fibrinopeptide-a and Burns

In this study, dynamic changes of fibrinopeptides A and B (FPA, FPB) in sera of burns patients are determined with an HPLC method. On this basis detrimental effects of FPA and FPB on vascular endothelial cells (VEC) are observed in vitro. The main results are as follows: (1) FPA and FPB in 18 burn patients' sera increase at day 2 postburn, reach peaks at days 5-7 postburn, then decline after day 15 postburn, and return to the control levels at day 25 postburn. The fluctuations in FPA and FPB levels in burn patients' sera are parallel to the progress of burn illness. The measurements of FPA and FPB levels in burn patients' sera may be useful in evaluating patients' condition. (2) FPA and FPB are detrimental to the cultured VEC in vitro. Characteristics of their injurious effects are: specific, irreversible and dose dependent. FPA and FPB may play an important role in endothelial injury.

Topics: Adolescent; Adult; Burns; Cells, Cultured; Child; Child, Preschool; Endothelium, Vascular; Female; Fibrinogen; Fibrinopeptide A; Fibrinopeptide B; Humans; Male; Middle Aged

Topics: alpha 1-Antitrypsin; Antithrombin III; Blood Proteins; Burns; Cell Division; Complement Activation; Endothelium; Endotoxins; Factor XII; Fibrinopeptide A; Fibronectins; Humans; Inflammation; Peritonitis; Prekallikrein; Sepsis; Wounds and Injuries

Topics: Adolescent; Adult; Aged; Animals; Brain Abscess; Burns; Child; Circadian Rhythm; Dogs; False Positive Reactions; Female; Fibrinogen; Fibrinopeptide A; Hemoglobinuria; Humans; Hydrogen-Ion Concentration; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Myocardial Infarction; Neoplasms; Thrombin

Topics: Blood Preservation; Blood Specimen Collection; Burns; Disseminated Intravascular Coagulation; Fibrinogen; Fibrinopeptide A; Freezing; Humans; Immune Sera; Neoplasms; Plasma; Radioimmunoassay; Streptokinase; Thrombin; Thrombophlebitis; Uremia; Venous Pressure; Wounds and Injuries