agents; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Propylene Glycols; Sphingosine; Transforming Growth Factor beta1; Ureteral Obstruction | 2014 |
FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Movement; Disease Models, Animal; Fibrosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Liver Cirrhosis; Mesenchymal Stem Cells; Mice; Mice, Inbred ICR; Mice, SCID; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Wound Healing | 2014 |
Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats.
Topics: Animals; Antibodies; Biomarkers; Clodronic Acid; Collagen Type III; Disease Models, Animal; Doxorubicin; Fibrosis; Fingolimod Hydrochloride; Inflammation; Kidney Diseases; Kidney Tubules; Leukocyte Count; Liposomes; Lymphangiogenesis; Lymphatic Vessels; Macrophages; Male; Myofibroblasts; Proteinuria; Rats, Wistar; RNA, Messenger; T-Lymphocytes; Vascular Endothelial Growth Factor Receptor-3 | 2015 |
Depletion of T lymphocytes ameliorates cardiac fibrosis in streptozotocin-induced diabetic cardiomyopathy.
Topics: Animals; Antigens, CD34; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Fingolimod Hydrochloride; Homeodomain Proteins; Lymphocyte Depletion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; T-Lymphocytes; Transforming Growth Factor beta1 | 2016 |
FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Erectile Dysfunction; Fibrosis; Fingolimod Hydrochloride; Male; Penile Erection; Random Allocation; Rats; Rats, Sprague-Dawley; Streptozocin | 2017 |
The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy.
Topics: Animals; Blood Pressure; Cell Movement; Cell Proliferation; Disease Models, Animal; Extracellular Matrix; Fibrosis; Fingolimod Hydrochloride; Hypertension; Immunosuppressive Agents; Kidney; Kidney Diseases; Lymphocytes; Macrophages; Male; Nephrectomy; Propylene Glycols; Proteinuria; Rats; Rats, Wistar; Sphingosine; Transforming Growth Factor beta | 2009 |
Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats.
Topics: Administration, Oral; Albuminuria; Animals; Blood Pressure; Body Weight; Chemokine CCL2; Chemokine CCL5; Chemokines; Creatinine; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Fibronectins; Fibrosis; Fingolimod Hydrochloride; Gene Expression Regulation; Immunosuppressive Agents; Inflammation Mediators; Kidney; Kidney Failure, Chronic; Lymphocytes; Macrophages; Male; Nephrectomy; Nephritis; Phenotype; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, CCR1; Receptors, CCR2; Receptors, CCR5; Sphingosine; Time Factors; Transforming Growth Factor beta1 | 2009 |
[FTY720 reduces peritubular micrangium loss in renal interstitial fibrotic rats].
Topics: Animals; Apoptosis; Capillaries; Fibrosis; Fingolimod Hydrochloride; Kidney Diseases; Kidney Tubules; Male; Propylene Glycols; Rats; Rats, Sprague-Dawley; Sphingosine; Vascular Diseases | 2009 |
Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.
Topics: Animals; beta-Alanine; Bleomycin; Blood Coagulation; Endothelial Cells; Fibrosis; Fingolimod Hydrochloride; Humans; Lung Injury; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Pneumonia; Propylene Glycols; Pulmonary Alveoli; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Survival Analysis; Thiophenes; Vascular Diseases | 2010 |
Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis.
Topics: Animals; Blood Pressure; Blood Urea Nitrogen; Body Weight; Creatinine; Extracellular Matrix; Fibrosis; Fingolimod Hydrochloride; Glomerulosclerosis, Focal Segmental; Heart Rate; Immunosuppressive Agents; Isoantibodies; Lymphocyte Count; Lymphocytes; Male; Propylene Glycols; Proteinuria; Rats; Rats, Wistar; Sphingosine | 2004 |
FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers.
Topics: Animals; Apoptosis; Blotting, Western; Chemokine CXCL2; Chemokines, CXC; DNA Primers; Down-Regulation; Endothelin-1; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Fingolimod Hydrochloride; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hepatocytes; HSP70 Heat-Shock Proteins; Immunosuppressive Agents; In Situ Nick-End Labeling; Inflammation; Intercellular Signaling Peptides and Proteins; Interleukin-10; Liver; Male; MAP Kinase Signaling System; Microscopy, Electron; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Propylene Glycols; Proteins; raf Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine; Time Factors; Up-Regulation | 2005 |
The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.
Topics: Animals; Cells, Cultured; Collagen Type IV; Connective Tissue Growth Factor; Fibrosis; Fingolimod Hydrochloride; Glomerular Mesangium; Immediate-Early Proteins; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Phosphorylation; Propylene Glycols; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Smad1 Protein; Smad2 Protein; Smad3 Protein; Sphingosine; Transforming Growth Factor beta; Up-Regulation | 2006 |
Effect of FTY720 on chronic cyclosporine nephropathy in rats.
Topics: Angiotensin II; Animals; Chronic Disease; Cyclosporine; Extracellular Matrix Proteins; Fibrosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Kidney; Kidney Diseases; Lymphocytes; Macrophages; Male; Osteopontin; Propylene Glycols; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Sphingosine; T-Lymphocytes; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |