fidarestat has been researched along with Diabetic Neuropathies in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 8 (61.54) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dominguez, JM; Grant, MB; Yorek, MA | 1 |
| Hirooka, H; Nadler, JL; Obrosova, IG; Shevalye, H; Stavniichuk, R | 1 |
| Kato, N; Oka, M | 1 |
| Hibi, C | 2 |
| Giannoukakis, N | 1 |
| Agthong, S; Middlemas, AB; Price, SA; Tomlinson, DR | 1 |
| Kato, N; Kihara, M; Kusunoki, S; Kuzumoto, Y; Low, PA | 1 |
| Drel, VR; Ilnytska, O; Lyzogubov, VV; Mashtalir, N; Nadler, JL; Obrosova, IG; Pavlov, IA | 1 |
| Hamada, Y; Hara, T; Hotta, N; Koh, N; Mori, K; Nakamura, J; Nakashima, E; Naruse, K; Sakakibara, F; Wakao, T | 1 |
| Kato, N; Makino, M; Mizuno, K; Suzuki, T; Yagihashi, S | 1 |
| Hotta, N; Ishii, J; Kaneko, T; Kikkawa, R; Koike, Y; Matsuoka, K; Sakamoto, N; Shigeta, Y; Sugimura, K; Takahashi, A; Toyota, T | 1 |
| Kato, N; Kurono, M; Matsubara, A; Mizuno, K; Nakano, K | 1 |
4 review(s) available for fidarestat and Diabetic Neuropathies
| Article | Year |
|---|---|
Aldose reductase inhibitors.
Topics: Aldehyde Reductase; Binding Sites; Clinical Trials as Topic; Crystallography, X-Ray; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Naphthalenes; Quinazolines | 2001 |
[Fidarestat (SNK-860)].
Topics: Aldehyde Reductase; Animals; Clinical Trials, Phase III as Topic; Diabetic Neuropathies; Diabetic Retinopathy; Endothelial Growth Factors; Humans; Hypoglycemic Agents; Imidazoles; Imidazolidines; Intercellular Signaling Peptides and Proteins; Lymphokines; Neural Conduction; Neurons, Afferent; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Fidarestat. Sanwa Kagaku/NC Curex/Sankyo.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Structure-Activity Relationship | 2003 |
[Aldose reductase inhibitor SNK-860].
Topics: Aldehyde Reductase; Animals; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diabetic Neuropathies; Enzyme Inhibitors; Erythrocyte Deformability; Humans; Imidazoles; Imidazolidines; Platelet Aggregation | 1997 |
1 trial(s) available for fidarestat and Diabetic Neuropathies
| Article | Year |
|---|---|
Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study.
Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Electrophysiology; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Hypesthesia; Imidazoles; Imidazolidines; Male; Middle Aged; Pain; Paresthesia; Placebos | 2001 |
8 other study(ies) available for fidarestat and Diabetic Neuropathies
| Article | Year |
|---|---|
Combination therapies prevent the neuropathic, proinflammatory characteristics of bone marrow in streptozotocin-induced diabetic rats.
Topics: Adipose Tissue; Animals; Bone Marrow; Cytokines; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fish Oils; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Hypoglycemic Agents; Imidazolidines; Inflammation; Insulin; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Neuropeptide Y; Nitric Oxide Synthase Type II; Pain Measurement; Rats; Rats, Sprague-Dawley; RNA, Messenger; Somatostatin; Stem Cells; Streptozocin; Thioctic Acid; Tyrosine 3-Monooxygenase | 2015 |
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy.
Topics: Aldehyde Reductase; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Glucose; Blotting, Western; Calcium; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme-Linked Immunosorbent Assay; Fructose; Ganglia, Spinal; Imidazolidines; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Sciatic Nerve; Sorbitol; Spinal Cord; Streptozocin | 2012 |
Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Imidazoles; Imidazolidines; Insulin; Male; Mitogen-Activated Protein Kinases; Motor Neurons; Neural Conduction; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Pyrimidines; Rats; Rats, Wistar; Spinal Cord; Time Factors; Tissue Distribution | 2004 |
Effect of the aldose reductase inhibitor fidarestat on experimental diabetic neuropathy in the rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehyde Reductase; Animals; Blood Flow Velocity; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Glutathione; Imidazolidines; Male; Mice; Neurons; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2006 |
High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Body Temperature Regulation; Diabetic Neuropathies; Dietary Fats; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Imidazolidines; Mice; Mice, Inbred C57BL; Neurons, Afferent; Obesity; Prediabetic State; Radioimmunoassay; Sensory Thresholds; Touch | 2007 |
Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats.
Topics: 2,3-Diphosphoglycerate; Aldehyde Reductase; Animals; Body Weight; Diabetic Neuropathies; Diphosphoglyceric Acids; Enzyme Inhibitors; Erythrocytes; Imidazoles; Imidazolidines; Male; Motor Neurons; Neural Conduction; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1995 |
Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Fructose; Glycated Hemoglobin; Imidazoles; Imidazolidines; Inositol; Male; Myelin Sheath; Nerve Fibers; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Sural Nerve; Tibial Nerve; Time Factors | 2000 |
Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozo
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Streptozocin | 1992 |