Page last updated: 2024-08-26

fibrinogen and Brain Hemorrhage

fibrinogen has been researched along with Brain Hemorrhage in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (25.00)	29.6817
2010's	17 (47.22)	24.3611
2020's	10 (27.78)	2.80

Authors

Authors	Studies
Aksoy, A; Binzenhöfer, L; Dabboura, S; Hagl, C; Hoffmann, S; Krogmann, A; Kühn, C; Lüsebrink, E; Majunke, N; Massberg, S; Orban, M; Peterss, S; Schäfer, A; Scherer, C; Schrage, B; Szczanowicz, L; Thiele, H; Westermann, D; Zimmer, S	1
Rao, VL; Sandoval Karamian, AG; Tam, LT; Tong, E; Yang, QZ; Yeom, KW	1
Abdelwahab, M; Casini, A; de Moerloose, P	1
Azizi, E; Ghaffarpasand, F; Khalili, H; Niakan, A; Vosoughi, M	1
Lou, M; Xu, J; Yan, S; Zhang, R; Zhang, X	1
Cardinale, M; Cungi, PJ; D'Aranda, E; Dagain, A; Esnault, P; Goutorbe, P; Joubert, C; Mathais, Q; Meaudre, E; Montcriol, A	1
Arcese, W; Breccia, M; Cicconi, L; De Bellis, E; Del Principe, MI; Di Giuliano, F; Divona, M; Garaci, F; Gurnari, C; Lo-Coco, F; Piciocchi, A; Scalzulli, E; Venditti, A; Voso, MT	1
Iwaniec, T; Neerman-Arbez, M; Undas, A; Vilar, R; Wypasek, E; Zdziarska, J	1
Chen, Y; Cheng, H; Cheng, Q; He, J; He, W; Huang, G; Liu, Y; Ruan, Y; Yuan, C; Zeng, Y	1
Barrett, NA; Benedetti, G; Breen, KA; Camporota, L; Doyle, AJ; Hunt, BJ; Mak, SM; Retter, A; Sanderson, B; Zhang, J	1
Barrett, NA; Camporota, L; Daly, K; Gillon, SA; Glover, GW; Ioannou, N; Langrish, CJ; Lockie, CJA; Mazumder, A; Meadows, CIS; Paramesh, K; Retter, A; Rowland, K; Taylor, D; Tricklebank, S; Wyncoll, DLA	1
Ding, J; Ding, Y; Elmadhoun, O; Geng, T; Hu, Y; Ji, X; Meng, R; Pan, L; Wang, Z; Ya, J; Zhou, D	1
Barbosa, R; Dean, R; Dewey, EN; Fair, KA; Farrell, DH; Hilliard, C; Hinson, H; Lin, A; McCully, BH; Rick, EA; Rowell, SE; Schreiber, MA	1
Friedlich, P; Klee, L; Perry, R; Ramanathan, R; Seri, I; Stein, J; Young, G	1
Berling, I; Isbister, GK	1
Beavers, C; Pahs, L; Schuler, P	1
Cotter, M; Coulter-Smith, S; Egan, K; Kevane, B; Kirkham, C; McCallion, N; Mooney, C; Neary, E; Ní Áinle, F; Regan, I	1
McBride, D; Tang, J; Zhang, JH	1
Chang, YJ; Chen, H; Chen, Y; Chen, YH; Han, W; Huang, XJ; Liu, KY; Mo, XD; Wang, FR; Wang, JZ; Wang, QM; Wang, Y; Xu, LP; Zhang, XH; Zhang, YY	1
Dolan, M; Ngaruiya, C	1
Alfieri, A; Callovini, G; Galarza, M; Gazzeri, R	1
Acemoglu, H; Akcay, F; Can, I; Demir, R; Kuyucu, M; Varoglu, AO	1
Coplin, WM; Frankel, M; Levine, SR; Lin, Y; Lyden, PD; Rhoney, DH	1
Hariharan, G; Parapurath, R; Ramachandran, S	1
Ataoglu, E; Ayta, S; Celkan, T; Civilibal, M; Duru, NS; Elevli, M; Yavuz, SC	1
Jacobs, IG; Mountain, D; Sistenich, V	1
Arkhipkin, AA; Karpova, OV; Kochetov, AG; Luk'ianov, AL; Novozhenova, IuV; Ramazanov, GR; Shamalov, NA; Skvortsova, VI	1
Guo, YJ; He, B; Li, GY; Li, YS; Lin, TS; Tang, XF; Tong, WS; Xu, JF; Yang, WJ; Yu, H; Zeng, JS; Zheng, P	1
Campbell, DJ; Chalmers, J; Colman, S; Jenkins, AJ; Kemp, BE; Lowe, GD; MacMahon, SW; Neal, BC; Patel, A; Rumley, A; Woodward, M	1
Fujieda, A; Kaneko, T; Katayama, N; Kobayashi, T; Matsumoto, T; Nobori, T; Sugimoto, Y; Tamaru, S; Wada, H; Yamaguchi, M; Yamamura, K	1
Huang, WC; McGinty, K; Miller, R; Whisnant, JK; Wong, WY	1
Igarashi, T; Komiyama, N; Komiyama, Y; Maeda, T; Miwa, M; Munakata, M; Sugatani, J; Takahashi, H; Takeda, T	1
Colvin, BT; de Lord, S; Dickinson, JP; Keeling, DM; Parameswaran, R	1
Abilleira, S; Alvarez-Sabín, J; Arenillas, J; Codina, A; Molina, C	1
Chiaretti, A; Currò, V; Piastra, M; Polidori, G; Tortorolo, L; Viola, L	1
Gerlach, R; Raabe, A; Seifert, V; Siegemund, A; Tölle, F; Zimmermann, M	1

Reviews

4 review(s) available for fibrinogen and Brain Hemorrhage

Article	Year
Afibrinogenemia caused by a novel homozygous missense mutation, FGB p.Cys241Tyr, in a male patient with recurrent intracranial bleeding: case report and review of literature. Haemophilia : the official journal of the World Federation of Hemophilia, 2021, Volume: 27, Issue:1 Topics: Afibrinogenemia; Child; Fibrinogen; Homozygote; Humans; Intracranial Hemorrhages; Male; Mutation, Missense	2021
Hematologic effects and complications of snake envenoming. Transfusion medicine reviews, 2015, Volume: 29, Issue:2 Topics: Animals; Antivenins; Blood Coagulation; Blood Coagulation Factors; Elapidae; Enzyme Activation; Fibrinogen; Hemorrhagic Disorders; Heparin; Humans; Intracranial Hemorrhages; Plasma; Prothrombin Time; Snake Bites; Snake Venoms; Thrombotic Microangiopathies; Viperidae; Wounds and Injuries	2015
Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage. Current drug targets, 2017, Volume: 18, Issue:12 Topics: Clinical Trials as Topic; Fibrinogen; Hematoma; Humans; Incidence; Intracranial Hemorrhages; Prognosis	2017
Biosurgical Hemostatic Agents in Neurosurgical Intracranial Procedures. Surgical technology international, 2017, Feb-07, Volume: 30 Topics: Cellulose, Oxidized; Drug Combinations; Fibrinogen; Hemostatics; Humans; Intracranial Hemorrhages; Neurosurgical Procedures; Thrombin	2017

Trials

3 trial(s) available for fibrinogen and Brain Hemorrhage

Article	Year
Effects of serum fibrinogen correction on outcome of traumatic cranial surgery: A randomized, single-blind, placebo-controlled clinical trial. Clinical neurology and neurosurgery, 2023, Volume: 229 Topics: Blood Coagulation Disorders; Blood Loss, Surgical; Brain Injuries, Traumatic; Fibrinogen; Humans; Intracranial Hemorrhages; Single-Blind Method	2023
Time of day, outcome, and response to thrombolytic therapy: the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Trial experience. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2010, Volume: 19, Issue:1 Topics: Circadian Rhythm; Double-Blind Method; Fibrinogen; Fibrinolytic Agents; Humans; Intracranial Hemorrhages; Prospective Studies; Recombinant Proteins; Stroke; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator; Tomography, X-Ray Computed; Treatment Outcome; United States	2010
Associations of inflammatory and hemostatic variables with the risk of recurrent stroke. Stroke, 2005, Volume: 36, Issue:10 Topics: Aged; Brain Ischemia; C-Reactive Protein; Case-Control Studies; Female; Fibrin Fibrinogen Degradation Products; Fibrinogen; Hemostasis; Humans; Inflammation; Intracranial Hemorrhages; Ischemic Attack, Transient; Male; Middle Aged; Odds Ratio; Perindopril; Placebos; Recurrence; Risk; Risk Factors; Stroke	2005

Other Studies

29 other study(ies) available for fibrinogen and Brain Hemorrhage

Article	Year
Intracranial haemorrhage in adult patients on venoarterial extracorporeal membrane oxygenation. European heart journal. Acute cardiovascular care, 2022, Jun-07, Volume: 11, Issue:4 Topics: Adult; Extracorporeal Membrane Oxygenation; Fibrinogen; Humans; Intracranial Hemorrhages; Lactates; Retrospective Studies; Shock, Cardiogenic	2022
Intracranial Hemorrhage in Term and Late-Preterm Neonates: An Institutional Perspective. AJNR. American journal of neuroradiology, 2022, Volume: 43, Issue:10 Topics: Brain; Cerebral Hemorrhage; Female; Fibrinogen; Hematoma, Subdural; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Intracranial Hemorrhages; Magnetic Resonance Imaging; Pregnancy	2022
High incidence of intracranial haemorrhage in Egyptian children with congenital afibrinogenaemia. Haemophilia : the official journal of the World Federation of Hemophilia, 2023, Volume: 29, Issue:2 Topics: Afibrinogenemia; Cerebral Hemorrhage; Child; Egypt; Fibrinogen; Hemostatics; Humans; Incidence; Infant; Intracranial Hemorrhages; Retrospective Studies	2023
Early Fibrinogen Depletion and Symptomatic Intracranial Hemorrhage After Reperfusion Therapy. Stroke, 2019, Volume: 50, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Fibrinogen; Fibrinolytic Agents; Humans; Intracranial Hemorrhages; Male; Middle Aged; Stroke; Thrombectomy; Thrombolytic Therapy; Tissue Plasminogen Activator; Young Adult	2019
Ability of Fibrin Monomers to Predict Progressive Hemorrhagic Injury in Patients with Severe Traumatic Brain Injury. Neurocritical care, 2020, Volume: 33, Issue:1 Topics: Abbreviated Injury Scale; Adult; Blood Coagulation Disorders; Brain Hemorrhage, Traumatic; Brain Injuries, Traumatic; Disease Progression; Female; Fibrin Fibrinogen Degradation Products; Fibrinogen; Glasgow Coma Scale; Glasgow Outcome Scale; Hospital Mortality; Humans; International Normalized Ratio; Intracranial Hemorrhages; Male; Middle Aged; Neurosurgical Procedures; Partial Thromboplastin Time; Platelet Count; Prospective Studies; Prothrombin Time; Risk Assessment; Young Adult	2020
Early intracranial haemorrhages in acute promyelocytic leukaemia: analysis of neuroradiological and clinico-biological parameters. British journal of haematology, 2021, Volume: 193, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Child; Female; Fibrinogen; Humans; Hydrocephalus; International Normalized Ratio; Intracranial Hemorrhages; L-Lactate Dehydrogenase; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Mortality; Neuroradiography; Precision Medicine; Predictive Value of Tests; Remission Induction; Risk Factors; Tomography, X-Ray Computed; Young Adult	2021
High fibrinogen-to-albumin ratio is associated with hemorrhagic transformation in acute ischemic stroke patients. Brain and behavior, 2021, Volume: 11, Issue:1 Topics: Albumins; Brain Ischemia; Cerebral Hemorrhage; Fibrinogen; Humans; Intracranial Hemorrhages; Ischemic Stroke; Risk Factors; Stroke	2021
A Comparison of Thrombosis and Hemorrhage Rates in Patients With Severe Respiratory Failure Due to Coronavirus Disease 2019 and Influenza Requiring Extracorporeal Membrane Oxygenation. Critical care medicine, 2021, 07-01, Volume: 49, Issue:7 Topics: Adult; C-Reactive Protein; Computed Tomography Angiography; COVID-19; Extracorporeal Membrane Oxygenation; Female; Fibrin Fibrinogen Degradation Products; Fibrinogen; Humans; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza B virus; Influenza, Human; Intracranial Hemorrhages; London; Male; Middle Aged; Pulmonary Embolism; Retrospective Studies; SARS-CoV-2; State Medicine; Tertiary Care Centers; Ultrasonography, Doppler; Venous Thromboembolism; Venous Thrombosis	2021
Severe Respiratory Failure, Extracorporeal Membrane Oxygenation, and Intracranial Hemorrhage. Critical care medicine, 2017, Volume: 45, Issue:10 Topics: Adult; Cohort Studies; Extracorporeal Membrane Oxygenation; Female; Fibrinogen; Humans; Intensive Care Units; Intracranial Hemorrhages; London; Male; Middle Aged; Multivariate Analysis; Respiration, Artificial; Respiratory Insufficiency; Retrospective Studies; Risk Factors; Severity of Illness Index; Time Factors	2017
The efficacy and safety of Batroxobin in combination with anticoagulation on cerebral venous sinus thrombosis. Journal of thrombosis and thrombolysis, 2018, Volume: 46, Issue:3 Topics: Aged; Anticoagulants; Batroxobin; Blood Coagulation Tests; Case-Control Studies; Drug Therapy, Combination; Female; Fibrinogen; Hemostatics; Humans; Intracranial Hemorrhages; Male; Middle Aged; Retrospective Studies; Sinus Thrombosis, Intracranial; Treatment Outcome	2018
Fibrinolytic Activation in Patients with Progressive Intracranial Hemorrhage after Traumatic Brain Injury. Journal of neurotrauma, 2021, 04-15, Volume: 38, Issue:8 Topics: Adult; Aged; Brain Injuries, Traumatic; Disease Progression; Female; Fibrinogen; Fibrinolysis; Glasgow Coma Scale; Humans; Intracranial Hemorrhages; Male; Middle Aged; Prospective Studies; Thrombelastography	2021
Antithrombin III administration in neonates with congenital diaphragmatic hernia during the first three days of extracorporeal membrane oxygenation. Journal of pediatric surgery, 2013, Volume: 48, Issue:9 Topics: Antithrombin III; Capillary Leak Syndrome; Case-Control Studies; Disseminated Intravascular Coagulation; Drug Administration Schedule; Drug Evaluation; Extracorporeal Membrane Oxygenation; Factor VIII; Female; Fibrinogen; Guideline Adherence; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Infant, Newborn; Inflammation; Intracranial Hemorrhages; Male; Plasma; Platelet Transfusion; Practice Guidelines as Topic; Retrospective Studies	2013
The Real-World Treatment of Hemorrhages Associated With Dabigatran and Rivaroxaban: A Multicenter Evaluation. Critical pathways in cardiology, 2015, Volume: 14, Issue:2 Topics: Aged; Aged, 80 and over; Antithrombins; Blood Coagulation Factors; Coagulants; Cohort Studies; Dabigatran; Epistaxis; Erythrocyte Transfusion; Factor VIIa; Factor VIII; Female; Fibrinogen; Gastrointestinal Hemorrhage; Humans; Intracranial Hemorrhages; Male; Middle Aged; Plasma; Platelet Transfusion; Recombinant Proteins; Retrospective Studies; Rivaroxaban	2015
Coagulation indices in very preterm infants from cord blood and postnatal samples. Journal of thrombosis and haemostasis : JTH, 2015, Volume: 13, Issue:11 Topics: Blood Coagulation Factors; Blood Coagulation Tests; Blood Component Transfusion; Cerebral Ventricles; Cross-Sectional Studies; Female; Fetal Blood; Fibrinogen; Gestational Age; Hemorrhagic Disorders; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Intensive Care, Neonatal; Intracranial Hemorrhages; Male; Partial Thromboplastin Time; Prospective Studies; Prothrombin Time; Recombinant Proteins; Reference Standards; Thrombin; Thromboplastin; Vitamin K	2015
Clinical characteristics and risk factors of Intracranial hemorrhage in patients following allogeneic hematopoietic stem cell transplantation. Annals of hematology, 2016, Volume: 95, Issue:10 Topics: Adolescent; Adult; Allografts; Anemia, Aplastic; Case-Control Studies; Child; Child, Preschool; Consciousness Disorders; Female; Fibrinogen; Graft vs Host Disease; Hematologic Neoplasms; Hematoma, Subdural; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infections; Intracranial Hemorrhages; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Count; Retrospective Studies; Risk Factors; Seizures; Survival Rate; Transplantation Conditioning; Young Adult	2016
Acute Promyelocytic Leukemia Presenting as Focal Neurologic Findings and Deteriorating Mental Status. The Journal of emergency medicine, 2017, Volume: 52, Issue:1 Topics: Blood Platelets; Consciousness; Emergency Service, Hospital; Factor VIII; Fibrinogen; Humans; Intracranial Hemorrhages; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Nervous System Diseases; Thrombocytopenia; Tomography, X-Ray Computed; Tretinoin	2017
Prognostic values of lesion volume and biochemical markers in ischemic and hemorrhagic stroke: a stereological and clinical study. The International journal of neuroscience, 2009, Volume: 119, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Brain; Brain Ischemia; Disability Evaluation; Female; Fibrinogen; Humans; Intracranial Hemorrhages; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Prognosis; Stroke; Time Factors; Young Adult	2009
Congenital Afibrinogenemia presenting as antenatal intracranial bleed: a case report. Italian journal of pediatrics, 2010, Jan-05, Volume: 36 Topics: Afibrinogenemia; Diagnosis, Differential; Female; Fibrinogen; Humans; Infant, Newborn; Intracranial Hemorrhages; Magnetic Resonance Imaging; Tomography, X-Ray Computed	2010
Spontaneous intracranial bleeding in a neonate with congenital afibrinogenemia. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2010, Volume: 21, Issue:6 Topics: Afibrinogenemia; Family; Fibrinogen; Humans; Infant, Newborn; Intracranial Hemorrhages; Male	2010
Characteristics, management and outcomes of adults with major trauma taking pre-injury warfarin in a Western Australian population from 2000 to 2005: a population-based cohort study. The Medical journal of Australia, 2010, Aug-16, Volume: 193, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Blood Coagulation Factors; Causality; Cohort Studies; Factor VIII; Female; Fibrinogen; Hemorrhage; Humans; Intracranial Hemorrhages; Male; Middle Aged; Plasma; Registries; Treatment Outcome; Vitamin K; Warfarin; Western Australia; Wounds and Injuries	2010
[The prognostic significance of fibrinogen concentration in patients with ischemic stroke without thrombolytic treatment]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010, Volume: 110, Issue:12 Pt 2 Topics: Aged; Cerebral Hemorrhage; Female; Fibrinogen; Humans; Intracranial Hemorrhages; Male; Middle Aged; Prognosis; Stroke; Thrombolytic Therapy	2010
Prognosis analysis and risk factors related to progressive intracranial haemorrhage in patients with acute traumatic brain injury. Brain injury, 2012, Volume: 26, Issue:9 Topics: Adult; Aged; Antifibrinolytic Agents; Brain Injuries; Cohort Studies; Disease Progression; Female; Fibrin Fibrinogen Degradation Products; Fibrinogen; Glasgow Coma Scale; Humans; Intracranial Hemorrhages; Logistic Models; Male; Middle Aged; Partial Thromboplastin Time; Prognosis; Retrospective Studies; Risk Factors; Thrombin Time; Tomography, X-Ray Computed	2012
Central venous catheter-related thrombosis after replacement therapy for intracranial bleeding in a patient with afibrinogenaemia. Haemophilia : the official journal of the World Federation of Hemophilia, 2008, Volume: 14, Issue:1 Topics: Adult; Afibrinogenemia; Anticoagulants; Catheterization, Central Venous; Female; Fibrinogen; Humans; Intracranial Hemorrhages; Thrombosis; Treatment Outcome	2008
Clinical efficacy and recovery levels of recombinant FVIIa (NovoSeven) in the treatment of intracranial haemorrhage in severe neonatal FVII deficiency. Haemophilia : the official journal of the World Federation of Hemophilia, 2000, Volume: 6, Issue:1 Topics: Antigens; Blood Coagulation Tests; Factor VII; Factor VII Deficiency; Factor VIIa; Fibrin Fibrinogen Degradation Products; Fibrinogen; Hematoma; Hemostasis; Hispanic or Latino; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intracranial Hemorrhages; Male; Platelet Count; Protamines; Prothrombin; Recombinant Proteins; Vitamin K	2000
Activation of coagulation in C57BL/6 mice given verotoxin 2 (VT2) and the effect of co-administration of LPS with VT2. Thrombosis research, 2000, Oct-01, Volume: 100, Issue:1 Topics: Animals; Antithrombin III; Blood Coagulation; Blood Coagulation Tests; Brain; Cytokines; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fibrinogen; Hemorrhage; Intracranial Hemorrhages; Kidney; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Models, Animal; Neutrophils; Peptide Hydrolases; Plasminogen Activator Inhibitor 1; Platelet Count; RNA, Messenger; Shiga Toxin 2; Shock; Thromboplastin; Time Factors; Tissue Distribution	2000
Spontaneous intracranial bleeding in two patients with congenital afibrinogenaemia and the role of replacement therapy. Haemophilia : the official journal of the World Federation of Hemophilia, 2000, Volume: 6, Issue:6 Topics: Adult; Afibrinogenemia; Fibrinogen; Humans; Infant, Newborn; Intracranial Hemorrhages; Male	2000
[Acute phase response after stroke: differences between ischemic stroke and intracerebral hemorrhage]. Medicina clinica, 2001, Jan-20, Volume: 116, Issue:2 Topics: Acute-Phase Reaction; Aged; Brain Infarction; Female; Fibrinogen; Humans; Intracranial Hemorrhages; Leukocytes; Male; Stroke	2001
Intracranial hemorrhage at the onset of thrombotic thrombocytopenic purpura in an infant: therapeutic approach and intensive care management. Pediatric emergency care, 2001, Volume: 17, Issue:1 Topics: Critical Care; Emergency Treatment; Erythrocyte Transfusion; Exchange Transfusion, Whole Blood; Female; Fibrinogen; Hemoglobins; Humans; Infant; Intracranial Hemorrhages; Leukocyte Count; Magnetic Resonance Imaging; Partial Thromboplastin Time; Plasma; Prothrombin Time; Purpura, Thrombotic Thrombocytopenic; Time Factors; Tomography, X-Ray Computed; Treatment Outcome	2001
Increased risk for postoperative hemorrhage after intracranial surgery in patients with decreased factor XIII activity: implications of a prospective study. Stroke, 2002, Volume: 33, Issue:6 Topics: Comorbidity; Factor XIII; Factor XIII Deficiency; Female; Fibrinogen; Germany; Humans; Incidence; Intracranial Hemorrhages; Intraoperative Period; Male; Middle Aged; Neurosurgical Procedures; Partial Thromboplastin Time; Platelet Count; Postoperative Hemorrhage; Postoperative Period; Prospective Studies; Prothrombin Time; Risk Assessment	2002