fidarestat has been researched along with Alloxan Diabetes in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 9 (47.37) | 29.6817 |
| 2010's | 7 (36.84) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, X; Guo, F; He, M; Jing, C; Li, Y; Ma, B; Parveen, S; Qiu, X; Yang, Y; Zhang, S; Zhu, C | 1 |
| Pal, PB; Ramana, KV; Shukla, K; Sonowal, H; Srivastava, SK | 1 |
| Ciddi, V; Dodda, D | 1 |
| Dominguez, JM; Grant, MB; Yorek, MA | 1 |
| Hattori, T; Matsubara, A; Ogura, Y; Taniguchi, K | 1 |
| Choi, R; Chung, CH; Hong, SW; Kim, BH; Kim, JH; Kim, SH; Koh, JH; Lee, EY; Lee, MY; Nam, SM; Sung, JK; Yoo, JH | 1 |
| Hirooka, H; Nadler, JL; Obrosova, IG; Shevalye, H; Stavniichuk, R | 1 |
| Amano, S; Hirooka, H; Inagaki, Y; Jomori, T; Kato, N; Makino, M; Okamoto, T; Takeuchi, M; Taniko, K; Yamagishi, Si | 1 |
| Abatan, OI; Frank, RN; Kumagai, AK; Minchenko, AG; Obrosova, IG; Stevens, MJ; Vasupuram, R; White, L | 1 |
| Agthong, S; Middlemas, AB; Price, SA; Tomlinson, DR | 1 |
| Chin, S; Otsuki, S; Uehara, K; Yagihashi, S; Yamagishi, S | 1 |
| Hirooka, H; Obrosova, IG; Pacher, P; Stevens, MJ; Szabó, C; Yorek, MA; Zsengeller, Z | 1 |
| Kato, N; Kihara, M; Kusunoki, S; Kuzumoto, Y; Low, PA | 1 |
| Ali, TK; Drel, VR; El-Remessy, AB; Julius, U; Obrosova, IG; Pacher, P; Shin, J | 1 |
| Akita, M; Kurono, M; Matsubara, A; Mizuno, K; Nakano, K | 1 |
| Hamada, Y; Hotta, N; Kakuta, H; Koh, N; Matsubara, A; Mizuno, K; Nakamura, J; Naruse, K; Sakakibara, F; Sasaki, H | 1 |
| Kato, N; Makino, M; Mizuno, K; Suzuki, T; Yagihashi, S | 1 |
| Aoki, T; Makino, M; Mizuno, K; Sassa, H; Sobajima, H; Suzuki, T; Taniko, K | 1 |
| Kato, N; Kurono, M; Matsubara, A; Mizuno, K; Nakano, K | 1 |
19 other study(ies) available for fidarestat and Alloxan Diabetes
| Article | Year |
|---|---|
Acetic acid derivatives of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide as a novel class of potent aldose reductase inhibitors.
Topics: Acetic Acid; Aldehyde Reductase; Animals; Benzothiadiazines; Cyclic S-Oxides; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Models, Molecular; Rats; Structure-Activity Relationship | 2010 |
Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins.
Topics: Aldehyde Reductase; Animals; Catalase; Cell Survival; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Heart; Heme Oxygenase-1; Hyperglycemia; Imidazolidines; Kidney; Membrane Proteins; Mice; Monocytes; Myocardium; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Superoxide Dismutase | 2017 |
Therapeutic potential of resveratrol in diabetic complications: In vitro and in vivo studies.
Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Glycation End Products, Advanced; Imidazolidines; Inhibitory Concentration 50; Kidney Function Tests; Lens, Crystalline; Male; Rats; Rats, Wistar; Resveratrol; Stilbenes; Streptozocin | 2014 |
Combination therapies prevent the neuropathic, proinflammatory characteristics of bone marrow in streptozotocin-induced diabetic rats.
Topics: Adipose Tissue; Animals; Bone Marrow; Cytokines; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fish Oils; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Hypoglycemic Agents; Imidazolidines; Inflammation; Insulin; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Neuropeptide Y; Nitric Oxide Synthase Type II; Pain Measurement; Rats; Rats, Sprague-Dawley; RNA, Messenger; Somatostatin; Stem Cells; Streptozocin; Thioctic Acid; Tyrosine 3-Monooxygenase | 2015 |
Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo.
Topics: Acridine Orange; Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Fluorophotometry; Fructose; Imidazolidines; Intercellular Adhesion Molecule-1; Leukocytes; Male; Microscopy, Fluorescence; Rats; Rats, Long-Evans; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sorbitol; Vascular Endothelial Growth Factor A | 2010 |
Aldose reductase inhibitor ameliorates renal vascular endothelial growth factor expression in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Imidazolidines; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2010 |
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy.
Topics: Aldehyde Reductase; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Glucose; Blotting, Western; Calcium; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme-Linked Immunosorbent Assay; Fructose; Ganglia, Spinal; Imidazolidines; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Sciatic Nerve; Sorbitol; Spinal Cord; Streptozocin | 2012 |
Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes.
Topics: Aldehyde Reductase; Animals; Blood-Retinal Barrier; Capillary Permeability; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; DNA; Endothelial Growth Factors; Enzyme Inhibitors; Fructose; Glucose; Imidazoles; Imidazolidines; Intercellular Signaling Peptides and Proteins; L-Iditol 2-Dehydrogenase; Lymphokines; Male; Pericytes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retina; RNA, Messenger; Sorbitol; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Angiogenesis Inducing Agents; Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Flow Cytometry; Fructose; Gene Expression; Glucose; Glutathione; Glutathione Peroxidase; Imidazoles; Imidazolidines; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Retina; Retinal Vessels; RNA, Messenger; Sorbitol; Superoxide Dismutase; Vascular Endothelial Growth Factor A | 2003 |
Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Imidazoles; Imidazolidines; Insulin; Male; Mitogen-Activated Protein Kinases; Motor Neurons; Neural Conduction; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Pyrimidines; Rats; Rats, Wistar; Spinal Cord; Time Factors; Tissue Distribution | 2004 |
Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice.
Topics: Actins; Aldehyde Reductase; Animals; Blood Glucose; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Ganglia, Spinal; Humans; Imidazolidines; Isoenzymes; Mice; Mice, Transgenic; Neural Conduction; Neurons; Protein Kinase C; Reference Values; Substance P | 2004 |
Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.
Topics: Aldehyde Reductase; Animals; Aorta; Arterioles; Cattle; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fructose; Imidazolidines; Male; Motor Neurons; Neural Conduction; Neurons, Afferent; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Tyrosine | 2005 |
Effect of the aldose reductase inhibitor fidarestat on experimental diabetic neuropathy in the rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehyde Reductase; Animals; Blood Flow Velocity; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Glutathione; Imidazolidines; Male; Mice; Neurons; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2006 |
Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.
Topics: Aldehyde Reductase; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blood Glucose; Blotting, Western; Cataract; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glial Fibrillary Acidic Protein; Imidazolidines; Immunohistochemistry; In Situ Nick-End Labeling; Neuroglia; Ophthalmoscopy; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Retina; Streptozocin; Tyrosine | 2008 |
Effects of an aldose reductase inhibitor, SNK-860, on the histopathological changes of retinal tissues in a streptozotocin-induced diabetic rat model.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Male; Rats; Rats, Sprague-Dawley; Retina; Retinal Vessels | 1993 |
Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats.
Topics: Aldehyde Reductase; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Electroretinography; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Sprague-Dawley; Retina; Sorbitol | 1995 |
Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Fructose; Glycated Hemoglobin; Imidazoles; Imidazolidines; Inositol; Male; Myelin Sheath; Nerve Fibers; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Sural Nerve; Tibial Nerve; Time Factors | 2000 |
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes.
Topics: Age Factors; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Fasting; Female; Glycated Hemoglobin; Humans; Imidazoles; Imidazolidines; Male; Rats; Rats, Sprague-Dawley; Rhodanine; Sciatic Nerve; Sex Factors; Sorbitol; Thiazolidines | 2001 |
Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozo
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Streptozocin | 1992 |