fibrinopeptide-a and Abortion--Spontaneous

fibrinopeptide-a has been researched along with Abortion--Spontaneous* in 1 studies

Other Studies

1 other study(ies) available for fibrinopeptide-a and Abortion--Spontaneous

Article	Year
Fibrinogen Milano IV, another case of congenital dysfibrinogenemia with an abnormal fibrinopeptide A release (A alpha 16 Arg----His). Haemostasis, 1992, Volume: 22, Issue:1 An abnormal fibrinogen, denoted as 'fibrinogen Milano IV', has been found in a 36-year-old woman without any bleeding manifestations or thrombotic tendency. Routine coagulation studies revealed prolonged thrombin and reptilase clotting times, very low plasma fibrinogen concentration determined by the functional assay but a normal fibrinogen concentration measured by the immunologic assay. Turbidity curves, measured following addition of thrombin to purified fibrinogen Milano IV, both in presence of calcium or EDTA, were markedly delayed. Release of fibrinopeptide B by thrombin was normal, whereas only half the normal amount of fibrinopeptide A was cleaved. The fibrinopeptide A peak of fibrinogen was preceded by an abnormal fibrinopeptide A. Both peaks were collected for amino acid analysis which showed an exchange of arginine by histidine in position 16 of the A alpha chain of the fibrinopeptide A. Topics: Abortion, Spontaneous; Adult; Afibrinogenemia; Amino Acids; Blood Coagulation Tests; Female; Fibrinogens, Abnormal; Fibrinopeptide A; Humans; Pregnancy; Thrombin	1992

Article

Year

Fibrinogen Milano IV, another case of congenital dysfibrinogenemia with an abnormal fibrinopeptide A release (A alpha 16 Arg----His).

Haemostasis, 1992, Volume: 22, Issue:1

An abnormal fibrinogen, denoted as 'fibrinogen Milano IV', has been found in a 36-year-old woman without any bleeding manifestations or thrombotic tendency. Routine coagulation studies revealed prolonged thrombin and reptilase clotting times, very low plasma fibrinogen concentration determined by the functional assay but a normal fibrinogen concentration measured by the immunologic assay. Turbidity curves, measured following addition of thrombin to purified fibrinogen Milano IV, both in presence of calcium or EDTA, were markedly delayed. Release of fibrinopeptide B by thrombin was normal, whereas only half the normal amount of fibrinopeptide A was cleaved. The fibrinopeptide A peak of fibrinogen was preceded by an abnormal fibrinopeptide A*. Both peaks were collected for amino acid analysis which showed an exchange of arginine by histidine in position 16 of the A alpha chain of the fibrinopeptide A*.

Topics: Abortion, Spontaneous; Adult; Afibrinogenemia; Amino Acids; Blood Coagulation Tests; Female; Fibrinogens, Abnormal; Fibrinopeptide A; Humans; Pregnancy; Thrombin

1992