Page last updated: 2024-08-26

fibrinogen and Deficiency of GP 2b 3a Complex

fibrinogen has been researched along with Deficiency of GP 2b 3a Complex in 92 studies

Research

Studies (92)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (16.30)	18.7374
1990's	31 (33.70)	18.2507
2000's	29 (31.52)	29.6817
2010's	15 (16.30)	24.3611
2020's	2 (2.17)	2.80

Authors

Authors	Studies
Jiang, M; Lin, ZH; Liu, H; Ma, ZN; Wang, ZY; Xie, ZL; Yang, F; Yang, L; Zhou, L	1
Fedorova, DV; Filkova, AA; Martyanov, AA; Morozova, DS; Novichkova, GA; Panteleev, MA; Sorokina, MA; Suntsova, EV; Sveshnikova, AAN; Uzueva, SS; Zharkov, PA	1
Bonna, A; Farndale, RW; Howes, JM; Induruwa, I; Jung, SM; Malcor, JD; Moroi, M; Warburton, EA	1
Lickert, S; Medalia, O; Schoen, I; Sorrentino, S; Studt, JD; Vogel, V	1
Alessi, MC; Ataullakhanov, FI; Biriukova, MI; Chambost, H; Demyanova, AS; Kostanova, EA; Kotova, YN; Kumskova, MA; Obydennyy, SI; Panteleev, MA; Podoplelova, NA; Rosenfeld, MA; Ryabykh, AA; Sokolov, AV	1
Du, LM; Fang, J; North, P; Nurden, AT; Nurden, P; Valentin, N; Wilcox, DA	1
Abaeva, AA; Alessi, MC; Ataullakhanov, FI; Canault, M; Chambost, H; Kolyadko, VN; Kotova, YN; Mazurov, AV; Nurden, AT; Obydennyy, SI; Panteleev, MA; Podoplelova, NA; Yakimenko, AO	1
Gärtner, F; Goedel, A; Haas, J; Jung, CB; Kurnik, K; Laugwitz, KL; Massberg, S; Moretti, A; Orban, M; Parrotta, E; Sandrock-Lang, K; Sinnecker, D; Wanner, G; Zieger, B	1
Hauschner, H; Mansour, W; Messineo, S; Mor-Cohen, R; Rosenberg, N; Savoia, A; Seligsohn, U	1
Buitrago, L; Coller, BS; Filizola, M; Liang, Y; Negri, A; Ouwehand, WH; Rendon, A; Simeoni, I	1
Baaten, CC; Beckers, EA; Berny-Lang, MA; Cosemans, JM; Hackeng, TM; Heemskerk, JW; Henskens, YM; Mastenbroek, TG; Mattheij, NJ; May, F; McCarty, OJ; Nolte, MW; Suylen, DP; Swieringa, F; van der Meijden, PE	1
Dahan, I; Dubrovsky, A; Eibauer, M; Medalia, O; Motahedeh, S; Sapra, KT; Shai, E; Sorrentino, S; Studt, JD; Tamir, A; Varon, D	1
Amoriello, A; Bafunno, V; D'Andrea, G; Del Vecchio, L; Grandone, E; Margaglione, M; Morabito, P; Vecchione, G	1
Coller, BS; Shattil, SJ	1
Ahmad, F; Biswas, A; Kannan, M; Saxena, R; Yadav, BK	1
Bagoly, Z; Kappelmayer, J; Muszbek, L; Nagy, B; Simon, Z	1
Ariëns, RA; Carvalho, FA; Connell, S; Miltenberger-Miltenyi, G; Pereira, SV; Santos, NC; Tavares, A	1
Abolghasemi, H; Aghaiipour, M; Ala, F; Faranoush, M; Farsinejad, A; Hadjati, E; Jazebi, M; Kazemi, A	1
Hauschner, H; Mor-Cohen, R; Rosenberg, N; Seligsohn, U	1
Budnik, I; Einav, Y; Livnat, T; Martinowitz, U; Misgav, M; Shenkman, B	1
Feijge, MA; Gilio, K; Hamulyák, K; Heemskerk, JW; Nergiz-Unal, R; Swieringa, F; van der Meijden, PE	1
Caen, JP; Combrié, R; Nurden, AT; Nurden, P; Poujol, C; Winckler, J	1
Ghosh, K; Kulkarni, B; Mohanty, D; Nair, S; Shetty, S	1
André, P; Bal Dit Sollier, C; Bellucci, S; Brouland, JP; Caen, J; Drouet, L; Hainaud, P; Simoneau, G	1
Arai, M; Honda, S; Kashiwagi, H; Kato, H; Kiyoi, T; Kosugi, S; Kurata, Y; Matsuzawa, Y; Tadokoro, S; Tomiyama, Y	1
Akkerman, JW; Kroner, CI; Litjens, PE; Van Willigen, G	1
Adelmeijer, J; de Groot, PG; Heijnen, HF; Lisman, T	1
Artoni, A; Coller, BS; Filizola, M; Hassan, SA; Weinstein, H	1
Bassus, S; Follert-Hagendorff, K; Jablonka, B; Just, M; Kirchmaier, CM; Santoso, S; Westrup, D	1
Alonso, S; Arias-Salgado, EG; Butta, N; González-Manchón, C; Larrucea, S; López, A; Parrilla, R	1
Ghosh, K; Mohanty, D; Nair, S; Shetty, S	1
Butta, N; González-Manchón, C; Jayo, A; Pabón, D; Xie, J	1
Awidi, AA; Coller, BS; Hauschner, H; Kenet, G; Landau, M; Mor-Cohen, R; Peretz, H; Rosenberg, N; Seligsohn, U; Shenkman, B	1
Chandy, M; Coller, BS; Nair, SC; Nelson, EJ; Peretz, H; Seligsohn, U; Srivastava, A	1
Bereczky, Z; Boda, Z; Hauschner, H; Kappelmayer, J; Losonczy, G; Muszbek, L; Rosenberg, N; Vereb, G	1
Brojer, E; Gruel, Y; Kunicki, TJ; Nugent, DJ	1
Fujimoto, T; Fujimura, K; Kuramoto, A; Noda, M; Shimomura, T; Takafuta, T	1
Brugge, JS; Clark, EA	1
Gill, JC; Lyman, S; Newman, PJ; Paddock, CM; Wilcox, DA	1
Coller, BS; Newman, PJ; Peretz, H; Seligsohn, U	1
Cox, AD; Devine, DV	1
Cazenave, JP; Jennings, LK; Jutzi, J; Kouns, WC; Kunicki, TJ; Lanza, F; Moog, S; Steiner, B	1
Chen, YP; Ginsberg, MH; O'Toole, TE; Rosa, JP; Ylänne, J	1
Handa, M; Ikeda, Y; Kawai, Y; Nagai, H; Watanabe, K	1
Irie, A; Kamata, T; Takada, Y; Tokuhira, M	1
Bron, N; Gouon, V; Guinet, JM; Kieffer, N; Melchior, C; Michels, S	1
Artçanuthurry, V; Caen, JP; Grelac, F; Lévy-Toledano, S; Maclouf, J; Rosa, JP	1
Springer, TA; Weber, C	1
Chen, F; Coller, BS; French, DL; Grimaldi, CM; Weiss, HJ; Wu, C	1
Ambo, H; Kinoshita, S; Kunicki, TJ; Kurata, Y; Matsuzawa, Y; Shiraga, M; Tomiyama, Y	1
Kestin, AS; Newman, PJ; Ward, CM	1
Dardik, R; Savion, N; Shenkman, B; Tamarin, I; Varon, D	1
Hamulyak, K; Heemskerk, JW; Meijer, EM; Novakova, I; Rosado, JA; Sage, SO	1
Dardik, R; Peretz, H; Rosenberg, N; Seligsohn, U; Trakhtenbrot, L; Yatuv, R; Zivelin, A	1
Boudreaux, MK; Catalfamo, JL	1
Fitzgerald, DJ; Fullard, J; Moran, N; Murphy, R; O'Neill, S; Ottridge, B	1
Ammerlaan, W; Chen, P; Kaplan, C; Kieffer, N; Lecompte, T; Melchior, C; Morel-Kopp, MC	1
Honda, S; Kashiwagi, H; Kiyoi, T; Kosugi, S; Kurata, Y; Matsuzawa, Y; Shiraga, M; Tadokoro, S; Tomiyama, Y	1
Clofent-Sanchez, G; Jacobin, MJ; Keller, A; Laroche-Traineau, J; Little, M; Nurden, A; Peter, K; Welschof, M	1
Combrié, R; Gauthier, B; Kunicki, T; Nurden, AT; Nurden, P; Pasquet, JM; Ruan, J	1
de Jesus, N; Dubernard, V; Legrand, C; Saumet, A	1
Bennett, JS	1
Bajt, ML; Berndt, MC; Frelinger, AL; Ginsberg, MH; Loftus, JC	1
Kurata, Y; Tomiyama, Y	1
Castillo, R; Diaz-Ricart, M; Escolar, G; Garrido, M; Maragall, S; Nurden, AT; Ordinas, A; Reverter, JC; Sanz, C; Villamor, N	1
Egberg, N; Lindahl, TL; Lundahl, J; Netré, C	1
Caen, JP; Chen, YP; Cieutat, AM; Djaffar, I; Pidard, D; Rosa, JP; Steiner, B	1
André, G; Cazenave, JP; Fournier, D; Lanza, F; Morales, M; Nurden, AT; Stierlé, A	1
Bachelot, C; Breton, M; Caen, JP; Chap, H; Grondin, P; Lévy-Toledano, S; Mauco, G; Plantavid, M; Sultan, C	1
Coller, BS; Norton, KJ; Scudder, LE; Seligsohn, U; West, SM	1
Fujimura, K; Kuramoto, A	1
Estry, DW; Mahoney, GJ; Mattson, JC; Oesterle, JR	1
O'Brien, JR	1
Anbo, H; Araki, Y; Handa, M; Ikeda, Y; Itagaki, I; Kamata, T; Kawai, Y; Kawano, K; Murata, M; Watanabe, K	1
Jungi, TW; Schalch, L; Trezzini, C	1
Hardisty, RM; Powling, MJ; Warkentin, TE	1
Berndt, MC; Breton-Gorius, J; Caen, JP; Cramer, EM; Massé, JM; Pidard, D; Savidge, GF; Vainchenker, W	1
Coller, BS; Nurden, AT; Peerschke, EI; Rosa, JP; Scudder, LE; Seligsohn, U	1
Ginsberg, MH; Kaufmann, A; Kunicki, TJ; Lightsey, A; Marguerie, G; Plow, EF	1
Bouillot, C; Disdier, M; Dubernard, V; Legrand, C; Nurden, AT; Pidard, D	1
Dubernard, V; Legrand, C; Nurden, AT	1
Agam, G; Dvilansky, A; Livne, A; Luria, R; Seligsohn, U; Shohat, O	1
Bennett, JS; Dunn, F; Hershock, D; Kieffer, N; Kornecki, E; Niewiarowski, S; Pidard, D; Soria, C; Soria, J; Tuszynski, GP	1
Cerbone, AM; Ciavarella, N; Di Minno, G; Iride, C; Montemurro, P; Scillitani, A; Semeraro, N	1
Ando, Y; Araki, Y; Ichitani, M; Ikeda, Y; Itagaki, I; Mori, Y; Murata, M; Sakai, K; Watanabe, K	1
Boukerche, H; McGregor, JL	1
Endo, Y; Iwamoto, K; Mamiya, S; Miura, A; Niitsu, H	1
Gorbunova, NA; Leytin, VL; Likhacheva, EA; Misselwitz, F; Repin, VS	1
Pidard, D	1
Belloc, F; Boisseau, MR; Combrie, R; Heilmann, E; Nurden, AT	1
Didry, D; Fournier, D; Legrand, C; Nurden, AT; Parquet, A; Pidard, D; Rosa, JP	1
Awidi, A; Holmberg, L; Kristoffersson, AC; Lamme, S; Nilsson, IM; Solum, NO	1

Reviews

4 review(s) available for fibrinogen and Deficiency of GP 2b 3a Complex

Article	Year
The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood, 2008, Oct-15, Volume: 112, Issue:8 Topics: Animals; Fibrinogen; Hematology; History, 20th Century; History, 21st Century; Humans; Medical Laboratory Science; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia	2008
Glanzmann thrombasthenia: new insights from an historical perspective. Seminars in hematology, 1994, Volume: 31, Issue:4 Topics: Antibodies, Monoclonal; Base Sequence; Fibrinogen; Gene Deletion; History, 20th Century; Humans; Iraq; Israel; Jews; Molecular Sequence Data; Platelet Membrane Glycoproteins; Saudi Arabia; Thrombasthenia	1994
Mechanisms of platelet adhesion and aggregation: an update. Hospital practice (Office ed.), 1992, Apr-15, Volume: 27, Issue:4 Topics: Fibrinogen; Glycoproteins; Humans; Integrins; Platelet Adhesiveness; Platelet Aggregation; Receptors, Cell Surface; Thrombasthenia; von Willebrand Diseases; von Willebrand Factor	1992
Shear-induced platelet aggregation. Lancet (London, England), 1990, Mar-24, Volume: 335, Issue:8691 Topics: Blood Circulation; Blood Coagulation Tests; Blood Viscosity; Fibrinogen; Hemofiltration; Humans; Integrin alpha2; Membrane Glycoproteins; Platelet Activation; Platelet Aggregation; Thrombasthenia; von Willebrand Diseases; von Willebrand Factor	1990

Other Studies

88 other study(ies) available for fibrinogen and Deficiency of GP 2b 3a Complex

Article	Year
[Effects of the ITGA2B Nonsense Mutation (c.2659C > T, p.Q887X) on Platelet Function in a Mouse Model of Glanzmann's Thrombasthenia Generated with CRISPR/Cas9 Technology]. Zhongguo shi yan xue ye xue za zhi, 2022, Volume: 30, Issue:2 Topics: Animals; Codon, Nonsense; CRISPR-Cas Systems; Disease Models, Animal; Fibrinogen; Humans; Integrin alpha2; Mice; Oligonucleotides; Platelet Glycoprotein GPIIb-IIIa Complex; RNA, Guide, Kinetoplastida; Thrombasthenia; Thrombin	2022
Heterogeneity of Integrin α International journal of molecular sciences, 2020, Apr-25, Volume: 21, Issue:9 Topics: Adolescent; Blood Coagulation; Blood Platelets; Calcium; Calcium Signaling; Child; Child, Preschool; Cluster Analysis; Computer Simulation; Cytosol; Female; Fibrinogen; Flow Cytometry; Hemorrhage; Humans; Male; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Purpura, Thrombocytopenic, Idiopathic; Thrombasthenia; Thrombosis	2020
Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation. Journal of thrombosis and haemostasis : JTH, 2018, Volume: 16, Issue:2 Topics: Binding Sites; Blood Platelets; Case-Control Studies; Collagen; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Humans; Platelet Activation; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Protein Binding; Protein Interaction Domains and Motifs; Protein Multimerization; Signal Transduction; Structure-Activity Relationship; Thrombasthenia; Thrombosis	2018
Morphometric analysis of spread platelets identifies integrin α Scientific reports, 2018, 04-03, Volume: 8, Issue:1 Topics: Adult; Biomechanical Phenomena; Blood Platelets; Cytoskeleton; Fibrinogen; Hemostasis; Humans; Ligands; Mechanical Phenomena; Phenotype; Platelet Glycoprotein GPIIb-IIIa Complex; Signal Transduction; Thrombasthenia	2018
Binding of Coagulation Factor XIII Zymogen to Activated Platelet Subpopulations: Roles of Integrin αIIbβ3 and Fibrinogen. Thrombosis and haemostasis, 2019, Volume: 119, Issue:6 Topics: Afibrinogenemia; Blood Coagulation; Blood Platelets; Enzyme Precursors; Factor VIII; Fibrinogen; Fibrinolysis; Humans; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Thrombasthenia	2019
C560Rβ3 caused platelet integrin αII b β3 to bind fibrinogen continuously, but resulted in a severe bleeding syndrome and increased murine mortality. Journal of thrombosis and haemostasis : JTH, 2013, Volume: 11, Issue:6 Topics: Animals; Blood Platelets; Bone Marrow Cells; Fibrinogen; Hemorrhage; Humans; Integrin beta3; Lentivirus; Megakaryocytes; Mice; Mutation; P-Selectin; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Syndrome; Thrombasthenia; Thrombosis	2013
Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates. The Journal of biological chemistry, 2013, Oct-11, Volume: 288, Issue:41 Topics: Blood Coagulation; Blood Platelets; Blotting, Western; Female; Fibrin; Fibrinogen; Flow Cytometry; Humans; Microscopy, Confocal; Oligopeptides; Phosphatidylserines; Platelet Aggregation; Polymerization; Thrombasthenia; Thrombosis; Thrombospondins; Transglutaminases	2013
Functional comparison of induced pluripotent stem cell- and blood-derived GPIIbIIIa deficient platelets. PloS one, 2015, Volume: 10, Issue:1 Topics: Adolescent; Blood Platelets; Cell Adhesion; Cells, Cultured; Female; Fibrinogen; Humans; Induced Pluripotent Stem Cells; Integrin alpha2; Models, Biological; Thrombasthenia	2015
Abnormal cytoplasmic extensions associated with active αIIbβ3 are probably the cause for macrothrombocytopenia in Glanzmann thrombasthenia-like syndrome. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2015, Volume: 26, Issue:3 Topics: Animals; Cell Line; Cricetinae; Cytoskeleton; DNA, Complementary; Fibrinogen; Genetic Vectors; Humans; Integrin alpha2; Integrin beta3; Megakaryocytes; Mesocricetus; Microtubules; Mutation, Missense; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Conformation; Protein Interaction Mapping; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Deletion; Thrombasthenia; Tubulin; von Willebrand Factor	2015
αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia. Proceedings of the National Academy of Sciences of the United States of America, 2015, Apr-14, Volume: 112, Issue:15 Topics: Alleles; Databases, Nucleic Acid; Exome; Fibrinogen; Gene Frequency; HEK293 Cells; High-Throughput Nucleotide Sequencing; Humans; Immunoblotting; Models, Molecular; Mutation, Missense; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Thrombasthenia	2015
Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII. Haematologica, 2016, Volume: 101, Issue:4 Topics: Animals; Blood Coagulation; Blood Platelets; Crotalid Venoms; Factor Va; Factor Xa; Factor XIII; Fibrin; Fibrinogen; Humans; Lectins, C-Type; Mice; Mice, Knockout; Molecular Probes; Phosphatidylserines; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Primary Cell Culture; Protein Binding; Thrombasthenia; Thrombin	2016
The macromolecular architecture of platelet-derived microparticles. Journal of structural biology, 2016, Volume: 193, Issue:3 Topics: Blood Platelets; Cell Adhesion; Cell-Derived Microparticles; Cryoelectron Microscopy; Cytoskeleton; Fibrinogen; Humans; Manganese; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia; Thrombin	2016
A beta3 Asp217-->Val substitution in a patient with variant Glanzmann Thrombasthenia severely affects integrin alphaIIBbeta3 functions. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2008, Volume: 19, Issue:7 Topics: Amino Acid Substitution; Animals; Child; CHO Cells; Cricetinae; Cricetulus; Fibrinogen; Humans; Integrin beta3; Male; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia; Valine	2008
Modulation of clinical phenotype of Glanzmann's thrombasthenia by thrombogenic mutations. Clinica chimica acta; international journal of clinical chemistry, 2009, Volume: 403, Issue:1-2 Topics: Antigens, Human Platelet; Blood Coagulation Factors; Blood Transfusion; Epistaxis; Fibrinogen; Homozygote; Humans; Mutation; Phenotype; Platelet Aggregation; Polymorphism, Genetic; Thrombasthenia	2009
Binding of plasma factor XIII to thrombin-receptor activated human platelets. Thrombosis and haemostasis, 2009, Volume: 102, Issue:1 Topics: Blood Coagulation; Blood Platelets; Cytosol; Eptifibatide; Factor XIII; Fibrinogen; Humans; Oligopeptides; P-Selectin; Peptide Fragments; Peptides; Plasma; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia	2009
Atomic force microscopy-based molecular recognition of a fibrinogen receptor on human erythrocytes. ACS nano, 2010, Aug-24, Volume: 4, Issue:8 Topics: Blood Platelets; Calcium; Eptifibatide; Erythrocyte Membrane; Erythrocytes; Female; Fibrinogen; Humans; Microscopy, Atomic Force; Mutation; Peptides; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Receptors, Fibrinogen; Reproducibility of Results; Substrate Specificity; Thrombasthenia	2010
Classification of Iranian patients with Glanzmann's Thrombasthenia using a flow cytometric method. Platelets, 2011, Volume: 22, Issue:5 Topics: Adolescent; Adult; Antibodies, Monoclonal; Blood Platelets; Case-Control Studies; Child; Child, Preschool; Female; Fibrinogen; Flow Cytometry; Hemorrhage; Humans; Infant; Integrin alphaV; Integrin beta3; Iran; Male; Middle Aged; Molecular Typing; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoprotein IIb; Protein Binding; Retrospective Studies; Severity of Illness Index; Thrombasthenia	2011
A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIb β3 to an active state. Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:2 Topics: Animals; Cell Line; Cricetinae; Fibrinogen; Flow Cytometry; Integrin beta3; Ligands; Mutagenesis, Site-Directed; Mutation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Signal Transduction; Structure-Activity Relationship; Thrombasthenia; Transfection	2012
The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann's thrombasthenia. Platelets, 2012, Volume: 23, Issue:8 Topics: Area Under Curve; Blood Coagulation; Calcium Chloride; Case-Control Studies; Eptifibatide; Factor XIII; Fibrinogen; Humans; Peptides; Platelet Aggregation Inhibitors; Platelet-Rich Plasma; Thrombasthenia; Thrombelastography; Thrombin; Thrombin Time; Thromboplastin; Tissue Plasminogen Activator	2012
Key role of integrin α(IIb)β (3) signaling to Syk kinase in tissue factor-induced thrombin generation. Cellular and molecular life sciences : CMLS, 2012, Volume: 69, Issue:20 Topics: Blood Coagulation; Blood Platelets; Blotting, Western; Fibrinogen; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Phosphoserine; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein-Tyrosine Kinases; Signal Transduction; Syk Kinase; Thrombasthenia; Thrombin; Thromboplastin	2012
A Ser752-->Pro substitution in the cytoplasmic domain of beta3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the alphaIIbbeta3 integrin and the platelet granule pool of fibrinogen. British journal of haematology, 2002, Volume: 118, Issue:4 Topics: Adenosine Diphosphate; Aged; Blood Platelets; Case-Control Studies; Fibrinogen; Humans; Integrin beta3; Male; Microscopy, Immunoelectron; Mutation; Platelet Activation; Platelet Membrane Glycoprotein IIb; Protein Binding; Stimulation, Chemical; Thrombasthenia	2002
Human platelet alloantigen polymorphism in Glanzmann's thrombasthenia and its impact on the severity of the disease. British journal of haematology, 2002, Volume: 119, Issue:2 Topics: Adolescent; Antigens, Human Platelet; Child; Child, Preschool; Female; Fibrinogen; Flow Cytometry; Humans; Integrin beta3; Isoantigens; Male; Platelet Membrane Glycoprotein IIb; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Protein Binding; Thrombasthenia	2002
Dissociation between fibrinogen and fibrin interaction with platelets in patients with different subtypes of Glanzmann's thrombasthenia: studies in an ex vivo perfusion chamber model. British journal of haematology, 2002, Volume: 119, Issue:4 Topics: Blood Platelets; Collagen Type III; Diffusion Chambers, Culture; Female; Fibrin; Fibrinogen; Heterozygote; Humans; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia; Thrombosis; von Willebrand Factor	2002
A naturally occurring Tyr143His alpha IIb mutation abolishes alpha IIb beta 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects. Blood, 2003, May-01, Volume: 101, Issue:9 Topics: Adult; Allosteric Regulation; Amino Acid Substitution; Blood Platelets; Clot Retraction; Codon; Dipeptides; Female; Fibrinogen; Heterozygote; Humans; Ligands; Mutation, Missense; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoprotein IIb; Point Mutation; Polymorphism, Restriction Fragment Length; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA, Messenger; Solubility; Structure-Activity Relationship; Thrombasthenia; Transfection	2003
Cytoplasmic regions of the beta3 subunit of integrin alphaIIbbeta3 involved in platelet adhesion on fibrinogen under flow conditions. Journal of thrombosis and haemostasis : JTH, 2003, Volume: 1, Issue:9 Topics: Amino Acid Sequence; Amino Acid Substitution; Cytochalasin D; Cytoplasm; Cytoskeleton; Fibrinogen; Humans; Integrin beta3; Molecular Mimicry; Peptide Fragments; Perfusion; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia	2003
Recombinant factor VIIa restores aggregation of alphaIIbbeta3-deficient platelets via tissue factor-independent fibrin generation. Blood, 2004, Mar-01, Volume: 103, Issue:5 Topics: Blood Platelets; Collagen; Factor VIIa; Factor X; Fibrin; Fibrinogen; Humans; Microscopy, Electron; Peptides; Perfusion; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Prothrombin; Receptor, PAR-1; Recombinant Proteins; Thrombasthenia; Thrombin; Thromboplastin; Time Factors	2004
Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3. The Journal of biological chemistry, 2004, Jun-04, Volume: 279, Issue:23 Topics: Alanine; Amino Acid Sequence; Blood Platelets; Cell Line; Crystallography, X-Ray; Cysteine; Dimerization; Disulfides; DNA, Complementary; Fibrinogen; Flow Cytometry; Humans; Integrin alphaVbeta3; Lysine; Models, Molecular; Models, Statistical; Molecular Sequence Data; Mutation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Software; Structure-Activity Relationship; Thrombasthenia; Transfection	2004
Glanzmann thrombasthenia Frankfurt I is associated with a point mutation Thr176Ile in the N-terminal region of alpha IIb subunit integrin. Thrombosis and haemostasis, 2004, Volume: 92, Issue:5 Topics: Blood Coagulation Tests; DNA Mutational Analysis; Female; Fibrinogen; Humans; Middle Aged; Mutation, Missense; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoprotein IIb; Point Mutation; Protein Binding; Protein Structure, Tertiary; RNA, Messenger; Thrombasthenia	2004
A variant thrombasthenic phenotype associated with compound heterozygosity of integrin beta3-subunit: (Met124Val)beta3 alters the subunit dimerization rendering a decreased number of constitutive active alphaIIbbeta3 receptors. Thrombosis and haemostasis, 2004, Volume: 92, Issue:6 Topics: Alleles; Amino Acid Sequence; Animals; Antigens, Human Platelet; Base Sequence; Binding Sites; Blood Platelets; Blotting, Western; Cell Membrane; CHO Cells; Cricetinae; Dimerization; DNA Mutational Analysis; DNA, Complementary; Family Health; Female; Fibrinogen; Flow Cytometry; Genetic Vectors; Heterozygote; Humans; Immunoblotting; Infant; Integrin beta3; Male; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Mutagenesis; Mutation; Phenotype; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; RNA, Messenger; Thrombasthenia; Time Factors; Transfection	2004
A novel Ser123Pro substitution in the MIDAS domain of integrin 3 associated with variant Glanzmann's thrombasthenia in an Indian patient. Haematologica, 2004, Volume: 89, Issue:12 Topics: Amino Acid Substitution; Child; Consanguinity; Exons; Female; Fibrinogen; Flow Cytometry; Humans; India; Integrin beta3; Mutation, Missense; Platelet Aggregation; Point Mutation; Protein Binding; Protein Structure, Tertiary; Thrombasthenia	2004
Type I Glanzmann thrombasthenia caused by an apparently silent beta3 mutation that results in aberrant splicing and reduced beta3 mRNA. Thrombosis and haemostasis, 2005, Volume: 93, Issue:5 Topics: Alleles; Alternative Splicing; Animals; Antibodies, Monoclonal; Blood Platelets; Child, Preschool; CHO Cells; Codon, Nonsense; Codon, Terminator; Cricetinae; DNA; Exons; Family Health; Fathers; Female; Fibrinogen; Flow Cytometry; Frameshift Mutation; Genetic Techniques; Homozygote; Humans; Immunoprecipitation; Integrin beta3; Male; Mice; Models, Genetic; Mothers; Mutation; Phenotype; Platelet Glycoprotein GPIIb-IIIa Complex; Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Thrombasthenia	2005
A 13-bp deletion in alpha(IIb) gene is a founder mutation that predominates in Palestinian-Arab patients with Glanzmann thrombasthenia. Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:12 Topics: Amino Acid Substitution; Animals; Arabs; Base Sequence; Cell Line; Cricetinae; DNA Mutational Analysis; Fibrinogen; Founder Effect; Haplotypes; Humans; Integrin beta3; Jordan; Molecular Epidemiology; Platelet Membrane Glycoprotein IIb; Sequence Deletion; Thrombasthenia; Transduction, Genetic	2005
Diversity of Glanzmann thrombasthenia in southern India: 10 novel mutations identified among 15 unrelated patients. Journal of thrombosis and haemostasis : JTH, 2006, Volume: 4, Issue:8 Topics: Adolescent; Adult; Binding Sites; Blood Platelets; Cell Membrane; Child; DNA Mutational Analysis; Female; Fibrinogen; Humans; Male; Mutation; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Thrombasthenia	2006
Three novel mutations in the glycoprotein IIb gene in a patient with type II Glanzmann thrombasthenia. Haematologica, 2007, Volume: 92, Issue:5 Topics: Animals; Cell Line; Codon, Nonsense; Cricetinae; DNA Mutational Analysis; Endoplasmic Reticulum; Fibrinogen; Genotype; Golgi Apparatus; Humans; Integrin alpha2; Integrin beta3; Male; Mesocricetus; Middle Aged; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Transport; Recombinant Fusion Proteins; Structure-Activity Relationship; Thrombasthenia; Transfection	2007
Further characterization of the thrombasthenia-related idiotype OG. Antiidiotype defines a novel epitope(s) shared by fibrinogen B beta chain, vitronectin, and von Willebrand factor and required for binding to beta 3. The Journal of experimental medicine, 1994, Dec-01, Volume: 180, Issue:6 Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibody Specificity; Binding Sites, Antibody; Blood Proteins; Enzyme-Linked Immunosorbent Assay; Epitopes; Fibrinogen; Glycoproteins; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Immunoglobulin Idiotypes; Isoantibodies; Kinetics; Macromolecular Substances; Mice; Rabbits; Thrombasthenia; Vitronectin; von Willebrand Factor	1994
50-kD integrin-associated protein does not detectably influence several functions of glycoprotein IIb-IIIa complex in human platelets. Blood, 1995, Sep-15, Volume: 86, Issue:6 Topics: Animals; Antigens, CD; Blood Platelets; Calcium; Carrier Proteins; CD47 Antigen; Cell Adhesion; CHO Cells; Cricetinae; Cricetulus; Erythrocytes; Fibrinogen; Humans; Integrin beta3; Leukemia, Erythroblastic, Acute; Leukemia, Promyelocytic, Acute; Neutrophils; Platelet Aggregation; Platelet Membrane Glycoproteins; Recombinant Fusion Proteins; Thrombasthenia; Transfection; Tumor Cells, Cultured	1995
Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets. Molecular and cellular biology, 1993, Volume: 13, Issue:3 Topics: Biological Transport; Cell Compartmentation; Cytoskeleton; Fibrinogen; Humans; Integrins; Octoxynol; Phosphotyrosine; Platelet Activation; Platelet Membrane Glycoproteins; Polyethylene Glycols; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Solubility; Thrombasthenia; Thrombin; Tyrosine	1993
Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association. The Journal of clinical investigation, 1995, Volume: 95, Issue:4 Topics: Adolescent; Amino Acid Sequence; Base Sequence; Blood Platelets; Calcium; Female; Fibrinogen; Flow Cytometry; Humans; Integrins; Molecular Sequence Data; Mutation; Platelet Membrane Glycoproteins; Protein Processing, Post-Translational; Structure-Activity Relationship; Thrombasthenia	1995
Factor XIIIa binding to activated platelets is mediated through activation of glycoprotein IIb-IIIa. Blood, 1994, Feb-15, Volume: 83, Issue:4 Topics: Adenosine Diphosphate; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Arachidonic Acid; Blood Platelets; Calcimycin; Collagen; Epinephrine; Fibrinogen; Fibronectins; Flow Cytometry; Humans; In Vitro Techniques; Kinetics; Membrane Glycoproteins; Membrane Proteins; Oligopeptides; Platelet Activation; Platelet Membrane Glycoproteins; Reference Values; Tetradecanoylphorbol Acetate; Thrombasthenia; Thrombin; Thrombospondins; Time Factors; Transglutaminases	1994
Activation of the fibrinogen binding site on platelets isolated from a patient with the Strasbourg I variant of Glanzmann's thrombasthenia. Blood, 1994, Aug-15, Volume: 84, Issue:4 Topics: Amino Acid Sequence; Antibodies, Monoclonal; Binding Sites; Blood Platelets; Fibrinogen; Flow Cytometry; Humans; Kinetics; Macromolecular Substances; Molecular Sequence Data; Peptide Fragments; Platelet Aggregation; Platelet Membrane Glycoproteins; Point Mutation; Reference Values; Thrombasthenia	1994
A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa). Blood, 1994, Sep-15, Volume: 84, Issue:6 Topics: Animals; Cell Adhesion; CHO Cells; Cricetinae; Cytoplasm; Fibrinogen; Humans; Integrin beta3; Integrins; Microscopy, Electron, Scanning; Platelet Membrane Glycoproteins; Point Mutation; Signal Transduction; Thrombasthenia; Transfection	1994
Evidence that plasma fibrinogen and platelet membrane GPIIb-IIIa are involved in the adhesion of platelets to an artificial surface exposed to plasma. Thrombosis research, 1993, Sep-15, Volume: 71, Issue:6 Topics: Adsorption; Afibrinogenemia; Blood Platelets; Blood Proteins; Cations, Divalent; Cell Adhesion; Fibrinogen; Humans; Isoantibodies; Oligopeptides; Peptide Fragments; Plasma; Platelet Membrane Glycoproteins; Polystyrenes; Thrombasthenia	1993
Critical residues of integrin alphaIIb subunit for binding of alphaIIbbeta3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3). The Journal of biological chemistry, 1996, Aug-02, Volume: 271, Issue:31 Topics: Amino Acid Sequence; Animals; Antibodies; Binding Sites; CHO Cells; Cricetinae; Fibrinogen; Humans; Immunochemistry; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia	1996
Serine 752 in the cytoplasmic domain of the beta 3 integrin subunit is not required for alpha v beta 3 postreceptor signaling events. Cell adhesion and communication, 1996, Volume: 4, Issue:1 Topics: Alanine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, CD; Cell Adhesion; CHO Cells; Cricetinae; Cytoskeleton; Extracellular Matrix Proteins; Fibrinogen; Genetic Complementation Test; Humans; Integrin beta3; Molecular Sequence Data; Oligopeptides; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Point Mutation; Proline; Protein Binding; Receptors, Vitronectin; Recombinant Fusion Proteins; Sequence Alignment; Serine; Signal Transduction; Thrombasthenia; Transfection; Vitronectin; von Willebrand Factor	1996
Reassessment of protein tyrosine phosphorylation in thrombasthenic platelets: evidence that phosphorylation of cortactin and a 64-kD protein is dependent on thrombin activation and integrin alphaIIb beta3. Blood, 1997, Jun-15, Volume: 89, Issue:12 Topics: Blood Platelets; Cortactin; Enzyme Activation; Fibrinogen; Humans; Kinetics; Microfilament Proteins; Oligopeptides; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Processing, Post-Translational; Thrombasthenia; Thrombin	1997
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. The Journal of clinical investigation, 1997, Oct-15, Volume: 100, Issue:8 Topics: Antigens, CD; Blood Platelets; Calcium; Cell Adhesion; Cell Adhesion Molecules; Fibrinogen; Humans; Integrins; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Magnesium; Movement; Neutrophils; Platelet Activating Factor; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia	1997
Glycoprotein IIb Leu214Pro mutation produces glanzmann thrombasthenia with both quantitative and qualitative abnormalities in GPIIb/IIIa. Blood, 1998, Mar-01, Volume: 91, Issue:5 Topics: Animals; Bleeding Time; Blood Platelets; CHO Cells; Cricetinae; Dual Specificity Phosphatase 2; Fibrinogen; Humans; Immunosorbent Techniques; Leucine; Male; Middle Aged; Mutation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Proline; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Thrombasthenia; Transfection	1998
A Glanzmann thrombasthenia-like phenotype caused by a defect in inside-out signaling through the integrin alpha(IIb)beta3. Thrombosis and haemostasis, 1998, Volume: 80, Issue:5 Topics: Adult; Antibodies, Monoclonal; Blood Platelets; Blood Proteins; Chymotrypsin; DNA, Complementary; Female; Fibrinogen; Hemorrhagic Disorders; Humans; Myosin Light Chains; Oligopeptides; Phenotype; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Processing, Post-Translational; Signal Transduction; Sodium-Calcium Exchanger; Thrombasthenia; Thrombin	1998
A Leu262Pro mutation in the integrin beta(3) subunit results in an alpha(IIb)-beta(3) complex that binds fibrin but not fibrinogen. Blood, 2000, Jul-01, Volume: 96, Issue:1 Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, CD; Cell Line; Child, Preschool; COS Cells; Female; Fibrin; Fibrinogen; Humans; Integrin beta3; Kidney; Leucine; Male; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Pedigree; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Point Mutation; Polymerase Chain Reaction; Proline; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Thrombasthenia; Transfection; Xenopus	2000
Testing of platelet deposition on polystyrene surface under flow conditions by the cone and plate(let) analyzer: role of platelet activation, fibrinogen and von Willebrand factor. Thrombosis research, 2000, Aug-15, Volume: 99, Issue:4 Topics: Afibrinogenemia; Coagulation Protein Disorders; Extracellular Matrix; Fibrinogen; Humans; Oligopeptides; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polystyrenes; Solubility; Surface Properties; Thrombasthenia; von Willebrand Diseases; von Willebrand Factor	2000
Fibrinogen binding to the integrin alpha(IIb)beta(3) modulates store-mediated calcium entry in human platelets. Blood, 2001, May-01, Volume: 97, Issue:9 Topics: Blood Platelets; Calcium; Fibrinogen; Humans; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Signal Transduction; Thrombasthenia	2001
Identification of a region in glycoprotein IIIa involved in subunit association with glycoprotein IIb: further lessons from Iraqi-Jewish Glanzmann thrombasthenia. Blood, 2001, Aug-15, Volume: 98, Issue:4 Topics: Animals; Binding Sites; Cell Adhesion; CHO Cells; Cricetinae; Endoplasmic Reticulum; Fibrinogen; Flow Cytometry; Frameshift Mutation; Humans; Immunohistochemistry; Iraq; Jews; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Subunits; Sequence Deletion; Thrombasthenia; Transfection	2001
Molecular and genetic basis for thrombasthenic thrombopathia in otterhounds. American journal of veterinary research, 2001, Volume: 62, Issue:11 Topics: Amino Acid Sequence; Animals; Base Sequence; Blood Platelets; Carrier State; CD36 Antigens; Clot Retraction; DNA, Complementary; Dog Diseases; Dogs; Female; Fibrinogen; Integrin alpha2; Male; Membrane Glycoproteins; Molecular Sequence Data; Mouth Mucosa; Pedigree; Platelet Aggregation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sequence Homology, Nucleic Acid; Thrombasthenia	2001
A Val193Met mutation in GPIIIa results in a GPIIb/IIIa receptor with a constitutively high affinity for a small ligand. British journal of haematology, 2001, Volume: 115, Issue:1 Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Line; Female; Fibrinogen; Humans; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Point Mutation; Protein Binding; Radioligand Assay; Reverse Transcriptase Polymerase Chain Reaction; Structure-Activity Relationship; T-Lymphocytes; Thrombasthenia; Transfection	2001
A naturally occurring point mutation in the beta3 integrin MIDAS-like domain affects differently alphavbeta3 and alphaIIIbbeta3 receptor function. Thrombosis and haemostasis, 2001, Volume: 86, Issue:6 Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Antigens, CD; CHO Cells; Clot Retraction; Codon; Cricetinae; Cricetulus; Dimerization; Female; Fibrinogen; Humans; Integrin beta3; Molecular Sequence Data; Mutation, Missense; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Transport; Receptors, Vitronectin; Recombinant Fusion Proteins; Structure-Activity Relationship; Thrombasthenia	2001
Missense mutations in the beta(3) subunit have a different impact on the expression and function between alpha(IIb)beta(3) and alpha(v)beta(3). Blood, 2002, Feb-01, Volume: 99, Issue:3 Topics: Adult; Amino Acid Sequence; Antigens, CD; Blood Platelets; Cell Line; DNA Mutational Analysis; Female; Fibrinogen; Gene Expression; Humans; Integrin beta3; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Protein Binding; Receptors, Vitronectin; Thrombasthenia; Transfection	2002
Human IgG monoclonal anti-alpha(IIb)beta(3)-binding fragments derived from immunized donors using phage display. Journal of immunology (Baltimore, Md. : 1950), 2002, Feb-15, Volume: 168, Issue:4 Topics: Aged; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Affinity; Antibody Specificity; Autoantibodies; CHO Cells; Complementarity Determining Regions; Cricetinae; Epitopes; Fibrinogen; Humans; Immunization; Immunoglobulin Fragments; Immunoglobulin G; Male; Middle Aged; Molecular Sequence Data; Peptide Library; Platelet Glycoprotein GPIIb-IIIa Complex; Purpura, Thrombocytopenic, Idiopathic; Sequence Homology, Amino Acid; Thrombasthenia; Tissue Donors	2002
A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia. Platelets, 2002, Volume: 13, Issue:2 Topics: Aged; Amino Acid Substitution; DNA Mutational Analysis; Family Health; Fibrinogen; Genetic Variation; Humans; Leucine; Male; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Proline; Protein Binding; Protein Subunits; Thrombasthenia	2002
Association of thrombospondin-1 with the actin cytoskeleton of human thrombin-activated platelets through an alphaIIbbeta3- or CD36-independent mechanism. The Biochemical journal, 2002, May-01, Volume: 363, Issue:Pt 3 Topics: Actins; Adult; Animals; Antigens, CD; Carrier Proteins; CD36 Antigens; CD47 Antigen; Cytochalasin D; Cytoskeleton; Fibrinogen; Flow Cytometry; Humans; Mice; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia; Thrombin; Thrombospondin 1	2002
A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site. The Journal of biological chemistry, 1992, Feb-25, Volume: 267, Issue:6 Topics: Amino Acid Sequence; Amino Acids; Animals; Antibodies, Monoclonal; Base Sequence; Binding Sites; CHO Cells; Chromatography, Affinity; Cricetinae; DNA; Fibrinogen; Flow Cytometry; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligopeptides; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Recombinant Proteins; RNA; Thrombasthenia	1992
[Anti-platelet antibody and platelet function]. Nihon rinsho. Japanese journal of clinical medicine, 1992, Volume: 50, Issue:2 Topics: Antigens, Human Platelet; Autoantibodies; Binding Sites; Blood Platelets; Epitopes; Fibrinogen; Humans; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombasthenia	1992
A variant of Glanzmann's thrombasthenia which fails to express a GPIIb-IIIa related epitope that is recognized by a specific monoclonal antibody (C17). British journal of haematology, 1992, Volume: 81, Issue:4 Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Arachidonic Acids; Collagen; Epitopes; Female; Fibrinogen; Humans; Middle Aged; Platelet Aggregation; Platelet Membrane Glycoproteins; Ristocetin; Thrombasthenia	1992
Studies of the platelet fibrinogen receptor in Glanzmann patients and uremic patients. Thrombosis research, 1992, Aug-15, Volume: 67, Issue:4 Topics: Adolescent; Adult; Blood Platelets; Blood Preservation; Erythropoietin; Female; Fibrinogen; Flow Cytometry; Genetic Carrier Screening; Humans; Male; Middle Aged; Platelet Membrane Glycoproteins; Thrombasthenia; Uremia	1992
Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. Proceedings of the National Academy of Sciences of the United States of America, 1992, Nov-01, Volume: 89, Issue:21 Topics: Amino Acid Sequence; Antibodies, Monoclonal; Base Sequence; Chromatography, Affinity; Female; Fibrinogen; Genetic Variation; Humans; Macromolecular Substances; Male; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Pedigree; Platelet Activation; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Proline; RNA, Messenger; Serine; Thrombasthenia	1992
A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg----214Trp mutation. The Journal of clinical investigation, 1992, Volume: 89, Issue:6 Topics: Adult; Amino Acid Sequence; Base Sequence; Blood Platelets; DNA; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Female; Fibrinogen; Humans; Integrin alpha2; Membrane Glycoproteins; Molecular Sequence Data; Mutation; Platelet Aggregation; Polymerase Chain Reaction; Thrombasthenia	1992
Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3',4'-bisphosphate. The Journal of biological chemistry, 1991, Dec-15, Volume: 266, Issue:35 Topics: Amino Acid Sequence; Blood Platelets; Chromatography, High Pressure Liquid; Fibrinogen; Humans; Kinetics; Molecular Sequence Data; Oligopeptides; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipids; Platelet Membrane Glycoproteins; Reference Values; Thrombasthenia; Thrombin	1991
Platelet fibrinogen and vitronectin in Glanzmann thrombasthenia: evidence consistent with specific roles for glycoprotein IIb/IIIA and alpha v beta 3 integrins in platelet protein trafficking. Blood, 1991, Nov-15, Volume: 78, Issue:10 Topics: Blood Platelets; Electrophoresis, Polyacrylamide Gel; Ethnicity; Fibrinogen; Glycoproteins; Humans; Integrins; Membrane Proteins; Molecular Weight; Platelet Membrane Glycoproteins; Receptors, Immunologic; Receptors, Vitronectin; Thrombasthenia; Vitronectin	1991
[Function and pathophysiology of platelet membrane glycoproteins]. Rinsho byori. The Japanese journal of clinical pathology, 1991, Volume: Suppl 91 Topics: Bernard-Soulier Syndrome; Binding Sites; Female; Fibrinogen; Humans; Male; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Binding; Thrombasthenia; von Willebrand Factor	1991
A comparison of the fibrinogen receptor distribution on adherent platelets using both soluble fibrinogen and fibrinogen immobilized on gold beads. European journal of cell biology, 1991, Volume: 54, Issue:2 Topics: Amino Acid Sequence; Blood Platelets; Cell Movement; Fibrinogen; Gold; Humans; Immunohistochemistry; Microscopy, Immunoelectron; Molecular Sequence Data; Oligopeptides; Platelet Adhesiveness; Platelet Membrane Glycoproteins; Thrombasthenia	1991
The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. The Journal of clinical investigation, 1991, Volume: 87, Issue:4 Topics: Afibrinogenemia; Bernard-Soulier Syndrome; Fibrinogen; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Binding; Stress, Mechanical; Thrombasthenia; Time Factors; von Willebrand Diseases; von Willebrand Factor	1991
The triggering of fibrinogen receptors on mononuclear phagocytes of healthy subjects and of a thrombasthenia Glanzmann patient promotes the generation of reactive oxygen species. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1990, Volume: 1, Issue:4-5 Topics: Amino Acid Sequence; Antibodies; Cells, Cultured; Cytokines; Fibrin; Fibrinogen; Fibronectins; Free Radicals; Humans; Leukocytes, Mononuclear; Luminescent Measurements; Macrophages; Molecular Sequence Data; Oligopeptides; Oxidation-Reduction; Oxygen; Peptide Fragments; Phagocytosis; Platelet Membrane Glycoproteins; Protein Binding; Signal Transduction; Thrombasthenia	1990
Measurement of fibrinogen binding to platelets in whole blood by flow cytometry: a micromethod for the detection of platelet activation. British journal of haematology, 1990, Volume: 76, Issue:3 Topics: Adenosine Diphosphate; Antibodies; Antigen-Antibody Complex; Blood Platelets; Fibrinogen; Flow Cytometry; Humans; Platelet Activation; Thrombasthenia; Time Factors	1990
Alpha-granule pool of glycoprotein IIb-IIIa in normal and pathologic platelets and megakaryocytes. Blood, 1990, Mar-15, Volume: 75, Issue:6 Topics: Antibody Specificity; Blood Platelet Disorders; Blood Platelets; Cell Degranulation; Cells, Cultured; Cytoplasmic Granules; Fibrinogen; Humans; Immunohistochemistry; Megakaryocytes; Microscopy, Electron; Platelet Membrane Glycoproteins; Syndrome; Thrombasthenia; Thrombin	1990
Studies on the binding of an alloimmune and two murine monoclonal antibodies to the platelet glycoprotein IIb-IIIa complex receptor. The Journal of laboratory and clinical medicine, 1986, Volume: 107, Issue:4 Topics: Adenosine Diphosphate; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Blood Platelet Disorders; Blood Platelets; Chymotrypsin; Dinoprostone; Dogs; Epitopes; Epoprostenol; Fibrinogen; Glycoproteins; Humans; Immunoglobulin Allotypes; Iraq; Israel; Membrane Proteins; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandins E; Radioimmunoassay; Receptors, Cell Surface; Thrombasthenia	1986
Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia. The Journal of clinical investigation, 1986, Volume: 78, Issue:4 Topics: Antibodies, Monoclonal; Antibody Specificity; Blood Platelet Disorders; Blood Platelets; Cations, Divalent; Epitopes; Fibrinogen; Humans; Immunoelectrophoresis, Two-Dimensional; Kinetics; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombasthenia	1986
Quantitation of platelet fibrinogen and thrombospondin in Glanzmann's thrombasthenia by electroimmunoassay. Thrombosis research, 1989, Mar-15, Volume: 53, Issue:6 Topics: Blood Platelet Disorders; Blood Platelets; Detergents; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Humans; Immunoblotting; Immunoelectrophoresis; Leupeptins; Membrane Glycoproteins; Octoxynol; Polyethylene Glycols; Thrombasthenia; Thrombospondins	1989
Studies on the mechanism of expression of secreted fibrinogen on the surface of activated human platelets. Blood, 1989, Volume: 73, Issue:5 Topics: Binding Sites, Antibody; Blood Platelets; Cell Membrane; Fibrin; Fibrinogen; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation; Receptors, Cell Surface; Thrombasthenia	1989
Lysine binding to activated human platelets and its similarity to fibrinogen binding. Biochimica et biophysica acta, 1985, Dec-12, Volume: 847, Issue:3 Topics: Alanine; Amines; Blood Platelets; Calcimycin; Fibrinogen; Glycoproteins; Humans; Lysine; Membrane Proteins; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Thrombasthenia	1985
Aggregation of chymotrypsin-treated thrombasthenic platelets is mediated by fibrinogen binding to glycoproteins IIb and IIIa. The Journal of laboratory and clinical medicine, 1985, Volume: 106, Issue:6 Topics: Antibodies, Monoclonal; Binding Sites, Antibody; Blood Platelet Disorders; Blood Platelets; Cell Membrane; Chymotrypsin; Fibrinogen; Glycoproteins; Humans; Membrane Proteins; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Thrombasthenia	1985
Aggregation of human peripheral blood mononuclear cells by calcium ionophore A23187. Comparison with the aggregation of platelets and defective response in Glanzmann's thrombasthenia. Agents and actions, 1988, Volume: 24, Issue:1-2 Topics: Adult; Blood Physiological Phenomena; Blood Platelet Disorders; Calcimycin; Cell Aggregation; Fibrinogen; Humans; Leukocytes, Mononuclear; Platelet Aggregation; Thrombasthenia	1988
Importance of fibrinogen and platelet membrane glycoprotein IIb/IIIa in shear-induced platelet aggregation. Thrombosis research, 1988, Jul-15, Volume: 51, Issue:2 Topics: Afibrinogenemia; Blood Platelets; Fibrinogen; Humans; Microscopy, Electron, Scanning; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Membrane Glycoproteins; Stress, Mechanical; Thrombasthenia	1988
Characterization of an anti-thrombospondin monoclonal antibody (P8) that inhibits human blood platelet functions. Normal binding of P8 to thrombin-activated Glanzmann thrombasthenic platelets. European journal of biochemistry, 1988, Jan-15, Volume: 171, Issue:1-2 Topics: Antibodies, Monoclonal; Antibody Specificity; Blood Platelet Disorders; Blood Platelets; Chemical Precipitation; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Fibrinogen; Glycoproteins; Humans; Immunoelectrophoresis, Two-Dimensional; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombasthenia; Thrombin; Thrombospondins	1988
[Studies on platelet function, especially platelet fibrinogen, in patients with thrombasthenia and essential athrombia]. Rinsho byori. The Japanese journal of clinical pathology, 1988, Volume: 36, Issue:2 Topics: Adult; Bleeding Time; Blood Platelet Disorders; Blood Platelets; Female; Fibrinogen; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Thrombasthenia	1988
Use of specific adhesion substrates for diagnosis of platelet disorders: platelet-collagen and platelet-fibrinogen interaction in von Willebrand's disease and Glanzmann's thrombasthenia. Thrombosis research, 1987, Dec-01, Volume: 48, Issue:5 Topics: Blood Platelet Disorders; Blood Platelets; Collagen; Female; Fibrinogen; Fibronectins; Humans; Male; Platelet Adhesiveness; Thrombasthenia; von Willebrand Diseases; von Willebrand Factor	1987
[Platelet glycoprotein complex IIb-IIIa: a polyvalent membrane receptor?]. Nouvelle revue francaise d'hematologie, 1987, Volume: 29, Issue:1 Topics: Blood Platelets; Fibrinogen; Glycoproteins; Membrane Glycoproteins; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombasthenia	1987
Protein synthesis and storage in human platelets: a defective storage of fibrinogen in platelets in Glanzmann's thrombasthenia. Biochimica et biophysica acta, 1987, Aug-13, Volume: 925, Issue:2 Topics: Blood Platelet Disorders; Blood Platelets; Blood Proteins; Fibrinogen; Glycoproteins; Humans; Molecular Weight; Thrombasthenia; Thrombospondins	1987
A variant of Glanzmann's thrombasthenia with abnormal glycoprotein IIb-IIIa complexes in the platelet membrane. The Journal of clinical investigation, 1987, Volume: 79, Issue:3 Topics: Adult; Antibodies, Monoclonal; Binding Sites, Antibody; Blood Platelet Disorders; Blood Platelets; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Female; Fibrinogen; Humans; Immunoelectrophoresis, Two-Dimensional; Platelet Membrane Glycoproteins; Thrombasthenia	1987
Platelet--von Willebrand factor interactions in type IIB von Willebrand's disease. Scandinavian journal of haematology, 1985, Volume: 35, Issue:3 Topics: Blood Platelets; Deamino Arginine Vasopressin; Fibrinogen; Humans; Platelet Aggregation; Ristocetin; Thrombasthenia; Thrombocytopenia; von Willebrand Diseases; von Willebrand Factor	1985