fibrin and Uveitis--Anterior

To describe the occurrence and associated factors for "fibrin web" (FW) formation following phacoemulsification in dogs.. A retrospective review of medical records of all dogs undergoing phacoemulsification (MU-Veterinary Health Center, 2014-2018) was conducted to associate FW formation with signalment, systemic co-morbidities, cataract stage, surgeon (resident vs faculty), phacoemulsification time, IOL, and intracameral injections including viscoelastic type. Both univariate and multivariate statistical analyses were performed to evaluate associations among variables with FW formation.. Data from 398 eyes on 201 dogs were included; 4 left eyes (4 dogs) developed presumptive endophthalmitis and were excluded from further analysis. Forty-eight eyes did not have cataract surgery. Hence, 350 eyes on 201 dogs were included in the analyses. Among these, 84 eyes (59 dogs) developed a FW. Univariate analyses showed that the odds of FW increased with age and phacoemulsification time. Additionally, FW web was associated lens type, lens brand, and viscoelastic type. Multivariate analyses showed that when comparing lens types in combination with a particular viscoelastic, viscoelastic impacted the estimated prevalence of FW formation the most. In contrast, when the data were analyzed by lens brand, lens brand impacted prevalence more than viscoelastic type. Diabetes mellitus was not associated with FW formation.. Based on the available data, intraocular lens implantation, viscoelastic type, dog age, and phacoemulsification time were associated with FW formation. Diabetes mellitus, gender, cataract stage, surgeon, intracameral injections other than viscoeleastic, and intra- and postoperative complications were not associated with FW formation.

Topics: Animals; Cataract; Dogs; Female; Fibrin; Male; Phacoemulsification; Retrospective Studies; Uveitis, Anterior

The aim of this study was to report a case of severe bilateral fibrinous anterior uveitis following pamidronate therapy in a patient on latanoprost.. This study is presented as an interventional case report.. Clinical examination showed bilateral severe fibrinous uveitis following an intravenous infusion of disodium pamidronate. Ocular signs and symptoms responded to stopping latanoprost and treatment with oral prednisolone (60 mg) and hourly topical prednisolone acetate 1%. The reintroduction of latanoprost resulted in a recurrence, which was stopped with subsequent improvement.. Mild anterior uveitis is an unfamiliar adverse effect of pamidronate therapy. However, severe fibrinous uveitis has not been previously described. This may be due to the compounding effect of latanoprost. This case highlights the importance of history taking and awareness of the otherwise uncommon side effect of this commonly prescribed medication.

Topics: Acute Disease; Administration, Topical; Aged, 80 and over; Anti-Inflammatory Agents; Bone Density Conservation Agents; Diphosphonates; Drug Interactions; Female; Fibrin; Glaucoma, Open-Angle; Humans; Infusions, Intravenous; Latanoprost; Osteoporosis, Postmenopausal; Pamidronate; Prednisolone; Prostaglandins F, Synthetic; Recurrence; Uveitis, Anterior

This study objectively compares efficacy of dexamethasone Na phosphate 0.1%, fluorometholone 0.1% (FML), loteprednol etabonate 0.5% (Lotemax [LE]; Bausch & Lomb Pharmaceuticals, Inc., Tampa, FL), prednisolone acetate 1% (Pred Forte [PRED F]; Allergan Pharmaceuticals, Irvine, CA), and generic prednisolone acetate 1% (PRED A). These steroids were administered for 24 hours or 72 hours to New Zealand white rabbits with endotoxin-induced uveitis. Intraocular pressure (IOP), slit-lamp examination, and confocal microscopy were performed daily. Internalization of the glucocorticoid receptor (GC) was assayed in iris tissue by Western blot, and protein in aqueous humor by Bradford assay. Only LE and PRED F treatments significantly internalized GC receptor after 72 hours of treatment. Only LE and PRED A reduced protein concentration between 24 hours and 72 hours of treatment. All drugs improved clinical signs after 24 hours of treatment. None of the steroids promoted return of the inflammation-induced corneal thickness to baseline. While none returned IOP to baseline, LE was most effective. Confocal microscopy indicated that only treatment with LE reverted the abnormal endothelial-cell shape to normal. In conclusion, all steroid treatments reduced uveitis to some degree but LE was consistently effective. A longer observation period may be required to document the return of IOP and corneal thickness to baseline values.

Topics: Acute Disease; Administration, Topical; Androstadienes; Animals; Aqueous Humor; Blotting, Western; Conjunctiva; Corneal Stroma; Dexamethasone; Endothelium, Corneal; Eye Proteins; Fibrin; Fluorometholone; Glucocorticoids; Intraocular Pressure; Lipopolysaccharides; Loteprednol Etabonate; Male; Particle Size; Prednisolone; Rabbits; Receptors, Glucocorticoid; Suspensions; Time Factors; Uveitis, Anterior; Vitreous Body

The endothelial cells of both eyes of 60 unilateral iridocyclitic patients were photographed with a specular microscope to establish the possible effect of iridocyclitis on corneal endothelial cells. Chronic severe iridocyclitis with mutton-fat keratic precipitates (KP) lowered the central endothelial cell count. Five patients out of the seven with mutton-fat KPs had a distinctly lower central cell density in the affected eye. In the remaining patients, no significant difference in cell densities could be demonstrated between affected and healthy eyes. Neither the inflammatory process itself nor the round white KPs had a deleterious effect on the central corneal endothelial cell densities.

Topics: Adolescent; Adult; Age Factors; Aged; Aqueous Humor; Cell Count; Child; Chronic Disease; Cornea; Endothelium; Female; Fibrin; Humans; Male; Microscopy; Middle Aged; Photography; Recurrence; Time Factors; Uveitis, Anterior

Topics: Animals; Aqueous Humor; Basement Membrane; Biological Transport; Capillary Permeability; Carbon; Ciliary Body; Endotoxins; Epithelium; Escherichia coli; Female; Fibrin; Hyperemia; Iris; Male; Microscopy, Electron; Rabbits; Serum Albumin, Radio-Iodinated; Time Factors; Uveitis, Anterior