fibrin has been researched along with Waldenstrom-Macroglobulinemia* in 4 studies
4 other study(ies) available for fibrin and Waldenstrom-Macroglobulinemia
| Article | Year |
|---|---|
Abnormal clot retraction, altered fibrin structure, and normal platelet function in multiple myeloma.
Clot retraction, measured by serum expression, is absent in some cases of multiple myeloma. Decreased clot retraction has been attributed to platelet dysfunction. A new instrument allows simultaneous measurement of platelet-mediated force development during clot retraction and of clot elastic modulus. We report 10 patients with immunoglobulin (Ig) G myeloma in whom the abnormalities of fibrin structure were quantitatively defined and platelet-fibrin interactions were assessed. Fiber mass-to-length ratios were calculated from gel turbidity. Platelet force development and clot elastic modula were measured in platelet-rich plasma gels. Fiber mass-to-length ratios for IgG myeloma patients were smaller (means +/- SE) (0.98 +/- 0.19 x 10(13) Da/cm) than for normal controls (1.36 +/- 0.06 x 10(13) Da/cm), indicating thinner fiber formation. Elastic modula of myeloma clots (51,013 +/- 14,660 dyn/cm2) were strikingly larger than modula for normal controls (23,355 +/- 1,887 dyn/cm2), indicating that such clots are mechanically less flexible. Platelet force development 1,200 s after thrombin addition was not diminished in myeloma patients (8,315 +/- 1,155 dyn) vs. controls (6,906 +/- 606 dyn). Abnormal clot retraction in myeloma appears to be primarily due to altered clot structure rather than platelet dysfunction. Topics: Aged; Blood Coagulation; Blood Platelets; Clot Retraction; Elasticity; Electrophysiology; Fibrin; Humans; Immunoglobulin G; Male; Middle Aged; Multiple Myeloma; Reference Values; Waldenstrom Macroglobulinemia | 1994 |
[Pathogenesis of purpura in Waldenstrom's disease].
Topics: Aged; Complement System Proteins; Cryoglobulins; Female; Fibrin; Humans; Immunoglobulin M; Middle Aged; Purpura; Waldenstrom Macroglobulinemia | 1978 |
[Structure of the fibrin clot in a patient with macroglobulinemia (author's transl)].
Topics: Fibrin; Hemorrhagic Disorders; Humans; Male; Microscopy, Electron; Middle Aged; Waldenstrom Macroglobulinemia | 1976 |
[Dysproteinemic diseases and hemorrhagic tendency].
Topics: Afibrinogenemia; Aged; Blood Coagulation Tests; Blood Platelets; Blood Protein Disorders; Factor VIII; Female; Fibrin; Hemorrhagic Disorders; Humans; Immunoglobulin G; Japan; Male; Middle Aged; Multiple Myeloma; Thromboplastin; Waldenstrom Macroglobulinemia | 1971 |