filipin has been researched along with Niemann-Pick Disease in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.03) | 18.7374 |
| 1990's | 10 (30.30) | 18.2507 |
| 2000's | 22 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Broadie, K; Liang, P; Patten, M; Phillips, SE; Woodruff, EA | 1 |
| Campenot, RB; Karten, B; Vance, DE; Vance, JE | 1 |
| Ahnert-Hilger, G; Herrmann, A; Hinz, B; Hollmann, S; Mitter, D; Ohm, TG; Reisinger, C; Treiber-Held, S; Yelamanchili, SV | 1 |
| Chang, TY; Maue, RA; Ninomiya, H; Ohgami, N; Ohno-Iwashita, Y; Reid, PC; Shimada, Y; Sugii, S | 1 |
| Davies, JP; Ioannou, YA; Walter, M | 1 |
| Albert, F; Distl, R; Harzer, K; Meske, V; Ohm, TG; Treiber-Held, S | 1 |
| Crowley, JR; Dudley-Rucker, N; Frolov, A; Ory, DS; Schaffer, JE; Zielinski, SE | 1 |
| Beheregaray, AP; Coelho, JC; Souza, FT | 1 |
| Distl, R; Glöckner, F; Meske, V; Ohm, TG; Schönheit, B; Tamanai, M; Treiber-Held, S | 1 |
| Corey, DA; Kelley, TJ; White, NM | 1 |
| Chikh, K; Millat, G; Simonot, C; Vanier, MT; Vey, S | 1 |
| Albert, F; Deisz, RA; Meske, V; Ohm, TG; Treiber-Held, S | 1 |
| Hashizume, T; Hayashi, Y; Hozumi, I; Inuzuka, T; Kimura, A; Matsuyama, Z; Sawada, M; Suzuki, Y; Tsurumi, H; Wakida, K | 1 |
| Cuisset, JM; De Sèze, J; Stojkovic, T; Turpin, JC; Tyvaert, L; Vanier, MT; Vermersch, P | 1 |
| Ban, N; Inagaki, N; Ninomiya, H; Takada, G; Takahashi, T; Tamura, H; Torisu, H | 1 |
| Huang, A; Maxfield, FR; Pipalia, NH; Ralph, H; Rujoi, M | 1 |
| Bi, X; Cheung, S; Liang, X; Liao, G; Liu, J; Xie, A; Yao, Y; Yu, Z | 1 |
| Evans, AH; Fietz, M; Velakoulis, D; Walterfang, M | 1 |
| Elleder, M; Ledvinová, J | 1 |
| Fensom, AH; Steinberg, SJ; Ward, CP | 1 |
| Inui, K; Nakano, T; Nanba, E; Ohno, K; Okada, S; Takeshita, K | 1 |
| Carstea, ED; Duthel, S; Pentchev, P; Rodriguez-Lafrasse, C; Vanier, MT | 1 |
| Akaboshi, S; Miyawaki, S; Ohno, K; Takeshita, K; Yano, T | 1 |
| Akaboshi, S; Ishida, G; Nakashima, K; Ohno, K; Takeshima, T; Taniguchi, M; Watanabe, Y; Yano, T | 1 |
| Blanchette-Mackie, EJ; Brady, RO; Dwyer, NK; Glick, JM; Neufeld, EB; Patel, S; Pentchev, PG; Strauss, JF; Watari, H | 1 |
| Chang, TY; Cruz, JC; Sugii, S; Yu, C | 1 |
| Davies, JP; Ioannou, YA | 1 |
| Dobrenis, K; Walkley, SU; Zervas, M | 1 |
| Higaki, K; Ninomiya, H; Ohno, K; Saji, M; Shinoda, Y; Taniguchi, M; Ukita, Y; Yamada, A | 1 |
| Kitagawa, T; Miyawaki, S; Nanba, E; Ohno, K; Sakiyama, T; Takeshita, K | 1 |
| Brady, RO; Brown, A; Comly, ME; Cooney, A; Goldin, E; Miller, SP; Pentchev, PG; Roff, CF; Vanier, MT | 1 |
| Argoff, CE; Blanchette-Mackie, EJ; Brady, RO; Brown, A; Comly, M; Dwyer, NK; Kaneski, CR; Pentchev, PG | 1 |
| Amende, LM; Blanchette-Mackie, J; Brady, RO; Butler, JD; Comly, ME; Dwyer, NK; Kruth, HS; Patel, S; Robinson, E; Sokol, J | 1 |
2 review(s) available for filipin and Niemann-Pick Disease
| Article | Year |
|---|---|
[Diagnosis of adult type of Niemann-Pick disease (type C) in two brothers by filipin staining of bone marrow smears].
Topics: Adolescent; Adult; Bone Marrow Cells; Brain; Family Health; Filipin; Foam Cells; Humans; Magnetic Resonance Imaging; Male; Niemann-Pick Diseases; Staining and Labeling | 2004 |
Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport.
Topics: Amines; Androstenes; Animals; Biological Transport; Cells, Cultured; Cholesterol; Cholesterol Esters; Disease Models, Animal; Fibroblasts; Filipin; Humans; Imipramine; Lysosomes; Mice; Morpholines; Niemann-Pick Diseases; Sphingosine; Structure-Activity Relationship | 1991 |
31 other study(ies) available for filipin and Niemann-Pick Disease
| Article | Year |
|---|---|
Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration.
Topics: Aging; Animals; Biological Transport, Active; Brain; Cell Survival; Cells, Cultured; Cholesterol; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Filipin; Gene Expression Regulation, Developmental; Genes, Lethal; Inclusion Bodies; Intracellular Membranes; Membrane Proteins; Mice; Mutation; Nerve Degeneration; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Organelles; Photoreceptor Cells, Invertebrate; Retinal Diseases | 2008 |
Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neurons.
Topics: Animals; Antigens, CD; Axonal Transport; Axons; Cell Division; Cell Survival; Cells, Cultured; Cholesterol; Cytoplasmic Vesicles; Filipin; Intracellular Signaling Peptides and Proteins; Lysosomal Membrane Proteins; Mice; Mice, Neurologic Mutants; Nerve Growth Factor; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Protein Biosynthesis; Proteins; Sympathetic Nervous System | 2002 |
The synaptophysin/synaptobrevin interaction critically depends on the cholesterol content.
Topics: Animals; Anticholesteremic Agents; Brain; CHO Cells; Cholesterol; Cricetinae; Cyclodextrins; Detergents; Filipin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Membrane Proteins; Membranes; Mice; Mice, Inbred BALB C; Niemann-Pick Diseases; Octoxynol; Protein Transport; R-SNARE Proteins; Rats; Solubility; Synaptic Vesicles; Synaptophysin; Up-Regulation | 2003 |
Biotinylated theta-toxin derivative as a probe to examine intracellular cholesterol-rich domains in normal and Niemann-Pick type C1 cells.
Topics: Animals; Bacterial Toxins; beta-Cyclodextrins; Biotinylation; Carrier Proteins; Cell Line; CHO Cells; Cholesterol; Cricetinae; Cyclodextrins; Female; Filipin; Flow Cytometry; Green Fluorescent Proteins; Hemolysin Proteins; Humans; Intracellular Signaling Peptides and Proteins; Luminescent Proteins; Membrane Glycoproteins; Membrane Microdomains; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Microscopy, Fluorescence; Molecular Probes; Mutation; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Pancreatic Elastase; Recombinant Fusion Proteins | 2003 |
Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes.
Topics: Animals; Biological Transport; Cell Membrane; Cells, Cultured; Cholesterol, LDL; DNA-Binding Proteins; Endoplasmic Reticulum; Endosomes; Fibroblasts; Filipin; Humans; Niemann-Pick Diseases; rab GTP-Binding Proteins; Recombinant Fusion Proteins; Riboflavin; Telomerase; Telomere; trans-Golgi Network; Up-Regulation | 2003 |
Cholesterol storage and tau pathology in Niemann-Pick type C disease in the brain.
Topics: Adolescent; Adult; Alzheimer Disease; Brain Chemistry; Cerebral Cortex; Cholesterol; Female; Filipin; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Neurons; Neuropil Threads; Niemann-Pick Diseases; tau Proteins; Tauopathies | 2003 |
NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.
Topics: Carrier Proteins; Cells, Cultured; Cholesterol; Cholesterol, LDL; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Fibroblasts; Filipin; Gas Chromatography-Mass Spectrometry; Genes, Reporter; Glycoproteins; Humans; Hydroxycholesterols; Intracellular Signaling Peptides and Proteins; Lipoproteins; Lipoproteins, LDL; Liver X Receptors; Luciferases; Membrane Glycoproteins; Microscopy, Fluorescence; Mutation; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Orphan Nuclear Receptors; Oxygen; Phenotype; Receptors, Cytoplasmic and Nuclear; Skin; Sterols; Transfection; Vesicular Transport Proteins | 2003 |
Effect of a peroxysomal proliferator agent on intracellular cholesterol accumulation in cultured fibroblasts from Niemann-Pick type C disease patients.
Topics: Case-Control Studies; Cells, Cultured; Cholesterol; Clofibrate; Esterification; Fibroblasts; Filipin; Humans; Niemann-Pick Diseases; Peroxisome Proliferators; Staining and Labeling | 2003 |
Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease.
Topics: Acyl Coenzyme A; Alzheimer Disease; Analysis of Variance; Animals; Anticholesteremic Agents; Astrocytes; Blotting, Western; Brain Chemistry; Calcium; Cerebral Cortex; Cholesterol; Dextrans; Drug Interactions; Filipin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microglia; Microtubules; Neurofibrillary Tangles; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Proteins; rho GTP-Binding Proteins; RNA, Messenger; tau Proteins; Tubulin | 2003 |
Mechanistic similarities between cultured cell models of cystic fibrosis and niemann-pick type C.
Topics: Actins; Animals; Blotting, Western; Cells, Cultured; Cholesterol; Cystic Fibrosis; Disease Models, Animal; Epithelial Cells; Fibroblasts; Filipin; Humans; Mice; Mice, Transgenic; Mutation, Missense; Niemann-Pick Diseases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Sphingomyelin Phosphodiesterase; Temperature | 2004 |
Niemann-Pick type C disease: importance of N-glycosylation sites for function and cellular location of the NPC2 protein.
Topics: Binding Sites; Biological Transport; Blotting, Western; Carrier Proteins; Cell Line; Cholesterol; DNA, Complementary; Fibroblasts; Filipin; Fluorescent Antibody Technique; Genetic Complementation Test; Glycoproteins; Glycosylation; Humans; Lysosomes; Mutagenesis, Site-Directed; Niemann-Pick Diseases; Oligonucleotides; Oligosaccharides; Protein Isoforms; Transfection; Vesicular Transport Proteins | 2004 |
Pathological cholesterol metabolism fails to modify electrophysiological properties of afflicted neurones in Niemann-Pick disease type C.
Topics: Action Potentials; Animals; Brain; Calcium Signaling; Cell Membrane; Cells, Cultured; Cholesterol; Disease Models, Animal; Female; Filipin; Intracellular Signaling Peptides and Proteins; Ion Channels; Male; Mice; Mice, Inbred BALB C; Mice, Neurologic Mutants; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Organ Culture Techniques; Patch-Clamp Techniques; Proteins; Synaptic Transmission; Vesicular Transport Proteins | 2005 |
[Presentation of Niemann-Pick type C disease with psychiatric disturbance in an adult].
Topics: Adult; Anti-Bacterial Agents; Female; Fibroblasts; Filipin; Humans; Liver Function Tests; Magnetic Resonance Imaging; Mental Disorders; Niemann-Pick Diseases; Schizophrenia | 2005 |
Niemann-Pick type C disease: novel NPC1 mutations and characterization of the concomitant acid sphingomyelinase deficiency.
Topics: Animals; Blotting, Western; Carrier Proteins; Cells, Cultured; Child, Preschool; Chlorocebus aethiops; Cholesterol, LDL; COS Cells; DNA Mutational Analysis; Female; Fibroblasts; Filipin; Humans; Immunohistochemistry; Infant; Infant, Newborn; Intracellular Signaling Peptides and Proteins; Male; Membrane Glycoproteins; Mutation; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Pedigree; Progesterone; Sphingomyelin Phosphodiesterase | 2006 |
Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.
Topics: Androstenes; Animals; Biological Transport; Carrier Proteins; Cell Survival; CHO Cells; Cholesterol; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Filipin; Heterocyclic Compounds; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Image Processing, Computer-Assisted; Intracellular Signaling Peptides and Proteins; Lysosomes; Membrane Glycoproteins; Microscopy; Microscopy, Fluorescence; Molecular Structure; Mutation; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Staining and Labeling | 2006 |
Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brain.
Topics: Animals; Autophagy; Brain; Cathepsin B; Cathepsin D; Child; Cholesterol; Filipin; Humans; Intracellular Signaling Peptides and Proteins; Lysosomes; Mice; Mice, Inbred BALB C; Mice, Knockout; Microtubule-Associated Proteins; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Proteins; Purkinje Cells | 2007 |
Images in neuroscience: psychosis and vertical supranuclear opthalmoplegia.
Topics: Adult; Female; Filipin; Humans; Magnetic Resonance Imaging; Niemann-Pick Diseases; Ophthalmoplegia; Psychotic Disorders | 2008 |
Filipin test for diagnosis of Niemann-Pick disease type C.
Topics: Cells, Cultured; Child, Preschool; Cholesterol; Esterification; Female; Fibroblasts; Filipin; Humans; Infant; Male; Microscopy, Fluorescence; Niemann-Pick Diseases; Skin | 1993 |
Complementation studies in Niemann-Pick disease type C indicate the existence of a second group.
Topics: beta-Galactosidase; Cells, Cultured; Cholesterol; Fibroblasts; Filipin; Genetic Complementation Test; Humans; Hybrid Cells; Infant; Lysosomes; Male; Mucolipidoses; Niemann-Pick Diseases; Skin; Sphingomyelin Phosphodiesterase | 1994 |
Altered sensitivities to potential inhibitors of cholesterol biosynthesis in Niemann-Pick type C fibroblasts.
Topics: Acetates; Adult; Amphotericin B; Anticholesteremic Agents; Cell Survival; Cells, Cultured; Cerulenin; Child; Cholecalciferol; Cholesterol; Cholesterol Esters; Fibroblasts; Filipin; Humans; Japan; Lipids; Male; Niemann-Pick Diseases; Pravastatin | 1993 |
Genetic heterogeneity in Niemann-Pick C disease: a study using somatic cell hybridization and linkage analysis.
Topics: Adolescent; Adult; Age Factors; Cells, Cultured; Child; Child, Preschool; Cholesterol; Chromosome Mapping; Chromosomes, Human, Pair 18; Female; Fetus; Fibroblasts; Filipin; Genetic Complementation Test; Genetic Linkage; Humans; Hybrid Cells; Infant; Liver; Niemann-Pick Diseases; Phenotype; Phospholipids; Polymerase Chain Reaction; Pregnancy; Skin; Sphingomyelins; Spleen | 1996 |
A C57BL/KsJ mouse model of Niemann-Pick disease (spm) belongs to the same complementation group as the major childhood type of Niemann-Pick disease type C.
Topics: 3T3 Cells; Adult; Animals; Cell Fusion; Cell Line; Cell Nucleus; Child; Cholesterol; Cholesterol Esters; Disease Models, Animal; Female; Filipin; Genetic Complementation Test; Humans; Male; Mice; Mice, Inbred C57BL; Niemann-Pick Diseases | 1997 |
Increased levels of GM2 ganglioside in fibroblasts from a patient with juvenile Niemann-Pick disease type C.
Topics: Adolescent; Bone Marrow Cells; Brain; Electroencephalography; Fibroblasts; Filipin; G(M2) Ganglioside; Humans; Magnetic Resonance Imaging; Male; Neurologic Examination; Niemann-Pick Diseases; Splenomegaly | 1998 |
Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.
Topics: Amino Acid Substitution; Animals; Carrier Proteins; CHO Cells; Cholesterol; Cricetinae; Endoplasmic Reticulum; Filipin; Green Fluorescent Proteins; Humans; Intracellular Signaling Peptides and Proteins; Luminescent Proteins; Lysosomes; Membrane Glycoproteins; Mutagenesis, Site-Directed; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Proteins; Recombinant Proteins; Sequence Deletion; Transfection | 1999 |
Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Membrane; Centrifugation, Density Gradient; CHO Cells; Cholesterol, LDL; Cloning, Molecular; Cricetinae; Endocytosis; Endoplasmic Reticulum; Filipin; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Mutation; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Proteins; Transfection | 2000 |
Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-activating
Topics: Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; COS Cells; Filipin; Glycosylation; Humans; Hydroxymethylglutaryl CoA Reductases; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Protein Structure, Secondary; Proteins; Recombinant Proteins; Sterols; Transfection | 2000 |
Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations.
Topics: Animals; Antigens, CD; Axons; Cats; Cerebral Cortex; Child; Child, Preschool; Cholesterol; Dendrites; Esterification; Filipin; G(M2) Ganglioside; Gangliosides; Genotype; Humans; Intracellular Signaling Peptides and Proteins; Lysosomal Membrane Proteins; Membrane Glycoproteins; Mice; Mutation; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Parvalbumins; Proteins; Reference Values | 2001 |
Progressive neuronal loss in the ventral posterior lateral and medial nuclei of thalamus in Niemann-Pick disease type C mouse brain.
Topics: Aging; Animals; Cell Size; Cholesterol; Detergents; Filipin; Immunohistochemistry; Liver; Macrophages; Mice; Mice, Neurologic Mutants; Nerve Degeneration; Neurons; Niemann-Pick Diseases; Octoxynol; Polyethylene Glycols; Purkinje Cells; Ventral Thalamic Nuclei | 2001 |
A cell line derived from sphingomyelinosis mouse shows alterations in intracellular cholesterol metabolism similar to those in type C Niemann-Pick disease.
Topics: 3T3 Cells; Animals; Biological Transport; Cholesterol; Disease Models, Animal; Filipin; Mice; Mice, Neurologic Mutants; Niemann-Pick Diseases | 1992 |
Type C Niemann-Pick disease: documentation of abnormal LDL processing in lymphocytes.
Topics: Cell Compartmentation; Cholesterol Esters; Cholesterol, LDL; Filipin; Heterozygote; Homozygote; Humans; In Vitro Techniques; Intracellular Membranes; Lipoproteins, LDL; Lymphocytes; Microscopy, Electron; Microscopy, Fluorescence; Niemann-Pick Diseases | 1990 |
Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol.
Topics: Cell Membrane; Cholesterol; Cholesterol Esters; Cholesterol, LDL; Esterification; Fibroblasts; Filipin; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lysosomes; Microscopy, Fluorescence; Niemann-Pick Diseases; Receptors, LDL; Sterol O-Acyltransferase | 1988 |