Page last updated: 2024-09-02

fingolimod hydrochloride and Bradyarrhythmia

fingolimod hydrochloride has been researched along with Bradyarrhythmia in 25 studies

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (16.00)	29.6817
2010's	18 (72.00)	24.3611
2020's	3 (12.00)	2.80

Authors

Authors	Studies
Gu, ZC; Lv, Y; Ma, CL; Zhao, Z; Zhong, MK	1
Cha, E; Gotina, L; Hwang, H; Joo, J; Kang, M; Kim, HJ; Kim, J; Lee, J; Lim, SM; Pae, AN; Park, JE; Park, JH; Park, KD; Seo, SH	1
Lanzillo, R; Petruzzo, M	1
Appel, S; Atassi, N; Berry, JD; Gill, A; Goyal, N; Grasso, DL; Macklin, EA; Mateen, F; Mejia, NI; Paganoni, S; Perrin, S; Rivner, M; Simpson, E; Tassinari, V; Vieira, F	1
Gurses, KM; Karabudak, R; Kocyigit, D; Tokgozoglu, L; Yalcin, MU	1
Guerrero, M; Roberts, E; Rosen, H; Urbano, M	1
Crump, N; Greene, SL; Kerr, F; Rotella, JA; Stephenson, M; Wong, A	1
Bijarnia, M; Comi, G; Gold, R; Gottschalk, R; Kappos, L; Palace, J; Siever, A; Tomic, D; von Rosenstiel, P	1
Botto, G; Pentimalli, F; Vanoli, E	1
Centonze, D; Germani, G; Lauretti, B; Macchiarulo, G; Marfia, GA; Motta, C; Rocchi, C; Rossi, S; Studer, V	1
Arruda, CC; Arruda, WO; Brooks, JB; Damasceno, A; Damasceno, CA; de Morais, MM; Finkelsztejn, A; Finkelsztejn, J; Fragoso, YD; Gama, PD; Giacomo, MC; Gomes, S; Goncalves, MV; Matta, AP; Oliveira, EM; Ribeiro, Y; Sato, HK; Tauil, CB	1
Hilz, MJ; Intravooth, T; Koehn, J; Lee, DH; Linker, RA; Moeller, S; Wang, R	1
Albert, C; Baier-Ebert, M; Dechend, R; Gerbershagen, K; Haas, J; Haverkamp, W; Hoffmann, O; Hoyer, S; Klotz, L; Lang, M; Lassek, C; Limmroth, V; Richter, S; Schieb, H; Schmidt, S; Schuh, K; Wagner, B; Wendt, G; Ziemssen, T	1
Bobylev, I; Joshi, A; Lehmann, HC; Ritter, C; Schneider, T; Svačina, MK	1
Weinstock-Guttman, B; Yeh, EA	1
Berger, JR; Espinosa, PS	1
Faber, H; Fischer, HJ; Weber, F	1
Bermel, RA; Cohen, JA; Hara-Cleaver, C; Ontaneda, D; Rudick, RA	1
Huggins, A; Sergott, RC	1
Chen, RR; Dinallo, RM; Fryer, RM; Harrington, KE; Harrison, PC; Horan, JC; Modis, LK; Muthukumarana, A; Nodop Mazurek, S; Patnaude, L; Reinhart, GA	1
Merkely, B; Széplaki, G	1
Enosawa, S; Fukuchi, K; Hakamata, Y; Iwanami, S; Kaneko, T; Kishi, T; Kobayashi, E; Kudou, S; Kuriyama, K; Matsumoto, K; Morishita, Y; Murakami, T; Shimizu, H; Takahashi, M; Takeyoshi, I; Yasue, T	1
Clemens, JJ; Davis, MD; Lynch, KR; Macdonald, TL	1
Cremer, M; Hmissi, A; Lang, P; Mayer, H; Schena, FP; Shoker, A; Sommerer, C; Szakaly, P; Tedesco-Silva, H; Yoshimura, N	1
Hunt, TL; Kovarik, JM; Maton, S; Neddermann, D; Riviere, GJ; Schmouder, RL	1

Reviews

5 review(s) available for fingolimod hydrochloride and Bradyarrhythmia

Article	Year
Risk for Cardiovascular Adverse Events Associated With Sphingosine-1-Phosphate Receptor Modulators in Patients With Multiple Sclerosis: Insights From a Pooled Analysis of 15 Randomised Controlled Trials. Frontiers in immunology, 2021, Volume: 12 Topics: Azetidines; Benzyl Compounds; Bradycardia; Drug-Related Side Effects and Adverse Reactions; Fingolimod Hydrochloride; Humans; Hypertension; Indans; Multiple Sclerosis; Oxadiazoles; Randomized Controlled Trials as Topic; Risk; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors	2021
Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012). Expert opinion on therapeutic patents, 2013, Volume: 23, Issue:7 Topics: Animals; Bradycardia; Cognition Disorders; Drug Design; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Multiple Sclerosis, Relapsing-Remitting; Patents as Topic; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2013
Vagomimetic effects of fingolimod: physiology and clinical implications. CNS neuroscience & therapeutics, 2014, Volume: 20, Issue:6 Topics: Animals; Atrioventricular Block; Bradycardia; Electrocardiography; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis, Relapsing-Remitting; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2014
Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis. Advances in therapy, 2011, Volume: 28, Issue:4 Topics: Activities of Daily Living; Administration, Oral; Bradycardia; Central Nervous System; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Progression; Female; Fingolimod Hydrochloride; Herpesviridae Infections; Humans; Immunosuppressive Agents; Macular Edema; Male; Multiple Sclerosis, Relapsing-Remitting; Neuroimmunomodulation; Neurologic Examination; Propylene Glycols; Receptors, Lysosphingolipid; Recurrence; Sphingosine; Treatment Outcome; Young Adult	2011
[Clinical significance of the cardiovascular effects of fingolimod treatment in multiple sclerosis]. Ideggyogyaszati szemle, 2012, Nov-30, Volume: 65, Issue:11-12 Topics: Atrioventricular Block; Bradycardia; Cardiovascular System; Clinical Trials as Topic; Drug Administration Schedule; Fingolimod Hydrochloride; Heart Conduction System; Humans; Hypertension; Immunosuppressive Agents; Interferon beta-1a; Interferon-beta; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Secondary Prevention; Sphingosine; Treatment Outcome	2012

Trials

4 trial(s) available for fingolimod hydrochloride and Bradyarrhythmia

Article	Year
Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability. Muscle & nerve, 2017, Volume: 56, Issue:6 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Bradycardia; Fatigue; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Male; Middle Aged; Single-Blind Method	2017
Assessment of cardiac safety during fingolimod treatment initiation in a real-world relapsing multiple sclerosis population: a phase 3b, open-label study. Journal of neurology, 2014, Volume: 261, Issue:2 Topics: Adolescent; Adult; Age Factors; Aged; Bradycardia; Disability Evaluation; Electrocardiography; Endpoint Determination; Female; Fingolimod Hydrochloride; Heart Conduction System; Heart Diseases; Heart Rate; Humans; Immunosuppressive Agents; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Patient Safety; Propylene Glycols; Sphingosine; Treatment Outcome; Young Adult	2014
FTY720 versus mycophenolate mofetil in de novo renal transplantation: six-month results of a double-blind study. Transplantation, 2007, Oct-15, Volume: 84, Issue:7 Topics: Adult; Biopsy; Bradycardia; Cohort Studies; Cyclosporine; Double-Blind Method; Female; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Mycophenolic Acid; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2007
A mechanistic study to assess whether isoproterenol can reverse the negative chronotropic effect of fingolimod. Journal of clinical pharmacology, 2008, Volume: 48, Issue:3 Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Area Under Curve; Atrial Fibrillation; Bradycardia; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Female; Fingolimod Hydrochloride; Heart Rate; Humans; Infusions, Intravenous; Isoproterenol; Male; Patient Dropouts; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Tachycardia; Time Factors	2008

Other Studies

16 other study(ies) available for fingolimod hydrochloride and Bradyarrhythmia

Article	Year
Exploration of Tetrahydroisoquinoline- and Benzo[ Journal of medicinal chemistry, 2023, 08-10, Volume: 66, Issue:15 Topics: Bradycardia; Fingolimod Hydrochloride; Humans; Multiple Sclerosis; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Tetrahydroisoquinolines	2023
Asymptomatic bradycardia after first fingolimod dose in a pediatric patient with multiple sclerosis - a case report. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021, Volume: 42, Issue:Suppl 1 Topics: Adolescent; Bradycardia; Child; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting	2021
Are there any clinical and electrocardiographic predictors of heart rate reduction in relapsing- remitting multiple sclerosis patients treated with fingolimod? Multiple sclerosis and related disorders, 2019, Volume: 27 Topics: Adult; Bradycardia; Electrocardiography; Female; Fingolimod Hydrochloride; Heart Rate; Humans; Male; Multiple Sclerosis, Relapsing-Remitting; Receptors, Lysosphingolipid; Retrospective Studies	2019
Deliberate fingolimod overdose presenting with delayed hypotension and bradycardia responsive to atropine. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2014, Volume: 10, Issue:2 Topics: Adult; Antidotes; Atropine; Bradycardia; Combined Modality Therapy; Drug Overdose; Female; Fingolimod Hydrochloride; Humans; Hypotension; Immunosuppressive Agents; Muscarinic Antagonists; Propylene Glycols; Sphingosine; Time Factors; Treatment Outcome	2014
The autonomic balance predicts cardiac responses after the first dose of fingolimod. Multiple sclerosis (Houndmills, Basingstoke, England), 2015, Volume: 21, Issue:2 Topics: Adult; Autonomic Nervous System; Bradycardia; Female; Fingolimod Hydrochloride; Heart Function Tests; Heart Rate; Humans; Immunosuppressive Agents; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Parasympathetic Nervous System	2015
The real-life experience with cardiovascular complications in the first dose of fingolimod for multiple sclerosis. Arquivos de neuro-psiquiatria, 2014, Volume: 72, Issue:9 Topics: Adult; Aged; Bradycardia; Cardiovascular Diseases; Female; Fingolimod Hydrochloride; Heart Rate; Humans; Immunosuppressive Agents; Male; Middle Aged; Multiple Sclerosis; Propylene Glycols; Sphingosine; Time Factors; Young Adult	2014
Central Autonomic Dysfunction Delays Recovery of Fingolimod Induced Heart Rate Slowing. PloS one, 2015, Volume: 10, Issue:7 Topics: Adult; Autonomic Nervous System; Blood Pressure; Bradycardia; Electrocardiography; Female; Fingolimod Hydrochloride; Hand Strength; Heart Rate; Humans; Immunosuppressive Agents; Male; Multiple Sclerosis; Valsalva Maneuver	2015
Electrocardiographic assessments and cardiac events after fingolimod first dose - a comprehensive monitoring study. BMC neurology, 2017, Jan-18, Volume: 17, Issue:1 Topics: Adult; Aged; Atrioventricular Block; Bradycardia; Electrocardiography, Ambulatory; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Young Adult	2017
Impact of Age and Polytherapy on Fingolimod Induced Bradycardia: a Preclinical Study. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2017, Volume: 12, Issue:1 Topics: Aging; Animals; Bradycardia; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Telemetry	2017
Delayed fingolimod-associated asystole. Multiple sclerosis (Houndmills, Basingstoke, England), 2011, Volume: 17, Issue:11 Topics: Administration, Oral; Antipsychotic Agents; Bradycardia; Electrocardiography; Fingolimod Hydrochloride; Heart Arrest; Humans; Immunosuppressive Agents; Male; Multiple Sclerosis; Propylene Glycols; Risperidone; Sphingosine; Time Factors; Young Adult	2011
Prolonged and symptomatic bradycardia following a single dose of fingolimod. Multiple sclerosis (Houndmills, Basingstoke, England), 2013, Volume: 19, Issue:1 Topics: Adult; Bradycardia; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Multiple Sclerosis; Propylene Glycols; Sphingosine	2013
Early tolerability and safety of fingolimod in clinical practice. Journal of the neurological sciences, 2012, Dec-15, Volume: 323, Issue:1-2 Topics: Adult; Bradycardia; Chest Pain; Drug Substitution; Female; Fingolimod Hydrochloride; Headache; Humans; Hypertension; Lymphopenia; Macular Edema; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nausea; Patient Acceptance of Health Care; Product Surveillance, Postmarketing; Propylene Glycols; Retrospective Studies; Sphingosine	2012
Gilenya safety update: cardiac and macula. Current opinion in ophthalmology, 2012, Volume: 23, Issue:6 Topics: Bradycardia; Drug Monitoring; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Macular Edema; Multiple Sclerosis; Propylene Glycols; Sphingosine	2012
The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat. PloS one, 2012, Volume: 7, Issue:12 Topics: Animals; Azetidines; Benzyl Compounds; Bradycardia; Cells, Cultured; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Hypertension; Immunosuppressive Agents; Male; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Substrate Specificity	2012
KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts. Circulation, 2005, Jan-18, Volume: 111, Issue:2 Topics: Animals; Bradycardia; Chemotaxis, Leukocyte; Chronic Disease; Cyclosporine; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Guinea Pigs; Heart Rate; Heart Transplantation; Immunosuppressive Agents; Male; Molecular Structure; Propylene Glycols; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Rats, Wistar; Skin Transplantation; Sphingosine; Sulfhydryl Compounds; Transplantation, Heterotopic; Transplantation, Homologous	2005
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. Bioorganic & medicinal chemistry letters, 2005, Aug-01, Volume: 15, Issue:15 Topics: Animals; Benzimidazoles; Binding Sites; Bradycardia; CHO Cells; Cricetinae; Fingolimod Hydrochloride; Immunosuppressive Agents; Lethal Dose 50; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Structure-Activity Relationship	2005