fibrin and Varicose-Veins

Topics: Antigens; Body Weight; Fibrin; Humans; Postoperative Complications; Prognosis; Risk; Serum Globulins; Thrombophlebitis; Time Factors; Varicose Veins

Topics: Abdomen, Acute; Blood Platelets; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Fibrin; Hematemesis; Humans; Hypertension, Portal; Ligation; Liver Cirrhosis; Male; Middle Aged; Pressure; Rupture, Spontaneous; Treatment Outcome; Varicose Veins

Topics: Blood Coagulation; Endothelium, Vascular; Endovascular Procedures; Fibrin; Fibrosis; Hot Temperature; Humans; Laser Therapy; Varicose Veins

Postoperative heparin prophylaxis after stripping of the long saphenous vein is a matter of controversial discussion, and practices vary by surgeon and country.. The aim of this study was to assess the extent of hypercoagulability by continued monitoring of activation markers of coagulation and fibrinolysis for a period of 3 weeks after stripping of the long saphenous vein and concomitant phlebectomy.. Including 21 patients, the following markers were measured preoperatively and on postoperative day 1, 2, 3, 7, 14, and 21: Activation products of coagulation: thrombin-antithrombin complex (TAT), thrombus precursor protein (TPP), and prothrombin-fragment F1+2 (F1+2), and markers of fibrinolysis: plasmin-alpha(2)-antiplasmin complexes (PAP), D-Dimer, tissue plasminogen activator (t-PA) antigen, and plasminogen activator inhibitor 1 (PAI-1) antigen.. TAT levels increased significantly until day 3 (p=.008) and normalized within 14 days. TPP levels increased significantly until day 7 (p=.02), decreasing to initial values within 21 days. PAP complexes increased significantly until day 2 (p=.02) reducing to baseline within the observation period. D-Dimer levels increased immediately after surgery (p<.001) until day 14 (p<.001) and returned to baseline until day 21.. Significant hemostatic activation after varicose vein surgery was observed and persisted until 3 weeks postoperatively, indicating that heparin prophylaxis for 2 to 3 weeks is advisable for at-risk patients.

Topics: Adult; alpha-2-Antiplasmin; Anesthesia, General; Female; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinolysin; Fibrinolysis; Humans; Male; Middle Aged; Monitoring, Physiologic; Peptide Fragments; Postoperative Period; Prothrombin; Saphenous Vein; Varicose Veins

Topics: Catheter Ablation; Equipment Design; Fibrin; Humans; Laser Therapy; Varicose Veins

Clearance of subcutaneous 125I-labelled fibrin was prolonged from the legs but not from the arms of patients with uncomplicated varicose veins and patients with healed ulcers, compared with controls. The euglobulin clot lysis time (ECLT) of blood from the arms and legs of those with healed ulcers was prolonged; venous congestion significantly shortened the ECLT of blood from all limbs except legs with healed ulcers. The clearance of interstitial fibrin of both legs and arms correlated with the response of the ECLT to venous congestion (P less than 0.05). The clearance of interstitial 125I-labelled albumin in five patients with healed ulcers was faster from the legs than from the arms, whereas the clearance of interstitial 125I-labelled fibrin was faster from the arms in all cases. These results suggest that there is a defect in interstitial fibrinolytic activity as well as vein wall production of plasminogen activator in legs with chronic venous insufficiency.

Topics: Arm; Fibrin; Fibrinolysis; Humans; Leg; Serum Albumin; Varicose Ulcer; Varicose Veins; Venous Insufficiency

A prospective study was carried out to confirm the validity of a predictive index for patients at risk of developing deep vein thrombosis. The index, which correctly identified nine out of 10 patients and incorrectly identified seven out of 52 patients as being at risk, is based on five variable--namely, the euglobulin lysis time, serum concentration of fibrin-related antigen, age, percentage overweight for height, and presence of varicose veins. Thus a population of patients at particularly high risk of developing postoperative deep vein thrombosis may be identified preoperatively by means of this index, so that prophylaxis may be used more rationally.

Topics: Adult; Aged; Antigens; Blood Coagulation Tests; Body Weight; Female; Fibrin; Humans; Postoperative Complications; Risk; Serum Globulins; Thrombophlebitis; Varicose Veins

Rabbit anti-human fibrin globulin (A.F.G.) was labelled with iodine (131I) and used as a thrombus-detecting agent. 131I-A.F.G. labelled thrombi were displayed by means of a gamma scintillation camera. Normal subjects and patients with thrombophlebitis of legs, acute fibrin depositions other than thrombi, and chronic varicosities were examined. The 131I-A.F.G. technique detected both formed thrombi and those that were forming and could discriminate between acute thrombosis and chronic varicosities. Thrombophlebitis and extravascular fibrin depositions were best demonstrated between 24 and 27 hours of 131I-A.F.G. injection. Radiolabelled A.F.G. in normal veins and chronic varicosities was best displayed within 6 hours of injection.

Topics: Acute Disease; Animals; Antibodies; Chronic Disease; Diagnosis, Differential; Female; Fibrin; Humans; Immunodiffusion; Iodine Radioisotopes; Isotope Labeling; Middle Aged; Rabbits; Radionuclide Imaging; Thrombophlebitis; Time Factors; Varicose Veins

A range of clinical data was obtained from 124 patients about to undergo operation and several coagulation tests were performed. No patient received prophylaxis for deep vein thrombosis, and isotopic scanning after operation showed that 20 patients had developed thrombosis. a simiple prognostic index for predicting which patients would develop postoperative deep vein thrombosis was constructed using the clinical and coagulation data obtained before operation. The five variables with the best predictive power-euglobulin lysis time, age, presence of varicose veins, fibrin related antigen, and percentage overweight-produced an equation that identfied 95% of those who developed deep vein thrombosis and misallocated only 28% of those who did not develop thrombosis. In view of the complications that low-dose heparin and dextran can cause, giving prophylaxis to under a third of the patients who will not develop deep vein thrombosis is clearly better than giving it to all.

Topics: Adult; Age Factors; Antigens; Body Weight; Fibrin; Humans; Middle Aged; Postoperative Complications; Prognosis; Serum Globulins; Thrombophlebitis; Varicose Veins

Topics: Adhesiveness; Blood Platelets; Erythrocytes; Fibrin; Humans; Microscopy, Electron, Scanning; Thrombophlebitis; Varicose Veins