fibrinogen has been researched along with Deficiency of GP 2b 3a Complex in 92 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 15 (16.30) | 18.7374 |
1990's | 31 (33.70) | 18.2507 |
2000's | 29 (31.52) | 29.6817 |
2010's | 15 (16.30) | 24.3611 |
2020's | 2 (2.17) | 2.80 |
Authors | Studies |
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Jiang, M; Lin, ZH; Liu, H; Ma, ZN; Wang, ZY; Xie, ZL; Yang, F; Yang, L; Zhou, L | 1 |
Fedorova, DV; Filkova, AA; Martyanov, AA; Morozova, DS; Novichkova, GA; Panteleev, MA; Sorokina, MA; Suntsova, EV; Sveshnikova, AAN; Uzueva, SS; Zharkov, PA | 1 |
Bonna, A; Farndale, RW; Howes, JM; Induruwa, I; Jung, SM; Malcor, JD; Moroi, M; Warburton, EA | 1 |
Lickert, S; Medalia, O; Schoen, I; Sorrentino, S; Studt, JD; Vogel, V | 1 |
Alessi, MC; Ataullakhanov, FI; Biriukova, MI; Chambost, H; Demyanova, AS; Kostanova, EA; Kotova, YN; Kumskova, MA; Obydennyy, SI; Panteleev, MA; Podoplelova, NA; Rosenfeld, MA; Ryabykh, AA; Sokolov, AV | 1 |
Du, LM; Fang, J; North, P; Nurden, AT; Nurden, P; Valentin, N; Wilcox, DA | 1 |
Abaeva, AA; Alessi, MC; Ataullakhanov, FI; Canault, M; Chambost, H; Kolyadko, VN; Kotova, YN; Mazurov, AV; Nurden, AT; Obydennyy, SI; Panteleev, MA; Podoplelova, NA; Yakimenko, AO | 1 |
Gärtner, F; Goedel, A; Haas, J; Jung, CB; Kurnik, K; Laugwitz, KL; Massberg, S; Moretti, A; Orban, M; Parrotta, E; Sandrock-Lang, K; Sinnecker, D; Wanner, G; Zieger, B | 1 |
Hauschner, H; Mansour, W; Messineo, S; Mor-Cohen, R; Rosenberg, N; Savoia, A; Seligsohn, U | 1 |
Buitrago, L; Coller, BS; Filizola, M; Liang, Y; Negri, A; Ouwehand, WH; Rendon, A; Simeoni, I | 1 |
Baaten, CC; Beckers, EA; Berny-Lang, MA; Cosemans, JM; Hackeng, TM; Heemskerk, JW; Henskens, YM; Mastenbroek, TG; Mattheij, NJ; May, F; McCarty, OJ; Nolte, MW; Suylen, DP; Swieringa, F; van der Meijden, PE | 1 |
Dahan, I; Dubrovsky, A; Eibauer, M; Medalia, O; Motahedeh, S; Sapra, KT; Shai, E; Sorrentino, S; Studt, JD; Tamir, A; Varon, D | 1 |
Amoriello, A; Bafunno, V; D'Andrea, G; Del Vecchio, L; Grandone, E; Margaglione, M; Morabito, P; Vecchione, G | 1 |
Coller, BS; Shattil, SJ | 1 |
Ahmad, F; Biswas, A; Kannan, M; Saxena, R; Yadav, BK | 1 |
Bagoly, Z; Kappelmayer, J; Muszbek, L; Nagy, B; Simon, Z | 1 |
Ariëns, RA; Carvalho, FA; Connell, S; Miltenberger-Miltenyi, G; Pereira, SV; Santos, NC; Tavares, A | 1 |
Abolghasemi, H; Aghaiipour, M; Ala, F; Faranoush, M; Farsinejad, A; Hadjati, E; Jazebi, M; Kazemi, A | 1 |
Hauschner, H; Mor-Cohen, R; Rosenberg, N; Seligsohn, U | 1 |
Budnik, I; Einav, Y; Livnat, T; Martinowitz, U; Misgav, M; Shenkman, B | 1 |
Feijge, MA; Gilio, K; Hamulyák, K; Heemskerk, JW; Nergiz-Unal, R; Swieringa, F; van der Meijden, PE | 1 |
Caen, JP; Combrié, R; Nurden, AT; Nurden, P; Poujol, C; Winckler, J | 1 |
Ghosh, K; Kulkarni, B; Mohanty, D; Nair, S; Shetty, S | 1 |
André, P; Bal Dit Sollier, C; Bellucci, S; Brouland, JP; Caen, J; Drouet, L; Hainaud, P; Simoneau, G | 1 |
Arai, M; Honda, S; Kashiwagi, H; Kato, H; Kiyoi, T; Kosugi, S; Kurata, Y; Matsuzawa, Y; Tadokoro, S; Tomiyama, Y | 1 |
Akkerman, JW; Kroner, CI; Litjens, PE; Van Willigen, G | 1 |
Adelmeijer, J; de Groot, PG; Heijnen, HF; Lisman, T | 1 |
Artoni, A; Coller, BS; Filizola, M; Hassan, SA; Weinstein, H | 1 |
Bassus, S; Follert-Hagendorff, K; Jablonka, B; Just, M; Kirchmaier, CM; Santoso, S; Westrup, D | 1 |
Alonso, S; Arias-Salgado, EG; Butta, N; González-Manchón, C; Larrucea, S; López, A; Parrilla, R | 1 |
Ghosh, K; Mohanty, D; Nair, S; Shetty, S | 1 |
Butta, N; González-Manchón, C; Jayo, A; Pabón, D; Xie, J | 1 |
Awidi, AA; Coller, BS; Hauschner, H; Kenet, G; Landau, M; Mor-Cohen, R; Peretz, H; Rosenberg, N; Seligsohn, U; Shenkman, B | 1 |
Chandy, M; Coller, BS; Nair, SC; Nelson, EJ; Peretz, H; Seligsohn, U; Srivastava, A | 1 |
Bereczky, Z; Boda, Z; Hauschner, H; Kappelmayer, J; Losonczy, G; Muszbek, L; Rosenberg, N; Vereb, G | 1 |
Brojer, E; Gruel, Y; Kunicki, TJ; Nugent, DJ | 1 |
Fujimoto, T; Fujimura, K; Kuramoto, A; Noda, M; Shimomura, T; Takafuta, T | 1 |
Brugge, JS; Clark, EA | 1 |
Gill, JC; Lyman, S; Newman, PJ; Paddock, CM; Wilcox, DA | 1 |
Coller, BS; Newman, PJ; Peretz, H; Seligsohn, U | 1 |
Cox, AD; Devine, DV | 1 |
Cazenave, JP; Jennings, LK; Jutzi, J; Kouns, WC; Kunicki, TJ; Lanza, F; Moog, S; Steiner, B | 1 |
Chen, YP; Ginsberg, MH; O'Toole, TE; Rosa, JP; Ylänne, J | 1 |
Handa, M; Ikeda, Y; Kawai, Y; Nagai, H; Watanabe, K | 1 |
Irie, A; Kamata, T; Takada, Y; Tokuhira, M | 1 |
Bron, N; Gouon, V; Guinet, JM; Kieffer, N; Melchior, C; Michels, S | 1 |
Artçanuthurry, V; Caen, JP; Grelac, F; Lévy-Toledano, S; Maclouf, J; Rosa, JP | 1 |
Springer, TA; Weber, C | 1 |
Chen, F; Coller, BS; French, DL; Grimaldi, CM; Weiss, HJ; Wu, C | 1 |
Ambo, H; Kinoshita, S; Kunicki, TJ; Kurata, Y; Matsuzawa, Y; Shiraga, M; Tomiyama, Y | 1 |
Kestin, AS; Newman, PJ; Ward, CM | 1 |
Dardik, R; Savion, N; Shenkman, B; Tamarin, I; Varon, D | 1 |
Hamulyak, K; Heemskerk, JW; Meijer, EM; Novakova, I; Rosado, JA; Sage, SO | 1 |
Dardik, R; Peretz, H; Rosenberg, N; Seligsohn, U; Trakhtenbrot, L; Yatuv, R; Zivelin, A | 1 |
Boudreaux, MK; Catalfamo, JL | 1 |
Fitzgerald, DJ; Fullard, J; Moran, N; Murphy, R; O'Neill, S; Ottridge, B | 1 |
Ammerlaan, W; Chen, P; Kaplan, C; Kieffer, N; Lecompte, T; Melchior, C; Morel-Kopp, MC | 1 |
Honda, S; Kashiwagi, H; Kiyoi, T; Kosugi, S; Kurata, Y; Matsuzawa, Y; Shiraga, M; Tadokoro, S; Tomiyama, Y | 1 |
Clofent-Sanchez, G; Jacobin, MJ; Keller, A; Laroche-Traineau, J; Little, M; Nurden, A; Peter, K; Welschof, M | 1 |
Combrié, R; Gauthier, B; Kunicki, T; Nurden, AT; Nurden, P; Pasquet, JM; Ruan, J | 1 |
de Jesus, N; Dubernard, V; Legrand, C; Saumet, A | 1 |
Bennett, JS | 1 |
Bajt, ML; Berndt, MC; Frelinger, AL; Ginsberg, MH; Loftus, JC | 1 |
Kurata, Y; Tomiyama, Y | 1 |
Castillo, R; Diaz-Ricart, M; Escolar, G; Garrido, M; Maragall, S; Nurden, AT; Ordinas, A; Reverter, JC; Sanz, C; Villamor, N | 1 |
Egberg, N; Lindahl, TL; Lundahl, J; Netré, C | 1 |
Caen, JP; Chen, YP; Cieutat, AM; Djaffar, I; Pidard, D; Rosa, JP; Steiner, B | 1 |
André, G; Cazenave, JP; Fournier, D; Lanza, F; Morales, M; Nurden, AT; Stierlé, A | 1 |
Bachelot, C; Breton, M; Caen, JP; Chap, H; Grondin, P; Lévy-Toledano, S; Mauco, G; Plantavid, M; Sultan, C | 1 |
Coller, BS; Norton, KJ; Scudder, LE; Seligsohn, U; West, SM | 1 |
Fujimura, K; Kuramoto, A | 1 |
Estry, DW; Mahoney, GJ; Mattson, JC; Oesterle, JR | 1 |
O'Brien, JR | 1 |
Anbo, H; Araki, Y; Handa, M; Ikeda, Y; Itagaki, I; Kamata, T; Kawai, Y; Kawano, K; Murata, M; Watanabe, K | 1 |
Jungi, TW; Schalch, L; Trezzini, C | 1 |
Hardisty, RM; Powling, MJ; Warkentin, TE | 1 |
Berndt, MC; Breton-Gorius, J; Caen, JP; Cramer, EM; Massé, JM; Pidard, D; Savidge, GF; Vainchenker, W | 1 |
Coller, BS; Nurden, AT; Peerschke, EI; Rosa, JP; Scudder, LE; Seligsohn, U | 1 |
Ginsberg, MH; Kaufmann, A; Kunicki, TJ; Lightsey, A; Marguerie, G; Plow, EF | 1 |
Bouillot, C; Disdier, M; Dubernard, V; Legrand, C; Nurden, AT; Pidard, D | 1 |
Dubernard, V; Legrand, C; Nurden, AT | 1 |
Agam, G; Dvilansky, A; Livne, A; Luria, R; Seligsohn, U; Shohat, O | 1 |
Bennett, JS; Dunn, F; Hershock, D; Kieffer, N; Kornecki, E; Niewiarowski, S; Pidard, D; Soria, C; Soria, J; Tuszynski, GP | 1 |
Cerbone, AM; Ciavarella, N; Di Minno, G; Iride, C; Montemurro, P; Scillitani, A; Semeraro, N | 1 |
Ando, Y; Araki, Y; Ichitani, M; Ikeda, Y; Itagaki, I; Mori, Y; Murata, M; Sakai, K; Watanabe, K | 1 |
Boukerche, H; McGregor, JL | 1 |
Endo, Y; Iwamoto, K; Mamiya, S; Miura, A; Niitsu, H | 1 |
Gorbunova, NA; Leytin, VL; Likhacheva, EA; Misselwitz, F; Repin, VS | 1 |
Pidard, D | 1 |
Belloc, F; Boisseau, MR; Combrie, R; Heilmann, E; Nurden, AT | 1 |
Didry, D; Fournier, D; Legrand, C; Nurden, AT; Parquet, A; Pidard, D; Rosa, JP | 1 |
Awidi, A; Holmberg, L; Kristoffersson, AC; Lamme, S; Nilsson, IM; Solum, NO | 1 |
4 review(s) available for fibrinogen and Deficiency of GP 2b 3a Complex
Article | Year |
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The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.
Topics: Animals; Fibrinogen; Hematology; History, 20th Century; History, 21st Century; Humans; Medical Laboratory Science; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia | 2008 |
Glanzmann thrombasthenia: new insights from an historical perspective.
Topics: Antibodies, Monoclonal; Base Sequence; Fibrinogen; Gene Deletion; History, 20th Century; Humans; Iraq; Israel; Jews; Molecular Sequence Data; Platelet Membrane Glycoproteins; Saudi Arabia; Thrombasthenia | 1994 |
Mechanisms of platelet adhesion and aggregation: an update.
Topics: Fibrinogen; Glycoproteins; Humans; Integrins; Platelet Adhesiveness; Platelet Aggregation; Receptors, Cell Surface; Thrombasthenia; von Willebrand Diseases; von Willebrand Factor | 1992 |
Shear-induced platelet aggregation.
Topics: Blood Circulation; Blood Coagulation Tests; Blood Viscosity; Fibrinogen; Hemofiltration; Humans; Integrin alpha2; Membrane Glycoproteins; Platelet Activation; Platelet Aggregation; Thrombasthenia; von Willebrand Diseases; von Willebrand Factor | 1990 |
88 other study(ies) available for fibrinogen and Deficiency of GP 2b 3a Complex
Article | Year |
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[Effects of the ITGA2B Nonsense Mutation (c.2659C > T, p.Q887X) on Platelet Function in a Mouse Model of Glanzmann's Thrombasthenia Generated with CRISPR/Cas9 Technology].
Topics: Animals; Codon, Nonsense; CRISPR-Cas Systems; Disease Models, Animal; Fibrinogen; Humans; Integrin alpha2; Mice; Oligonucleotides; Platelet Glycoprotein GPIIb-IIIa Complex; RNA, Guide, Kinetoplastida; Thrombasthenia; Thrombin | 2022 |
Heterogeneity of Integrin α
Topics: Adolescent; Blood Coagulation; Blood Platelets; Calcium; Calcium Signaling; Child; Child, Preschool; Cluster Analysis; Computer Simulation; Cytosol; Female; Fibrinogen; Flow Cytometry; Hemorrhage; Humans; Male; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Purpura, Thrombocytopenic, Idiopathic; Thrombasthenia; Thrombosis | 2020 |
Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation.
Topics: Binding Sites; Blood Platelets; Case-Control Studies; Collagen; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Humans; Platelet Activation; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Protein Binding; Protein Interaction Domains and Motifs; Protein Multimerization; Signal Transduction; Structure-Activity Relationship; Thrombasthenia; Thrombosis | 2018 |
Morphometric analysis of spread platelets identifies integrin α
Topics: Adult; Biomechanical Phenomena; Blood Platelets; Cytoskeleton; Fibrinogen; Hemostasis; Humans; Ligands; Mechanical Phenomena; Phenotype; Platelet Glycoprotein GPIIb-IIIa Complex; Signal Transduction; Thrombasthenia | 2018 |
Binding of Coagulation Factor XIII Zymogen to Activated Platelet Subpopulations: Roles of Integrin αIIbβ3 and Fibrinogen.
Topics: Afibrinogenemia; Blood Coagulation; Blood Platelets; Enzyme Precursors; Factor VIII; Fibrinogen; Fibrinolysis; Humans; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Thrombasthenia | 2019 |
C560Rβ3 caused platelet integrin αII b β3 to bind fibrinogen continuously, but resulted in a severe bleeding syndrome and increased murine mortality.
Topics: Animals; Blood Platelets; Bone Marrow Cells; Fibrinogen; Hemorrhage; Humans; Integrin beta3; Lentivirus; Megakaryocytes; Mice; Mutation; P-Selectin; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Syndrome; Thrombasthenia; Thrombosis | 2013 |
Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates.
Topics: Blood Coagulation; Blood Platelets; Blotting, Western; Female; Fibrin; Fibrinogen; Flow Cytometry; Humans; Microscopy, Confocal; Oligopeptides; Phosphatidylserines; Platelet Aggregation; Polymerization; Thrombasthenia; Thrombosis; Thrombospondins; Transglutaminases | 2013 |
Functional comparison of induced pluripotent stem cell- and blood-derived GPIIbIIIa deficient platelets.
Topics: Adolescent; Blood Platelets; Cell Adhesion; Cells, Cultured; Female; Fibrinogen; Humans; Induced Pluripotent Stem Cells; Integrin alpha2; Models, Biological; Thrombasthenia | 2015 |
Abnormal cytoplasmic extensions associated with active αIIbβ3 are probably the cause for macrothrombocytopenia in Glanzmann thrombasthenia-like syndrome.
Topics: Animals; Cell Line; Cricetinae; Cytoskeleton; DNA, Complementary; Fibrinogen; Genetic Vectors; Humans; Integrin alpha2; Integrin beta3; Megakaryocytes; Mesocricetus; Microtubules; Mutation, Missense; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Conformation; Protein Interaction Mapping; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Deletion; Thrombasthenia; Tubulin; von Willebrand Factor | 2015 |
αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia.
Topics: Alleles; Databases, Nucleic Acid; Exome; Fibrinogen; Gene Frequency; HEK293 Cells; High-Throughput Nucleotide Sequencing; Humans; Immunoblotting; Models, Molecular; Mutation, Missense; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Thrombasthenia | 2015 |
Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII.
Topics: Animals; Blood Coagulation; Blood Platelets; Crotalid Venoms; Factor Va; Factor Xa; Factor XIII; Fibrin; Fibrinogen; Humans; Lectins, C-Type; Mice; Mice, Knockout; Molecular Probes; Phosphatidylserines; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Primary Cell Culture; Protein Binding; Thrombasthenia; Thrombin | 2016 |
The macromolecular architecture of platelet-derived microparticles.
Topics: Blood Platelets; Cell Adhesion; Cell-Derived Microparticles; Cryoelectron Microscopy; Cytoskeleton; Fibrinogen; Humans; Manganese; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia; Thrombin | 2016 |
A beta3 Asp217-->Val substitution in a patient with variant Glanzmann Thrombasthenia severely affects integrin alphaIIBbeta3 functions.
Topics: Amino Acid Substitution; Animals; Child; CHO Cells; Cricetinae; Cricetulus; Fibrinogen; Humans; Integrin beta3; Male; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia; Valine | 2008 |
Modulation of clinical phenotype of Glanzmann's thrombasthenia by thrombogenic mutations.
Topics: Antigens, Human Platelet; Blood Coagulation Factors; Blood Transfusion; Epistaxis; Fibrinogen; Homozygote; Humans; Mutation; Phenotype; Platelet Aggregation; Polymorphism, Genetic; Thrombasthenia | 2009 |
Binding of plasma factor XIII to thrombin-receptor activated human platelets.
Topics: Blood Coagulation; Blood Platelets; Cytosol; Eptifibatide; Factor XIII; Fibrinogen; Humans; Oligopeptides; P-Selectin; Peptide Fragments; Peptides; Plasma; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia | 2009 |
Atomic force microscopy-based molecular recognition of a fibrinogen receptor on human erythrocytes.
Topics: Blood Platelets; Calcium; Eptifibatide; Erythrocyte Membrane; Erythrocytes; Female; Fibrinogen; Humans; Microscopy, Atomic Force; Mutation; Peptides; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Receptors, Fibrinogen; Reproducibility of Results; Substrate Specificity; Thrombasthenia | 2010 |
Classification of Iranian patients with Glanzmann's Thrombasthenia using a flow cytometric method.
Topics: Adolescent; Adult; Antibodies, Monoclonal; Blood Platelets; Case-Control Studies; Child; Child, Preschool; Female; Fibrinogen; Flow Cytometry; Hemorrhage; Humans; Infant; Integrin alphaV; Integrin beta3; Iran; Male; Middle Aged; Molecular Typing; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoprotein IIb; Protein Binding; Retrospective Studies; Severity of Illness Index; Thrombasthenia | 2011 |
A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIb β3 to an active state.
Topics: Animals; Cell Line; Cricetinae; Fibrinogen; Flow Cytometry; Integrin beta3; Ligands; Mutagenesis, Site-Directed; Mutation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Signal Transduction; Structure-Activity Relationship; Thrombasthenia; Transfection | 2012 |
The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann's thrombasthenia.
Topics: Area Under Curve; Blood Coagulation; Calcium Chloride; Case-Control Studies; Eptifibatide; Factor XIII; Fibrinogen; Humans; Peptides; Platelet Aggregation Inhibitors; Platelet-Rich Plasma; Thrombasthenia; Thrombelastography; Thrombin; Thrombin Time; Thromboplastin; Tissue Plasminogen Activator | 2012 |
Key role of integrin α(IIb)β (3) signaling to Syk kinase in tissue factor-induced thrombin generation.
Topics: Blood Coagulation; Blood Platelets; Blotting, Western; Fibrinogen; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Phosphoserine; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein-Tyrosine Kinases; Signal Transduction; Syk Kinase; Thrombasthenia; Thrombin; Thromboplastin | 2012 |
A Ser752-->Pro substitution in the cytoplasmic domain of beta3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the alphaIIbbeta3 integrin and the platelet granule pool of fibrinogen.
Topics: Adenosine Diphosphate; Aged; Blood Platelets; Case-Control Studies; Fibrinogen; Humans; Integrin beta3; Male; Microscopy, Immunoelectron; Mutation; Platelet Activation; Platelet Membrane Glycoprotein IIb; Protein Binding; Stimulation, Chemical; Thrombasthenia | 2002 |
Human platelet alloantigen polymorphism in Glanzmann's thrombasthenia and its impact on the severity of the disease.
Topics: Adolescent; Antigens, Human Platelet; Child; Child, Preschool; Female; Fibrinogen; Flow Cytometry; Humans; Integrin beta3; Isoantigens; Male; Platelet Membrane Glycoprotein IIb; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Protein Binding; Thrombasthenia | 2002 |
Dissociation between fibrinogen and fibrin interaction with platelets in patients with different subtypes of Glanzmann's thrombasthenia: studies in an ex vivo perfusion chamber model.
Topics: Blood Platelets; Collagen Type III; Diffusion Chambers, Culture; Female; Fibrin; Fibrinogen; Heterozygote; Humans; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia; Thrombosis; von Willebrand Factor | 2002 |
A naturally occurring Tyr143His alpha IIb mutation abolishes alpha IIb beta 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects.
Topics: Adult; Allosteric Regulation; Amino Acid Substitution; Blood Platelets; Clot Retraction; Codon; Dipeptides; Female; Fibrinogen; Heterozygote; Humans; Ligands; Mutation, Missense; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoprotein IIb; Point Mutation; Polymorphism, Restriction Fragment Length; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA, Messenger; Solubility; Structure-Activity Relationship; Thrombasthenia; Transfection | 2003 |
Cytoplasmic regions of the beta3 subunit of integrin alphaIIbbeta3 involved in platelet adhesion on fibrinogen under flow conditions.
Topics: Amino Acid Sequence; Amino Acid Substitution; Cytochalasin D; Cytoplasm; Cytoskeleton; Fibrinogen; Humans; Integrin beta3; Molecular Mimicry; Peptide Fragments; Perfusion; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia | 2003 |
Recombinant factor VIIa restores aggregation of alphaIIbbeta3-deficient platelets via tissue factor-independent fibrin generation.
Topics: Blood Platelets; Collagen; Factor VIIa; Factor X; Fibrin; Fibrinogen; Humans; Microscopy, Electron; Peptides; Perfusion; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Prothrombin; Receptor, PAR-1; Recombinant Proteins; Thrombasthenia; Thrombin; Thromboplastin; Time Factors | 2004 |
Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3.
Topics: Alanine; Amino Acid Sequence; Blood Platelets; Cell Line; Crystallography, X-Ray; Cysteine; Dimerization; Disulfides; DNA, Complementary; Fibrinogen; Flow Cytometry; Humans; Integrin alphaVbeta3; Lysine; Models, Molecular; Models, Statistical; Molecular Sequence Data; Mutation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Software; Structure-Activity Relationship; Thrombasthenia; Transfection | 2004 |
Glanzmann thrombasthenia Frankfurt I is associated with a point mutation Thr176Ile in the N-terminal region of alpha IIb subunit integrin.
Topics: Blood Coagulation Tests; DNA Mutational Analysis; Female; Fibrinogen; Humans; Middle Aged; Mutation, Missense; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoprotein IIb; Point Mutation; Protein Binding; Protein Structure, Tertiary; RNA, Messenger; Thrombasthenia | 2004 |
A variant thrombasthenic phenotype associated with compound heterozygosity of integrin beta3-subunit: (Met124Val)beta3 alters the subunit dimerization rendering a decreased number of constitutive active alphaIIbbeta3 receptors.
Topics: Alleles; Amino Acid Sequence; Animals; Antigens, Human Platelet; Base Sequence; Binding Sites; Blood Platelets; Blotting, Western; Cell Membrane; CHO Cells; Cricetinae; Dimerization; DNA Mutational Analysis; DNA, Complementary; Family Health; Female; Fibrinogen; Flow Cytometry; Genetic Vectors; Heterozygote; Humans; Immunoblotting; Infant; Integrin beta3; Male; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Mutagenesis; Mutation; Phenotype; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; RNA, Messenger; Thrombasthenia; Time Factors; Transfection | 2004 |
A novel Ser123Pro substitution in the MIDAS domain of integrin 3 associated with variant Glanzmann's thrombasthenia in an Indian patient.
Topics: Amino Acid Substitution; Child; Consanguinity; Exons; Female; Fibrinogen; Flow Cytometry; Humans; India; Integrin beta3; Mutation, Missense; Platelet Aggregation; Point Mutation; Protein Binding; Protein Structure, Tertiary; Thrombasthenia | 2004 |
Type I Glanzmann thrombasthenia caused by an apparently silent beta3 mutation that results in aberrant splicing and reduced beta3 mRNA.
Topics: Alleles; Alternative Splicing; Animals; Antibodies, Monoclonal; Blood Platelets; Child, Preschool; CHO Cells; Codon, Nonsense; Codon, Terminator; Cricetinae; DNA; Exons; Family Health; Fathers; Female; Fibrinogen; Flow Cytometry; Frameshift Mutation; Genetic Techniques; Homozygote; Humans; Immunoprecipitation; Integrin beta3; Male; Mice; Models, Genetic; Mothers; Mutation; Phenotype; Platelet Glycoprotein GPIIb-IIIa Complex; Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Thrombasthenia | 2005 |
A 13-bp deletion in alpha(IIb) gene is a founder mutation that predominates in Palestinian-Arab patients with Glanzmann thrombasthenia.
Topics: Amino Acid Substitution; Animals; Arabs; Base Sequence; Cell Line; Cricetinae; DNA Mutational Analysis; Fibrinogen; Founder Effect; Haplotypes; Humans; Integrin beta3; Jordan; Molecular Epidemiology; Platelet Membrane Glycoprotein IIb; Sequence Deletion; Thrombasthenia; Transduction, Genetic | 2005 |
Diversity of Glanzmann thrombasthenia in southern India: 10 novel mutations identified among 15 unrelated patients.
Topics: Adolescent; Adult; Binding Sites; Blood Platelets; Cell Membrane; Child; DNA Mutational Analysis; Female; Fibrinogen; Humans; Male; Mutation; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Thrombasthenia | 2006 |
Three novel mutations in the glycoprotein IIb gene in a patient with type II Glanzmann thrombasthenia.
Topics: Animals; Cell Line; Codon, Nonsense; Cricetinae; DNA Mutational Analysis; Endoplasmic Reticulum; Fibrinogen; Genotype; Golgi Apparatus; Humans; Integrin alpha2; Integrin beta3; Male; Mesocricetus; Middle Aged; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Transport; Recombinant Fusion Proteins; Structure-Activity Relationship; Thrombasthenia; Transfection | 2007 |
Further characterization of the thrombasthenia-related idiotype OG. Antiidiotype defines a novel epitope(s) shared by fibrinogen B beta chain, vitronectin, and von Willebrand factor and required for binding to beta 3.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibody Specificity; Binding Sites, Antibody; Blood Proteins; Enzyme-Linked Immunosorbent Assay; Epitopes; Fibrinogen; Glycoproteins; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Immunoglobulin Idiotypes; Isoantibodies; Kinetics; Macromolecular Substances; Mice; Rabbits; Thrombasthenia; Vitronectin; von Willebrand Factor | 1994 |
50-kD integrin-associated protein does not detectably influence several functions of glycoprotein IIb-IIIa complex in human platelets.
Topics: Animals; Antigens, CD; Blood Platelets; Calcium; Carrier Proteins; CD47 Antigen; Cell Adhesion; CHO Cells; Cricetinae; Cricetulus; Erythrocytes; Fibrinogen; Humans; Integrin beta3; Leukemia, Erythroblastic, Acute; Leukemia, Promyelocytic, Acute; Neutrophils; Platelet Aggregation; Platelet Membrane Glycoproteins; Recombinant Fusion Proteins; Thrombasthenia; Transfection; Tumor Cells, Cultured | 1995 |
Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.
Topics: Biological Transport; Cell Compartmentation; Cytoskeleton; Fibrinogen; Humans; Integrins; Octoxynol; Phosphotyrosine; Platelet Activation; Platelet Membrane Glycoproteins; Polyethylene Glycols; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Solubility; Thrombasthenia; Thrombin; Tyrosine | 1993 |
Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association.
Topics: Adolescent; Amino Acid Sequence; Base Sequence; Blood Platelets; Calcium; Female; Fibrinogen; Flow Cytometry; Humans; Integrins; Molecular Sequence Data; Mutation; Platelet Membrane Glycoproteins; Protein Processing, Post-Translational; Structure-Activity Relationship; Thrombasthenia | 1995 |
Factor XIIIa binding to activated platelets is mediated through activation of glycoprotein IIb-IIIa.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Arachidonic Acid; Blood Platelets; Calcimycin; Collagen; Epinephrine; Fibrinogen; Fibronectins; Flow Cytometry; Humans; In Vitro Techniques; Kinetics; Membrane Glycoproteins; Membrane Proteins; Oligopeptides; Platelet Activation; Platelet Membrane Glycoproteins; Reference Values; Tetradecanoylphorbol Acetate; Thrombasthenia; Thrombin; Thrombospondins; Time Factors; Transglutaminases | 1994 |
Activation of the fibrinogen binding site on platelets isolated from a patient with the Strasbourg I variant of Glanzmann's thrombasthenia.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Binding Sites; Blood Platelets; Fibrinogen; Flow Cytometry; Humans; Kinetics; Macromolecular Substances; Molecular Sequence Data; Peptide Fragments; Platelet Aggregation; Platelet Membrane Glycoproteins; Point Mutation; Reference Values; Thrombasthenia | 1994 |
A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa).
Topics: Animals; Cell Adhesion; CHO Cells; Cricetinae; Cytoplasm; Fibrinogen; Humans; Integrin beta3; Integrins; Microscopy, Electron, Scanning; Platelet Membrane Glycoproteins; Point Mutation; Signal Transduction; Thrombasthenia; Transfection | 1994 |
Evidence that plasma fibrinogen and platelet membrane GPIIb-IIIa are involved in the adhesion of platelets to an artificial surface exposed to plasma.
Topics: Adsorption; Afibrinogenemia; Blood Platelets; Blood Proteins; Cations, Divalent; Cell Adhesion; Fibrinogen; Humans; Isoantibodies; Oligopeptides; Peptide Fragments; Plasma; Platelet Membrane Glycoproteins; Polystyrenes; Thrombasthenia | 1993 |
Critical residues of integrin alphaIIb subunit for binding of alphaIIbbeta3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3).
Topics: Amino Acid Sequence; Animals; Antibodies; Binding Sites; CHO Cells; Cricetinae; Fibrinogen; Humans; Immunochemistry; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia | 1996 |
Serine 752 in the cytoplasmic domain of the beta 3 integrin subunit is not required for alpha v beta 3 postreceptor signaling events.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, CD; Cell Adhesion; CHO Cells; Cricetinae; Cytoskeleton; Extracellular Matrix Proteins; Fibrinogen; Genetic Complementation Test; Humans; Integrin beta3; Molecular Sequence Data; Oligopeptides; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Point Mutation; Proline; Protein Binding; Receptors, Vitronectin; Recombinant Fusion Proteins; Sequence Alignment; Serine; Signal Transduction; Thrombasthenia; Transfection; Vitronectin; von Willebrand Factor | 1996 |
Reassessment of protein tyrosine phosphorylation in thrombasthenic platelets: evidence that phosphorylation of cortactin and a 64-kD protein is dependent on thrombin activation and integrin alphaIIb beta3.
Topics: Blood Platelets; Cortactin; Enzyme Activation; Fibrinogen; Humans; Kinetics; Microfilament Proteins; Oligopeptides; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Processing, Post-Translational; Thrombasthenia; Thrombin | 1997 |
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor.
Topics: Antigens, CD; Blood Platelets; Calcium; Cell Adhesion; Cell Adhesion Molecules; Fibrinogen; Humans; Integrins; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Magnesium; Movement; Neutrophils; Platelet Activating Factor; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia | 1997 |
Glycoprotein IIb Leu214Pro mutation produces glanzmann thrombasthenia with both quantitative and qualitative abnormalities in GPIIb/IIIa.
Topics: Animals; Bleeding Time; Blood Platelets; CHO Cells; Cricetinae; Dual Specificity Phosphatase 2; Fibrinogen; Humans; Immunosorbent Techniques; Leucine; Male; Middle Aged; Mutation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Proline; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Thrombasthenia; Transfection | 1998 |
A Glanzmann thrombasthenia-like phenotype caused by a defect in inside-out signaling through the integrin alpha(IIb)beta3.
Topics: Adult; Antibodies, Monoclonal; Blood Platelets; Blood Proteins; Chymotrypsin; DNA, Complementary; Female; Fibrinogen; Hemorrhagic Disorders; Humans; Myosin Light Chains; Oligopeptides; Phenotype; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Processing, Post-Translational; Signal Transduction; Sodium-Calcium Exchanger; Thrombasthenia; Thrombin | 1998 |
A Leu262Pro mutation in the integrin beta(3) subunit results in an alpha(IIb)-beta(3) complex that binds fibrin but not fibrinogen.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, CD; Cell Line; Child, Preschool; COS Cells; Female; Fibrin; Fibrinogen; Humans; Integrin beta3; Kidney; Leucine; Male; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Pedigree; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Point Mutation; Polymerase Chain Reaction; Proline; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Thrombasthenia; Transfection; Xenopus | 2000 |
Testing of platelet deposition on polystyrene surface under flow conditions by the cone and plate(let) analyzer: role of platelet activation, fibrinogen and von Willebrand factor.
Topics: Afibrinogenemia; Coagulation Protein Disorders; Extracellular Matrix; Fibrinogen; Humans; Oligopeptides; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polystyrenes; Solubility; Surface Properties; Thrombasthenia; von Willebrand Diseases; von Willebrand Factor | 2000 |
Fibrinogen binding to the integrin alpha(IIb)beta(3) modulates store-mediated calcium entry in human platelets.
Topics: Blood Platelets; Calcium; Fibrinogen; Humans; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Signal Transduction; Thrombasthenia | 2001 |
Identification of a region in glycoprotein IIIa involved in subunit association with glycoprotein IIb: further lessons from Iraqi-Jewish Glanzmann thrombasthenia.
Topics: Animals; Binding Sites; Cell Adhesion; CHO Cells; Cricetinae; Endoplasmic Reticulum; Fibrinogen; Flow Cytometry; Frameshift Mutation; Humans; Immunohistochemistry; Iraq; Jews; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Subunits; Sequence Deletion; Thrombasthenia; Transfection | 2001 |
Molecular and genetic basis for thrombasthenic thrombopathia in otterhounds.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blood Platelets; Carrier State; CD36 Antigens; Clot Retraction; DNA, Complementary; Dog Diseases; Dogs; Female; Fibrinogen; Integrin alpha2; Male; Membrane Glycoproteins; Molecular Sequence Data; Mouth Mucosa; Pedigree; Platelet Aggregation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sequence Homology, Nucleic Acid; Thrombasthenia | 2001 |
A Val193Met mutation in GPIIIa results in a GPIIb/IIIa receptor with a constitutively high affinity for a small ligand.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Line; Female; Fibrinogen; Humans; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Point Mutation; Protein Binding; Radioligand Assay; Reverse Transcriptase Polymerase Chain Reaction; Structure-Activity Relationship; T-Lymphocytes; Thrombasthenia; Transfection | 2001 |
A naturally occurring point mutation in the beta3 integrin MIDAS-like domain affects differently alphavbeta3 and alphaIIIbbeta3 receptor function.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Antigens, CD; CHO Cells; Clot Retraction; Codon; Cricetinae; Cricetulus; Dimerization; Female; Fibrinogen; Humans; Integrin beta3; Molecular Sequence Data; Mutation, Missense; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Transport; Receptors, Vitronectin; Recombinant Fusion Proteins; Structure-Activity Relationship; Thrombasthenia | 2001 |
Missense mutations in the beta(3) subunit have a different impact on the expression and function between alpha(IIb)beta(3) and alpha(v)beta(3).
Topics: Adult; Amino Acid Sequence; Antigens, CD; Blood Platelets; Cell Line; DNA Mutational Analysis; Female; Fibrinogen; Gene Expression; Humans; Integrin beta3; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Protein Binding; Receptors, Vitronectin; Thrombasthenia; Transfection | 2002 |
Human IgG monoclonal anti-alpha(IIb)beta(3)-binding fragments derived from immunized donors using phage display.
Topics: Aged; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Affinity; Antibody Specificity; Autoantibodies; CHO Cells; Complementarity Determining Regions; Cricetinae; Epitopes; Fibrinogen; Humans; Immunization; Immunoglobulin Fragments; Immunoglobulin G; Male; Middle Aged; Molecular Sequence Data; Peptide Library; Platelet Glycoprotein GPIIb-IIIa Complex; Purpura, Thrombocytopenic, Idiopathic; Sequence Homology, Amino Acid; Thrombasthenia; Tissue Donors | 2002 |
A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia.
Topics: Aged; Amino Acid Substitution; DNA Mutational Analysis; Family Health; Fibrinogen; Genetic Variation; Humans; Leucine; Male; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Proline; Protein Binding; Protein Subunits; Thrombasthenia | 2002 |
Association of thrombospondin-1 with the actin cytoskeleton of human thrombin-activated platelets through an alphaIIbbeta3- or CD36-independent mechanism.
Topics: Actins; Adult; Animals; Antigens, CD; Carrier Proteins; CD36 Antigens; CD47 Antigen; Cytochalasin D; Cytoskeleton; Fibrinogen; Flow Cytometry; Humans; Mice; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia; Thrombin; Thrombospondin 1 | 2002 |
A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antibodies, Monoclonal; Base Sequence; Binding Sites; CHO Cells; Chromatography, Affinity; Cricetinae; DNA; Fibrinogen; Flow Cytometry; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligopeptides; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Recombinant Proteins; RNA; Thrombasthenia | 1992 |
[Anti-platelet antibody and platelet function].
Topics: Antigens, Human Platelet; Autoantibodies; Binding Sites; Blood Platelets; Epitopes; Fibrinogen; Humans; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombasthenia | 1992 |
A variant of Glanzmann's thrombasthenia which fails to express a GPIIb-IIIa related epitope that is recognized by a specific monoclonal antibody (C17).
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Arachidonic Acids; Collagen; Epitopes; Female; Fibrinogen; Humans; Middle Aged; Platelet Aggregation; Platelet Membrane Glycoproteins; Ristocetin; Thrombasthenia | 1992 |
Studies of the platelet fibrinogen receptor in Glanzmann patients and uremic patients.
Topics: Adolescent; Adult; Blood Platelets; Blood Preservation; Erythropoietin; Female; Fibrinogen; Flow Cytometry; Genetic Carrier Screening; Humans; Male; Middle Aged; Platelet Membrane Glycoproteins; Thrombasthenia; Uremia | 1992 |
Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Base Sequence; Chromatography, Affinity; Female; Fibrinogen; Genetic Variation; Humans; Macromolecular Substances; Male; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Pedigree; Platelet Activation; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Proline; RNA, Messenger; Serine; Thrombasthenia | 1992 |
A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg----214Trp mutation.
Topics: Adult; Amino Acid Sequence; Base Sequence; Blood Platelets; DNA; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Female; Fibrinogen; Humans; Integrin alpha2; Membrane Glycoproteins; Molecular Sequence Data; Mutation; Platelet Aggregation; Polymerase Chain Reaction; Thrombasthenia | 1992 |
Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3',4'-bisphosphate.
Topics: Amino Acid Sequence; Blood Platelets; Chromatography, High Pressure Liquid; Fibrinogen; Humans; Kinetics; Molecular Sequence Data; Oligopeptides; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipids; Platelet Membrane Glycoproteins; Reference Values; Thrombasthenia; Thrombin | 1991 |
Platelet fibrinogen and vitronectin in Glanzmann thrombasthenia: evidence consistent with specific roles for glycoprotein IIb/IIIA and alpha v beta 3 integrins in platelet protein trafficking.
Topics: Blood Platelets; Electrophoresis, Polyacrylamide Gel; Ethnicity; Fibrinogen; Glycoproteins; Humans; Integrins; Membrane Proteins; Molecular Weight; Platelet Membrane Glycoproteins; Receptors, Immunologic; Receptors, Vitronectin; Thrombasthenia; Vitronectin | 1991 |
[Function and pathophysiology of platelet membrane glycoproteins].
Topics: Bernard-Soulier Syndrome; Binding Sites; Female; Fibrinogen; Humans; Male; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Binding; Thrombasthenia; von Willebrand Factor | 1991 |
A comparison of the fibrinogen receptor distribution on adherent platelets using both soluble fibrinogen and fibrinogen immobilized on gold beads.
Topics: Amino Acid Sequence; Blood Platelets; Cell Movement; Fibrinogen; Gold; Humans; Immunohistochemistry; Microscopy, Immunoelectron; Molecular Sequence Data; Oligopeptides; Platelet Adhesiveness; Platelet Membrane Glycoproteins; Thrombasthenia | 1991 |
The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.
Topics: Afibrinogenemia; Bernard-Soulier Syndrome; Fibrinogen; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Binding; Stress, Mechanical; Thrombasthenia; Time Factors; von Willebrand Diseases; von Willebrand Factor | 1991 |
The triggering of fibrinogen receptors on mononuclear phagocytes of healthy subjects and of a thrombasthenia Glanzmann patient promotes the generation of reactive oxygen species.
Topics: Amino Acid Sequence; Antibodies; Cells, Cultured; Cytokines; Fibrin; Fibrinogen; Fibronectins; Free Radicals; Humans; Leukocytes, Mononuclear; Luminescent Measurements; Macrophages; Molecular Sequence Data; Oligopeptides; Oxidation-Reduction; Oxygen; Peptide Fragments; Phagocytosis; Platelet Membrane Glycoproteins; Protein Binding; Signal Transduction; Thrombasthenia | 1990 |
Measurement of fibrinogen binding to platelets in whole blood by flow cytometry: a micromethod for the detection of platelet activation.
Topics: Adenosine Diphosphate; Antibodies; Antigen-Antibody Complex; Blood Platelets; Fibrinogen; Flow Cytometry; Humans; Platelet Activation; Thrombasthenia; Time Factors | 1990 |
Alpha-granule pool of glycoprotein IIb-IIIa in normal and pathologic platelets and megakaryocytes.
Topics: Antibody Specificity; Blood Platelet Disorders; Blood Platelets; Cell Degranulation; Cells, Cultured; Cytoplasmic Granules; Fibrinogen; Humans; Immunohistochemistry; Megakaryocytes; Microscopy, Electron; Platelet Membrane Glycoproteins; Syndrome; Thrombasthenia; Thrombin | 1990 |
Studies on the binding of an alloimmune and two murine monoclonal antibodies to the platelet glycoprotein IIb-IIIa complex receptor.
Topics: Adenosine Diphosphate; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Blood Platelet Disorders; Blood Platelets; Chymotrypsin; Dinoprostone; Dogs; Epitopes; Epoprostenol; Fibrinogen; Glycoproteins; Humans; Immunoglobulin Allotypes; Iraq; Israel; Membrane Proteins; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandins E; Radioimmunoassay; Receptors, Cell Surface; Thrombasthenia | 1986 |
Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia.
Topics: Antibodies, Monoclonal; Antibody Specificity; Blood Platelet Disorders; Blood Platelets; Cations, Divalent; Epitopes; Fibrinogen; Humans; Immunoelectrophoresis, Two-Dimensional; Kinetics; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombasthenia | 1986 |
Quantitation of platelet fibrinogen and thrombospondin in Glanzmann's thrombasthenia by electroimmunoassay.
Topics: Blood Platelet Disorders; Blood Platelets; Detergents; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Humans; Immunoblotting; Immunoelectrophoresis; Leupeptins; Membrane Glycoproteins; Octoxynol; Polyethylene Glycols; Thrombasthenia; Thrombospondins | 1989 |
Studies on the mechanism of expression of secreted fibrinogen on the surface of activated human platelets.
Topics: Binding Sites, Antibody; Blood Platelets; Cell Membrane; Fibrin; Fibrinogen; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation; Receptors, Cell Surface; Thrombasthenia | 1989 |
Lysine binding to activated human platelets and its similarity to fibrinogen binding.
Topics: Alanine; Amines; Blood Platelets; Calcimycin; Fibrinogen; Glycoproteins; Humans; Lysine; Membrane Proteins; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Thrombasthenia | 1985 |
Aggregation of chymotrypsin-treated thrombasthenic platelets is mediated by fibrinogen binding to glycoproteins IIb and IIIa.
Topics: Antibodies, Monoclonal; Binding Sites, Antibody; Blood Platelet Disorders; Blood Platelets; Cell Membrane; Chymotrypsin; Fibrinogen; Glycoproteins; Humans; Membrane Proteins; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Thrombasthenia | 1985 |
Aggregation of human peripheral blood mononuclear cells by calcium ionophore A23187. Comparison with the aggregation of platelets and defective response in Glanzmann's thrombasthenia.
Topics: Adult; Blood Physiological Phenomena; Blood Platelet Disorders; Calcimycin; Cell Aggregation; Fibrinogen; Humans; Leukocytes, Mononuclear; Platelet Aggregation; Thrombasthenia | 1988 |
Importance of fibrinogen and platelet membrane glycoprotein IIb/IIIa in shear-induced platelet aggregation.
Topics: Afibrinogenemia; Blood Platelets; Fibrinogen; Humans; Microscopy, Electron, Scanning; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Membrane Glycoproteins; Stress, Mechanical; Thrombasthenia | 1988 |
Characterization of an anti-thrombospondin monoclonal antibody (P8) that inhibits human blood platelet functions. Normal binding of P8 to thrombin-activated Glanzmann thrombasthenic platelets.
Topics: Antibodies, Monoclonal; Antibody Specificity; Blood Platelet Disorders; Blood Platelets; Chemical Precipitation; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Fibrinogen; Glycoproteins; Humans; Immunoelectrophoresis, Two-Dimensional; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombasthenia; Thrombin; Thrombospondins | 1988 |
[Studies on platelet function, especially platelet fibrinogen, in patients with thrombasthenia and essential athrombia].
Topics: Adult; Bleeding Time; Blood Platelet Disorders; Blood Platelets; Female; Fibrinogen; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Thrombasthenia | 1988 |
Use of specific adhesion substrates for diagnosis of platelet disorders: platelet-collagen and platelet-fibrinogen interaction in von Willebrand's disease and Glanzmann's thrombasthenia.
Topics: Blood Platelet Disorders; Blood Platelets; Collagen; Female; Fibrinogen; Fibronectins; Humans; Male; Platelet Adhesiveness; Thrombasthenia; von Willebrand Diseases; von Willebrand Factor | 1987 |
[Platelet glycoprotein complex IIb-IIIa: a polyvalent membrane receptor?].
Topics: Blood Platelets; Fibrinogen; Glycoproteins; Membrane Glycoproteins; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombasthenia | 1987 |
Protein synthesis and storage in human platelets: a defective storage of fibrinogen in platelets in Glanzmann's thrombasthenia.
Topics: Blood Platelet Disorders; Blood Platelets; Blood Proteins; Fibrinogen; Glycoproteins; Humans; Molecular Weight; Thrombasthenia; Thrombospondins | 1987 |
A variant of Glanzmann's thrombasthenia with abnormal glycoprotein IIb-IIIa complexes in the platelet membrane.
Topics: Adult; Antibodies, Monoclonal; Binding Sites, Antibody; Blood Platelet Disorders; Blood Platelets; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Female; Fibrinogen; Humans; Immunoelectrophoresis, Two-Dimensional; Platelet Membrane Glycoproteins; Thrombasthenia | 1987 |
Platelet--von Willebrand factor interactions in type IIB von Willebrand's disease.
Topics: Blood Platelets; Deamino Arginine Vasopressin; Fibrinogen; Humans; Platelet Aggregation; Ristocetin; Thrombasthenia; Thrombocytopenia; von Willebrand Diseases; von Willebrand Factor | 1985 |