finasteride has been researched along with Disease Models, Animal in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (4.11) | 18.2507 |
| 2000's | 21 (28.77) | 29.6817 |
| 2010's | 37 (50.68) | 24.3611 |
| 2020's | 12 (16.44) | 2.80 |
| Authors | Studies |
|---|---|
| Dahai, Y; En-Si, W; Jiazhen, W; Jinfeng, L; Jing, Y; Lijuan, Y; Shuang, Z; Xuexun, F; Yongtao, L; Zhuo, L | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Li, X; Peng, C; Peng, Y; Sun, C; Wu, Y | 1 |
| Goudarzi, M; Kalantar, H; Kalantar, M; Kalantari, H; Mansouri, E; Shabani, E | 1 |
| Fano-Sizgorich, D; Gasco, M; Gonzales, GF; Vásquez-Velásquez, C | 1 |
| Ivanova, EA; Kalinina, TS; Kudryashov, NV; Kurshin, AA; Shimshirt, AA; Voronina, TA; Zhmurenko, LA | 1 |
| Chi, NJ; Feng, J; Liu, MY; Shi, XP; Wen, AD | 1 |
| Cao, J; Li, B; Li, Q; Li, X; Panday, R; Ullah, MW; Wang, L; Yang, G; Zhang, Y | 1 |
| Amin, HAA; Elbaz, EM; Helmy, HS; Ibrahim, SM; Kamel, AS | 1 |
| An, HJ; Jin, BR; Ju, JY; Lee, M; Nugroho, A | 1 |
| Bortolato, M; Bosse, GD; Cadeddu, R; Farero, RD; Floris, G; Gaikwad, NW; Keefe, KA; Lee, SJ; Peterson, RT; Phillips, PE; Vigato, E; Zhang, T | 1 |
| El-Gowilly, SM; El-Mas, MM; Sallam, MY | 1 |
| Kolasa, A; Machaliński, B; Rogińska, D; Rzeszotek, S; Wiszniewska, B | 1 |
| Aguirre, JI; Alerte, J; Bassett, TE; Borst, SE; Chen, C; Conover, CF; Flores, M; Jiron, JM; Phillips, EG; Prock, H; Teurlings, T; Vasconez, A; Yarrow, JF; Ye, F | 1 |
| Higashi, T; Nakashima, K; Okumura, A; Sato, T; Yoshizawa, K | 1 |
| Joshi, S; Kapur, J; Rajasekaran, K; Williamson, J | 1 |
| Li, K; Si, H; Wang, Y; Yang, Z; Zhang, C | 1 |
| Ogaeri, T; Samsonov, M; Sokabe, M; Tanaka, M | 1 |
| Deslauriers, J; Grignon, S; Maurice-Gélinas, C; Monpays, C; Sarret, P | 1 |
| Choi, BR; Karna, KK; Kim, HK; Lee, SW; Park, JK; So, I; Soni, KK | 1 |
| An, N; Chen, H; Fan, X; He, G; Li, F; Peng, J | 1 |
| An, HJ; Chung, KS; Jin, BR; Kim, HJ | 1 |
| Bak, DH; Choi, MJ; Kim, BJ; Kim, JH; Lee, BC; Lee, E; Lee, HS; Lee, S; Mun, SK; Na, J; Park, BC; Ryu, CH | 1 |
| Kalakh, S; Mouihate, A | 1 |
| Bäckström, T; Bortolato, M; Cadeddu, R; Floris, G; Nordkild, P; Segerdahl, M | 1 |
| Nambiar, D; Singh, RP | 1 |
| Brown, R; Donner, NC; Handa, RJ; Kudwa, AE; McGivern, RF | 1 |
| Chow, E; Gane, J; Jeffrey, M; Lang, M; Wu, C; Zhang, L | 1 |
| Hwang, ES; Lee, DG; Mavlonov, GT; Park, SY; Shin, HS; Yi, TH | 1 |
| Adjei, S; Afriyie, DK; Asare, GA; Bugyei, K; Hong, ZF; Lin, JM; Peng, J | 1 |
| Li, J; Sun, Q; Yang, C; Yang, J; Zhang, L; Zou, Y | 1 |
| Cagnon, VH; Hetzl, AC; Kido, LA; Montico, F | 1 |
| Antoshina, EE; Belitsky, GA; Blagosklonny, MV; Chernova, OB; Gorkova, TG; Kirsanov, KI; Lesovaya, EA; Salimov, RM; Shipaeva, EV; Trukhanova, LS; Yakubovskaya, MG | 1 |
| Abbiati, F; Bini, V; Bortolato, M; Caruso, D; Casti, A; Devoto, P; Frau, R | 1 |
| Hrnčić, D; Macut, Dj; Mladenović, D; Rašić-Marković, A; Stanojlović, O | 1 |
| Jeong, MY; Jung, Y; Kang, J; Kim, HL; Park, J; Seok Ahn, K; Sethi, G; Um, JY; Youn, DH | 1 |
| Bini, V; Bortolato, M; Caruso, D; Devoto, P; Fanni, S; Frau, R; Marrosu, F; Pardu, A; Puligheddu, M; Roncada, P; Scheggi, S; Soggiu, A | 1 |
| Crombie, GK; Cumberland, AL; Hirst, JJ; Palliser, HK; Walker, DW | 1 |
| Chadha, VD; Dhawan, DK; Jan, G; Passi, ND | 1 |
| Finn, DA; Ford, MM; Fretwell, A; Strong, MN; Tanchuck, M; Yoneyama, N | 1 |
| Beadles-Bohling, AS; Crabbe, JC; Finn, DA; Ford, MM; Gililland-Kaufman, KR; Mark, GP; Snelling, C; Tanchuck, MA | 1 |
| Arora, SK; Chakrabarti, A; Hota, D; Khanduja, KL; Prakash, A; Singh, S | 1 |
| Finn, DA; Kaufman, KR; Strong, MN; Tanchuck, MA | 1 |
| Kapur, J; Lawrence, C; Martin, BS; Sun, C; Williamson, J | 1 |
| Fornari, A; Rhoden, CR; Rhoden, EL; Ribeiro, EP; Zettler, CG | 1 |
| Beckley, EH; Finn, DA; Scibelli, AC | 1 |
| Cho, YH; Ha, US; Han, CH; Lee, CB; Lee, HR; Sohn, DW; Yim, SH | 1 |
| Dhir, A; Rogawski, MA | 1 |
| Gao, PJ; Lu, YL; Shen, ZJ; Wang, XJ; Wu, W; Zhang, CM; Zhang, MG | 1 |
| Gangisetty, O; Gould, J; Reddy, DS | 1 |
| Ramanathan, G; Samba Reddy, D | 1 |
| Batstone, D; Batstone, GR; Doble, A | 1 |
| Budziszewska, B; Lasoń, W; Tetich, M; van Luijtelaar, G | 1 |
| Castaneda, DC; O'Malley, BW; Reddy, DS; Rogawski, MA | 1 |
| Bostwick, DG; Civantos, F; Montironi, R; Qian, J; Roehrborn, CG | 1 |
| Crabbe, JC; Finn, DA; Gorin, RE; Long, SL; Tanchuck, MA | 1 |
| Frye, C; Homanics, G; Ruderman, Y; Smith, SS; Yuan, M | 1 |
| Burnham, WM; Edwards, HE; Vimal, S | 1 |
| Burnham, WM; Likhodii, S; Perez-Cruz, C | 1 |
| Murphy, NP; Okabe, C; Sakoori, K | 1 |
| Becker, RE; Dalrymple, SL; Denmeade, SR; Isaacs, JT; Xu, Y | 1 |
| Baudendistel, KT; Henry, H; Heverhagen, JT; Jia, G; Knopp, MV; Levine, AL; Polzer, H; Rosol, TJ; von Tengg-Kobligk, H | 1 |
| Fukuzumi, H; Ikeda, T; Matsuda, T; Narita, H; Takubo, T; Taniguchi, T | 1 |
| Asamoto, M; Cho, YM; Shirai, T; Suzuki, S; Takahashi, S; Tang, M | 1 |
| Gao, H; Li, SK; Li, YQ; Shou, KR; Wang, YS; Wu, YG; Xin, ZC | 1 |
| Bortolato, M; Bourov, Y; Devoto, P; Frau, R; Gessa, GL; Marrosu, F; Mereu, G; Orrù, M | 1 |
| Dall'olio, R; Gandolfi, O; Locchi, F; Rimondini, R | 1 |
| Burnet, M; Groebe, K; Klemm, M; Poznanović, S; Proikas-Cezanne, T; Schoepf, R; Schrattenholz, A; Schwall, GP; Soskić, V; Stegmann, W; Zengerling, H | 1 |
| Droz, JP | 1 |
| Ball, RA; Leder, P; Ornitz, DM; Richie, JP; Tutrone, RF | 1 |
| Akaza, H; Ami, Y; Ideyama, Y; Imada, S; Koiso, K; Takenaka, T | 1 |
| Reddy, DS; Rogawski, MA | 1 |
| Kim, HY; Reddy, DS; Rogawski, MA | 1 |
3 review(s) available for finasteride and Disease Models, Animal
| Article | Year |
|---|---|
Advances in prostate cancer chemoprevention: a translational perspective.
Topics: Androgen Antagonists; Animals; Anticarcinogenic Agents; Antioxidants; Azasteroids; Carotenoids; Chemoprevention; Clinical Trials as Topic; Curcumin; Disease Models, Animal; Dutasteride; Finasteride; Flavonoids; Genistein; Humans; Lycopene; Male; Phytochemicals; Polyphenols; Prostate; Prostatic Neoplasms; Risk Factors; Selenium; Silybin; Silymarin; Tea; Vitamin E | 2013 |
Chronic prostatitis.
Topics: Adult; Age Distribution; Aged; Animals; Chronic Disease; Disease Models, Animal; Finasteride; Humans; Incidence; Male; Middle Aged; Pelvic Pain; Prognosis; Prostatitis; Quality of Life; Randomized Controlled Trials as Topic; Risk Factors; Severity of Illness Index; Treatment Outcome | 2003 |
Does finasteride alter the pathology of the prostate and cancer grading?
Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Animals; Disease Models, Animal; Enzyme Inhibitors; Finasteride; Humans; Male; Neoplasm Staging; Prostate; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms | 2004 |
70 other study(ies) available for finasteride and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and bioactivity of new Finasteride conjugate.
Topics: 5-alpha Reductase Inhibitors; Acylation; Animals; Cell Proliferation; Disease Models, Animal; Finasteride; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Male; Prostatic Hyperplasia; Rats | 2011 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Chemical profiles of the active fraction from Prinsepia utilis Royle leaves and its anti-benign prostatic hyperplasia evaluation in animal models.
Topics: Animals; China; Disease Models, Animal; Finasteride; Male; Plant Extracts; Plant Leaves; Prostate; Prostatic Hyperplasia; Rats; Rats, Sprague-Dawley; Urological Agents | 2021 |
Berberine ameliorates testosterone-induced benign prostate hyperplasia in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Dihydrotestosterone; Disease Models, Animal; Drugs, Chinese Herbal; Finasteride; Interleukin-1beta; Male; Oxidative Stress; Prostate; Prostatic Hyperplasia; Rats; Rats, Wistar; Testosterone; Tumor Necrosis Factor-alpha | 2021 |
Inflammatory pathway employed by Red Maca to treat induced benign prostatic hyperplasia in rats.
Topics: 5-alpha Reductase Inhibitors; Animals; Disease Models, Animal; Finasteride; Humans; Interferon-gamma; Interleukin-4; Lepidium; Male; Plant Extracts; Prostate; Prostatic Hyperplasia; Rats; Signal Transduction; Testosterone; Th1 Cells; Th2 Cells; Tumor Necrosis Factor-alpha | 2020 |
Antiexudative Effects of Finasteride and a New Pyrazolo[C]Pyridine Derivative GIZh-72 in Acetic Acid-Induced Experimental Peritonitis.
Topics: 5-alpha Reductase Inhibitors; Acetic Acid; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Finasteride; Humans; Injections, Intraperitoneal; Male; Mice; Peritonitis; Pyrazoles; Pyridines | 2020 |
[Ruyi Jinhuang Plaster suppresses BPH by reducing the expressions of P38, JNK2, NF-кBP65 and STAT3 in the prostate tissue of rats].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Finasteride; Male; Mitogen-Activated Protein Kinase 9; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Prostatic Hyperplasia; Rats; STAT3 Transcription Factor; Testosterone; Testosterone Propionate | 2018 |
Water-stable and finasteride-loaded polyvinyl alcohol nanofibrous particles with sustained drug release for improved prostatic artery embolization - In vitro and in vivo evaluation.
Topics: 5-alpha Reductase Inhibitors; Animals; Cell Survival; Combined Modality Therapy; Delayed-Action Preparations; Disease Models, Animal; Dogs; Drug Stability; Embolization, Therapeutic; Finasteride; Male; Nanofibers; Particle Size; Polyvinyl Alcohol; Prostatic Hyperplasia; Treatment Outcome | 2020 |
Immunomodulatory effect of diallyl sulfide on experimentally-induced benign prostate hyperplasia via the suppression of CD4+T/IL-17 and TGF-β1/ERK pathways.
Topics: Allyl Compounds; Animals; Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; Disease Models, Animal; Finasteride; Immunologic Factors; Interleukin-17; Male; MAP Kinase Signaling System; Prostate-Specific Antigen; Prostatic Hyperplasia; Rats; Rats, Wistar; Receptors, Androgen; Sulfides; Testosterone Propionate; Transforming Growth Factor beta1 | 2020 |
Carica papaya leaf extract inhibits prostatitis-associated prostatic hyperplasia via the TRAF6/TAK1/MEK/NF-κB pathway.
Topics: Animals; Anti-Inflammatory Agents; Carica; Cell Line; Cell Proliferation; Cytokines; Disease Models, Animal; Finasteride; Inflammation Mediators; Male; MAP Kinase Kinase Kinases; Mice, Inbred BALB C; NF-kappa B; Plant Extracts; Plant Leaves; Prostate; Prostatic Hyperplasia; Prostatitis; Rats, Wistar; Signal Transduction; TNF Receptor-Associated Factor 6 | 2021 |
The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder.
Topics: 5-alpha Reductase Inhibitors; Animals; Disease Models, Animal; Finasteride; Humans; Male; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Zebrafish | 2021 |
Cardiac and Brainstem Neuroinflammatory Pathways Account for Androgenic Incitement of Cardiovascular and Autonomic Manifestations in Endotoxic Male Rats.
Topics: 5-alpha Reductase Inhibitors; Androstenedione; Animals; Aromatase Inhibitors; Autonomic Nervous System; Blood Pressure; Brain Stem; Disease Models, Animal; Encephalitis; Endotoxemia; Finasteride; Heart; Heart Diseases; Heart Rate; Inflammation Mediators; Male; Oligopeptides; Orchiectomy; Rats, Wistar; Receptors, LHRH; Testosterone | 2021 |
Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring-Preliminary Study.
Topics: 5-alpha Reductase Inhibitors; Animals; Disease Models, Animal; Female; Finasteride; Male; Paternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Odorant; Spermatogenesis; Testis; Transcriptome | 2021 |
Testosterone Plus Finasteride Prevents Bone Loss without Prostate Growth in a Rodent Spinal Cord Injury Model.
Topics: 5-alpha Reductase Inhibitors; Androgens; Animals; Bone Remodeling; Bone Resorption; Disease Models, Animal; Finasteride; Male; Muscle, Skeletal; Prostate; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Testosterone | 2017 |
Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety Disorders; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Freezing Reaction, Cataleptic; Male; Mice, Inbred C57BL; Muscle Relaxants, Central; Muscle Strength; Muscle Tonus; Pregnanediones; Pregnanolone; Restraint, Physical; Stress, Psychological | 2017 |
Neurosteroid-sensitive δ-GABA
Topics: Animals; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; Down-Regulation; Electroencephalography; Epilepsy, Temporal Lobe; Female; Finasteride; Hippocampus; Lithium Compounds; Male; Neuronal Plasticity; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Status Epilepticus; Video Recording | 2017 |
Evaluation of a novel dry eye model induced by oral administration of finasteride.
Topics: 5-alpha Reductase Inhibitors; Administration, Oral; Animals; Biomarkers; Cytokines; Disease Models, Animal; Dry Eye Syndromes; Female; Finasteride; Lacrimal Apparatus; Rats | 2017 |
The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats.
Topics: 5-alpha Reductase Inhibitors; Age Factors; Aging; Analysis of Variance; Animals; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Infarction, Middle Cerebral Artery; Male; Motor Skills; Neuroprotective Agents; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Time Factors | 2019 |
The 5α-reductase inhibitor finasteride increases suicide-related aggressive behaviors and blocks clozapine-induced beneficial effects in an animal model of schizophrenia.
Topics: 5-alpha Reductase Inhibitors; Acoustic Stimulation; Aggression; Animals; Animals, Newborn; Antipsychotic Agents; Clozapine; Disease Models, Animal; Exploratory Behavior; Female; Finasteride; Interpersonal Relations; Male; Mice; Mice, Inbred C57BL; Polydeoxyribonucleotides; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Suicide | 2018 |
Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model.
Topics: Administration, Oral; Animals; Benzofurans; Disease Models, Animal; Drug Therapy, Combination; Finasteride; Indoles; Male; Prostatic Hyperplasia; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Sulfonamides; Tamsulosin; Testosterone | 2018 |
Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias.
Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Finasteride; Hypospadias; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Rats; Signal Transduction; Urethra | 2018 |
Chinese Skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats.
Topics: 5-alpha Reductase Inhibitors; Animals; Apoptosis; Biomarkers; Disease Models, Animal; Finasteride; Inflammation; Male; Medicine, Chinese Traditional; Plant Extracts; Prostate; Prostatic Hyperplasia; Rats; Rats, Sprague-Dawley; Scutellaria baicalensis; Testosterone | 2019 |
Development of finasteride polymer microspheres for systemic application in androgenic alopecia.
Topics: 5-alpha Reductase Inhibitors; Alopecia; Animals; Disease Models, Animal; Drug Carriers; Finasteride; Hair Follicle; Injections; Male; Mice; Mice, Inbred C57BL; Polylactic Acid-Polyglycolic Acid Copolymer | 2019 |
Enhanced remyelination during late pregnancy: involvement of the GABAergic system.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Bicuculline; Corpus Callosum; Demyelinating Diseases; Disease Models, Animal; Female; Finasteride; GABA Antagonists; Lysophosphatidylcholines; Male; Microglia; Multiple Sclerosis; Myelin Proteins; Myelin Sheath; Nerve Tissue Proteins; Oligodendrocyte Precursor Cells; Oligodendroglia; Pregnancy; Pregnancy Complications; Pregnanolone; Puerperal Disorders; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Remyelination | 2019 |
Isoallopregnanolone reduces tic-like behaviours in the D1CT-7 mouse model of Tourette syndrome.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Haloperidol; Housing, Animal; Male; Mice; Pregnanolone; Tics; Tourette Syndrome | 2020 |
Central 5-alpha reduction of testosterone is required for testosterone's inhibition of the hypothalamo-pituitary-adrenal axis response to restraint stress in adult male rats.
Topics: 5-alpha Reductase Inhibitors; Adrenocorticotropic Hormone; Animals; Corticosterone; Dihydrotestosterone; Disease Models, Animal; Estradiol; Finasteride; Hypothalamo-Hypophyseal System; Injections, Intra-Articular; Male; Orchiectomy; Pituitary-Adrenal System; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Physiological; Testosterone; Time Factors | 2013 |
Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling.
Topics: Action Potentials; Animals; Anticonvulsants; Berberine Alkaloids; Carbamazepine; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Electrodes, Implanted; Finasteride; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Midazolam; Picrotoxin; Progesterone; Seizures | 2014 |
Ginsenoside F2 reduces hair loss by controlling apoptosis through the sterol regulatory element-binding protein cleavage activating protein and transforming growth factor-β pathways in a dihydrotestosterone-induced mouse model.
Topics: Alopecia; Animals; Apoptosis; Caspase 12; Cell Proliferation; Dihydrotestosterone; Disease Models, Animal; Finasteride; Ginsenosides; Hair Follicle; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Signal Transduction; Sterol Regulatory Element Binding Proteins; Transforming Growth Factor beta | 2014 |
Treatment of benign prostatic hyperplasia with Croton membranaceus in an experimental animal model.
Topics: Animals; Croton; Dihydrotestosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Male; Medicine, Traditional; Plant Extracts; Plant Roots; Prostate-Specific Antigen; Prostatic Hyperplasia; Rats; Rats, Sprague-Dawley | 2014 |
Effects of E/Z isomers of lycopene on experimental prostatic hyperplasia in mice.
Topics: Acid Phosphatase; Animals; Carotenoids; Disease Models, Animal; Estradiol; Finasteride; Lycopene; Male; Mice; Mice, Inbred ICR; Prostate; Prostatic Hyperplasia; Protein Tyrosine Phosphatases; Solanum lycopersicum; Testosterone | 2014 |
Prostatic angiogenic responses in late life: antiangiogenic therapy influences and relation with the glandular microenvironment in the transgenic adenocarcinoma of mouse prostate (TRAMP) model.
Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Angiogenesis Inhibitors; Animals; Blotting, Western; Cyclohexanes; Disease Models, Animal; Endostatins; Fibroblast Growth Factor 2; Finasteride; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indoles; Male; Mice; Mice, Transgenic; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Prostatic Neoplasms; Pyrroles; Sesquiterpenes; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2015 |
Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats.
Topics: Aging; Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Drug Administration Schedule; Finasteride; Male; Nanomedicine; Prostate; Prostatic Hyperplasia; Rats; Rats, Wistar; Sirolimus; Sulpiride; Testosterone; TOR Serine-Threonine Kinases | 2015 |
Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Antipsychotic Agents; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Haloperidol; Injections, Intraperitoneal; Male; Nucleus Accumbens; Pregnenolone; Prepulse Inhibition; Random Allocation; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Social Isolation; Stress, Psychological | 2015 |
The Influence of Finasteride on Mean and Relative Spectral Density of EEG Bands in Rat Model of Thioacetamide-Induced Hepatic Encephalopathy.
Topics: 5-alpha Reductase Inhibitors; Ammonia; Animals; Brain; Brain Waves; Central Nervous System Agents; Disease Models, Animal; Electrocorticography; Finasteride; Fourier Analysis; Hepatic Encephalopathy; Male; Rats, Wistar; Severity of Illness Index; Thioacetamide | 2016 |
Chrysophanic acid reduces testosterone-induced benign prostatic hyperplasia in rats by suppressing 5α-reductase and extracellular signal-regulated kinase.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Anthraquinones; Cell Line; Cell Proliferation; Disease Models, Animal; Down-Regulation; Estrogen Receptor alpha; Extracellular Signal-Regulated MAP Kinases; Finasteride; Male; Nuclear Receptor Coactivator 1; Organ Size; Phosphorylation; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Rats, Sprague-Dawley; Receptors, Androgen; Signal Transduction; Testosterone Propionate; Time Factors | 2017 |
The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation.
Topics: 5-alpha Reductase Inhibitors; Acoustic Stimulation; Animals; Antipsychotic Agents; Brain; Cholestenone 5 alpha-Reductase; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Gene Expression Regulation, Enzymologic; Male; Pregnanolone; Psychotic Disorders; Rats; Rats, Sprague-Dawley; Reflex, Startle; Sleep Deprivation; Steroids | 2017 |
Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero.
Topics: 5-alpha Reductase Inhibitors; Animals; Animals, Newborn; Anxiety; Brain; Disease Models, Animal; Exploratory Behavior; Female; Finasteride; Guinea Pigs; Hydrocortisone; Nerve Tissue Proteins; Neurotransmitter Agents; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Radioimmunoassay; Sex Factors; Statistics, Nonparametric | 2017 |
Cancer Targeting Potential of
Topics: Acid Phosphatase; Animals; Carcinogenesis; Carcinogens; Disease Models, Animal; Electrophoresis; Finasteride; Hydrogen-Ion Concentration; Kinetics; Male; Methylnitrosourea; Prostate; Prostatic Neoplasms; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Technetium; Time Factors; Tissue Distribution | 2017 |
Inhibition of 5alpha-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Cholestenone 5 alpha-Reductase; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Finasteride; Male; Mice; Mice, Inbred C57BL; Pregnanolone; Receptors, GABA-A; Time Factors | 2008 |
The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Alcohol-Induced Disorders, Nervous System; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epilepsy; Finasteride; Genetic Predisposition to Disease; Hippocampus; Mice; Mice, Transgenic; Neurons; Pentylenetetrazole; Pregnanolone; Substance Withdrawal Syndrome | 2008 |
Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Electrophoresis, Agar Gel; Enzyme Inhibitors; Finasteride; Indomethacin; Male; Mice; Neurons; Picrotoxin; Pregnanolone; Seizures | 2010 |
Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Acute Disease; Alcohol-Induced Disorders, Nervous System; Animals; Castration; Central Nervous System Depressants; Desoxycorticosterone; Disease Models, Animal; Enzyme Inhibitors; Ethanol; Female; Finasteride; gamma-Aminobutyric Acid; Male; Mice; Neural Inhibition; Neurotransmitter Agents; Pregnanolone; Progesterone; Receptors, GABA-A; Substance Withdrawal Syndrome | 2010 |
Endogenous neurosteroid synthesis modulates seizure frequency.
Topics: Animals; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Female; Finasteride; Gonadotropins; Lithium; Neurotransmitter Agents; Pilocarpus; Pregnanolone; Rats | 2010 |
Effects of the chronic use of finasteride and doxazosin mesylate on the histomorphometric characteristics of the prostate: experimental study in rats.
Topics: 5-alpha Reductase Inhibitors; Adrenergic alpha-1 Receptor Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Doxazosin; Drug Administration Schedule; Drug Therapy, Combination; Finasteride; Follow-Up Studies; Male; Prostate; Prostatic Hyperplasia; Rats; Rats, Wistar; Time Factors; Treatment Outcome | 2011 |
Progesterone receptor antagonist CDB-4124 increases depression-like behavior in mice without affecting locomotor ability.
Topics: Animals; Depression; Depression, Postpartum; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Finasteride; Locomotion; Mice; Mice, Inbred DBA; Mifepristone; Norpregnadienes; Premenstrual Syndrome; Progesterone; Receptors, Progesterone; Single-Blind Method; Swimming | 2011 |
Does finasteride have a preventive effect on chronic bacterial prostatitis? Pilot study using an animal model.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Finasteride; Humans; Male; Pilot Projects; Prostatitis; Rats; Rats, Wistar; Treatment Outcome; Urinary Tract Infections | 2011 |
Role of neurosteroids in the anticonvulsant activity of midazolam.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Finasteride; GABA Antagonists; Isoquinolines; Male; Mice; Midazolam; Neurotransmitter Agents; Pentylenetetrazole; Receptors, GABA; Seizures | 2012 |
Effects of oral finasteride on erectile function in a rat model.
Topics: 5-alpha Reductase Inhibitors; Administration, Oral; Animals; Dihydrotestosterone; Disease Models, Animal; Erectile Dysfunction; Finasteride; Male; Penile Erection; Penis; Prostate; Rats; Rats, Sprague-Dawley; Testosterone | 2012 |
A mouse kindling model of perimenstrual catamenial epilepsy.
Topics: 5-alpha Reductase Inhibitors; Animals; Diazepam; Disease Models, Animal; Epilepsy; Female; Finasteride; Gonadotropins; Hippocampus; Kindling, Neurologic; Menstrual Cycle; Mice; Mice, Inbred C57BL; Pregnanolone; Progesterone; Rats; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; RNA, Messenger; Substance Withdrawal Syndrome | 2012 |
Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Epilepsy; Female; Finasteride; Hippocampus; Kindling, Neurologic; Mice; Mice, Inbred C57BL; Progesterone; Statistics, Nonparametric | 2012 |
Finasteride inhibits the progesterone-induced spike-wave discharges in a genetic model of absence epilepsy.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Action Potentials; Animals; Disease Models, Animal; Enzyme Inhibitors; Epilepsy, Absence; Finasteride; Male; Progesterone; Rats | 2003 |
Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; Finasteride; Kindling, Neurologic; Male; Mice; Mice, Knockout; Mutation; Pregnanolone; Progesterone; Receptors, Progesterone; Seizures; Steroids | 2004 |
Effects of finasteride on chronic and acute ethanol withdrawal severity in the WSP and WSR selected lines.
Topics: Alcohol Withdrawal Seizures; Animals; Behavior, Animal; Cholestenone 5 alpha-Reductase; Disease Models, Animal; Enzyme Inhibitors; Ethanol; Finasteride; Handling, Psychological; Male; Mice; Mice, Inbred Strains; Receptors, GABA; Seizures; Severity of Illness Index; Substance Withdrawal Syndrome | 2005 |
Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha,5beta-THP: a possible model of premenstrual dysphoric disorder.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Female; Finasteride; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnanolone; Premenstrual Syndrome; Receptors, GABA-A | 2006 |
The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses.
Topics: Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Enzyme Inhibitors; Finasteride; Mineralocorticoid Receptor Antagonists; Pentylenetetrazole; Rats; Receptors, GABA; Receptors, Mineralocorticoid; Receptors, Progesterone; Seizures; Spironolactone | 2005 |
Deoxycorticosterone's anticonvulsant effects in infant rats are blocked by finasteride, but not by indomethacin.
Topics: Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Epilepsy, Tonic-Clonic; Finasteride; Indomethacin; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
Lack of evidence of a role for the neurosteroid allopregnanolone in ethanol-induced reward and c-fos expression in DBA/2 mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Brain; Central Nervous System Depressants; Conditioning, Psychological; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Ethanol; Finasteride; Male; Mice; Mice, Inbred DBA; Motor Activity; Pregnanolone; Progesterone; Proto-Oncogene Proteins c-fos; Reward; Ventral Tegmental Area | 2006 |
Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Administration, Oral; Animals; Azasteroids; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Dihydrotestosterone; Disease Models, Animal; Dutasteride; Enzyme Activation; Enzyme Inhibitors; Finasteride; Gene Expression Profiling; Humans; Male; Mass Spectrometry; Mice; Mice, Nude; Molecular Conformation; Prostatic Neoplasms; Protein Isoforms; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2006 |
Pharmacokinetic parameters as a potential predictor of response to pharmacotherapy in benign prostatic hyperplasia: a preclinical trial using dynamic contrast-enhanced MRI.
Topics: Animals; Contrast Media; Disease Models, Animal; Dogs; Enzyme Inhibitors; Finasteride; Gadolinium; Heterocyclic Compounds; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Microcirculation; Organometallic Compounds; Prospective Studies; Prostate; Prostatic Hyperplasia; Random Allocation; Statistics, Nonparametric; Treatment Outcome | 2006 |
[Pharmacological and clinical profile of finasteride (PROPECIA)].
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Alopecia; Animals; Clinical Trials as Topic; Dihydrotestosterone; Disease Models, Animal; Enzyme Inhibitors; Female; Finasteride; Haplorhini; Humans; Male | 2006 |
Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model.
Topics: Adenocarcinoma; Androgen Antagonists; Animals; Animals, Genetically Modified; Antigens, Viral, Tumor; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Enzyme Inhibitors; Finasteride; Flutamide; Male; Prostate; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Testosterone | 2007 |
[The establishment of hypospadias rat model and embryoteratogenic test of Atrazine].
Topics: Animals; Atrazine; Disease Models, Animal; Female; Finasteride; Hypospadias; Male; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens | 2007 |
Antipsychotic-like properties of 5-alpha-reductase inhibitors.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androstanes; Animals; Antipsychotic Agents; Azasteroids; Brain; Disease Models, Animal; Dopamine Agonists; Dutasteride; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Finasteride; Gonadal Steroid Hormones; Hyperkinesis; Male; Psychotic Disorders; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensory Gating; Stereotyped Behavior; Testosterone; Treatment Outcome | 2008 |
Olanzapine counteracts stress-induced anxiety-like behavior in rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety Disorders; Benzodiazepines; Brain; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Finasteride; gamma-Aminobutyric Acid; Male; Maze Learning; Olanzapine; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Restraint, Physical; Stress, Psychological | 2008 |
A connection between the mitochondrial permeability transition pore, autophagy, and cerebral amyloidogenesis.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Apoptosis; Autophagy; Azasteroids; Brain Diseases; Disease Models, Animal; Dutasteride; Enzyme Inhibitors; Finasteride; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial ADP, ATP Translocases; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; N-Methylaspartate; Neocortex; Neurons; Neuroprotective Agents; Plaque, Amyloid; Potassium Cyanide; Presenilins; Sex Factors; Testosterone | 2008 |
[Chemoprevention of cancer of the prostate].
Topics: Aged; Aged, 80 and over; Animals; Disease Models, Animal; Finasteride; Food; Humans; Male; Middle Aged; Prostatic Neoplasms; Rats; Rats, Wistar; Risk Factors | 1995 |
Benign prostatic hyperplasia in a transgenic mouse: a new hormonally sensitive investigatory model.
Topics: 5-alpha Reductase Inhibitors; Androstenes; Animals; Azasteroids; Dihydrotestosterone; Disease Models, Animal; Fibroblast Growth Factor 3; Fibroblast Growth Factors; Finasteride; Flutamide; Genes, Viral; Male; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Orchiectomy; Phenotype; Prostate; Prostatic Hyperplasia; Proto-Oncogene Proteins; Sexual Maturation; Testosterone | 1993 |
Promoting effects and mechanisms of action of androgen in bladder carcinogenesis in male rats.
Topics: Administration, Oral; Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Butylhydroxybutylnitrosamine; Carcinogens; Carcinoma; Cholestenone 5 alpha-Reductase; Disease Models, Animal; Enzyme Inhibitors; Finasteride; Flutamide; Gonadotropin-Releasing Hormone; Immunohistochemistry; Leuprolide; Male; Mice; Mice, Inbred C3H; Oxidoreductases; Rats; Rats, Wistar; Urinary Bladder Neoplasms | 1997 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Finasteride; Menstruation; Oxidoreductases; Pentylenetetrazole; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Seizures; Steroids; Valproic Acid | 2000 |
Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.
Topics: 20-alpha-Dihydroprogesterone; Adult; Animals; Behavior, Animal; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Finasteride; Gonadotropins, Equine; Humans; Menstrual Cycle; Pentylenetetrazole; Pregnanolone; Progesterone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome | 2001 |