Compounds > fingolimod hydrochloride
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fingolimod hydrochloride and Acute Myelogenous Leukemia

fingolimod hydrochloride has been researched along with Acute Myelogenous Leukemia in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's13 (86.67)24.3611
2020's2 (13.33)2.80

Authors

AuthorsStudies
Arriazu, E; Cayuela, ML; García-Ramírez, P; Guruceaga, E; Marcotegui, N; Martínez-Balsalobre, E; Mateos, MC; Odero, MD; Oyarzábal, J; Peris, I; Pippa, R; Prósper, F; Rabal, O; Vicente, C1
Gründer, A; Jutzi, JS; Koellerer, C; Müller-Tidow, C; Nofer, JR; Pahl, HL; Potì, F; Riccetti, L; Sanders, MA; Simoni, M; Valk, PJ; Vorbach, S; Zhou, F1
Bui, V; Chen, C; Wang, HG; Young, MM1
Chauvet, P; Coiteux, V; Gauthier, J; Magro, L; Varlet, P; Vermersch, P; Yakoub-Agha, I1
Blanco-Prieto, MJ; Christensen, DJ; Dominguez, A; Moreno-Miralles, I; Odero, MD; Pippa, R; Vitek, MP1
Andreeff, M; Burks, JK; Calin, G; Coombes, KR; Duvvuri, SR; Hail, N; Jacamo, R; Konopleva, M; Kornblau, SM; Pan, R; Qiu, Y; Ruvolo, PP; Ruvolo, VR; Yoo, SY; Zeng, Z; Zhang, N; Zhou, L1
Chen, L; Chen, SJ; Jiang, H; Li, KK; Li, L; Liu, H; Liu, YF; Lu, J; Luo, C; Luo, LF; Song, H; Wang, J1
Blanco-Prieto, MJ; Castello-Cros, R; Cirauqui, C; Estella-Hermoso de Mendoza, A; Imbuluzqueta, E; Odero, MD; Pippa, R1
D'Crus, A; Enjeti, AK; Melville, K; Rowlings, P; Verrills, NM1
Dun, MD; Flanagan, HM; Morris, JC; Ross, BK; Toop, HD; Verrills, NM1
Ashman, LK; Don, AS; Dun, MD; Enjeti, A; Flanagan, H; Guthridge, MA; Harrison, C; Kahl, R; Lee, EM; Lock, RB; Mashkani, B; Moore, A; Morris, J; Panicker, N; Powell, JA; Skelding, KA; Smith, AM; Thomas, D; Toop, H; Verrills, NM1
Chen, CS; de Necochea-Campion, R; Liu, X; Mirshahidi, S; Shouse, G1
Ashman, LK; Carpenter, H; Guthridge, MA; Horan, M; McDougall, F; Neviani, P; Perrotti, D; Powell, JA; Roberts, KG; Sim, AT; Smith, AM; Thomas, D; Verrills, NM1
Huang, Q; Huang, SA; Li, XQ; Yang, Y1
Huang, Q; Huang, S; Li, X; Lu, Y; Yang, Y1

Reviews

1 review(s) available for fingolimod hydrochloride and Acute Myelogenous Leukemia

ArticleYear
A systematic evaluation of the safety and toxicity of fingolimod for its potential use in the treatment of acute myeloid leukaemia.
    Anti-cancer drugs, 2016, Volume: 27, Issue:6

    Topics: Antineoplastic Agents; Cardiovascular Diseases; Fingolimod Hydrochloride; Humans; Infections; Leukemia, Myeloid, Acute; Observational Studies as Topic

2016

Other Studies

14 other study(ies) available for fingolimod hydrochloride and Acute Myelogenous Leukemia

ArticleYear
A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity.
    Cancer letters, 2020, 01-01, Volume: 468

    Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Cardiotoxicity; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Female; Fingolimod Hydrochloride; Heart Rate; Histone Chaperones; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Protein Binding; Protein Phosphatase 2; Toxicity Tests, Acute; Xenograft Model Antitumor Assays; Zebrafish

2020
Enhanced expression of the sphingosine-1-phosphate-receptor-3 causes acute myelogenous leukemia in mice.
    Leukemia, 2020, Volume: 34, Issue:3

    Topics: Animals; Fingolimod Hydrochloride; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Signal Transduction; Sphingosine-1-Phosphate Receptors; Transcriptome; Transgenes

2020
FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia.
    Cell death & disease, 2019, 11-07, Volume: 10, Issue:11

    Topics: Apoptosis; Caspases; Cell Membrane; Fingolimod Hydrochloride; Humans; Leukemia, Myeloid, Acute; Necroptosis; Phosphatidylserines; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators

2019
Successful treatment with fingolimod of graft-versus-host disease of the central nervous system.
    Blood advances, 2018, 01-09, Volume: 2, Issue:1

    Topics: Aged; Allografts; Central Nervous System Diseases; Fingolimod Hydrochloride; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Male; Receptors, Lysosphingolipid; Treatment Outcome

2018
Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity.
    Leukemia, 2014, Volume: 28, Issue:9

    Topics: Cell Line, Tumor; DNA-Binding Proteins; Fingolimod Hydrochloride; Histone Chaperones; Humans; Leukemia, Myeloid, Acute; Peptides; Propylene Glycols; Protein Phosphatase 2; Sphingosine; Transcription Factors

2014
The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.
    Biochimica et biophysica acta, 2014, Volume: 1843, Issue:9

    Topics: Drug Resistance, Neoplasm; Fingolimod Hydrochloride; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; MicroRNAs; Models, Biological; Phosphorylation; Propylene Glycols; Protein Kinase C-alpha; Protein Phosphatase 2; Proto-Oncogene Proteins c-myc; RNA, Small Interfering; Signal Transduction; Sphingosine; src-Family Kinases

2014
FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line; Ceramides; Core Binding Factor Alpha 2 Subunit; Fingolimod Hydrochloride; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Mice, Nude; Models, Molecular; Oncogene Proteins, Fusion; Propylene Glycols; Protein Phosphatase 2; RUNX1 Translocation Partner 1 Protein; Sphingolipids; Sphingosine

2014
Lipid Nanosystems Enhance the Bioavailability and the Therapeutic Efficacy of FTY720 in Acute Myeloid Leukemia.
    Journal of biomedical nanotechnology, 2015, Volume: 11, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Proliferation; Cytarabine; Drug Delivery Systems; Enzyme Activation; Female; Fingolimod Hydrochloride; HL-60 Cells; Humans; Idarubicin; Leukemia, Myeloid, Acute; Lipids; Mice; Mice, Transgenic; Nanoparticles; Nanotechnology; Propylene Glycols; Sphingosine

2015
Development of novel PP2A activators for use in the treatment of acute myeloid leukaemia.
    Organic & biomolecular chemistry, 2016, May-18, Volume: 14, Issue:20

    Topics: Antineoplastic Agents; Drug Design; Enzyme Activation; Fingolimod Hydrochloride; Leukemia, Myeloid, Acute; Protein Phosphatase 2

2016
Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors.
    Oncotarget, 2016, Jul-26, Volume: 7, Issue:30

    Topics: Animals; Cell Line, Tumor; Enzyme Activation; Fingolimod Hydrochloride; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mice; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Protein Phosphatase 2; Sorafenib

2016
Novel B55α-PP2A mutations in AML promote AKT T308 phosphorylation and sensitivity to AKT inhibitor-induced growth arrest.
    Oncotarget, 2016, Sep-20, Volume: 7, Issue:38

    Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Codon; Enzyme Inhibitors; Fingolimod Hydrochloride; Gene Expression Regulation, Leukemic; Heterocyclic Compounds, 3-Ring; Humans; Immunophenotyping; Leukemia, Myeloid, Acute; Mutation; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt

2016
Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers.
    Cancer research, 2010, Jul-01, Volume: 70, Issue:13

    Topics: Aged; Animals; Apoptosis; Cell Growth Processes; Cell Line, Tumor; Enzyme Activation; Female; Fingolimod Hydrochloride; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred DBA; Phosphorylation; Propylene Glycols; Protein Phosphatase 2; Protein Subunits; Proto-Oncogene Proteins c-kit; Signal Transduction; Sphingosine

2010
[Influence of PP2A activator on proliferation of HL-60 cells and analysis of PP2A activity changes in patients with acute myeloid leukemia].
    Zhongguo shi yan xue ye xue za zhi, 2011, Volume: 19, Issue:3

    Topics: Adult; Aged; Apoptosis; Case-Control Studies; Cell Proliferation; Enzyme Activators; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Okadaic Acid; Propylene Glycols; Protein Phosphatase 2; Sphingosine; Young Adult

2011
Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.
    Journal of cellular biochemistry, 2012, Volume: 113, Issue:4

    Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Enzyme Activation; Enzyme Reactivators; Fingolimod Hydrochloride; Humans; Leukemia, Myeloid, Acute; Mutation; Propylene Glycols; Protein Phosphatase 2; Proto-Oncogene Proteins c-kit; Sphingosine

2012