Page last updated: 2024-09-02

fingolimod hydrochloride and Brain Ischemia

fingolimod hydrochloride has been researched along with Brain Ischemia in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (4.17)	29.6817
2010's	16 (66.67)	24.3611
2020's	7 (29.17)	2.80

Authors

Authors	Studies
Arai, K; Esposito, E; Lee, J; Li, W; Lizasoain, I; Lo, EH; Mandeville, ET; Mandeville, JB; Moro, MÁ; Nakano, T; Park, JH; Quinto-Alemany, D; Waeber, C; Zhang, F	1
Malone, K; Moore, AC; Shearer, JA; Waeber, C	1
He, J; Lin, L; Qin, C; Shang, K; Tian, DS; Wang, W; Wu, LJ; Yang, LL; Zhan, KB; Zhou, LQ; Zou, J	1
Higashikawa, K; Houkin, K; Kawabori, M; Kihara, A; Kuge, Y; Midori, YA; Ohno, Y; Wang, Z; Yasui, H	1
Choi, JW; Gaire, BP	1
Diaz Diaz, AC; Malone, K; Moore, AC; Shearer, JA; Waeber, C	1
Bayat, M; Haghani, M; Naseh, M; Rafati, A; Vatanparast, J	1
Hou, X; Pang, X	1
Campbell, B; Lin, L; Lou, M; Shi, FD; Zhang, M; Zhang, R; Zhang, S; Zhou, Y	1
Fan, WH; Liu, Q; Murugan, M; Qin, C; Shang, K; Tian, DS; Wang, W; Wu, LJ	1
Fan, WH; Li, X; Liu, JL; Qin, C; Tian, DS; Wang, MH	1
Brait, VH; Chamorro, A; Gallizioli, M; Justicia, C; Meissner, A; Miró-Mur, F; Planas, AM; Salas-Perdomo, A; Urra, X	1
Arumugam, TV; Chen, CLH; Choi, YK; Ihara, M; Kinoshita, H; Lim, YA; Maki, T; Saito, S; Takahashi, R; Wong, PT; Yamamoto, Y; Yasuda, K	1
Brede, M; Deppermann, C; Göb, E; Göbel, K; Herrmann, AM; Kleinschnitz, C; Kraft, P; Lorenz, K; Meuth, SG; Nieswandt, B; Pfeilschifter, W; Schuhmann, MK; Stoll, G; Thielmann, I	1
Altay, O; Hasegawa, Y; Rolland, W; Suzuki, H; Zhang, JH	1
Fu, Y; Han, W; Hao, J; Li, YJ; Liu, Q; Ren, L; Shi, FD; Sun, N; Xue, R; Yan, Y; Yu, C; Zhang, N	1
Choi, JW; Chun, J; Han, JE; Jeon, S; Moon, E; Ryu, JH	1
Fluri, F; Kleinschnitz, C; Krstic, M; Schuhmann, MK	1
Czech, B; Huwiler, A; Kahles, T; Mazaheri-Omrani, N; Neumann-Haefelin, T; Pfeilschifter, J; Pfeilschifter, W; Rami, A; Strobel, MA	1
Hasegawa, Y; Rolland, W; Sozen, T; Suzuki, H; Zhang, JH	1
Alsharif, N; Brinkmann, V; Guo, S; Hwang, SK; Kim, HH; Liao, JK; Lo, EH; Qin, T; Shin, HK; Waeber, C; Wei, Y; Yemisci, M; Yung, LM	1
Bauer, H; Liesz, A; Mracsko, E; Schwarting, S; Sommer, C; Sun, L; Veltkamp, R; Zhou, W; Zorn, M	1
Czech-Zechmeister, B; Foerch, C; Huwiler, A; Koch, A; Mirceska, A; Pfeilschifter, J; Pfeilschifter, W; Rami, A; Steinmetz, H; Sujak, M	1
Konoeda, F; Shichita, T; Yoshimura, A	1

Reviews

3 review(s) available for fingolimod hydrochloride and Brain Ischemia

Article	Year
Sphingosine 1-Phosphate Receptors in Cerebral Ischemia. Neuromolecular medicine, 2021, Volume: 23, Issue:1 Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Lysophospholipids; Neovascularization, Physiologic; Nerve Tissue Proteins; Neuroprotective Agents; Phosphotransferases (Alcohol Group Acceptor); Rats; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors	2021
The emerging role of FTY720 as a sphingosine 1-phosphate analog for the treatment of ischemic stroke: The cellular and molecular mechanisms. Brain and behavior, 2021, Volume: 11, Issue:6 Topics: Animals; Brain Ischemia; Endothelial Cells; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Ischemic Stroke; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Stroke	2021
[Role of T lymphocytes in ischemic brain injury]. Rinsho shinkeigaku = Clinical neurology, 2010, Volume: 50, Issue:11 Topics: Animals; Antibodies, Neutralizing; Brain Ischemia; Corynebacterium; Cytokines; Disease Progression; Fingolimod Hydrochloride; Humans; Inflammation Mediators; Interleukin-17; Interleukin-23; Mice; Molecular Targeted Therapy; Propylene Glycols; Sphingosine; T-Lymphocytes; Time Factors	2010

Trials

2 trial(s) available for fingolimod hydrochloride and Brain Ischemia

Article	Year
Rationale and design of combination of an immune modulator Fingolimod with Alteplase bridging with Mechanical Thrombectomy in Acute Ischemic Stroke (FAMTAIS) trial. International journal of stroke : official journal of the International Stroke Society, 2017, Volume: 12, Issue:8 Topics: Brain Ischemia; Combined Modality Therapy; Fibrinolytic Agents; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Mechanical Thrombolysis; Reperfusion Injury; Research Design; Stroke; Time-to-Treatment; Tissue Plasminogen Activator	2017
Impact of an immune modulator fingolimod on acute ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America, 2014, Dec-23, Volume: 111, Issue:51 Topics: Adult; Aged; Brain Ischemia; Case-Control Studies; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphocyte Subsets; Male; Middle Aged; Propylene Glycols; Single-Blind Method; Sphingosine; Stroke	2014

Article

Year

Rationale and design of combination of an immune modulator Fingolimod with Alteplase bridging with Mechanical Thrombectomy in Acute Ischemic Stroke (FAMTAIS) trial.

International journal of stroke : official journal of the International Stroke Society, 2017, Volume: 12, Issue:8

Topics: Brain Ischemia; Combined Modality Therapy; Fibrinolytic Agents; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Mechanical Thrombolysis; Reperfusion Injury; Research Design; Stroke; Time-to-Treatment; Tissue Plasminogen Activator

2017

Impact of an immune modulator fingolimod on acute ischemic stroke.

Proceedings of the National Academy of Sciences of the United States of America, 2014, Dec-23, Volume: 111, Issue:51

Topics: Adult; Aged; Brain Ischemia; Case-Control Studies; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphocyte Subsets; Male; Middle Aged; Propylene Glycols; Single-Blind Method; Sphingosine; Stroke

2014

Other Studies

19 other study(ies) available for fingolimod hydrochloride and Brain Ischemia

Article	Year
Fingolimod Does Not Reduce Infarction After Focal Cerebral Ischemia in Mice During Active or Inactive Circadian Phases. Stroke, 2022, Volume: 53, Issue:12 Topics: Animals; Brain Edema; Brain Ischemia; Disease Models, Animal; Fingolimod Hydrochloride; Hemorrhage; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Sphingosine; Stroke	2022
The impact of fingolimod on Treg function in brain ischaemia. European journal of immunology, 2023, Volume: 53, Issue:9 Topics: Animals; Brain Ischemia; Fingolimod Hydrochloride; Gene Expression; Interleukin-10; Mice; T-Lymphocytes, Regulatory	2023
Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization. Brain research, 2020, 01-01, Volume: 1726 Topics: Angiogenesis Inducing Agents; Animals; Brain; Brain Ischemia; Encephalitis; Fingolimod Hydrochloride; Male; Mice, Inbred C57BL; Microglia; Neovascularization, Physiologic; Neuroprotective Agents	2020
FTY720 Protects Against Ischemia-Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model. Translational stroke research, 2020, Volume: 11, Issue:5 Topics: Animals; Apoptosis; Brain Ischemia; Endothelial Cells; Fingolimod Hydrochloride; Inflammation; Organophosphates; Rats, Sprague-Dawley; Sphingosine; Tight Junction Proteins	2020
The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia. Journal of neuroinflammation, 2021, Jan-30, Volume: 18, Issue:1 Topics: Aging; Animals; Brain Ischemia; Diet, High-Fat; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocytes, Regulatory	2021
Synergistic protective effect of FTY720 and vitamin E against simulated cerebral ischemia in vitro. Molecular medicine reports, 2017, Volume: 16, Issue:1 Topics: Animals; Antioxidants; Astrocytes; Biomarkers; Brain Ischemia; Cell Survival; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Synergism; Fingolimod Hydrochloride; Inflammation Mediators; Neuroprotective Agents; Rats; Vitamin E	2017
Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway. Stroke, 2017, Volume: 48, Issue:12 Topics: Animals; Brain Ischemia; Carotid Stenosis; Cell Polarity; Cognitive Dysfunction; Corpus Callosum; Cytokines; Fingolimod Hydrochloride; Macrophage Activation; Memory, Short-Term; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Ranvier's Nodes; Signal Transduction; STAT3 Transcription Factor; White Matter	2017
Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice. PloS one, 2017, Volume: 12, Issue:11 Topics: Animals; Apoptosis; Autophagy; Behavior, Animal; Brain Ischemia; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Thrombosis; TOR Serine-Threonine Kinases	2017
Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke. Scientific reports, 2019, 06-05, Volume: 9, Issue:1 Topics: Animals; Brain; Brain Ischemia; Fingolimod Hydrochloride; Hemoglobins; Hemorrhage; Lymphocytes; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Cells; Reperfusion Injury; RNA, Messenger; Sphingosine; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Stroke; T-Lymphocytes; Thrombocytopenia; Up-Regulation	2019
Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion. Brain research, 2019, 10-01, Volume: 1720 Topics: Animals; Brain Ischemia; Cell Differentiation; Disease Models, Animal; Female; Fingolimod Hydrochloride; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Oligodendrocyte Precursor Cells; Oligodendroglia; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; White Matter	2019
FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection. Stroke, 2013, Volume: 44, Issue:11 Topics: Animals; Brain Ischemia; Enzyme Inhibitors; Fingolimod Hydrochloride; Homeodomain Proteins; Hypoxia; Immunosuppressive Agents; Inflammation; Lymphocytes; Lymphopenia; Male; Mice; Mice, Transgenic; Middle Cerebral Artery; Neurons; Neuroprotective Agents; Propylene Glycols; Sphingosine; Stroke; Thrombosis	2013
Role of the sphingosine metabolism pathway on neurons against experimental cerebral ischemia in rats. Translational stroke research, 2013, Volume: 4, Issue:5 Topics: Animals; Brain Ischemia; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Male; Neurons; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats; Rats, Sprague-Dawley; Sphingosine	2013
Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling. Mediators of inflammation, 2015, Volume: 2015 Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Fingolimod Hydrochloride; Lysophospholipids; Male; Mice; Mice, Inbred ICR; Microinjections; Neuroglia; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Stroke; Tumor Necrosis Factor-alpha	2015
Fingolimod (FTY720) Reduces Cortical Infarction and Neurological Deficits During Ischemic Stroke Through Potential Maintenance of Microvascular Patency. Current neurovascular research, 2016, Volume: 13, Issue:4 Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Fingolimod Hydrochloride; Infarction, Middle Cerebral Artery; Male; Mice, Inbred C57BL; Microvessels; Stroke	2016
The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochemical and biophysical research communications, 2009, Nov-13, Volume: 389, Issue:2 Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Blood-Brain Barrier; Brain; Brain Ischemia; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Neutrophils; Propylene Glycols; Sphingosine	2009
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke, 2010, Volume: 41, Issue:2 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Fingolimod Hydrochloride; Immunosuppressive Agents; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Nerve Degeneration; Neuroprotective Agents; Oxadiazoles; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Stroke; Thiophenes; Treatment Outcome	2010
Fingolimod provides long-term protection in rodent models of cerebral ischemia. Annals of neurology, 2011, Volume: 69, Issue:1 Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; In Vitro Techniques; Inflammation; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine; Stroke	2011
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia. PloS one, 2011, Volume: 6, Issue:6 Topics: Animals; Brain Edema; Brain Ischemia; Fingolimod Hydrochloride; Immunosuppressive Agents; Interleukin-6; Leukocytes; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Propylene Glycols; Sphingosine; Tumor Necrosis Factor-alpha	2011
Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochemical and biophysical research communications, 2011, Sep-23, Volume: 413, Issue:2 Topics: Animals; Brain Ischemia; Enzyme Activation; Fingolimod Hydrochloride; Gene Deletion; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Sphingosine	2011