fibrin and Tuberculosis

In this report, we present a 68-year-old man with rice body formation in the flexor tendon sheath of the fingers without any inflammatory diseases such as tuberculosis or rheumatoid arthritis. The patient visited our institute in March 2004 with a one-month history of swelling and pain of the right distal forearm. Laboratory data were within normal limits, and the rheumatoid factor was negative. He had no history of tuberculosis, and the tuberculin reaction was weakly positive. Magnetic resonance (MR) images showed a mass measuring 6 cm x 4 cm around the flexor tendons of the forearm. Many rice bodies had been erupted from a small hole of the fibrous wall of the mass at the time of incisional biopsy performed in June 2004. Histological diagnosis was synovitis with fibrous loose bodies. In July 2004, spontaneous ruptures of the right fourth and fifth flexor tendons occurred. Open repair was performed in August 2004. The patient regained good function of the operated fingers with no evidence of recurrence at the latest follow-up in March 2009.

Topics: Aged; Fibrin; Humans; Magnetic Resonance Imaging; Male; Tenosynovitis; Tuberculosis

The fibrinolytic system is known to play an important role in the inflammatory response to bacterial infections. In the present study, relationships between protein components of the fibrinolytic system and infectivity by Mycobacterium avium were analyzed. Infections were initiated through noninvasive intratracheal administration of M. avium 724 in mice individually deficient for plasminogen, tissue-type plasminogen activator, urokinase-type plasminogen activator, and urokinase-type plasminogen activator receptor, along with wild-type control mice. There were no differences in lung colony counts among all mouse genotypes throughout a 10-week infection. However, in tissue-type plasminogen activator and plasminogen-deficient mice an earlier dissemination of M. avium to other organs was observed. Nevertheless, the M. avium growth rates in the liver, spleen, and lung did not differ between the various mouse populations throughout a 10-week infection. Histochemical and immunohistochemical analyses at 5 and 10 weeks after infection demonstrated that plasminogen-deficient mice, compared to wild-type mice, had enhanced fibrin and fibronectin deposition, as well as increased neutrophil infiltration within liver granulomas. These results suggest that plasmin(ogen) plays a role in the turnover of extracellular matrix proteins within granulomas and has a limited effect in the early dissemination of M. avium from lungs. Thus, plasmin(ogen) functions in limiting progressive fibrosis in the granuloma during a chronic mycobacterial infection.

Topics: Animals; Colony Count, Microbial; Cytokines; Extracellular Matrix Proteins; Fibrin; Fibrinolysis; Fibronectins; Liver; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Mycobacterium bovis; Neutrophils; Plasminogen Activators; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Spleen; Tissue Plasminogen Activator; Tuberculosis; Urokinase-Type Plasminogen Activator

The first evidence of the interaction of Mycobacterium tuberculosis with the plasminogen system is herein reported. By FACScan analysis and affinity blotting, lysine-dependent binding of plasminogen to M. tuberculosis was demonstrated. The binding molecules were 30-, 60-, and 66-kDa proteins present in cell wall and soluble protein extracts. The activation of plasminogen, which occurred only in presence of fibrin and was not inhibited by the host serpin, alpha(2)-antiplasmin, was also demonstrated.

Topics: alpha-2-Antiplasmin; Fibrin; Humans; In Vitro Techniques; Mycobacterium tuberculosis; Plasminogen; Protein Binding; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tuberculosis

Topics: Aged; Fibrin; Humans; Lung; Plasminogen; Recurrence; Tuberculosis

Topics: Aged; Aminosalicylic Acids; Antibodies; Antigen-Antibody Reactions; Binding Sites; Binding, Competitive; Blood Coagulation; Blood Coagulation Tests; Calcium; Enzyme Activation; Factor XIII; Female; Fibrin; Hemorrhage; Humans; Isoniazid; Male; Middle Aged; Peptides; Tuberculosis

Topics: Adenocarcinoma; Adenoma; Adrenal Gland Neoplasms; Breast Diseases; Breast Neoplasms; Female; Fibrin; Fluorescent Antibody Technique; Genital Neoplasms, Female; Hodgkin Disease; Humans; Lymph Nodes; Lymphatic Diseases; Melanoma; Methods; Neoplasms; Neoplasms, Nerve Tissue; Ovarian Neoplasms; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Tuberculosis

Topics: Adrenal Cortex Hormones; Antitubercular Agents; Drug Therapy; Fibrin; Focal Infection; Lymphocytes; Tuberculosis; Tuberculosis, Pulmonary

In a study of caseous pulmonary nodules, it was found possible to identify the cellular and connective tissue background of the caseous material. In the absence of liquefaction, the connective tissues were found to retain their reaction to special stains indefinitely, and fibrin could be identified for periods up to one year after the onset of caseation. This allowed recognition of the part of lung involved and of pathological changes which had preceded caseation. Identification of the site of the suppurative "focus" in the respiratory bronchiole was important because bacilli could be found there most readily. Though lesions often outlined the acinus with clarity, the only value of the term "acinar" was to define the limits of one particular lesion.

Topics: Coloring Agents; Connective Tissue; Elastin; Fibrin; Granulation Tissue; Humans; Lung; Pathology; Staining and Labeling; Terminology as Topic; Tuberculosis; Tuberculosis, Pulmonary

Topics: Fibrin; Humans; Orthopedic Equipment; Resins, Synthetic; Resorcinols; Surgical Procedures, Operative; Tissue Adhesives; Tuberculosis; Tuberculosis, Osteoarticular

Topics: Blood Coagulation; Cerebrospinal Fluid; Fibrin; Hemophilia A; Medicine; Tuberculosis; Tuberculosis, Meningeal

Topics: Arthritis; Arthroplasty; Fibrin; Humans; Tuberculosis; Tuberculosis, Osteoarticular

Topics: Arthritis; Arthroplasty; Fibrin; Humans; Tuberculosis; Tuberculosis, Osteoarticular

Topics: Animals; Collapse Therapy; Fibrin; Lung; Porifera; Tuberculosis; Tuberculosis, Pulmonary

Topics: Fibrin; Fibrinolysis; Humans; Lymph Nodes; Neoplasms; Research; Tuberculosis; Tuberculosis, Lymph Node

Topics: Fibrin; Tuberculosis; Tuberculosis, Pulmonary

Topics: Blindness; Deoxyribonuclease I; Fibrin; Humans; Streptodornase and Streptokinase; Streptokinase; Tuberculosis; Tuberculosis, Meningeal

Topics: Fibrin; Streptomycin; Tuberculosis; Tuberculosis, Pulmonary

Topics: Blood; Fibrin; Fibrinolysin; Humans; Meninges; Tuberculosis; Tuberculosis, Meningeal

Topics: Blood; Fibrin; Tuberculosis